5CSL,5I6I


Conserved Protein Domain Family
ACC_central

?
pfam08326: ACC_central (This model is not part of the current CDD release)
Acetyl-CoA carboxylase, central region
The region featured in this family is found in various eukaryotic acetyl-CoA carboxylases, N-terminal to the catalytic domain (pfam01039). This enzyme (EC:6.4.1.2) is involved in the synthesis of long-chain fatty acids, as it catalyzes the rate-limiting step in this process.
Statistics
?
PSSM-Id: 518186
Aligned: 105 rows
Threshold Bit Score: 509.806
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
?
Program:
Drawing:
Aligned Rows:
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
5CSL_A         747 TLDDPSKVKHALPFEGML--PDFGSP------V-IEG-------TKPAYKFKSLVSTLENILKGYDn-----QVIMNASL 805  Saccharomyce...
XP_002987673   734 DLDDPSAVRKAVPFSEGF--PALGTP------IpVPG--------KVHHRCALIINASNMILAGYE-------HNVDEVV 790 
XP_009148001   840 DLADPSTVRKAEPFHGGF--PRLGLP------TeISA--------KVHQRCAATLDAARMILAGYE-------HQVDEVV 896 
31_pfamImport    1 DLDDPSAVRKAEPFHGCF--PPLGPP------TaVAG--------KVHQRCAASINAARMILAGYE-------HNIDEVV 57  
B9FK36         842 DLDDPSAVKRAEPFEDTF--PQMGLP------IaASG--------QVHKLCAASLNACRMILAGYE-------HDIDKVV 898  Japanese rice
XP_003581375   843 DLDDPSAVKRAEPFDGFF--PEMSLP------IaASC--------QVHKRCAASLNAARMVLAGYE-------HPINKVV 899 
XP_002997355   766 ELDDPSCVKKSDVFMGKL--PSA---------EnTNGs-----sTKSVHKMRKSLAVLKCVLQGYYapedltQ----KAL 825 
XP_002185458   756 ALDNPENVATVSVFEGDLqvTGWGQSiarnttSsSNGstsnngtRNAHLVLRKAVQALHRATDGYIl----lPETIDAAM 831 
Q54J08         720 ELSDQSSIQKSTVFTGSL--TKMSPP------T-LIG-------NKPHQLLNYTLGKISNVLCGYE------SNDLNQLL 777  Dictyosteliu...
Q38970         744 DLDDPSAVRKAEPFHGSF--PRLGLP------TaISG--------RVHQRCAATLNAARMILAGYE-------HKVDEVV 800  thale cress
5CSL_A         806 QQLIEVLRNPKLPYSEWKLHISALHSRLPAKLDEQME---ELV----ARSLRR--G--AVFPARQLSKLIDMAVKNPEyn 874  Saccharomyce...
XP_002987673   791 QTLLSCLDDPQLPVLQWQECIAVLASRIPTNLKARLDlklKEY-----EASSGseRgaADFPAKGVREVLEEFLASATd- 864 
XP_009148001   897 QDLVSCLDSPELPFLQWQECFAVLATRLPKDLRIMLEskyMEY------ECISrnSltADFPAKLLKGILEAHVASCDe- 969 
31_pfamImport   58 QDLLNSLDSPELPFLQWQECMAVLATRLPKELRNALDsifKEY------EVLLstQknVEFPAKMLKGVMEAYLLSCTe- 130 
B9FK36         899 PELVYCLDTPELPFLQWEELMSVLATRLPRNLKSELEgkyEEY------KVKFdsGiiNDFPANMLRVIIEENLACGSe- 971  Japanese rice
XP_003581375   900 QDLVCCLDTPELPFLQWEELMSVLATRLPRDLKSELEgkySDY------KLTVdhGknKDFPTKTLRGIIEENLACCSe- 972 
XP_002997355   826 VDLFQVLNEPLLPVEEIREAMSSLAGRIPLDVFAKITdkiQTF----KKAVAEdpTaaHEFNAAEIADILDEHKKTLDtd 901 
XP_002185458   832 ADLMQAVADPFLPVLEIREQLSVLSSRLPATLLRSIStmvREY----------------ENPA------LASHVSSISdt 889 
Q54J08         778 NDTIKQLSNQKLPLFEFKEQLSIVQSRIPQSLFKLIN---DELnkfeFNNDDDdeDdsELFNSKNLQLSISLYLNKLLl- 853  Dictyosteliu...
Q38970         801 QDLLNCLDSPELPFLQWQECFAVLATRLPKNLRNMLEskyREF------ESISrnSltTDFPAKLLKGILEAHLSSCDe- 873  thale cress
5CSL_A         875 pDK-----LLGAVVEPLADIAHKYSNGLEA------HEHSIFVHFLEEYYEVEKLFNgpNVREENIILKLRDENPK-DLD 942  Saccharomyce...
XP_002987673   865 qDRa----TQERLVEPLLTLAKSYEGGRRG------HACSIVKALFEEYLLVEEHFSqgtGTQADVIESLRHVHKK-DLW 933 
XP_009148001   970 nERg----ALERLIEPLMSLIKSYEGGRES------HACVIVRSLFEEYLSIEELFNdn--mLPDVIERMRHEYTKvDRS 1037
31_pfamImport  131 kERv----TQERLVEPLMSLAKSYEGGRES------HAHVIVQSLFEEYLSVEEIFNdn--iQADVIERLRLQYKK-DLL 197 
B9FK36         972 kEKa----TNERLVEPLMSLLKSYEGGRES------HAHFVVKSLFEEYLYVEELFSdg--iQSDVIERLRLQHSK-DLQ 1038 Japanese rice
XP_003581375   973 kEKa----TNERLVEPLMSLLKSYEGGREN------HAHFIVKSLFEEYLSVEELFSdd--iQSDVIERLRLQHSK-DLQ 1039
XP_002997355   902 rKRs----DFEASVVALRDITTKYKHGLAS------GEEAVLTELINEYFTVETVYAns-hNIEDVVMALRQQNSA-DLN 969 
XP_002185458   890 sARa----TFEALITPLREAVLPYNRGKASgvpgaqRAVDSFLIALEKWTANERWFCdg-kSYADAVEELRQGHKN-DPG 963 
Q54J08         854 -ENeqlsiAIQLLIKPIILLAEKYNDGVSF------AAINIFKNYLEEFIQIETNLQ--NKNIQTVLKSIRPTYKD-NIS 923  Dictyosteliu...
Q38970         874 kERg----ALERLIEPLMSLAKSYEGGRES------HARVIVHSLFEEYLSVEELFNdn--mLADVIERMRQLYKK-DLL 940  thale cress
5CSL_A         943 KVALTVLSHSKVSAKNNLILAILKHYQplck-------lssKVSAIFSTPLQHIVELe-SKATAKVALQAREILIQGALP 1014 Saccharomyce...
XP_002987673   934 KVVDIVLSHQGIKTKNALMLRLIEALVypn---------psA----YRDQLVRLAALs-DSNYTELAVKSSLLLEQSKLS 999 
XP_009148001  1038 KIVDIVLSHQGLKSKNKLVLGLMEHFVnan---------paV----YRDKLIRFLKLn-HTNYSEVVLKASQLLKQRKLS 1103
31_pfamImport  198 KVVDIVLSHQGVRSKNKLILRLMEALVypn---------paA----YRDKLIRFSALn-HTSYSELTLKASQLLEHTKLS 263 
B9FK36        1039 KVVDIVLSHQSVRNKTKLILKLMESLVypn---------paA----YRDQLIRFSSLn-HKAYYKLALKASELLEQTKLS 1104 Japanese rice
XP_003581375  1040 KVVDIVLSHQGVRNKTKLILTLMEKLVypn---------psA----YRDQLIRFSSLn-HKRYYKLALKASELLEQTKLG 1105
XP_002997355   970 KVFSIARSHKALEAKNKLLLQLLAQMArgtavtpr----ksmksasFVPLLEKLATFk-EKQYSLVALEARQLLIDNKMP 1044
XP_002185458   964 YILSVCRAHEQLQTTSKLVTSIMTAIGvgskinptggagtesVILHAESAISEIGSMgsNDLYREVALKARKLLMQESLP 1043
Q54J08         924 KVVDIAQSLHPQSKKYKFILLLLNKIQe------------qGLVCDFVEQFKKLSSL--GGNCMEISLKAKHIMVHSQLP 989  Dictyosteliu...
Q38970         941 KIVDIVLSHQGIKNKNKLVLRLMEQLVypn---------paA----YRDKLIRFSTLn-HTNYSELALKASQLLEQTKLS 1006 thale cress
5CSL_A        1015 SVKERTEQIEHILK-----SSVVKVAYGSSNpkrSEPDLNILKDLIDSNYVVFDVLLQFLT---HQDPV-VTAAAAQVYI 1085 Saccharomyce...
XP_002987673  1000 GIRADIARSLSEL------GMFTEDENGSKRs-gKSAIDERMEYWVDAPVAVEDALVALFDhgdHGDHT-LQRRVIETYI 1071
XP_009148001  1104 ELRSSI---LSEL------EMFAEDGESMDTpkrKCA----MEDLVSAPLAVEDALVGLFD---HSDRT-LQRLVVETYI 1166
31_pfamImport  264 DLRTSIARSLSEL------EMFTEEGERLNTprrKNAIEERMEDLVSAPLAVEDALIALFD---HIDHT-LQRRVVETYV 333 
B9FK36        1105 ELRARIARSLSEL------EMFTEESKGLSMhkrEIAIKESMEDLVTAPLPVEDALISLFD---CSDTT-VQQRVIETYI 1174 Japanese rice
XP_003581375  1106 ELRTSIARSLSEL------EMFTEERVGLSLqerTLAIDESMGDLVTAPLPVEDALISLFD---CTDQT-LQQRVIETYI 1175
XP_002997355  1045 SYRDRLSQVEKVLK-----DYIANGS--------STNLAEACANLLDQSQPLFDLLISLLD---HEDQK-IRELALELYA 1107
XP_002185458  1044 SLELRKGRFVAAAShvataD--------------GANLSSTVTDLLADQTPMVDLLFPLLK---SSSSGlESVGLAEIFV 1106
Q54J08         990 SNKQRSNDLINSLKsilnvNNEQQQQVDEKV---QDNKDEKISKLSKQTNEISDILIPMFFnesNNDDD-IRKLAMEVYV 1065 Dictyosteliu...
Q38970        1007 ELRSNIARSLSEL------EMFTEDGENMDTpkrKSAINERIEDLVSASLAVEDALVGLFD---HSDHT-LQRRVVETYI 1076 thale cress
5CSL_A        1086 RRAYRAYTI-GDIRVHEGVt---VP-IVEWKFQ-----LPSAAFSTFP-----------------------TVKSKMGMN 1132 Saccharomyce...
XP_002987673  1072 RRLYQPYLVkGSVRMQWQR----SAmLASWQFYeegplRVAAAAEE-----------------------------SEPV- 1117
XP_009148001  1167 RRLYQPYVVkESVRMQWHQ----YGfIASWEFL-------DDHMERKNtegsdd-----------qetsekVFVEKRRK- 1223
31_pfamImport  334 RRLYQPYLEkGSVRMQWHR----SAlIALWKFS-------EEHAAMRDgsgyp--------------msdePKIEKHVE- 387 
B9FK36        1175 ARLYQPHLVkDSIKMKWIE----SGvIALWEFP-------EGHFDARNg------------------------GAVLGD- 1218 Japanese rice
XP_003581375  1176 SRLYQPHLVkDSVQLKYKE----SGvIGIWEFA-------EEHANIRNg-----------------------QKPTLPE- 1220
XP_002997355  1108 LRVYRSYLI-ESMETMSFN----DIfAKTFQFK----------SPVVDalavg-------------vapaeSYDDLASLL 1159
XP_002185458  1107 RRMYRSFSMkDIIRDGERRs---------FKFA----------FMEKQ--------------------------AEGAVS 1141
Q54J08        1066 RHSYRSYYVeDTKVTLSNDegssGFsFIEWHFYinlpqQSNLGGSNSGsptygsplirsisssggssggsgFQISPRPSM 1145 Dictyosteliu...
Q38970        1077 RRLYQPYVVkDSVRMQWHR----SGlLASWEFL-------EEHMERKNiglddp------------dtsekGLVEKRSK- 1132 thale cress
5CSL_A        1133 RAV---SVSDLSYV--AN-SQSSP--------------------LREGILMAVDHLDDVDE--ILSQSLEVI-----P-R 1178 Saccharomyce...
XP_002987673  1118 --------------------------------------------KWRGAMAVLSSLNTLSS--TVRTALEEW-------- 1143
XP_009148001  1224 --------------------------------------------KKKGFMVIIKSLEFLPNi-ITAAALTET-----N-H 1252
31_pfamImport  388 --------------------------------------------KRWGVMVIIKSLQFLPT--AINVALKETahssgSnA 421 
B9FK36        1219 --------------------------------------------KRWGAMVIVKSLESLSM--AIRFALKETsh------ 1246 Japanese rice
XP_003581375  1221 --------------------------------------------KRWGAMVILKSLESVST--AIGVALKDAsh------ 1248
XP_002997355  1160 RRNssaSSLDLGEQnsEEsSEEQEpaekplakpvesyqkispsfERHGAIARLANLETFQK--SFTDVMSLF-------- 1229
XP_002185458  1142 NLStvaSLMDLKRVvsSGsLMETNdepsesggvipvkqgipadtLRIGVCMVVDNVSDVADadTIQNVSSQFvan----- 1216
Q54J08        1146 SIFnglSMLRTDSTdsLTaMEDQTk-------------------LRYGMMVFFENEKKFEE--KLPLILTRY-----N-E 1198 Dictyosteliu...
Q38970        1133 --------------------------------------------RKWGAMVIIKSLQFLPS--IISAALRET-----K-- 1159 thale cress
5CSL_A        1179 HQSSSNgpapdrsgssASL--SNVANVCVA--STEGFEs---EEE----ILVRLREILDLNKQE-----LINASIRRITF 1242 Saccharomyce...
XP_002987673  1144 --FGVTqet----kdsNHTrlGNVLHIALV--GRKNQLsahqDSGdegqTQERVEKLAKGLKGEtlrglLQAAGVGVVSC 1215
XP_009148001  1253 IDYGESags---------plsGNIMHIAvl-----------dSENeedqAQERVEK---ILKEEevsssLCSAGVGVVSC 1309
31_pfamImport  422 SDEPSRsgs----sasASH--GNMLHVALV--GMNNQMsllqDSGdedqAQERINKLAKILKEEtigssLCSAGVDVVSC 493 
B9FK36        1247 --------------ytSSE--GNMMHIALL--GADNKMhiiqESGd---dADRIAKLPLILKDNvt--dLHASGVKTISF 1303 Japanese rice
XP_003581375  1249 --------------ysSSE--GNIMHIALL--GDDNQInkseDSGdndqAQDRIDKLSVILKQNivtadLRAAGVKVVSC 1310
XP_002997355  1230 --PLAKktl----svrKDPl-VNVLHVILV-------DehseESK----LLEQAEAYLKSVDVD-----LRAHNIRRVTF 1286
XP_002185458  1217 --------------sgSDP--VNVLYFIVL-----NSDigldEAShq-eIAKKCELILQGSHAL-----LEQAGVRGVTF 1269
Q54J08        1199 ENNKKSqls----lspNES--TDILSVIISiyPESISQ----ENQ----AISSFQSILKGYIKE-----LSIARIRRITF 1259 Dictyosteliu...
Q38970        1160 HNDYETaga---------plsGNMMHIAIV--GINNQMsllqDSGdedqAQERVNKLAKILKEEevsssLCSAGVGVISC 1228 thale cress
5CSL_A        1243 MF--GF-K--------DGSYPKYYTFNGp----NYNENETIRHIEPALAFQLELGR--LS-NFNIKPIFTDNR---NIHV 1301 Saccharomyce...
XP_002987673  1216 II--QRdE---------GRGPIRHCFHWsqetkSYAEDPLYRHVEAPLSGFLELDN--LKeLGTMKYSLSRDR---QWHL 1279
XP_009148001  1310 II--ERdE---------GRTPMRHSFHWsmekqYYAEEPMLRHLEPPLSIYLELDK--LRgYENIQYTPTRDR---QWHL 1373
31_pfamImport  494 II--QRdE---------GRAPMRHSFHWlsdklHYEEEPLLRHLEPPLSTFLELDK--LKgYTDIQYTPSRDR---QWHM 557 
B9FK36        1304 IV--QRdE---------ARMTMRRTFLWsdeklSYEEEPILRHVEPPLSALLELDKlkVKgYNEMKYTPSRDR---QWHI 1369 Japanese rice
XP_003581375  1311 IV--QRdG---------ARMPMRRTFLLsdeklCFEEEPILRHVEPPLSALLELDKlkVKgYNEMKYTPSRDR---QWHI 1376
XP_002997355  1287 SVrpQNiEdisvhnadMALYPNIYTFPGr---mNYSEDKILRHMEAPLAYKLELRR--LQ-NYSVTPLASENK---NVHL 1357
XP_002185458  1270 VMnqhy------defeEYRAPAMFTFRFp----aYKEIALYRGIDPVRAPQLDLNR--VAaNFDIRGLGSHNSatgQAHL 1337
Q54J08        1260 IC--CGgD--------EGKPLKYFTFREr---hMYMEDPIFRHIEPAMAYHLEVRK--LS-NFDITHVPTTSQ---RIHL 1320 Dictyosteliu...
Q38970        1229 II--QRdE---------GRTPMRHSFHWslekqYYVEEPLLRHLEPPLSIYLELDK--LKgYSNIQYTPSRDR---QWHL 1292 thale cress
5CSL_A        1302 YEAVSKTSP--------LDK--RFFTRGIIRTGHIRDDIsiq-------------eyLTSEA-NRLMSDILDNLEV---- 1353 Saccharomyce...
XP_002987673  1280 YSVQEKKGKs-------TVK--RTFLRTFVRQTKTLDED------------------GTFESvIKALQGALEELEV---- 1328
XP_009148001  1374 YTVTDNKPV--------PVR--RMFLRSLVRQGQDNQ---------------------LSQTlVRSLMDAMEELELna-- 1420
31_pfamImport  558 YTVVDKPLTy------------RMFLRTLVRQPNSQDSEmavdga-------kmampFTATSiLRSLNAALEELELhg-- 616 
B9FK36        1370 YTLRNTENP---------KMlhRVFFRTLVRQPSVSNKFssgqigdmevgsaeeplsFTSTSiLRSLMTAIEELEL---- 1436 Japanese rice
XP_003581375  1377 YTLRNTENP---------KMlhRVFFRTLVRQPTAGNKFtsgrtsdieaghaeeslsFTSSSiLRSLMTAIEELEL---- 1443
XP_002997355  1358 YLAKMKDSDah----iiTDRfqRIFVRAVVRQLDHDGSGsrs-------------qyDAYPGpERSLVDALNALEVnlsn 1420
XP_002185458  1338 YEAVPKKAAlasdhkasKAA--RVFVRSLGFVTD-----------------------MNQTSfDRILVDTLNAFDL---- 1388
Q54J08        1321 YYAQEKGKKetd---pdADR--SFFVRSVIRYSDLYGHSneik-----------vdiLLSQI-ETLLSESIESLEIam-- 1381 Dictyosteliu...
Q38970        1293 YTVTDKPVP---------IK--RMFLRSLVRQATMNDGFilqqgqdkqlsqtlismaFTSKCvLRSLMDAMEELELna-- 1359 thale cress
5CSL_A        1354 ----TDTSNSDLNHIFINFIA--VFDI-SP-------------------EDVEAAFGGFLERFGKRLLRLRVSSAEIRII 1407 Saccharomyce...
XP_002987673  1329 -----AEGRAEHVHMYLCVLR--PQGVrSLass--------------ivMWLEALVHKIYAALGTRMYRLAVLAWELRMS 1387
XP_009148001  1421 --hkEDGMKPDHAHMFLCLLP--EQQInDLvpyprivevnaeveettmeMILEETVREIHKSAGVRMHRLGVCEWEVRLC 1496
31_pfamImport  617 --hnA-NVKSDHVHLYLCILR--EQQLlDLlpnfsdvei-kgeeekaiyMILEQMARSIHETVGVKMYRLAVCEWEVKLR 690 
B9FK36        1437 -----HAIRTGHSHMYLHVLK--EQKLlDLvpvsgntvldvgqdeataySLLKEMAMKIHELVGARMHHLSVCQWEVKLK 1509 Japanese rice
XP_003581375  1444 -----HAIRTGHSHMYLCILR--EQKLlDLvpvsgstvvdvgqdeatacSLLKEMALKIHELVGARMHHLSVCQWEVKLK 1516
XP_002997355  1421 plvkKSSLPTKNNHVYLNILP--QAIV-DP-------------------QYLEGVIRILAYRYAERLEQLGVSTVELKII 1478
XP_002185458  1389 ----CSVKSRMDNHVFINVASdfEKTVlDP-------------------VTVEHVVAGILKKHGERITTMGIVEVEIRIV 1445
Q54J08        1382 --snKKYEKAQNHSIFLNVMP--EVMF-DE-------------------KMIGYVVQEIGDRLGKRLWKLRVGRVEVRGR 1437 Dictyosteliu...
Q38970        1360 --hnA-AMKPDHAHMFLCILR--EQQIdDLvpfprrvevnaedeettveMILEEAAREIHRSVGVRMHRLGVCEWEVRLW 1434 thale cress
5CSL_A        1408 IKdpQTGAPV-PLRALINNVSGYVIKTEMYTEVKNAK-GEWVFKSL---G--KPGSMH 1458 Saccharomyces cerevisiae S288C
XP_002987673  1388 LG------GEgIWRVVVSNATGYTCKVEIYREVRDPLtKQTVYSSPfpgCegPLHGVP 1439
XP_009148001  1497 LS--SSGLASgAWRVVVTNVTGRTCTVHIYREAEATGsNSLIYQS----It-NKGPLH 1547
31_pfamImport  691 IG--YVGLASgAWRVVITNLTGHTCTIHVYRELEDTNrHEVVYHS----KlsTSAPVH 742 
B9FK36        1510 LD--CDGPASgTWRIVTTNVTSHTCTVDIYREMEDKEsRKLVYHP----AtpAAGPLH 1561 Japanese rice
XP_003581375  1517 LD--SDGPASgTWRVVTTNVTSHTCTVDIYREAEDTEaQKLVYHS----AtsLSAPLH 1568
XP_002997355  1479 ARfnSEAPAI-PVRLVAENPTGYVVRVQAYVEAAGHD--EPIFTSI-------GDETH 1526
XP_002185458  1446 CRlsSESHPI-ALRLVSSNPTGYVHVMSTYVEAADDSsDERKFKLI--------GNTK 1494
Q54J08        1438 IR--KGDGLI-PVRFFVQNPTGYAFQVQCYYEQQNSI-GQMVFAVV---Pg-SSKGSW 1487 Dictyostelium discoideum
Q38970        1435 LV--SSGLACgAWRVVVANVTGRTCTVHIYREVETPGrNSLIYHS----It-KKGPLH 1485 thale cress
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap