Conserved Protein Domain Family
FAST_2
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pfam08368: FAST_2 (This model is not part of the current CDD release)
FAST kinase-like protein, subdomain 2
This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This subdomain is often found associated with the FAST kinase-like protein, subdomain 2.
Links
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Statistics
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PSSM-Id: 518218
Aligned: 69 rows
Threshold Bit Score: 71.0534
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_002195028  645 HSSLMKLNRAVCLECPEFHVPWFHEPY--CQRVFHNSMSQV---SPQRQHIHRMLTEILGGSH-YSRISVLTPYYYEIDF 718
Q5M9G9        449 FQKLVHINSTALLEYPEYKGPFLPASA--VAPS---PSPSNkkmTPLQKELQDALKALLGNND-TGSLEVATQYGWVLDA 522 Norway rat
XP_003504815  449 FQKLVHINTTALLEHPEYKGPFLPASA--VALC---PSSSSkqmTPLQKELQETLKELLGSTD-QGRLDVVTQYGWVLDA 522
17_pfamImport   1 FQKLLHISATAQLEHPEYTGPLLPASD--WAPW---LLACDgkaTPLQKELRDTLRGLLGSPS-RGSFAVATQYGWVLDA 74 
XP_003797637  452 FQKLLHINATAQLEHPEYTGPFLPASA--VAPR---SLALDktvTPLQKELQGILKGLLGSAN-EGSFEVATQYGWVLDA 525
XP_011229093  452 FQKLLHINATTQLEHPGYTGPRLPASA--LVPRLSVLQTKV---TPLQKELQDVLKGLLGSSG-GGSFMVPTQYGWVLDA 525
Q3SZK4        452 FQKLLHINATAQLEHPEYTGPLLPTSA--LVPS---PSALEqkmTPLQKELQETLKGLLGSAD-KGSFMVPTQYGWVLDA 525 domestic cattle
XP_003450964  457 KLKLLHIAATLSLEHPG----SLDTLP--SQSVLSVPASSSp-lSPLQRTLRETLLKFVGGKSeALRTGVDTVYGWSIDG 529
XP_064410631  456 ILKLIHINSTARLETAEYKGPYLPDSF--LISQ---RLQGEksaSSLQIGLREALKSAIGDEA-KYRCGIDTVYGWNLGG 529 coelacanth
XP_056660861  305 CQKLVHINATAQLEHPKYIGPYLPLATcqQAFR--LQTSTSrkmTPMQKDLQDIMKGWLGSED-KVRFGETTQYGWELDA 381 gray short-tai...

XP_002195028  719 ECVLDVNKKPLS 730
Q5M9G9        523 EVLLDAEGHFLP 534 Norway rat
XP_003504815  523 EVLLDTDGHFLP 534
17_pfamImport  75 EVLLDTDGQFLP 86 
XP_003797637  526 EVLLDADGQFLP 537
XP_011229093  526 EVLLDPDSQFLP 537
Q3SZK4        526 EVLLDTESQLLP 537 domestic cattle
XP_003450964  530 ELIVDADNKPVD 541
XP_064410631  530 EVLLDVDSKPLP 541 coelacanth
XP_056660861  382 ELVLDVENQPLP 393 gray short-tailed opossum
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