Conserved Protein Domain Family
CTNNB1_binding

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pfam08347: CTNNB1_binding (This model is not part of the current CDD release)
N-terminal CTNNB1 binding
This region tends to appear at the N-terminus of proteins also containing DNA-binding HMG (high mobility group) boxes (pfam00505) and appears to bind the armadillo repeat of CTNNB1 (beta-catenin), forming a stable complex. Signaling by Wnt through TCF/LCF is involved in developmental patterning, induction of neural tissues, cell fate decisions and stem cell differentiation. Isoforms of HMG T-cell factors lacking the N-terminal CTNNB1-binding domain cannot fulfill their role as transcriptional activators in T-cell differentiation.
Statistics
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PSSM-Id: 518202
Aligned: 14 rows
Threshold Bit Score: 191.638
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003224258  19 GGGSGD-DLGAPDELIPFQDEGDEQDKGA-GG--RGSAHGDLDELKSSLVHESESRGAgggggSSSeseaerp--ppppr 92 
Q9W7C0         7 GGGGGDpELCATDEMIPFKDEGDPHKEQIfAEisHSEEEGDLAEIKSSLVNETEISPN-----SNS-------------- 67  zebrafish
4_pfamImport   1 SGGGGDpELCATDEMIPFKDEGDPHKEQIfAElsHSEEEGDLADIKSSLVNESESSPN-----SNS-------------- 61 
3_pfamImport   1 SGGGGDpELCATDEMIPFKDEGDPHKEQIfAElsHSEEEGDLADIKSSLVNESESSPN-----SNS-------------- 61 
XP_003410438   9 GGGGGDpELCATDEMIPFKDEGDPQKEKIfAEisHPEEEGDLADIKSSLVNESEIIPA-----SNG-------------- 69 
Q8JHX2         5 GSGGGD-DLGATDEMLAFKDEG-EQEEKI-PE--NAFTERDLADLKSSLVNESEGSGSpaaaaD---------------- 63  chicken
NP_001092656  10 GAGGGD-DLGAPDELLAFQDEGEEQDDKSrDS--AAGPERDLAELKSSLVNESEGAAG-----DAGvpgagagargeaev 81 
XP_005458373   5 SREDGD-DLGASDELIAFKDEG-EQEEKR-----NVSAERDLDDVKSSLVNESETN-------SSSdseadrr--peprp 68 
XP_011603100   5 NGEDGD-DLGANDELIAFKDEG-EHEEKR-----NVSAERDLDDVKSSLVNESETN-------SSSdsevpgdrrpkpgv 70  torafugu
XP_029685619   5 NGGGGD-DLGANDEMISFKDEG-EQEEKI-SE--NVSAERDLDDVKSSLVNESE---S-----SSDseqaerr--pqtra 69  torafugu
XP_003224258  93 pRESF-QKPRDSPASV----AEVLRRQQD-G--------GFFKG-TPYPSYP-FLMIPELG---SPYLQSGALSpggart 153
Q9W7C0        68 -HDAArQSQITPDSYH----EKHRDHPDD-Gkl----qdLYSKG-HPYPSYPgYIMMTNMNn--EPYMNNGSLS------ 128 zebrafish
4_pfamImport  62 --HGVrQSQIP-DSYH----EKHRDHQEDgSkihnnv--tnccghAPYTVTPvPVLP-------EPYLRQEPISi----- 120
3_pfamImport  62 -HEIVkQH------FS----STYKGHRES----------VYHKHfPPHPSGPcYTAPRSFYpfsFPCLPFSSLSv----- 115
XP_003410438  70 -HEVArQAQTSQESYH----DKAREHPDE-Gkhp--dggLYNKG-PSYSGYSgYIMMPNMNn--DPYMSNGSLS------ 132
Q8JHX2        64 -PEAIrRVQDPQRVYQ----EKLPDHMDDaGmkh--qdpGMYKG-SAYSGYP-FLMLSD------PYLPNGSMSp----- 123 chicken
NP_001092656  82 gAEALgREHTSQRLFP----DKLPESLED-GlkapectsGMYKD-TVYSAFN-LLM---------HYPPpsgagqh---- 141
XP_005458373  69 gVE---SRARQNQVCE----EALRKQQRD-G--------RLLQP-SPYVGYP-FFMFPDLGnlcSPYLANGALTagarty 130
XP_011603100  71 dLE---RRARHG---QlldeDVFRRRQ-D-G--------GLFHP-SPYVGYP-FFMIPDLGnfcSPYLPNGALAsnarty 132 torafugu
XP_029685619  70 dSESY-DKARD---YF----SEALRRQQD-G--------GFFKS-PHYPGYP-FLMIPDLT---NPYLPNGSLSpsarty 127 torafugu
XP_003224258 154 ylqvkwplldvpagatlkdtrspSPAHL-SNKVPVVQHAHHMHPLTPLITYSNDHFSPGSPPSHLSPEI-DPKT--GIPR 229
Q9W7C0       129 -----------------------PPIPRtSNKVPVVQPSHAVHPLTPLITYSDEHFAPGPHSGHHPQDV-NPKQa-GMPR 183 zebrafish
4_pfamImport 121 ----------------------sLPQ---SNKVPVVQPSHAVHPLTPLITYSDEHFAPGSHSGHHPHDG-SSKQgrGMPR 174
3_pfamImport 116 ----------------------sPP----SNKVPVVQPSHAVHPLTPLITYSDEHFAPGSHSGHHPHDG-SSKQgrGMPR 168
XP_003410438 133 -----------------------PPIPRtSNKVPVVQPSHAVHPLTPLITYSDEHFSPGSHPSHIPSDV-NSKQ--GMPR 186
Q8JHX2       124 ----------------------------lSNKVPVVQPSHGVHPLTPLIPYSNDHFSHGSHSPHLPADI-SQKQ--AVHR 172 chicken
NP_001092656 142 ----------------------pqpqpplHNKAS--QPSHGVPQLSPLY----DHFS-SPHPTPAPADI-SQKQ--GVHR 189
XP_005458373 131 lpfqwpl---ldvpgrasvrdtaTPSHL-SSSVPMVQHPHVSH-LHPLLSYSPEAFSPPRASPGFSPEA----A--GVSR 199
XP_011603100 133 lpfqwpl---ldvaarsairdstNAAHL-PNNVPMVQHPHMTH-LHPLLSYSPEAFSPQRASPGFSPD-----T--GISR 200 torafugu
XP_029685619 128 lqmkwpll-dvpgsaglkdsrspTPGHL-SNKVPVVQHAHHVHPLTPLITYSNEHFSPGTPPSHLSPEIlDPKT--GIPR 203 torafugu
XP_003224258 230 PPHPSELSPYYPLSPGAIGQIPHPLGW 256
Q9W7C0       184 HHPGPDIPNFYPLSPGGVGQMTPPLGW 210 zebrafish
4_pfamImport 175 QHPGPDMPNFYSLSPGGVGQITPPLGW 201
3_pfamImport 169 QHPGPDMPNFYSLSPGGVGQITPPLGW 195
XP_003410438 187 HPPAPDIPTFYPLSPGGVGQITPPLGW 213
Q8JHX2       173 PSQTSDIPGFYPLPPAGVGQITPSMGW 199 chicken
NP_001092656 190 PLQTPDLSGFYSLTSGSMGQLPHTVSW 216
XP_005458373 200 SPH----ASCYPVSPGAMPQIPHPLGW 222
XP_011603100 201 SPH----TACYPVSPGGMAQITHPLGW 223 torafugu
XP_029685619 204 TPHPSELSPYYPLSPGAVGSIAHPLGW 230 torafugu
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