8J07,8J07,8J07,8GLV,8GLV,8J07,8J07,8J07,8GLV,8J07,3VKG,8GLV,7K58,7K5B,7KEK


Conserved Protein Domain Family
DHC_N2

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pfam08393: DHC_N2 (This model is not part of the current CDD release)
Dynein heavy chain, N-terminal region 2
Dyneins are described as motor proteins of eukaryotic cells, as they can convert energy derived from the hydrolyzis of ATP to force and movement along cytoskeletal polymers, such as microtubules. This region is found C-terminal to the dynein heavy chain N-terminal region 1 (pfam08385) in many members of this family. No functions seem to have been attributed specifically to this region.
Statistics
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PSSM-Id: 518234
Aligned: 475 rows
Threshold Bit Score: 71.513
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
8J07_g6        1013 LSRMVKEFQPYLDLWTTASDW----LR---WSES-----WmndplSAI---DAEQLEKNV---V--EAF-Ktm---hkCV 1068 human
EFO86788        630 MRLFVGEIESLQSLFVATSGY----YK---HVNAffesrR-----TLV---NIDASRNFI---E--QFTvQ-------LS 682 
XP_045096425    610 MRHFVGEIESLESLFVATSGY----YK---HVNAffesrR-----TLV---NIDASRNFI---E--QFTiQ-------LS 662 
125_pfamImport    1 IPSTERKLEARKGVWELLSQA----TM---QINE-----WkrilfSKF---VVAHAQEKV---N--DWLnQasllvqtLP 60  
Q57VL9          750 LRV----FDVLEQFWCSVFDStrvkDYyiiPLSAl----------------NSEKTIDEVqrcR--RLLhSsv---rnLR 804  Trypanosoma...
XP_001562550    445 MNH----FEIIEQFWITVFEStklrELyrtPVSSv----------------NANAFIERArewR--RLIhStir-----n 497 
Q4QIP4          778 MTH----FETIEQFWITVFEStklrELyrtPVSSv----------------NASGFVERArewR--RLIhSsir-----n 830  Leishmania ...
XP_001747718    801 VETTETRLQLLKTCYSLFHESeaarQA--------------------LvkhDIASLQIDA-------------------- 840 
91_pfamImport     1 LNALAVELKLKSELWEAVCEA----DE---HLEAcstdtI-----RSV---DLDTMGVVA---SrvDRVvEni------- 55  
XP_002110236    958 LTAILKNIDIRQEMWKYIEVS----EG---RIRD-----WmntsfYKL---DVTKLIHKV---N--EWKnAsvqlrnqLP 1017
8J07_g6        1069 --K-QfkdmpACQEvaldI--------RAR--------IE----EFKP-YIPLIQGL-RNPGMrIRHWETLSNQIni--- 1120 human
EFO86788        683 vfEsSlathrAAKH----Fia----yaRNE--------VD----TFKK-NFSVAEVMsCRRLL-DAHWLRMSEIVgf--- 737 
XP_045096425    663 ifEsSltthrAAKH----Fia----yaRNE--------VD----SFKK-NFSVAEVMsCRRLL-DAHWLRMSEIVgf--- 717 
125_pfamImport   61 aqD-N-----VFKE----T--------MQL--------IE----NFSQ-QLPLLLKL-SSPTLkHKHWRHIFKGLgl--- 105 
Q57VL9          805 --GyP-----GLVC----L--------GRQ--------QEqvlaDFES-LQTLLAYL-STPGLrKNHWKEIGRILqlgr- 854  Trypanosoma...
XP_001562550    498 lrGyP-----ALVR----L--------GRE--------QElalaKFEE--LELFLELiTTPGLrKSHWRDIAKLIstqlr 550 
Q4QIP4          831 lrAyP-----ALVH----L--------GRE--------QElalaKFEE--LELFLELiTTPGLrKSHWRDIAKLIsvqlr 883  Leishmania ...
XP_001747718    841 ----------ATAQ----Ld------gMEQtwgschvqLS---------DAPVLQHVaKNLHF-AHQWLQVVELCqtpel 890 
91_pfamImport    56 --------rqCSAQ----VvgafeldrLEK--------LQ----ATLHgLAPVIRDL-RNPHLaERHWSKLEHKMqcslv 110 
XP_002110236   1018 igD-R-----VLDY----W--------KKS--------LV----DIER-HTPFLAKL-STKSLkARHWKDIFIGIgq--- 1062
8J07_g6        1121 --------------nvRPKANLTFARCLEMNLqdH--IESISKVAEVAGKEYAIEQALDKMEKEWST----------IL- 1173 human
EFO86788        738 --------------dlTPYANSSIAQICELGL--EahLQQLKPIAFSAEREATAADQLHSIVTFWSQ----------EH- 790 
XP_045096425    718 --------------dlTPYANSSIAQICELGL--EahLQQLKPIAFSAEREATAADQLHAIVTFWSQ----------EH- 770 
125_pfamImport  106 --------------myETEWHLTVADLLPKSL--LeyQNSITKVWQDAKAEADMEQAFRKLQRRWNV----------EH- 158 
Q57VL9          855 ------------kqstQIDSNVTLKQLLENGI--IdhLDEIKLIVDPAFLDFEAEATLERMKSDAKK----------TRf 910  Trypanosoma...
XP_001562550    551 -----------ddillVTNMTVTVKRLLDAGL--LdhIVPLAQIVSQARCDYDVENELEEMRSYAKR----------TH- 606 
Q4QIP4          884 -----------ddvmlVTNMTVTVKRLLDAGL--LdhIVPLAQIVSQARCDYEVENELEEMRSYAKR----------TH- 939  Leishmania ...
XP_001747718    891 eeeel-dsirdvlaipKRWEDILVADLIQAGA--LakKPSVVKLVEKARARHLFVAHVAAIAE-WLRtelveteirgSAl 966 
91_pfamImport   111 sivvetaansevpatlDSTDSTETLQLLDANA--VayGTTIRHVSEEASAEAAMAGSFLSVVRTWEA----------QE- 177 
XP_002110236   1063 --------------pyDSTWLFTTKELLSFDL--ElhTSLINSVVARADAEFALEGSFQQICKVWED----------KK- 1115
8J07_g6        1174 --FNVLP-YKATd-----------------------------tYILKS--PDEASQLLDDHIVMTQNMSFS-PYKkp-fE 1217 human
EFO86788        791 --LEMRF-HVQW-------------------------------KLSLAvkLRDLHSRVQTDINTLKHMTNVeQIT----D 832 
XP_045096425    771 --LEMRF-HSQW-------------------------------KLSLAvkLRDLYRRVQNDINTLKHMTNVeQIT----D 812 
125_pfamImport  159 --FRLAN-F--Ivkvctwtgiwcski---nylfdwlilgicspFLCDC--FENLLALAEDSVMTLSNMMLS-PHIse-fR 226 
Q57VL9          911 -vFEVAEgSNDA-------------------------------LILSPrcRTSISSQLEAFSHELSALRQV-EHLsqytI 957  Trypanosoma...
XP_001562550    607 --FALENsAVHDdl----------------------------nTPPLKgnRHEMVCRIEECMLKCRAMRRR-PNLgpsvL 655 
Q4QIP4          940 --LVLENtAAKNdl----------------------------sALLLQepQREMMYRIEEYVLKCRAMRRR-PNLgpsvL 988  Leishmania ...
XP_001747718    967 hgM----------------------------------------RTLAVanLGSLLRQTVNRRADLRQLLKS-SYRt--vQ 1003
91_pfamImport   178 --IPVES-KKDRdgr--------------------------dvFCIGD--CIELTSLIEESQVLLRVMDLS-TYSlv-vQ 224 
XP_002110236   1116 --LQLTK-HIPIvqvsnvnqtpmstdsnvneiakqdsrmdddaLVLMG--VEELKVQLEDHQITLRGMLVS-SHLad-lR 1188
8J07_g6        1218 QRINSWENKLKLTQEVLEEWLNCQRSW-------LYLEPIFSSe----D-INQQLPVESK---RYQTMERIWKk---IMK 1279 human
EFO86788        833 DSLPQWIEWTCRTETILKAWCETQQKW-------MRVANIFVTcrdtlQ-VSFDSNIQQD---LYYLLQKEYE----LLR 897 
XP_045096425    813 DSLPQWTEWTARAETILKAWCETQQKW-------MRVANIFVTcrdtlQ-VKNLFNVTQK---SEELFTEGIR----ITE 877 
125_pfamImport  227 QEVENWVHLLQELEELLGFWQRYQQEW-------VFLSKIFYE-----TeVSIQKPELFC---RFRTVDSNYRd---MMQ 288 
Q57VL9          958 SSVMEFDSVVQRMKETLLTWEDVEKEWkevlpfgITLETTTDEdfiglT--PRDLKLLRE---KVSSTSDTFKs---LAA 1029 Trypanosoma...
XP_001562550    656 RAVDEWVDACEKSREVLLAWDNVKMRW-------MRLRACVSSlrsavSeGICSAEEARTitqKLTTASAAFKgmgaILR 728 
Q4QIP4          989 KSLDEWVDACEKSRGVLLAWDQVKGRW-------VNLRACLSSlrsavAeGICSAEEARLitkSLTMASDAFKelcaILR 1061 Leishmania ...
XP_001747718   1004 SGITELSRRTNRTFEILTDLQSLQDNW-------MALQS-----------LRSLFKRHQSvakAFEHFKCQWVpvaqTIE 1065
91_pfamImport   225 ERLPKMLHDLEHTKESLELLQMCQRKW-------DYTQRLVSI-----D-FARTFPEQAK---QLQKYDGAWR------- 281 
XP_002110236   1189 YQVEAWSTMLQQLNEIIDSWSNCQQKW-------LLLYNVFQR-----KrIKTDLSKQYQ---EFEKINSGYKd---FLR 1250
8J07_g6        1280 ------------------NA-YE-N----------Revinvcs------------dlrmldS-LRDCNKILDLVQKGLSE 1316 human
EFO86788        898 tcakyf-------ikierNVvKDaTiyrvmqlphlP-------------------------CwIEKIRKMVVVIIQGVRG 945 
XP_045096425    878 nlcqifpnhreerskrcdHLsSDaTtpfalldrenP---------------------------------------FNVRG 918 
125_pfamImport  289 ------------------AT-SC-S----------PrvlnivrhgkktgtpgqfqgqclrsV-FMEELSTMEKISNQLLF 337 
Q57VL9         1030 ------------------TLrkaqytlft-----------------------ammqeniqdQ-VTLARTILGDVRKILAS 1067 Trypanosoma...
XP_001562550    729 kpqfslyta--------------------------------------------mmqdtiqdF-LLTIKSEVDDADEVLRG 763 
Q4QIP4         1062 kpqfslyta--------------------------------------------mmqdtiqdF-LLTIKSEVDDAAELLRG 1096 Leishmania ...
XP_001747718   1066 ksp------------vlgQLsda-----------------------------------mvrEqLTACRTAWHTLQERISD 1098
91_pfamImport   282 ------------------SL----TlglynrslclPfgvsp----------------ehrqA-LKGILEGFEAAAKTLAD 322 
XP_002110236   1251 ------------------SV-VE-N----------PkvlnlvnrrrsqkahkdvhgenllqL-LFNYSDTQDQIIKHLYF 1299
8J07_g6        1317 YLETKRSAFPRFYF-LSDDELLEILSQT-KDPT-AVqphLR-KCFENIARLLFQE----------------------DLE 1370 human
EFO86788        946 LLDGMRMINSRLCL-SSELHLLNLFSTTsIDTRlQL---LLkDCFPSLRRLCFNRr---------------------NQL 1000
XP_045096425    919 LLDGMRMINARLCL-SSELSLLNLFSTTtIDSRlKL---LLkDCFPSLRRLCFNRr---------------------NQL 973 
125_pfamImport  338 LLDSPRCEFPRLNF-LSDGDVIKLLSLH-PNHS-ALlplVR-KCFPSVKELVLKTldqqhhtm------tsmdlsdlQMS 407 
Q57VL9         1068 SLDAKREVFPRFYL-MDDESLLSFLSVHnAT---KLkrhLT-TLYSRVCDVNLEG-----------------------NV 1119 Trypanosoma...
XP_001562550    764 VTERRRALFPRFRF-LPDSELIEFQSVQsAHSFvHLfq----yLYPRITDVEVV------------------------DR 814 
Q4QIP4         1097 MTERRRALFPRFRF-LPDSELMGFQSVQsAHSFaHIfq----yLYPGITDVEVI------------------------DG 1147 Leishmania ...
XP_001747718   1099 AVGQLRSVAP-VLFaLPKGTIAASVGLPaVDqa----haLLpQLWTAVRHLVVAD-----------------------RD 1150
91_pfamImport   323 HLLIKRQVFP-AFFkLSDLELATLLSKc-RDVG-YIpsfLF-QCFDNVGQIVFGTrda----------------fqdILQ 382 
XP_002110236   1300 LLEEARNEFPRFYF-ISNHQLLDIMSYA-DNPS-ALaqfVN-HCFPGILSLKLILpeqtisvmrnttneinaafnahLLQ 1375
8J07_g6        1371 i-tHMYSAEGEEVQLcfsiyps--snvedwLREVERSMKASVHDI-IEKA 1416 human
EFO86788       1001 ---ELVDLLGEKVTVdltkteiesqepcelIRSIETAFASKLTDI-ITYE 1046
XP_045096425    974 ---ELVDLLGEKITVdltkaeienqepcelIRSIETAFASKLTDI-ITYE 1019
125_pfamImport  408 v-iGVNGNLGEKLPFssplpsn--ynllawLSDLEQRMREAVFRL-LWDC 453 
Q57VL9         1120 v-tSFITTDGSVLRtdtpiels-plpveqwMKTFDRTLRSSLLNE-IKMS 1166 Trypanosoma brucei
XP_001562550    815 ivtAVVATDGARLPLssplalt-kdtpdawIQRFDHAVRASLVAA-VKEC 862 
Q4QIP4         1148 vatAVVAADGARLPLssplalt-kdtpdawIQCFDRAVRASLVAA-VKEC 1195 Leishmania major
XP_001747718   1151 l-sGLCCHSGEIFHLrqpfrlr--gglaewLPAVQHEVATSLHEQrLAAW 1197
91_pfamImport   383 vtsRVYG-DSEAIPMgknlkar--gpveqwLAAVEKRLAEQLRRS-TKQA 428 
XP_002110236   1376 v-sALEGNLDEVVELttrikae--sqphkwFAAVETGMKESLAII-LQDC 1421
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