Conserved Protein Domain Family
MAP2_projctn

?
pfam08377: MAP2_projctn 
MAP2/Tau projection domain
This domain is found in the MAP2/Tau family of proteins which includes MAP2, MAP4, Tau, and their homologs. All isoforms contain a conserved C-terminal domain containing tubulin-binding repeats (pfam00418), and a N-terminal projection domain of varying size. This domain has a net negative charge and exerts a long-range repulsive force. This provides a mechanism that can regulate microtubule spacing which might facilitate efficient organelle transport.
Statistics
?
PSSM-Id: 429957
Aligned: 3 rows
Threshold Bit Score: 1767.65
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_017451787  378 DKVADVPVSEATTVLGDVHSPAVEGFVGEN--ISGEEKGTTDQE---KKETSTPSVQEPTLTETEPQTKLEETSKVSIee 452 
XP_039768624  455 DKMGDMPMSTVITQSMEVHKLTIRESHGQRgcGVGEDKDIPRWEndlRKEHFLPNGQKFALFESEPYRKPEEKSSVLV-- 532 
P11137        377 DKMAEAPPSEAMTLPKDAHIPVVEEHVMGK--VLEEEKEAINQEtvqQRDTFTPSGQEPILTEKETELKLEEKTTISDke 454  human
XP_017451787  453 TVAKEEESLKLKDDKAGVIQTSTEHSFSKEDQKGEEQTIEALKQDSFPISLEQAVTDAAMATKTLEKVTSEPEAVSEKRe 532 
XP_039768624  533 SLPQDSKLLKGLDEEKSTTRSLGGQTIKKEEPPSKGAQVDQFRRDSFPGAQGRDLMLAAALSETLDKMPVAPSPRSDPA- 611 
P11137        455 AVPKESKPPKPADEEIGIIQTSTEHTFS--EQKDQEPTTDMLKQDSFPVSLEQAVTDSAMTSKTLEKAMTEPSALIEKSs 532  human
XP_017451787  533 iQGLFEEDIADKS-KLEGAGSATVAEvEMPFYEDKSGMSKYFETSALKEDVTRSTGLGSDYYELSDSRGNAQESLDTVSP 611 
XP_039768624  612 -RSLSQEREIGKDiRADKAGAPPPTE-ERPLDEDKSGMSKYFETSTLKEEATKSLQQDSDYYELSDSKESAYESYDTVAP 689 
P11137        533 iQELFEMRVDDKD-KIEGVGAATSAElDMPFYEDKSGMSKYFETSALKEEATKSIEPGSDYYELSDTRESVHESIDTMSP 611  human
XP_017451787  612 KNQQDEKELlaka-sqpSPPAHEAGYSTLAQSYtsdhPSELPEEPSSPQERMFTIDPKVYGEKRDLHSKNKDDLTLSRSL 690 
XP_039768624  690 MFKDGDQES--------SAPACEVGYSTLAQGY----PSDIAEEPSSPQERMFTIDPKVYGEKRDLHSKNKDDLTLSRSL 757 
P11137        612 MHKNGDKEFqtgkesqpSPPAQEAGYSTLAQSY----PSDLPEEPSSPQERMFTIDPKVYGEKRDLHSKNKDDLTLSRSL 687  human
XP_017451787  691 GLGGRSAIEQRSMSINLPMSCLDSIALGFNFGRGHDLSPLASDILTNTSGSMDEGDDYLPPTTPAVEKIPCFPIESK--- 767 
XP_039768624  758 GLGGRSAIEQRSMSINLPMSCLDSIALGFNFGRGHDLSPLASDILTNTSGSMDEGDDYLPATTPGLEKAPGFPTEGReek 837 
P11137        688 GLGGRSAIEQRSMSINLPMSCLDSIALGFNFGRGHDLSPLASDILTNTSGSMDEGDDYLPATTPALEKAPCFPVESK--- 764  human
XP_017451787  768 ----------EEEDKTEQA----------KVTGGQTTQVETSSESPFPAKEYYKNGTVMAPDLPEMLDLAGTRSRLASVS 827 
XP_039768624  838 eeegeeeeeeEEEEEVEEAeqaegqkkagKAVEVESSQVESPSESPFLAKEYYKNGAVMAPDLPEMLDLAGTRSRLASVS 917 
P11137        765 ----------EEE-QIEKV----------KATGEESTQAEISCESPFLAKDFYKNGTVMAPDLPEMLDLAGTRSRLASVS 823  human
XP_017451787  828 ADAEVARRKSVPSEAVVAESSTG-LPPVADDSQ-PVKPDSQLEDMGYCVFNKYTVPLPSPVQDSENLSGESGSFYEGTDD 905 
XP_039768624  918 ADTESARRKSVPADVGGHDSGAGvLSPIGNKNHvAVKDDSQMEDLGYCVFNKYTVPLPSPVQDSENLQGDSGLFYEGADD 997 
P11137        824 ADAEVARRKSVPSETVVEDSRTG-LPPVTDENHvIVKTDSQLEDLGYCVFNKYTVPLPSPVQDSENLSGESGTFYEGTDD 902  human
XP_017451787  906 KVRRDLATDLSLIEVKLAAAGRVKDEFTAEKEASPPSSADKSGLSREFDQDRKANDKLDTVLEKSEEHVDSK------EH 979 
XP_039768624  998 KLRRDLATDLSLIEVKLAATGRVKQDVGGEKEPSPPVSGDKAGLSRELDQDRKATDKLDTVLEKGEEPMDSKetllpeEH 1077
P11137        903 KVRRDLATDLSLIEVKLAAAGRVKDEFSVDKEASAHISGDKSGLSKEFDQEKKANDRLDTVLEKSEEHADSK------EH 976  human
XP_017451787  980 AKESE-EVGDKVELFGLGVTYEQTSAKELITTKETAP---ERAEKGLSSVPEVAEVETTTKADQGLDVAAKKDDQSPLdI 1055
XP_039768624 1078 GKLGPgEVVTKVEMVSSEPAVDLASIQVMTQSQDTSPfmtEKVEPLLGSVPEVAETEPLPKAEPRTDPSAKADPSQPV-V 1156
P11137        977 AKKTE-EAGDEIETFGLGVTYEQALAKDLSIPTDASS---EKAEKGLSSVPEIAEVEPSKKVEQGLDFAV----QGQLdV 1048 human
XP_017451787 1056 KVSDFGQMASGMSVDAGKTIelkfeVDQQLTLSSEAPQETDSFMGIESSHVKDGAKVSETEVKEKVAKPDLVHQEAVDKE 1135
XP_039768624 1157 QVSDFGSTAAEQDGASQGPA-----AQQEGAGLARGGQDVELLVGAEAGDGKEGTRGSEAEIKEKVAKPDLVHQEAVDKE 1231
P11137       1049 KISDFGQMASGLNIDDRRATelkleATQDMTPSSKAPQEADAFMGVESGHMKEGTKVSETEVKEKVAKPDLVHQEAVDKE 1128 human
XP_017451787 1136 ESYESSGEH----ESLTMESLKPDEGKKETSPETSLIQDEVALKlSVEIPCPPpvSEADSSIDEKAEVQMEFIQLPKEES 1211
XP_039768624 1232 ESYESSGEHdvtpEGGAGEPSKPDEGKKEPAKEPPTLPDEVTVR-ALEAELPP--SSVDAVLVEGADIQMEPIQQPKRDS 1308
P11137       1129 ESYESSGEH----ESLTMESLKADEGKKETSPESSLIQDEIAVKlSVEIPCPPavSEADLATDERADVQMEFIQGPKEES 1204 human
XP_017451787 1212 TETPDIPAIPSDVTQPqpeAVVSEPAEVRGEE-----EEIEAEGEYDKLLFRSDTLQITDLLVPGSREEF----VETCPg 1282
XP_039768624 1309 QEAPGISITPSEALEP---TLLKPGSEASADEnkegqEEVEARGESDRLLFRSETLQLADLSIPTDREESekrgVEDVP- 1384
P11137       1205 KETPDISITPSDVAEPlheTIVSEPAEIQSEE-----EEIEAQGEYDKLLFRSDTLQITDLGVSGAREEF----VETCPs 1275 human
XP_017451787 1283 EHKGVVESVVTIEDDFITVVQTTTDEGELGSHSVRFAAPVQPEEERRPYPH----------------------------D 1334
XP_039768624 1385 EHKGGIESVVTIEDDFITVVQTTTDDGESGSHSVRFAALDQAEVESRPSPPggeeeeeeeeeeeeegggggggeeeeeeA 1464
P11137       1276 EHKGVIESVVTIEDDFITVVQTTTDEGESGSHSVRFAALEQPEVERRPSPH----------------------------D 1327 human
XP_017451787 1335 -EELEVLMAAEAQAEPKDGSPDAPATPEK-EEVPFSEYKTETYDDYKDETTIDDSIMDADSLWVDTQDDDRSILTEQLET 1412
XP_039768624 1465 -SEPEAEELMDDRPEPKEGSPEAPASPDKeEEVGLSEYKTETLDDYRDETTIDDSIMDADSLWVDTQDDDRSIMTEQLET 1543
P11137       1328 eEEFEVEEAAEAQAEPKDGSPEAPASPER-EEVALSEYKTETYDDYKDETTIDDSIMDADSLWVDTQDDDRSIMTEQLET 1406 human
XP_017451787 1413 IPKEERAEKEARRPSLEKHRKEKPFKTGRGRISTPERKVAKKEPSTVSRDEVRRKKAVYKKAELAKKSEVQAHSPSRKLI 1492
XP_039768624 1544 VPKEEKSEKEARRPSLDKHRKEKPFKAGRGRISTPERKIAKKEPSTVSRDEVRKKKAVYKKAELAKKTEVQAHSPSRKFI 1623
P11137       1407 IPKEEKAEKEARRSSLEKHRKEKPFKTGRGRISTPERKVAKKEPSTVSRDEVRRKKAVYKKAELAKKTEVQAHSPSRKFI 1486 human
XP_017451787 1493 LKPAIKYTRPTHLSCVKRK 1511
XP_039768624 1624 LKPAIKYTRPTHLSCVKRK 1642
P11137       1487 LKPAIKYTRPTHLSCVKRK 1505 human
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap