Conserved Protein Domain Family
FAST_2

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pfam08368: FAST_2 
FAST kinase-like protein, subdomain 2
This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This subdomain is often found associated with the FAST kinase-like protein, subdomain 2.
Statistics
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PSSM-Id: 400599
View PSSM: pfam08368
Aligned: 81 rows
Threshold Bit Score: 72.2149
Threshold Setting Gi: 0
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007240095 476 AQLIQLYMTVKLECPSYdlQSPWFLRKLHMESFLFAGNSIetemdHNLCRDVMVGLQSLLGNRNYFTSGVLTQFGYTL-- 553 Mexican tetra
XP_002411711 437 QKLKFLDSALTLECKQY--YGPFLPRDYSAKSVKRDGRL------LRLMCSLQEDMEQVVGVEN-FSFSVVQPR---Lpl 504 black-legged tick
EEN58993     480 KKLTQLMLAVELECPQF--KPQKLMKKFnqpldpql--paprffdHPTMYILQQSLSNVLGGRQYLVHNVMLPSGYIA-- 553 Florida lancelet
7_pfamImport   1 -QLTQLHLSSSLECSYY--WGPRLPFFLHVKNFSSVDHAFetpmeSRFYNQVKGPLTEMLGGRLY-NTRIFTRSGYTI-- 74 
XP_005450460 449 GQLTQLHLSTTLECTYY--WGPRLPFFLHVKRFSSAGQAFetpmeSLLYKQVKGPLAHLLGGTLY--STRMIHGGYTI-- 522 Nile tilapia
XP_012396653 488 AQLTQLYLAVVLECPFY--KGPKLLQQYQVKSFLIPPYLLetpmdLHLYKIVSVALIHLLEGRIYFASKVSTPCCYTV-- 563 Tasmanian devil
XP_012427260 444 SQLTQLFLTVTLECPFY--EGPKLLSKYQVKAFPTPqss----pdVHLFKRVKTGLLYLLKKRIYFASEVSTPYFYIV-- 515 zebra finch
XP_008122664 287 RYLSLLDTAMALEVPGY--DGPRLDPRFHVQMFDGALTADdanrkYSFKGLVGEGLQRLVGRDG-FQQDVVVPPGYGV-- 361 green anole
CAF90269     412 RYLSLLDAAVELEFREY--SGPRLQDAHKVLMFDHALTADevnrkYSYKGLVAEALRQLLGEHK-YRQDQVLPPGYYT-- 486 spotted green p...
XP_005994284 205 RYLSLLDSAVELEYEDY--SGPRLEERYKVMMFDHALTADevnrkYSYKGLVAEALRQLVGEQC-YKQDEVLPPGYYT-- 279 coelacanth
XP_007240095 554 ------DVEIKLDK-EGCVL 566 Mexican tetra
XP_002411711 505 ldmyiiDYVVQLNK-QGKPV 523 black-legged tick
EEN58993     554 ------DFEVKLDK-EGHVL 566 Florida lancelet
7_pfamImport  75 ------DVEMCLDE-NGYVL 87 
XP_005450460 523 ------DVEICLDE-GGFVL 535 Nile tilapia
XP_012396653 564 ------DIEIKLDE-EGFVL 576 Tasmanian devil
XP_012427260 516 ------DIEIKLDE-EGFLL 528 zebra finch
XP_008122664 362 ------DFLLHVSSlSGEVL 375 green anole
CAF90269     487 ------DFLLWMNG-PGQVL 499 spotted green pufferfish
XP_005994284 280 ------DFLLWINN-SGSVv 292 coelacanth
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