Conserved Protein Domain Family
CTNNB1_binding

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pfam08347: CTNNB1_binding 
N-terminal CTNNB1 binding
This region tends to appear at the N-terminus of proteins also containing DNA-binding HMG (high mobility group) boxes (pfam00505) and appears to bind the armadillo repeat of CTNNB1 (beta-catenin), forming a stable complex. Signaling by Wnt through TCF/LCF is involved in developmental patterning, induction of neural tissues, cell fate decisions and stem cell differentiation. Isoforms of HMG T-cell factors lacking the N-terminal CTNNB1-binding domain cannot fulfill their role as transcriptional activators in T-cell differentiation.
Statistics
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PSSM-Id: 400583
View PSSM: pfam08347
Aligned: 18 rows
Threshold Bit Score: 188.446
Threshold Setting Gi: 148744056
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003224258   1 MPQLQpdpgaaersrdgggGGSGD-DLGAPDELIPFQDEGdEQDKGagGRGS---AHGDLDELKSSLVHESESRGAgggg 76  green anole
EEN52158      26 MPQLN--------------GSGGD-DLGASDETISFKDEG-EQEEKsaENVS-----NDLSDIKSSLVNESESSQS---- 80  Florida lancelet
XP_003410438   1 MPQLSgg----------ggGGGGDpELCATDEMIPFKDEGdPQKEKifAEIShpeEEGDLADIKSSLVNESEIIPA---- 66  African savanna...
9_pfamImport   1 MPQLSgg-----------gGGGGDpELCANDEMIPFKDEGdPQKEKifAEIShpeEEGDLADIKSSLVNESEINPS---- 65 
Q9W7C0         1 MPQLSg------------gGGGGDpELCATDEMIPFKDEGdPHKEQifAEIShseEEGDLAEIKSSLVNETEISPN---- 64  zebrafish
3_pfamImport   1 MPQLS--------------GGGGDpELCATDEMIPFKDEGdPHKEQifAELShseEEGDLADIKSSLVNESESSPN---- 62 
4_pfamImport   1 MPQLS--------------GGGGDpELCATDEMIPFKDEGdPHKEQifAELShseEEGDLADIKSSLVNESESSPN---- 62 
Q8JHX2         1 MPQLG--------------SGGGD-DLGATDEMLAFKDEG-EQEEKipENAF---TERDLADLKSSLVNESEGSGS---- 57  chicken
AAI42318       1 MPQLDsgg---------ggAGGGD-DLGAPDELLAFQDEGeEQDDKsrDSAAg--PERDLAELKSSLVNESEGAAGdagv 68  cattle
KAE8614210     1 MPQMN--------------SAGED-DLGASDEMISFKDEG-DQEEKirESAF---TERDLADLKSSLVNESEVSSH---- 57  tropical clawed...
XP_003224258  77 gSSSE-----SEa-------eRPPPPPRPRESF-QKPRDspaSVAEvLRRQQDG--GFFKGT--PYPSYPFLMIPE---- 135 green anole
EEN52158      81 -GAVP-----SE------------GSKPPLQSYpRE-----------DSRRGDE--GSKAESvpVVSRGPAYLTPGgviv 129 Florida lancelet
XP_003410438  67 -SNGH-----EVa----------RQAQTSQESYhDKARE---HPDE--GKHPDG--GLYNKGp-SYSGYSGYIMMPn--- 119 African savanna...
9_pfamImport  66 -TISH-----EAa----------RRSQVPQDSY-DKARE---HPDE-AGKHPDG--VLYNKG--PYQGYPGYIMMPn--- 117
Q9W7C0        65 -SNSH-----DAa----------RQSQITPDSYhEKHRD---HPDD--GKLQD----LYSKGh-PYPSYPGYIMMTn--- 115 zebrafish
3_pfamImport  63 -SNSH-----GV-----------RQSQI-PDSYhEKHRD---HQED-GSKIHNN--VTNCCGhaPYTVTPVPVLPE---- 114
4_pfamImport  63 -SNSH-----EI-------------VKQHFSSTyKGHRE-----------------SVYHKHfpPHPSGPCYTAPRsfyp 106
Q8JHX2        58 -PAAA-----ADp-------eAIRRVQDPQRVYqEKLPD---HMDDaGMKHQDP--GMYKGS--AYSGYPFLMLSD---- 113 chicken
AAI42318      69 pGAGA-----GArgeaevgaeALGREHTSQRLFpDKLPE---SLED-GLKAPECtsGMYKDT--VYSAFNLLMHYPppsg 137 cattle
KAE8614210    58 -PRVPeshpeAM-----------RRTQDAQLVYqDKLTD---HMED-GVKHQDE--GMYKGS--GYPSYPFLMLSD---- 113 tropical clawed...
XP_003224258 136 ---LGSPYLQSGALSPGGArtylqvkwplldvpagatlkdtrspspaHLSNKVPVVQHAHHMHpLTPLITYSNDHFSPG- 211 green anole
EEN52158     130 snmGVYPH-PNGSLAASA------------------------------TSNKVSVVHGPPHPGpLTQLMMYSNEHFAPGt 178 Florida lancelet
XP_003410438 120 --mNNDPYMSNGSLSPPIP----------------------------RTSNKVPVVQPSHAVHpLTPLITYSDEHFSPG- 168 African savanna...
9_pfamImport 118 ---mNDPYMSNGSLSPPIA----------------------------RTSCQLSVVQPAHVLHaLGEFFTYTEQGFKPGv 166
Q9W7C0       116 --mNNEPYMNNGSLSPPIP----------------------------RTSNKVPVVQPSHAVHpLTPLITYSDEHFAPG- 164 zebrafish
3_pfamImport 115 ------PYLRQEPISISL-----------------------------PQSNKVPVVQPSHAVHpLTPLITYSDEHFAPG- 158
4_pfamImport 107 fsfPCLPF-SSLSVSPP--------------------------------SNKVPVVQPSHAVHpLTPLITYSDEHFAPG- 152
Q8JHX2       114 ------PYLPNGSMSPL--------------------------------SNKVPVVQPSHGVHpLTPLIPYSNDHFSHG- 154 chicken
AAI42318     138 agqHPQPQPPL--------------------------------------HNKAS--QPSHGVPqLSPLYD----HFSSP- 172 cattle
KAE8614210   114 ------PYLSNGSVSAL--------------------------------SSKVPVVQPSHGVHpL---IPYNNESFSHG- 151 tropical clawed...
XP_003224258 212 SPPSHlsp-----eiDPKT--GIPRPPHPSelspYYPLSPGAIGQIPHPLGW 256 green anole
EEN52158     179 --PPHigvppnsievDPKT--GIPRPRHPAdlppMYAIPPNQLPQLGPSYPk 226 Florida lancelet
XP_003410438 169 SHPSHips-----dvNSKQ--GMPRHPPAPdiptFYPLSPGGVGQITPPLGW 213 African savanna elephant
9_pfamImport 167 SHPSFlps-----rkNVRQ--GMPRHPPGPdiptFYPLSPGGVGQITPPLGW 211
Q9W7C0       165 PHSGHhpq-----dvNPKQa-GMPRHHPGPdipnFYPLSPGGVGQMTPPLGW 210 zebrafish
3_pfamImport 159 SHSGHhph-----dgSSKQgrGMPRQHPGPdmpnFYSLSPGGVGQITPPLGW 205
4_pfamImport 153 SHSGHhph-----dgSSKQgrGMPRQHPGPdmpnFYSLSPGGVGQITPPLGW 199
Q8JHX2       155 SHSPHlpa-----diSQKQ--AVHRPSQTSdipgFYPLPPAGVGQITPSMGW 199 chicken
AAI42318     173 -HPTPapa-----diSQKQ--GVHRPLQTPdlsgFYSLTSGSMGQLPHTVSW 216 cattle
KAE8614210   152 SHSTHlpa-----dlNQKQ--GVHRPAQTAdiptFYPLPSGGVGQISPSVGW 196 tropical clawed frog
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