5NUG,3VKG


Conserved Protein Domain Family
DHC_N2

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pfam08393: DHC_N2 
Dynein heavy chain, N-terminal region 2
Dyneins are described as motor proteins of eukaryotic cells, as they can convert energy derived from the hydrolysis of ATP to force and movement along cytoskeletal polymers, such as microtubules. This region is found C-terminal to the dynein heavy chain N-terminal region 1 (pfam08385) in many members of this family. No functions seem to have been attributed specifically to this region.
Statistics
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PSSM-Id: 400618
View PSSM: pfam08393
Aligned: 563 rows
Threshold Bit Score: 52.6661
Threshold Setting Gi: 167526770
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5NUG_A        1319 VQVal----eeL-QDLKGVWSELSKV----WE---QIDQmkeqpwvsvQPRKLRQNLD--ALL-NQL---K--------- 1371
EAY20035       835 LSNik----sdF-DMLLPAWSIAVEI----DT---TAQDwfgtifkqlDVQMISDTVV--EWE-NTL---Kklmedieaa 896  Trichomonas ...
EGD80062      1651 adTil----eqI-DLLTDCWQRMREW----DA---RFEQwmplplaqlDLEEMNAFVS--SFL-NAL---Thaqht---- 1708 Salpingoeca ...
XP_001747718   801 VETte----trL-QLLKTCYSLFHESeaarQAlv------------khDIASLQIDA----------------------- 840  Monosiga bre...
53_pfamImport    1 LNAla----veL-KLKSELWEAVCEA----DE---HLEAcstdtirsvDLDTMGVVASrvDRVvENI---R--------- 56  
EEY54935        32 LHDla----aeL-KLKSELWEAVCEA----DG---HLSAcsgdtirsvDLDKMNDVAShvDLVvENI---R--------- 87   Phytophthora...
XP_001318628   692 FDEtklfegrrLsNCLMKLWVSTKEY----SMeneKIAGtqi---gliDTEEISKKFE--KWVgS-I------------- 748  Trichomonas ...
XP_003110956   630 MRLfv----geI-ESLQSLFVATSGY----YK---HVNAffesrrtlvNIDASRNFIE--QFTvQ--------------- 680  Caenorhabdit...
CAP35738       610 MRHfv----geI-ESLESLFVATSGY----YK---HVNAffesrrtlvNIDASRNFIE--QFTiQ--------------- 660  Caenorhabdit...
XP_002110236   958 LTAil----knI-DIRQEMWKYIEVS----EG---RIRDwmntsfyklDVTKLIHKVN--EWKnASVqlrN--------- 1014 Trichoplax a...
5NUG_A        1372 S-------------FP--A-Rlrq---yaSYEFV--------QRL--------LK----GYMK-INMLVIEL-KSEALKD 1410
EAY20035       897 KnqdrhkkflregvHP--LeA--------PYKEL--------QAR--------VQ----YILM-HIPIIRYI-CNPNYRQ 944  Trichomonas ...
EGD80062      1709 ----------lsttFA--KiA--------TYTNK--------AAD--------AS----LLL----DISEMV-RSPWFGQ 1743 Salpingoeca ...
XP_001747718   841 -----------------------------ATAQLd------gMEQtwgschvqLS---------DAPVLQHVaKNLHF-A 875  Monosiga bre...
53_pfamImport   57 Q----------------------------CSAQVvgafeldrLEK--------LQ----ATLHgLAPVIRDL-RNPHLAE 95  
EEY54935        88 Q----------------------------CATQVassfelerLEK--------LQ----ATLHgLVPVIRDL-RNPHLVE 126  Phytophthora...
XP_001318628   749 ------------------NdAcdglkefqIPRNI--------AIL--------VEsnvkEFKS-YIPIINAL-SSIYLRN 792  Trichomonas ...
XP_003110956   681 --------------LSvfEsSlat---hrAAKHFia----yaRNE--------VD----TFKK-NFSVAEVMsCRRLL-D 725  Caenorhabdit...
CAP35738       661 --------------LSifEsSltt---hrAAKHFia----yaRNE--------VD----SFKK-NFSVAEVMsCRRLL-D 705  Caenorhabdit...
XP_002110236  1015 Q-------------LPigD-R--------VLDYW--------KKS--------LV----DIER-HTPFLAKL-STKSLKA 1050 Trichoplax a...
5NUG_A        1411 RHWKQLMKRLhv--------------nwVV----SELTLGQIWDVDLqkN--EAIVKDVLLVAQGEMALEEFLKQIREVW 1470
EAY20035       945 RHWKQISETAg-----------------FQigpnDDYTWNWLIEFGV--EqhIIAIASISKAATNEAKIEIAIAQMCDDL 1005 Trichomonas ...
EGD80062      1744 RYVRRTSVLVv-----------------LNid-vnITTYGYLHASKP--PqrVEALEDLFVQAEEEQRREQQWKELNEKW 1803 Salpingoeca ...
XP_001747718   876 HQWLQVVELCqtpeleeee-ldsirdvlAIpkrwEDILVADLIQAGA--LakKPSVVKLVEKARARHLFVAHVAAIAE-W 951  Monosiga bre...
53_pfamImport   96 RHWSKLEHKMqcslvsivvetaansevpATldstDSTETLQLLDANA--VayGTTIRHVSEEASAEAAMAGSFLSVVRTW 173 
EEY54935       127 RHWSKLEHKLqcsl-----------lpsIMq---------QLLDVNV--VahASAIRHVSEEASAEAAIAGSFQSLVRTW 184  Phytophthora...
XP_001318628   793 RHWTMINDLFk-----------------LDhpldQSATLYYLIDIIV--LnkEKEIMDIVKIAENEYILEDFLDGIIASF 853  Trichomonas ...
XP_003110956   726 AHWLRMSEIVg-----------------FDltpyANSSIAQICELGL--EahLQQLKPIAFSAEREATAADQLHSIVTFW 786  Caenorhabdit...
CAP35738       706 AHWLRMSEIVg-----------------FDltpyANSSIAQICELGL--EahLQQLKPIAFSAEREATAADQLHAIVTFW 766  Caenorhabdit...
XP_002110236  1051 RHWKDIFIGIg-----------------QPydstWLFTTKELLSFDL--ElhTSLINSVVARADAEFALEGSFQQICKVW 1111 Trichoplax a...
5NUG_A        1471 NT----------YE---LDLVNYQNKc------------------------------rLIRG--WDDLFNK--V------ 1497
EAY20035      1006 QK----------LR---FKVTKTEHGi-------------------------------HLDDpaTALL-----Llakhqq 1036 Trichomonas ...
EGD80062      1804 DS----------MV---LPIKRQg----------------------------------------STLLGRDayLlenvsa 1830 Salpingoeca ...
XP_001747718   952 LRtelveteirgSAlhgMr---------------------------------------TLAVanLGSLLRQ--T------ 984  Monosiga bre...
53_pfamImport  174 EA----------QE---IPVESKKDRdgr--------------------------dvfCIGD--CIELTSL--I------ 204 
EEY54935       185 KS----------QN---IPIEARKDRdgr--------------------------dayCIGD--CSELTSL--I------ 215  Phytophthora...
XP_001318628   854 YDwtfsitlfncSN---F----------------------------------------------IKEGISR--L------ 876  Trichomonas ...
XP_003110956   787 SQ----------EH---LEMRFHVQWk-------------------------------LSLAvkLRDLHSR--V------ 814  Caenorhabdit...
CAP35738       767 SQ----------EH---LEMRFHSQWk-------------------------------LSLAvkLRDLYRR--V------ 794  Caenorhabdit...
XP_002110236  1112 ED----------KK---LQLTKHIPIvqvsnvnqtpmstdsnvneiakqdsrmdddalVLMG--VEELKVQ--L------ 1168 Trichoplax a...
5NUG_A        1498 -KEHI-------NSVSAMKLS-PYYkVFEEDALSWEDKLNRIMALFDVWIDVQRR--WVYLEGIFTG-----SadiKHLL 1561
EAY20035      1037 iMQEIfvppyiqPFISKVKEY-ELL---AANTRQILKQSIETEERINELQPAMEStdLKTQHSKMTNffe----dkVKDF 1108 Trichomonas ...
EGD80062      1831 lRDEIvhaemvlLNLSRSDAS-PEL---KSKARALHEKITTFEQRLSQWEDCERA--WSRVHAPMTAgln----nnSEEF 1900 Salpingoeca ...
XP_001747718   985 -VNRR-------ADLRQLLKS-SYRtV-QSGITELSRRTNRTFEILTDLQSLQDN--WMALQSl------------RSLF 1040 Monosiga bre...
53_pfamImport  205 -EESQ-------VLLRVMDLS-TYSlVVQERLPKMLHDLEHTKESLELLQMCQRK--WDYTQRLVSI-----Df--ARTF 266 
EEY54935       216 -EESQ-------VLLRVMELS-TYSlVVEERLPKMMSQLNHTNESLELLLICQRK--WDYTQRLVSI-----Df--ARTF 277  Phytophthora...
XP_001318628   877 -QDQM-------RDLRKVKKS-NFKnLFLQKIEKHENFVTQMQDFVTLLRKIYNL--YLYQNDFMEA---------EDTI 936  Trichomonas ...
XP_003110956   815 -QTDI-------NTLKHMTNVeQIT---DDSLPQWIEWTCRTETILKAWCETQQK--WMRVANIFVTcrdtlQv--SFDS 879  Caenorhabdit...
CAP35738       795 -QNDI-------NTLKHMTNVeQIT---DDSLPQWTEWTARAETILKAWCETQQK--WMRVANIFVTcrdtlQv--KNLF 859  Caenorhabdit...
XP_002110236  1169 -EDHQ-------ITLRGMLVS-SHLaDLRYQVEAWSTMLQQLNEIIDSWSNCQQK--WLLLYNVFQR-----Kr-iKTDL 1231 Trichoplax a...
5NUG_A        1562 PVETQ---RFQSISTEFL-A--LMkkvsksplvmdvlniqgvqrslerladllgkiqkal------------geylerer 1623
EAY20035      1109 SNFAT---NFKLSATFHM----ILsnqstadecnsiaqdlvkvrdqlqdvlem-------------------------kr 1156 Trichomonas ...
EGD80062      1901 AHAVT---IYKSTMRQWR----ALcqlgyrsehvlrdlcspevgqrlaeyhhqfqecysl-----------liatvdays 1962 Salpingoeca ...
XP_001747718  1041 KRHQSvakAFEHFKCQWVpVaqTIekspvlgqlsdamvreqltacrtawhtlqeri-------------------sdavg 1101 Monosiga bre...
53_pfamImport  267 PEQAK---QLQKYDGAWRsltlglynrslclpfgvspehrqalkgilegfeaaak---------------tladhllikr 328 
EEY54935       278 PDQAK---QLQKHDTLWRaltlglfnrpqclpfggstehrqslvqvlegfeaaak---------------ilaehleikr 339  Phytophthora...
XP_001318628   937 SHQYSfylTFGDIKSNLT-D--LLskctccvlsismtekleviydkirelkekiypy------------------lqnrr 995  Trichomonas ...
XP_003110956   880 NIQQD---LYYLLQKEYE----LLrtcakyfikiernvvkdatiyrvmqlphlpcwiekirkmvvv---iiqgvrglldg 949  Caenorhabdit...
CAP35738       860 NVTQK---SEELFTEGIR----ITenlcqifpnhreerskrcdhlssdattpfalldrenpfn----------vrglldg 922  Caenorhabdit...
XP_002110236  1232 SKQYQ---EFEKINSGYK-D--FLrsvvenpkvlnlvnrrrsqkahkdvhgenllqllfnysdtqdqiikhlyflleear 1305 Trichoplax a...
5NUG_A        1624 ssfprfyfvgdedlleiignsknvaklQKH-FK-KMFAGVSSIILNEdn----------------------svVlGISSR 1679
EAY20035      1157 kafprfrllsdsqliqvisngetpskiPTI-FS-LMYPSIASAVFESnt----------------------ycL-GFNSQ 1211 Trichomonas ...
EGD80062      1963 vtctrlymltppevlqlvgqarslhsiKPL-IC-KCFSDVSDLLLAEgr----------------------kiD-GLLAP 2017 Salpingoeca ...
XP_001747718  1102 qlrsvapvlfalpkgtiaasvglpavdQAHaLLpQLWTAVRHLVVADrd-----------------------lS-GLCCH 1157 Monosiga bre...
53_pfamImport  329 qvfpaffklsdlelatllskcrdvgyiPSF-LF-QCFDNVGQIVFGTrdafq----------------dilqvTsRVYG- 389 
EEY54935       340 qvfpvlfqlsdlelatllskcrdvgciQAF-LY-QCFENVGRIVFGTrdgfq----------------dilqiTsRVYG- 400  Phytophthora...
XP_001318628   996 keyyrlqylanselfnyisstknperfSEQ-VK-SLFPSLDGMIIENnk-----------------------iI-GVIGK 1049 Trichomonas ...
XP_003110956   950 mrminsrlclsselhllnlfsttsidtrlqlLLkDCFPSLRRLCFNRrn------------------------qlELVDL 1005 Caenorhabdit...
CAP35738       923 mrminarlclsselsllnlfstttidsrlklLLkDCFPSLRRLCFNRrn------------------------qlELVDL 978  Caenorhabdit...
XP_002110236  1306 nefprfyfisnhqlldimsyadnpsalAQF-VN-HCFPGILSLKLILpeqtisvmrnttneinaafnahllqvS-ALEGN 1382 Trichoplax a...
5NUG_A        1680 EGEEVMfktpvsitehpKIN------EW----------LTLVEKEMRVTLAKL-LAES 1720
EAY20035      1212 GGEYFEfiqkvri-------tpecieGW----------FIAFDQQITNTLKTL-GRKI 1251 Trichomonas vaginalis G3
EGD80062      2018 SGETIRfaqsiva--------tgpthlWlpqlfsemqdFVKFDilsaherldrlwsev 2067 Salpingoeca rosetta
XP_001747718  1158 SGEIFHlrqpf--rlrgGLA------EW----------LPAVQHEVATSLHEQrLAAW 1197 Monosiga brevicollis MX1
53_pfamImport  390 DSEAIPmg--------kNLKargpveQW----------LAAVEKRLAEQLRRS-TKQA 428 
EEY54935       401 EAETIAmg--------kNLKargpveQW----------LAAVEKRLAEQLRRS-TKQA 439  Phytophthora infestans T30-4
XP_001318628  1050 NSEQLRlnpieyd------------------ikdvpllLKTIEMKIEEKLTKTvIDIA 1089 Trichomonas vaginalis G3
XP_003110956  1006 LGEKVTvdltktei----------------esqepcelIRSIETAFASKLTDI-ITYE 1046 Caenorhabditis remanei
CAP35738       979 LGEKITvdltkaei----------------enqepcelIRSIETAFASKLTDI-ITYE 1019 Caenorhabditis briggsae
XP_002110236  1383 LDEVVElttri--kaesQPH------KW----------FAAVETGMKESLAII-LQDC 1421 Trichoplax adhaerens
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