3IG3,5V6T,6VXK


Conserved Protein Domain Family
Plexin_cytopl

?
pfam08337: Plexin_cytopl (This model is not part of the current CDD release)
Plexin cytoplasmic RasGAP domain
This family features the C-terminal regions of various plexins. Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels. The cytoplasmic region, which has been called a SEX domain in some members of this family, is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins. This domain acts as a RasGAP domain.
Statistics
?
PSSM-Id: 518194
Aligned: 35 rows
Threshold Bit Score: 596.539
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
3IG3_A         49 QIPFLDYRTYAVRVLFPG---IEAHPVLkeLD--TP---Pn----vEK-ALRLFGQLLHSRAFLLTFIHTLEAQS-SFSM 114  house mouse
XP_002112670 1252 GAPQHPFRVYIHKMLFPNvkhGEMHPVFapIS--VR---GsrksrlED-SLSSFLDLLLRDKFLITFIATLEKQP-DFKP 1324
XP_002113113 1233 SIPYLPFNGYAIKILFPD---NEEYAVHhfLN--QR---EgrryddDD-AVLLFADLLYKKKFLKIYLHTIENQQ-DFSM 1302
XP_069045535 1653 GIPFLDYRMYAERIFFPG---HRESPLHrdLD--VQ---EcrrqtvEQ-GLVQLSNLLNSKLFLTKFIHTLESQR-TFSP 1722
XP_002935540 1356 GIPFLDYKTYVERIFFPV---NIDSPIPksLD--VP---AgrrstvEQ-GLTQLSNLLNNKLFLTKLIETLDAQL-TLSQ 1425
XP_008102077 1342 GIPFLDYNTYTQRVFFPA---QGDVPLRrvLD--LP---EgrratvEQ-GLGQLSNLLNSKVFLLTLIRTLEAQP-TFSQ 1411
Q9QY40       1317 GIPFLDYRTYAERAFFPG---HVGCPLQpgLEglGE---EgrsvtvRQ-GLTQLSNLLNSKLFLLTLIHTLEEQP-SFSQ 1388 house mouse
XP_004998121 1444 eahprpfGEYARRVYFTA---LDTHPLPvrPR--FPgtnD---------CIEQFTFFLQQDDFLRAFVGVMEGEGrAFSV 1509
XP_019851565 1263 QLPFHDFPTYATKVFFPAa--NTNHPVL--SP--PKvphGmthdsmCV-LLDEFRELVFDKKFLVAFIRTLESRP-KFNL 1334
XP_018671834 1290 riiylppwEYITQVLFNQ---RSGHPVLdeNA--Mvgq-----gtvKQdALKSLLSVIKNKDVLLVLVRTLEEQR-KFTV 1358 vase tunicate
3IG3_A        115 RDRGTVASLTMVALQSRLDYATGLLKQLLADLIEKNLe-SKnHPKLLLRRTESVAEKMLTNWFTFLLHKFL-KECAGEPL 192  house mouse
XP_002112670 1325 KDKCNIASFLIVALHENMDYVTKVLMKLLIEMIRKLP--PKgQPQLFLKRNDSITEKLLSNWLALCLYQYS-NKRFGQPL 1401
XP_002113113 1303 KDRCNVASLLMVALQHRMGYVTEILCHLLRELIHKSV--AKnHPKLILRRTECIAEKLLTNWLSFFFYPYL-FGSIGDSL 1379
XP_069045535 1723 RDRAYVASLLTVSLHGKLEYFTDILKTLLNDLVEQYV--AK-NPKLMLRRTETVVEKLLTNWMSICLYAFL-RDSAGESL 1798
XP_002935540 1426 RDRCHAASLLTVALHGKLEYLTDVMKTLLANLIDQCV--AK-NPKLLFRRTETIVEKLLTNWMSICLQTDL-REAAAEPL 1501
XP_008102077 1412 RDRCHAASLLSLALHGRLEYLTDIMQTLLSDLAAHCV--SR-NPKLMLRRTETMVEKLLTNWMSICLYSYL-REVAGEPL 1487
Q9QY40       1389 RDRCHVASLLSLALHSKLEYLTDIMRTLLGDLAAHYV--HK-NPKLMLRRTETMVEKLLTNWLSICLYTFL-KEVAGEPL 1464 house mouse
XP_004998121 1510 RDRCQVASLLMCSANGDEAMGTHTLSTLLDQYFTAn---SRrDPRLMLRRTESVAEKLLTAWLTTGMHDAV-LRDAARPL 1585
XP_019851565 1335 QDKSTMASLLMVACLKDISYSTEVLEALLGNLIRRSLsnTKnHPKLLLRRTESVAEKLLTNWFCVTLYPYM-LECAGAPL 1413
XP_018671834 1359 QEKGNMASLLTICLFDDLPYYTRVMLELLTGLIQKHV--SR-NPKLLLRRSESVVEKMVSHWLSINLYDECiNEQAGKPL 1435 vase tunicate
3IG3_A        193 FLLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLTLHCVCPes-------------------eGSAQVPVKV 253  house mouse
XP_002112670 1402 YLLYHAIKQQISKGPVDQKTGEARYCLSEEKLLREQVDETEISVMASIG----------------------DGQQISLKL 1459
XP_002113113 1380 YVLYQAIKQQVDKGPVDEITADAKHSLSEDKLIRQNIDYQTLTLSAHF-----------------------ERTTELVKV 1436
XP_069045535 1799 YMLFRAIKHQVDKGPVDAVTGKAKYTLNDNRLLREDVEYRTLTLNVLMQgg------------------gnDAQPVQSKV 1860
XP_002935540 1502 YMLYCAIKYQVDKGPVDAVTGKAKRTLNDCHLLREDIDYHPMTLTVIVKsg-------------------rETHHVPVRV 1562
XP_008102077 1488 YMLFRAIKYQVNKGPVDAVTGKAKRTLNDGRLLREDVEYRPLTLTVLVRgagp--------------sggsETQRIPVRV 1553
Q9QY40       1465 YMLFRAIKYQVDKGPVDAVTGKAKRTLNDSHLLREDVEFQPLTLMALVGpeadr------------aagnsGVHRVPARV 1532 house mouse
XP_004998121 1586 YNLTQALKIYAWKGPVDAVTGAATYTLNADALLRERVEYEPLTLHVDM-----------------------NRQVYEVHV 1642
XP_019851565 1414 FVLFKAVKAQLEKGPIDVITGDARNSLSEEKLLRQPLDFKVMECEVEMGnshtllrhtrkedagvepdpsnADDIQTIKV 1493
XP_018671834 1436 FLLTKAVHYLVSSAPCDVIAKKAFNSLNEMTLLGTELQYETVVLHATIVeeg-----------------gkVTTSVDVKV 1498 vase tunicate
3IG3_A        254 LNCDSITQAKDKLLDTVYKGIPYSQRPKAEDMDL-----Ew-RQGRMAr--IILQDEDITTKIE-CDWKRVNSLAHYQ-- 322  house mouse
XP_002112670 1460 FDCDTITQAKEKILDAIYINQPYSARPSVAEFELea-vtV--RHGQPPy-rLPMFDEDSSNEVYeNGWYKLNTIGHYK-- 1533
XP_002113113 1437 LDCDSITQTKEKILDAIYKSAAYSRRTPAEEIDL-----EwiRDTPSGlvrIILKNEDDSSNIS-GRWKRINTLKHYQ-- 1508
XP_069045535 1861 LDCDTITQVKEKILDQVYKGTSYSHRPHTDSLDL-----Ew-RSGVAGh--LILSDEDLTSVVQ-GNWKRLNTLQHYK-- 1929
XP_002935540 1563 LDTDTITQVKQKILNQVYKGTPFSQRPAATTLDL-----Ew-RSGNAGh--LTLSDEDLTSLIQ-DQWKRLNTLHHYK-- 1631
XP_008102077 1554 LDTDTITQVKEKILDQVYKGVPFSQRPSVHSLDL-----Ew-RSGVAGh--LTLSDEDLTSVTQ-KEWKRLNTLQHYK-- 1622
Q9QY40       1533 LDTDTITQVKEKVLDQIYKGTPFSQRPSVHSLDL-----Ew-RSGLAGh--LTLSDEDLTSVTQ-NHWKRLNTLQHYK-- 1601 house mouse
XP_004998121 1643 NSCDTIGQILEKL-----KLVVTTAGADVSDFDTrvlvlQr-EEGl-----RVLKDIDDSSKMS-AGWVQLNTASFYG-- 1708
XP_019851565 1494 MDTDSVSQTKEKLLDFIYGNRPVSKRPSIAEVEL-----El-CRGNAG---IPLKDQDTTSRRE-GEWMRINTLGHFNil 1563
XP_018671834 1499 VNVDSIKQAKTKIIEAVYKDKPYSECPKPDDLDF-----AlmNSSESTg--ITLSDVDGMSVVD-GKYTKINTLKHYN-- 1568 vase tunicate
3IG3_A        323 -VTDGSLV---ALVPKQvsaYNmans------ftftRSL----------SRYESLLRAAsSPDSLRSRApmltp----dq 378  house mouse
XP_002112670 1534 -ITDNTTL---KLHRVYnrnSDtfsisttyqytrpsRNQlharynnvsnQVTLGGNKENlSQPLPNQVR----------- 1598
XP_002113113 1509 -IPDGASV---VVIPRTs-----------------aSS------------LSVSSNSSTrYPVSSRSLLgrlsvde---n 1552
XP_069045535 1930 -VTDGATV---ALVPRHs-----------------kHIHhd------nhDYIAGEKTPMleda----------------d 1966
XP_002935540 1632 -VPDNATV---ALIPRLhnnQCetpsns----------------------------------figgeKTpmled----gd 1669
XP_008102077 1623 -VPDGATV---GLIPRLhndISq------------gTGQ----------SFFSGENTPMledg----------------e 1660
Q9QY40       1602 -VPDGATV---VLIPQVhngGTv------------sQSLgq-------tGCPSGENTPMledg----------------e 1642 house mouse
XP_004998121 1709 -MRDGDQL---AFVKSDtdgGDar-----------rRRNnnss---ssgGGGGGGGGGSlFKVRTKSKSridp------- 1763
XP_019851565 1564 eMAEAAIAdpkKPIPRFrltARn------------qTLSpgrp---vsgAVGYDVPGTIvASASITSQTsllasvnspsf 1628
XP_018671834 1569 -VPDNAVV---VLRPHDvenQApq----------dvSS------------PLLP-------------------------- 1596 vase tunicate
3IG3_A        379 eagTK-LWHLVRNHD-HTDHregd-------------------rgsKMVSEIYLTRLLATKGTLQKFVDDLFETVFSTah 437  house mouse
XP_002112670 1599 ---EK-AFHLMKHSDsNTTNe-------------------------RILPEAFLMCLLLTKGTLQQYTQDLFESLFTLph 1649
XP_002113113 1553 gethynLWHLIKPMD-ENSTdpn---------------------anKLVSEVFLTRLLSTKHILQTFVDDLFSQMFTVpq 1610
XP_069045535 1967 eggVK-LWHLVKASE-EPELpkhrrgs------------lrereraKAIPEIYLTRLLSMKGTLQKFVDDLFQVILST-- 2030
XP_002935540 1670 eggIR-TWHLVKPVE-EPEVfknrkss------------lrereraKAIPEIFLTRLLSMKGTLQKFVDDAFQVMLGV-- 1733
XP_008102077 1661 eggVR-LWHLVKPSE-EPEPtkqqqdrr-----------sslreraKAIPEIYLTRLLSMKGTLQKFVDDAFQAVLSV-- 1725
Q9QY40       1643 eggVR-LWHLVKATE-EAEGakvrrsslr--------drerersraKAIPEIYLTRLLSMKGTLQKFVDDTFQAILSM-- 1710 house mouse
XP_004998121 1764 --macePWHLVKPDT-DGTAaaaa------------------aaatRVPSEIFLTYLMTVKTALQPFVDDLVDAVFNI-- 1820
XP_019851565 1629 dtnTR-LFHLVKPEAnEGDQ--------------------------KIVSEVFLTRLLSTKRIIQSYVDDLFHAIFSVp- 1680
XP_018671834 1597 ---PKhMYHLIN----PSEEeqsngytdvqsdagkkademldnlmkRPFQEMFLTRMVKAKTTIQEYVDGVFNSILR--- 1666 vase tunicate
3IG3_A        438 RGSALPLAIKYMFDFLDEQADQRQISDP-DVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKNSITDACLSVVAQTFMDSCS 516  house mouse
XP_002112670 1650 HSNTFPLAIKYLFDFLNSQASQMQFNDP-AVVKSWKNNTLPLRYYINIIRNPQFLFDIDKSPIVDSCLSVISQAFGDACS 1728
XP_002113113 1611 TLYHFPKVIKYLFDFLDYEAFKLGFTTEnDVAHTWKNNCLPLRFYINIVKNPHHAFDVNKSGTVDSCLSVIAQAFMDSCS 1690
XP_069045535 2031 -SRPVPLAVKYFFDLLDEQAAHHGISDS-ETIHIWKTNSLPLRFWINIIKNPQFIFDVQASDNVDAVLSVIAQTFMDSCT 2108
XP_002935540 1734 -NRQVPIAIKYFFDFLDEMAEKHEITDA-ETVHIWKTNSLMLRFWVLILKNPQMVFDVEVSENVDSILAVIAQTFIDSCT 1811
XP_008102077 1726 -NRPVPIAVKYLFDLLDELAVQHGVNEP-ETLHIWKTNSLLLRFWVNTLKNPQFIFDVRVSDNVDANLSVIAQTFIDACT 1803
Q9QY40       1711 -NRPVPIAVKYLFDFLDELAEKHGIEDP-ETLHIWKTNSLLLRFWVNVLKNPQLIFDVQVSDNEDAILAVIAQTFIDSCM 1788 house mouse
XP_004998121 1821 --DQPSPAVRFLFHFLDDQARKHNISDP-RTTHIWKSNAFPLRFWINLIKNPDFLLHVQQTRTVSSGLSTVAQVIMDSCS 1897
XP_019851565 1681 AGKSLPRAIKIVFDFLDAQAAENGITDP-EILHTWKTNTLPLRFWVNLIKNPDFVFDINKSATIDACFTVIAQAYIDACS 1759
XP_018671834 1667 -PKPISKTVRYFFQFLDREADRHKINDP-EVLHIWKTNSLLLRYWVNVLKNPEFVFDLNKTDIVDSCLNVITQAFMDACT 1744 vase tunicate
3IG3_A        517 TSEHRLGKDSPSNKLLYAKDIPNYKSWVERYYRDIAKMASISDQDMDAYLVEQSRLHAND--------FNVLSALSELYF 588  house mouse
XP_002112670 1729 VSDTKVSKDSPSNRLLYAREIPRYRDKVAEFYKSIQNLPTVSEKEMMKEMKLLSETLKDD--------LDKSSALLQLYD 1800
XP_002113113 1691 ITDNRLGKDSPSNKLLYARETSDYKARVQKFYADIQYMPPVSLDELLHTHEDMMRRFRVKr------nFNSLNAVHELFT 1764
XP_069045535 2109 IAEHKLGRDSPINKLLYARDIPRYKQMVERYYADIRQTISASDQEMNSALAELSRNYSGE--------LNYLVALHELYK 2180
XP_002935540 1812 ISEHKVGRDSPVNKLLYAREIPRYKQLVENYYADIKKTAAASYQEMNSFLTEQSGVHSTE--------LNSLVALQELYN 1883
XP_008102077 1804 TAEHKVGRDSPVNKLLYAREIPHYKQMVEKYYADIRQTVPASYQEMNSALTELSGKYSSD--------LNCLVALQELYN 1875
Q9QY40       1789 VSEHKVGRDSPVNKLLYAREIPRYKQMVEKYYADIRQSSPASYQEMNSALAELSGNYSSA--------PHCLEALRELYN 1860 house mouse
XP_004998121 1898 VSDQQLGKHSPANKHLYRKEVAEYKQKIANFYTAISRLPPPTDAELQASFASAQSGEQAC---------DRPDAVCGLME 1968
XP_019851565 1760 TAEVRYTKDTPSARLLYANEVKQYKEEVLQYYRDIMAQPQPTAEDNKSYFQEMAENYFQSfeskeglhFHSDSALLEIYR 1839
XP_018671834 1745 TTNRKLGHDSPSNKLLYAKDADNYKVMVKEFFINISNTPTVTQEEVTQILQKQSASYASR--------FNQMVALNGIYE 1816 vase tunicate
3IG3_A        589 YVTK 592  house mouse
XP_002112670 1801 YAYS 1804
XP_002113113 1765 YATK 1768
XP_069045535 2181 YINK 2184
XP_002935540 1884 YINK 1887
XP_008102077 1876 YINK 1879
Q9QY40       1861 HIHR 1864 house mouse
XP_004998121 1969 YALR 1972
XP_019851565 1840 YAIQ 1843
XP_018671834 1817 HLVK 1820 vase tunicate
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap