8J07,8GLV,8J07,7K5B,8GLV,7K5B,8J07,6F1T


Conserved Protein Domain Family
DHC_N1

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pfam08385: DHC_N1 (This model is not part of the current CDD release)
Dynein heavy chain, N-terminal region 1
Dynein heavy chains interact with other heavy chains to form dimers, and with intermediate chain-light chain complexes to form a basal cargo binding unit. The region featured in this family includes the sequences implicated in mediating these interactions. It is thought to be flexible and not to adopt a rigid conformation.
Statistics
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PSSM-Id: 518230
Aligned: 176 rows
Threshold Bit Score: 269.488
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
8J07_n0        250 LGKIEDCMKVWIKQTEQVLAENNQLLKEaddvGPRAELEHWKKRLSKFNYLLEQLKSPDVKAVLAVLAAAKSkllktWRE 329  human
XP_002141723   295 LSGLQMSLTQWIRDIQSLARFQRDIGL-----SVTSEVKFWSSYERSLQQIMQQIQSVEVEWSLAVLRQTKK-----FLA 364 
Q5CSZ3         289 LSSLQVSITQWIREIQSLARFQRDIGL-----SVTSEVKFWSSYERSLQQILKQVQSPEVEWSLSVLRQSKK-----FLA 358  Cryptosporid...
XP_004993240   227 LDALSKTLARWTREIQQVTKLERDPSTG----SAMQEVSFWRNLGTALQAIKKQRESPAVTLTIGILQHGRR-----FHA 297 
XP_004993770   220 VKSLERVVLRWIKDIQQVTRLERDLSTG----SARQEIRFWLSMERALSQLKVRLAEDDVTLTLAVLREAKR-----LTI 290 
XP_009154484   279 LNSIQNHVIGWIKSIQGVTKLAKDGPSTq--ySAAQEINFWLSLESALNKLDDERHSDGVVLTLDILKKAKR-----QQA 351 
Q5KFR9         285 LNKLQADVNSWIKEIQAVTKLNRDVASG----TASQEINFWTSMEHALEGIEQQLGGEEVTLVLDVLKHAKR-----FHA 355  Cryptococcus...
57_pfamImport    1 LNKLQSEVNSWIKEIQNVTKLSRDVASG----TASQEINFWLAMEKALESIEEQLRSDPIVLTLDILKTAKR-----FHA 71  
3_pfamImport     1 LNKLQSEVNNWVKEVQKVTKLSRDVASG----TASQEVNFWLSMEKALEGIEKQLKSEPVQLSLDILKHAKR-----FHA 71  
XP_006680792   194 LNKLQSDVNEWIKEIQKLTLLDRDPESG----SARQEIEFWIALERALNHIDLQLHSDEILLTLDTLRAAKR-----FHA 264 
8J07_n0        330 M-----DIRITDATNEAKDNVKYLYTLekCCDPLYSs-DPLSMMDAIPTLINAIKMIYSISHYYntSEKITSLFVKVTNQ 403  human
XP_002141723   365 AislevDTGLKQTLERVQSVNSLIHDL--PINDLLVasTVDEIISAVHLFFQHI-RKIKAVAAYp-ISRVFQLVEVYSAD 440 
Q5CSZ3         359 AislevDTGLKQSIEKVQNINTLIHDI--PINDLLVatSIDEITSAVTLFFQQL-RKIKGAASYp-ISRTFQLVEVYSND 434  Cryptosporid...
XP_004993240   298 TmsfdqDSGLDAKIKLVNDYNELMHGF--PAKDLLAasDTEQLRQALVTIFSHL-KRIRKT-KYp-VKRCQNLILAISRD 372 
XP_004993770   291 LksfetDTNLS-MYDTVLDYNTLMKDF--PINAILIatDIKKLVEAMLEVFQHM-KKVKHT-RYp-RERFIELIKAISRD 364 
XP_009154484   352 VvsfetDTGLKDALETVRNYNTLMRDF--PLDELSSatSLGKVAEAIVLIFNHLNKKWRVC-NYp-IRRALKLVEGISED 427 
Q5KFR9         356 TvsfiaDTGLKEAADLVHKHNILMKDF--PLDELLAatDLEKIQDAIYLIFAHINKKLKLS-PYp-IRRTLPLVEAISSD 431  Cryptococcus...
57_pfamImport   72 TvsfmsDTGLRGATEIVTKYNQLMKDF--PLNELLSatDLAKVQDSLHMIFGHVNKKLKLS-PYp-IRRALPLVEAISQD 147 
3_pfamImport    72 TvsfiaDTGLNDAFKTVHDYNVLMKDF--PLNELLAatDLNKIKDSINQIFLHVNKKLKLS-PYp-VRRILPLVEAISRD 147 
XP_006680792   265 TvsflaDTGIKEKTEKVQRYNQLMKDF--PINDLLSstDLDKIGESILLIFSHINKKFKIS-PYp-IKRMLKLIEAISKD 340 
8J07_n0        404 IISACKAYITnnGta---sIWn--qPqdVVEEKILSAIKLKQEYQLCFh----KTKqklkqnpnakqfDF---SEmYifg 471  human
XP_002141723   441 MTRQLYKVLQ--NtpskvsLMnleyP--LFEHLVNGCNELAQTWEDEWrllkeIIR------------DLi--KKrG--- 499 
Q5CSZ3         435 MTKQMYKVLQ--Nnpt-tsLMllefP--VFEHLVNGCNELGQVWEDEWrelkdVIR------------DLi--KKrG--- 492  Cryptosporid...
XP_004993240   373 MAAQLTAILS--Nl----eLMhmsyA--DFDRTIHGCSRLFKTWEEEVerfrtQLR------------MQl--RQnP--- 427 
XP_004993770   365 VNSQLLKILS--Kk----kLMhmpiP--EFENLYNQCNQLFREWNDKsdf-rtIIQ------------ELrstQRgG--- 420 
XP_009154484   428 MNEQIHNLLR--Gr----sIMslsyD--DFSELMRSVDLIWETWDDQIksftaVAR------------EIt--RKkN--- 482 
Q5KFR9         432 FNDQLLKVLS--Sq----rLMymdyT--KFEEVMATAAEVFATWDENMkdftnVAR------------EVs--RKrA--- 486  Cryptococcus...
57_pfamImport  148 LNDQLLKVLG--Sq----rLAyldyA--AFERSMSACSAVFHAWDEGLkefttVAR------------DVt--RKrN--- 202 
3_pfamImport   148 LENQLHKVLS--Sq----rLTyldyP--LFEQAMRAAEGVFQAWDESFkeftnVAR------------EVt--RKrG--- 202 
XP_006680792   341 LNTQMLKTLS--Ss----sIMmipwE--EFDFCIRKTDQVFRIWEEQLkefinVAR------------ELv--RKrS--- 395 
8J07_n0        472 KFETFH--------------RRLAKIIDIFTTLKTYsvlqdsTIEG---------------------------------- 503  human
XP_002141723   500 LSERAHpkldfn---hipliQRLNDIVAFRKQHQKLkdt-lvELLTsrsgdtrnettas----------------trggm 559 
Q5CSZ3         493 LSERAHpkmdfa---hvpliQRLNDIVIFRKQHQKLkdt-llELLSiqtsassneqtdqnpls-------algieqnsgi 561  Cryptosporid...
XP_004993240   428 --DPNMrtlkilhpehrplqERIEELRKFRASHEQLrnv-ieRVLRapapgeavtg----------------------sl 482 
XP_004993770   421 -----RatarrvvpehkalqERLALVHDFRLRHDDLkqr-isVVLKqrgiepd--------------------------- 467 
XP_009154484   483 --TDFVpvkvip--rhaktqERLRYIAQFRHNHEQLqkt-ivTVLGnkdgtdgassdkg---------------gaaive 542 
Q5KFR9         487 --EKFIsikinp--ihaklqERITYLRAFRRSHEQL------RVMTsstrsfsglg----------------------nd 534  Cryptococcus...
57_pfamImport  203 --EKFIpikina--rhaalqERVGYFRQFRKQHHQL------QVMVgplgtevggakrittgat------aeggqeryas 266 
3_pfamImport   203 --ERFIpikidp--ghaklqERVLYFRHFRKQHHQL------QVMVgplssetkrstavngdgakengdvdgelarewss 272 
XP_006680792   396 --EKFLvlkins--ahvplqERLSFVHIFRRQHEDLcst-ilKVIKsesasikqsslaptsa----------saqrtkdl 460 
8J07_n0        504 -------LEDMATkyqgIVATIKkkEyNFLDQRKMD---FDQDYEEFCKQTNDLHNELRKFMDVTFAKIqNTNQalRMLK 573  human
XP_002141723   560 dmlqtlaKKDLEQ----AYACVA--NiNILDLSSIGletWEAGKQAYNNKMDASETLLIKQLREQLNNA-SNTL--DMFH 630 
Q5CSZ3         562 dalqslaKKDLQQ----AYACVA--NiNILDLSAIGleaWEAGKQAYNNKVDASETLLIKQLREQLSGC-GNTL--EMFR 632  Cryptosporid...
XP_004993240   483 daqdvqaVKDVDS----AYNMMK--DiDALDLSDQGarlWSTRLQAYHDRIALVEARVSSKLRDQLGAA-RSAN--DMFR 553 
XP_004993770   468 -adednaLAEVEN----AYDEMR--SvDVLDLEEEGqraWDRACESYEARVNQVEDTIIKHLCHELDHA-AKSS--DMFR 537 
XP_009154484   543 elgdvdaVEEVSA----AYEVVR--HvDVLDVSTKGtdvWIQAEKEYTERTSRVEDSIITRLRDRLGKA-KTAN--EMFR 613 
Q5KFR9         535 vpfdidmEEEVRL----SYENVK--NvNVLDVSPEGseiWYTAETAYNDRVARIENQIISRLRDKLATA-RNAQ--EMFR 605  Cryptococcus...
57_pfamImport  267 vlndvdmDAEVKL----AYENVK--NvDVLDVSSEGteiWVTAETSYNERVARVENQIIARLRDRLASA-RNAN--EMFR 337 
3_pfamImport   273 tlgdidmEVEVRQ----AYEGIK--GiDVLDVSDDGtqiWIAAETGYNERVARVENHIISRLRDRLGGA-KNAN--EMFR 343 
XP_006680792   461 dleasgaQEDVVS----AFDTIR--SvNVLDLSPEGtqsWVAAENIYTERIAQVEGQIISRLRDRLASA-RNAT--DMFR 531 
8J07_n0        574 KFEr----lNIPNL--GIDDKYQLILENYGADIDMISKLYTKqKYDp-----PlarN-QPPIAGKILWARQLFHRIQQPM 641  human
XP_002141723   631 ILGrynvlfFRPRIrnAVEEYQNILLEKVEADFKLLQTRYQN-PYQsnaasqFsylRdIPNVGGTLIWSHLLQDRIQNIY 709 
Q5CSZ3         633 ILGrynplfFRPRIrsAVEEYQSILLEKVQSDFQLLQLRYQN-PYQrsaasqFsclRdIPNIGGMLVWSHLLQERIQSIY 711  Cryptosporid...
XP_004993240   554 ILSryetlvNRKNIksEIKSHSGQLLSRVLTDIDKLHHKFAV-EFEattnarLskaRdVPPVSAKIVWIKQFEHKLDLYL 632 
XP_004993770   538 IFRhyyallDRPRIrnAVRSYQKQLMSNVKDDIIELHKKFKM-QYHnsnnshMsaaRdIPPTSGQIIWMAQIERQLDDYL 616 
XP_009154484   614 VFEkfnpllVRPKVrgAITAYQTQLLDNVKNAIASLHERFKQ-QYGgseaqmMaqlRdIPPVAGAILWVRQIETQLDNYM 692 
Q5KFR9         606 VFSkfntlfVRPKIrgAIQEYQTRLIESVKEDIHRLRQKFTE-NYRnsqayhMsqmRdFPSVSSAIIWARQIERQLLTYM 684  Cryptococcus...
57_pfamImport  338 VFSkfnalfVRPKIrgAIAEYQSELIDSVKEDIRALHDKFKR-SYAqseayhMsqlRdHPPVSGAIVWAKQIERQLLAYM 416 
3_pfamImport   344 VFSkfnalfVRPKIrgAIAEYQSQLIDSVKDDIRRLQDKFKS-GYQsseayqMsqlRdHPPISGAIIWARQIERQLSGYM 422 
XP_006680792   532 VFSkfnalfIRPKIrgAIHEYQTQLIERVKEDIHRLHEKFAA-QHDdvemlrMvrlRdLMPISSSVIWARQIERQLGEYM 610 
8J07_n0        642 QLFQq-Hpavls-taeaKPIIRSYNRMAKVLLefEVLFHRAWLRQIEeihvG-------LEAS--LLVKapgTGel---- 706  human
XP_002141723   710 QKLEsiFgsnwefeaqgHKVKSDGDQITSKIH--PSKIVDYWLQRRKd---Dkvt-ydlNKP---VFGLq-kNYnatis- 778 
Q5CSZ3         712 FKLEdiFgpnwefesqgHKVKTDGDHITSKIH--PNQIVDFWLQQRKd---Dklt-ydlNKP---VLGLm-kSGnlstt- 780  Cryptosporid...
XP_004993240   633 SRVDnvLgigwdklpegKKLRRSAEELRAKLD--HDAVFNHW--Q-E----Qaak-lehSSSTtkALGVv-qNKagkl-- 699 
XP_004993770   617 ERVGhvLgpnwmkhvdgRELKERGETFKEKLR--QANPYDLWLQEIEt---Qdi---tfKNT---IFDIe-lFRgektr- 683 
XP_009154484   693 SKVHavLgeewmfhadgEKLQIESNMFRKKLS--TREIYQAWVQD-V----Qsrd-isvSGR---LFAIl-rSRganga- 759 
Q5KFR9         685 KRVEdvLgkgwesyaegHKLQMESASFRTKLD--TRPLYDAWISD-I----TkrgnltiTGR---LFDVi-rTRatatna 753  Cryptococcus...
57_pfamImport  417 KRVEdvLgkgwelyaegTKLQAESQSFRRKLD--TRPIYDAWLHD-I----Qrrn-lqiTGR---LFDIt-kSRaqggl- 483 
3_pfamImport   423 KRVEdvLgtewshyadgQRLQTESQSFRAKLS--TRPIYDAWLVD-I----Nrrn-lqiSGR---LFNIt-kSRqqaga- 489 
XP_006680792   611 KRVEdvLgrgweqyaegQKLSQEERAFKNQLN--TRPIFDRWVAN-I----Ssre-iniGGR---IFDIt-rNRargge- 677 
8J07_n0        707 ------fVNFDPQILILFRETECMAQMGLE--VSPLATSLFQKRDRYKRNFSNMKMMLAEYQRVKSKIpaaIE------- 771  human
XP_002141723   779 --nsilvTTIDPNILSLFKDLRIIQSYSYR--VPYSVKVLSDELKLLYPYITRLNSLCMNWMRISTFL---EMepgkris 851 
Q5CSZ3         781 --sfilaSTIDSGILSLFKDLRIIQSYAYR--VPYSVKVLADELKLLYPYISHLNSLCINWMRIATQL---EVepgkris 853  Cryptosporid...
XP_004993240   700 ----elvVDVPRVAIEANNESRNLKFLGHR--PRVGLARKFMFARTSYSFCMSLDGSVRTYKHTLAKL---ADapk--lk 768 
XP_004993770   684 ---lemfVNFHERLITMAKEVRIMGWLKNVprVPKLAVVKAKKANMLYPYVISLKNSIKTYSIAMNQL---DDrph--lt 755 
XP_009154484   760 ---lelsVNFDNHAISLFKEVRNLTWLNFQ--VPHRITTTAKQAQRVYPYALSLMESVAGYFSAVRAI---QEtps--va 829 
Q5KFR9         754 qgqlqlvVQFDPQVIALFKEVRSLIWLGFP--VPLTISHKAKDAKRVYPHAVSLMESVKTYTQTLELI---ESnpd--va 826  Cryptococcus...
57_pfamImport  484 ---lqlvVNFDAQIITLFKEVRNLVWLGFS--VPHTISNIAKDAKRVYPHAVSLMETVRTYSQTIAKL---QAnpg--ia 553 
3_pfamImport   490 ---lqltVNFDPQIITLFKEVRNLLWLGFQ--VPHTISNVAKDAKRVYPYAVSLMETVRTYSQTVAKL---EAnpd--ia 559 
XP_006680792   678 ---lqltVNFDDQIIAVFKEIRNLLWHQFV--VPHPIVNVAKDAKRVYPFAVSLAETVRTWDKTLNLL---SQnks--ic 747 
8J07_n0        772 QLIVPHLAKVDEALQPGLAaLTWTSLNIEAY 802  human
XP_002141723   852 PLLTPYRNDVYNVIQDGLT-LKWSSDHLDAF 881 
Q5CSZ3         854 PLLTPFRQEVYNIIQEGIS-LSWSSDRLEGF 883  Cryptosporidium parvum
XP_004993240   769 PLVAKYHDRIHRLLHDHID-LTWGDHRVERF 798 
XP_004993770   756 PLVARWYNRVHDQIAYGMD-LTWESP-LEAY 784 
XP_009154484   830 PLMASYEKEVQNLFATGVR-LRWESF-INSY 858 
Q5KFR9         827 ILLASYRSHALQMIERGIK-MQWDHL-VNAY 855  Cryptococcus neoformans
57_pfamImport  554 ALVAEFRTNAQQQITKGMN-VRWEHV-VNSF 582 
3_pfamImport   560 SLVATSHKKAQEQIAKGMS-YRWDHF-VNTF 588 
XP_006680792   748 WLVATYHKSVQTLISKGIQ-LRWDYF-INTY 776 
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