3NBY,4GMX,3ICQ,3A6P,2XWU


Conserved Protein Domain Family
Xpo1

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pfam08389: Xpo1 (This model is not part of the current CDD release)
Exportin 1-like protein
The sequences featured in this family are similar to a region close to the N-terminus of yeast exportin 1 (Xpo1, Crm1). This region is found just C-terminal to an importin-beta N-terminal domain (pfam03810) in many members of this family. Exportin 1 is a nuclear export receptor that interacts with leucine-rich nuclear export signal (NES) sequences, and Ran-GTP, and is involved in translocation of proteins out of the nucleus.
Statistics
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PSSM-Id: 518231
Aligned: 57 rows
Threshold Bit Score: 58.0032
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3NBY_A  125 EKVYIGKLNMILVQILKQEW----PKHWPTFISDI---V---GASRT-S--------------ESLCQNNMVILKLLSEE 179  house mouse
Q5CYM5  121 QSYLKNKISELYVTMIYADY----PENWPSAFLDI---V---SLVTA-H--------------DWMPDMFIRILCTFDKM 175  Cryptosporidium parvum
O94258  101 PAYISNAVQHLLTLLFLQLY----PSNWNDFFASL---QgviAASSQ----------------SEFSNFYLKVLLSIGDE 157  Schizosaccharomyces...
Q6C715  112 PVHMKNKLGETLAYLFIMTY----TEIWDTFFYDF---E---RLLES-Penq--------fgnPRAADLYLRVLNDIHRE 172  Yarrowia lipolytica...
Q7RWV9  103 PANVQNKLTQTLTYLFVALY----GEGWETFFDDF---L---ALTSS-Qngas-------rdnLSGVMLYLRILSSVHDE 164  Neurospora crassa O...
Q5ASE3  102 PPNIQNKIAQTITFLFSALY----GNGWESFFDDL---L---SLTHK-Spsst------trdnPLGIIFYLRVINSIHDE 164  Aspergillus nidulan...
Q6BL58  102 PVYLKNKFAGIMGNLFCFTY----LSINPTFLKDL---L---ALIADnN--------------LIAIDIYSRIIIAVHTE 157  Debaryomyces hansen...
Q5A0E2  100 PTHLRNKFAQILAKQFCQVY----INIYPNFIKDL---L---ELINV-Seatst-----npnnLLAIDYYTRVLIGIHSE 163  Candida albicans SC...
P33418  102 PDFLMNKISEVLTTLFMLMYsdcnGNQWNSFFDDL---M---SLFQV-DsaisntspstdgniLLGLEFFNKLCLMINSE 174  Saccharomyces cerev...
3ICQ_T  103 PAYISNAVQHLLTLLFLQLY----PSNWNDFFASLqgvI---AASSQ-S--------------E-FSNFYLKVLLSIGDE 159  fission yeast
3NBY_A  180 VFD--FSSGQITQVKAKHLKDSMCNE--FSQIFQLCQFVMENSQNA-P-------LVHATLETLLRFLNWIPLGYIFETK 247  house mouse
Q5CYM5  176 IVSniGLQSAEDISIRRKIKDIMRVNgdLNHIVQAWIFVVSKHKSQ-SltkdriqLLSSSMKMMESFIDWIDISYAVNNE 254  Cryptosporidium parvum
O94258  158 IADslVLKTDVQIQKDNLVKDAIRANd-MSDIVSFVYEMMLAYSNA-Kny----gTVGLCLQVYAQWVSWININLIVNEP 231  Schizosaccharomyces...
Q6C715  173 IGDtlIIRDPAVQSRNNDLKDLIRNRd-MARLADSWKKILMYYKDQ-QleplateIVNNALRVIGGWVSWAELTLIAEPE 250  Yarrowia lipolytica...
Q7RWV9  165 IADlmISRQGNESKRNNDLKDLIRERh-MQKIAMSWQDILAQWTNK-Hd-----gVVELTLKVIGKWVSWIDISLVVSQD 237  Neurospora crassa O...
Q5ASE3  165 IGDvlVSRSRAEQERANALKDLIRVRd-MQKIASSWQEILSQWMDG-Dd-----lIVEMSLKAVGSWVSWIDIGLVVNQT 237  Aspergillus nidulan...
Q6BL58  158 ISDkfISRSREVQDRNNLLKDQIRTNd-MNLLVDNWQKILRNPELI-Qhn---neVLNNFLKIIGYYINWMEITLFISND 232  Debaryomyces hansen...
Q5A0E2  164 IGDkyITRSQEIHNRNNLLKDAIRTQd-MQQMVTSWIQIL---TNP-Sfah-seeILNNTLKIVGQYVSWMEISLFISPE 237  Candida albicans SC...
P33418  175 IADqsFIRSKESQLKNNNIKDWMRDNd-IMKLSNVWFQCLKLDEQI-Vsqc--pgLINSTLDCIGSFISWIDINLIIDAN 250  Saccharomyces cerev...
3ICQ_T  160 IADslVLKTDVQIQKDNLVKDAIRANd-MSDIVSFVYEMMLAYSNAkNy-----gTVGLCLQVYAQWVSWININLIVNEP 233  fission yeast
3NBY_A  248 --LIStLIYKFLNVPMF----------RNVSLKCL 270  house mouse
Q5CYM5  255 --VLS-IILSFLNPIDSp--------vVVETLNFL 278  Cryptosporidium parvum
O94258  232 --CMN-LLYSFLQIEEL----------RCAACETM 253  Schizosaccharomyces pombe 972h-
Q6C715  251 --ALE-AIFNLLSSPKS----------RIHACDCL 272  Yarrowia lipolytica CLIB122
Q7RWV9  238 --MQN-LILPLVGRVNNtsnn--idtvRDTAIDTL 267  Neurospora crassa OR74A
Q5ASE3  238 --MLD-LLFQQLGRAQKaelregedkvRDAAVDVF 269  Aspergillus nidulans FGSC A4
Q6BL58  233 --FIN-IIFQYLNKPDQ----------RNETCLTL 254  Debaryomyces hansenii CBS767
Q5A0E2  238 --FIN-TVFSFLQNSKL----------RNTTCETL 259  Candida albicans SC5314
P33418  251 nyYLQ-LIYKFLNLKET----------KISCYNCI 274  Saccharomyces cerevisiae S288C
3ICQ_T  234 --CMN-LLYSFLQIEEL----------RCAACETM 255  fission yeast
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