Conserved Protein Domain Family
P4Ha_N
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pfam08336: P4Ha_N (This model is not part of the current CDD release)
Prolyl 4-Hydroxylase alpha-subunit, N-terminal region
The members of this family are eukaryotic proteins, and include all three isoforms of the prolyl 4-hydroxylase alpha subunit. This enzyme (EC:1.14.11.2) is important in the post-translational modification of collagen, as it catalyzes the formation of 4-hydroxyproline. In vertebrates, the complete enzyme is an alpha2-beta2 tetramer; the beta-subunit is identical to protein disulphide isomerase. The function of the N-terminal region featured in this family does not seem to be known.
Links
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Statistics
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PSSM-Id: 518193
Aligned: 154 rows
Threshold Bit Score: 83.4761
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EFX74258      17 ASADLANTFRLEQKVVNVLGELVAQTEAKLSIIRHYLEDYQSV-VEEKASSEEefierVAGNP----IHAYRLMKRLYFD 91 
XP_001964699   1 MTKVFGYEQRMLGYMQKFLDDNQSKLDFLKARLREFEVEREEArEWGAAYFDS-----PLNKY----LLNKRLTVDWQLV 71 
Q8IMI2        31 SVVNMDDLLNMEDDLVSKLEGYAEKLSYKANTIRWGIQQMr---EQLDKSKKE-----QSFDL----FNRYSFIRHMQAD 98  fruit fly
Q2PDP5       204 SKSKVINILKIQENVVKYLENYIYALETKLKTIDEALIDLATYhIQFERDKLA-----IASSP----VASYSLIHHMQSD 274 fruit fly
EDW39336     154 SIYKLREYLELQGNLVLNLEYYVYHLEIKLHKIQEALLDMEKVhALFEEDKRA-----FVSNP----VNSFSLIRHMHSD 224
XP_002069834  30 svsdMISLQDLKHSLISELELYATELKGKLQSVKKGISHLETQiRRLEDNILG-----QEYNQ----INYFSSLRRLHSD 100
XP_002024158  35 SLESLLPMIKLKEAYVNNFKSYEEALKIHLKQVHLAIKHAEDLlSA------------LTAKPghnlWHQFRLIRHMYWD 102
EDW39337       2 SIYDLGELLTHNKVLVNHLEAYADKLQQRVDLIDSYVEIMKEk----iARAQR-----MDHDP----PSSFSFMRHMQFD 68 
Q0KHY7        33 SIYDMSKLIDYEHYLLNILQKFANALQKRVDTLEYYLEMTDY------DREKN-----LAEDP----IKHFRITRRLHSD 97  fruit fly
NP_730342     33 SESQLS-LLKLKETHVNNLQSYKKVLKKHLQKIRRAIRQSEELlKS------------TKTSPrn-lIYGYKVLRHLHND 98  fruit fly

EFX74258      92 WQTVEKEI-------KADNWRS-IFAFiitlilervrmGAK-FPKEEDFFGAAQALVRLQDTYELNMTQLARGNLWG 159
XP_001964699  72 ENLMETHS-------GKKPLARlQKVMgh-------klMPKkTELEGAIDGLLRLQTVYRLEAKDIARGMLDGTDYS 134
Q8IMI2        99 WLMWKQYL-------D--KPVI-RDELnyk-----qmdNLR-MPQELDLFDASEAIRRMQATYAMLSNDIAEGFLDG 159 fruit fly
Q2PDP5       275 WTHWQLFL-------QEDPGKDeLASLmsi---------kkyLPTKNDISEVCHGISKMLNAYLMTAQDIANGVILG 335 fruit fly
EDW39336     225 WMKWQLYL-------S--GDPG-QEQLaym-----retSAY-LPTKDDIADALLGMERVRSVYGLEPQDMASGLLSD 285
XP_002069834 101 WPKWLQFM-------RQNVAKEtQDRVqem---------rhkLPIEDDYYGALNSIYVLLDVYLITPQDFAKGLLNG 161
XP_002024158 103 WPQYFKLMqkvlgskEIams----------------qsRLHeQPTGIDFEEALGAIYKLQTVYSLDPGDMAGGILRG 163
EDW39337      69 WPNILWYL-------EQQPGEAqATGIsll---------hsdLPTTKDLEETLNGLWRIQTIYNLNGSDMAKGLLMG 129
Q0KHY7        98 YVNWVWFM-------EEQPWGTlVKDIi---------aIAPeMPTLKDVEEAIRGLRLIQWTYSLPTAEMAKGVLQD 158 fruit fly
NP_730342     99 WPQYFRLLkkdlgleQIavs----------------qmLLTqQPTSVDFEESMGAMHRLQTVYNLDSYAMTEGFIDD 159 fruit fly
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