Conserved Protein Domain Family
NERD

?
pfam08378: NERD (This model is not part of the current CDD release)
Nuclease-related domain
The nuclease-related domain (NERD) is found in a range of bacterial as well as archaeal and plant proteins. It has distant similarity to endonucleases (hence its name) and its predicted secondary structure is helix - sheet - sheet - sheet - sheet - weak sheet/long loop - helix - sheet - sheet. The majority of NERD-containing proteins are single-domain, but in several cases proteins containing NERD have additional domains which in 75% of cases are involved in DNA processing.
Statistics
?
PSSM-Id: 518225
Aligned: 337 rows
Threshold Bit Score: 32.81
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_011778295   63 ASMNAE---EAVET-ALR----------------------KAGw--KHVFLRR--RVFVPRlq---hNREIDVVAVGPV- 108 
WP_012798518   18 eneffryfaRAVKA-FFE----------------------KKG---IDALL----IGMPKClv--nqDLQIDALLITDSk 65   Slackia helio...
WP_012875301   68 QNVRTD---QRLAT-ALKs--------------------lSNR---YWLGNW---IPVGSV--------IVDGILVGPEg 109  Thermobaculum...
WP_015529397   48 RRKNLI---RLSESfYLN----------------------NEFg--KHKIFYQ--IAQgkne----ktpQAYILILIPSg 94   [Ruminococcus...
34_pfamImport   1 KARTPEmamKRVKK-AIReg------------------shKKT---YFFVPPK--GSLt----------gVDLIALLPGk 46  
WP_012937741   49 TWEGGR---KRTLD-AVKs--------------------gSRK---DFTDVSS--YTFDFS--------PDSLCILLPHd 91   Acidaminococc...
WP_009163798   47 HDAAAA---KRVGK-KLRr--------------------lCKK---DGAVLDAgrFAVPGG--------KADLLLVSSRg 91   Pyramidobacte...
WP_237700545   37 KKTLKA---RLLEK-ALQp--------------------------lRADEVRS--IVIPDGig---gVLEVERLLLMEQg 81   Methylophaga ...
27_pfamImport   1 KLLRER---RHIQKlQFAcegvletdlphlafirdfayrvMRT---DWNERHF--FLYRPViewngaTVELSHLIIGPTh 72  
Q7NCK9        212 IGSPDP---YDIKIgKLL----------------------LHQlqvDGILLTG--VAIPYKk----dSIRYDNILLCDRg 260  Gloeobacter v...
XP_011778295  109 VLVVEVKHWRG-SVWCNg--------QRWFQQvhktaralefedirednvvkaaalrrHIEN---DkrVPLPDFNLLSDC 176 
WP_012798518   66 MIIIDFKDYSGeLTLPDeqd---frrGRWETSa-------------------------GIQVkggSspNPFYQTGLQRER 117  Slackia helio...
WP_012875301  110 VLVIETRNHGG-VTECNg--------NKWKRRkni--------------------lvrFFTGe-pSlgNPSIDLQASLEA 159  Thermobaculum...
WP_015529397   95 IYVLNVKNQSGkVVLKKhg-----dyKQYYTEkgkkg-----------------qadkQHEYl--Fk-NPMDESRFFAKR 149  [Ruminococcus...
34_pfamImport  47 ALLLRVIH-KGyRIYGHnq------dSTWRVTd------------------------nASSLi--Vk-NPVRALEESEAV 92  
WP_012937741   92 ILLLRVV-YHGyRIQGSer------sEQWELKd-------------------------NSGIi--SvpNPLQLLEKEREK 137  Acidaminococc...
WP_009163798   92 IFALRCIGWGi-RVFGSag------sPEWRVEd-------------------------NNETr--RipNPLTEARSAAAA 137  Pyramidobacte...
WP_237700545   82 LLVLETYPLAG-HLFGAeh------iDQWTQIi------------------------eGRSYk-fP--NPLRHVHNSMHA 127  Methylophaga ...
27_pfamImport  73 LYIIE-------WLEGDrsiyhiskeKTWVHQp-------------------------LKGEn-tRvvNPLIALTRTEEL 119 
Q7NCK9        261 IFVIEGKNYTG-TIRGDt-------nSSWQTHt-------------------------GSPIkssRgeNPLQQCDKQVMA 307  Gloeobacter v...
XP_011778295  177 LQESEgdGTWYEDRrlhkqcgtVIIPVVVFT 207 
WP_012798518  118 LARIL----ETFCRnlskfnprHITTMVCFQ 144  Slackia heliotrinireducens
WP_012875301  160 ITKDLq-EAGFGDV--------PVSGAVVFT 181  Thermobaculum terrenum
WP_015529397  150 IEQRI----GATKI--------PVRSVIIFP 168  [Ruminococcus] torques
34_pfamImport  93 FKETLak-eGAHHV--------KVETIAVFA 114 
WP_012937741  138 LEKSLe-AAHSPQL--------PIHTFVIGA 159  Acidaminococcus fermentans
WP_009163798  138 LTAQL--EEQGLAA--------TARPLAVFA 158  Pyramidobacter piscolens
WP_237700545  128 L-QML-----APKV--------PIFCRVVFT 144  Methylophaga thiooxydans
27_pfamImport 120 IRQIL---PDYAGV--------LQKVVIA-- 137 
Q7NCK9        308 LKNFF----AEYAV--------FVNGAVVFP 326  Gloeobacter violaceus
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap