Conserved Protein Domain Family
COG4_m

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pfam08318: COG4_m (This model is not part of the current CDD release)
COG4 transport protein, middle alpha-helical bundle
This region is found in conserved oligomeric golgi complex component 4. COG mediates the proper glycosylation of proteins trafficking through the Golgi apparatus and it is a member of the CATCHR (complexes associated with tethering containing helical rods) family, together with the exocyst, GARP and DSL1 complexes, sharing structural and functional features. They consist of alpha-helical bundles at the middle/C-terminal (described as domains A-D/E) and a N-terminal coiled-coil region. This entry represents the middle region comprising alpha-helical bundles corresponding to domains B and C. Mutations in COG4 cause fatal congenital disorders of glycosylation (CDGs) in humans.
Statistics
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PSSM-Id: 518181
Aligned: 95 rows
Threshold Bit Score: 151.967
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ERS99807     259 FPLIGRTDVGLDVYGRYVCQGVAESARNVFRGEtpqpaavpaaAS--RHDGFFFANALAKLFTHISQIVEGHGALVERHY 336 
XP_001638516 197 FPLLNQHAKGLGKYSHYLCSMVAATAQQNLEQIdi-------tKDsdRHANVLFANTLTMLFEGIARMVEEHQPFVETYY 269 
EFJ37060     188 FAPLGLHEEGIKAYVSYLRRSVDHRARDGFAAVk------------eTPDQADFVAALNNIFKDIAEAIEENEELLKSLN 255 
1_pfamImport   4 FSPLNLEEEGLQMYVNYLKKVIGMRSRLEYEHLvel----meqSSg-NQSNVNFVGCLTNLFKDIVLAVQENSEILRSLC 78  
XP_028218458 226 FTPLGVEEEGLQVYVGYLKKVVAMRSRMEFEQLve----------mmDQQNVNFVRCLTNLFKDIVLAIEENSEILSGLC 295 
Q8L838       210 YSPLGMETEGLQLYVGYLKKVIALRGRMEYENVvel--------meqGLGQVNFVGCLTNLFKDIVMAIEENDEILRGLC 281  thale cress
XP_004243228 206 YPPLALEEEGLQVYVMYLKKVIAMRSRLEYEQLvem----msdQQgsSQNQLNFVSCLTNLFKDIVLAIEENDETLRSLC 281 
ERM93568     213 FPMLGLRAEGLQIYVSYLRKVISMRTRMEFDTVkef----idqSR--PPSEINFVNCLTSLFKDIVLAVEENDAVLRELC 286 
XP_002468432 224 FPLLGLADEGLQVYVAYLKKVVALRARADFEHLael----tsaTQp-TSERLDFVGCLTRLFKDIVLAVEENDAVLRELR 298 
XP_002681378 152 FSPLCMNEDGLSLYVDFL----SDKCRKELESLdeve--rltyIRkqQQQYVSFIDIITQILDIIVSYIEDCEDFVTSNF 225 
ERS99807     337 GGGQM-IKVISRLQKEADVQGGIVVDAWSDERGVDRKLTDVK-SYPFSFLvqsfgmkgaggsssnsnaggggggdgasrv 414 
XP_001638516 270 GPGQM-PTLLQILQVECDKQADQILDAFVKRRDLQHKIKSVTkSLNIKGS------------------------------ 318 
EFJ37060     256 GEDGL-VYAIRELQEECDSRGSAIVKKYMEFRGLAKLEKEII-AQTNAEK------------------------------ 303 
1_pfamImport  79 GEDGI-VYAICELQEECDSRGSSILKKYLDYRKLARLTSEIN-SYKNRLS------------------------------ 126 
XP_028218458 296 GEDGI-VYAICELQEECDSRGSVILNKYMEYRQLAKLSSEIN-AHNTNLL------------------------------ 343 
Q8L838       282 GEDGV-AYAICELQEECDLRGSLILKKYMDFRKLAILASDINnSPNLNIL------------------------------ 330  thale cress
XP_004243228 282 GEDGI-VYAICELQEECDSRGSTIIKKYMEYRKLAKVTSEIN-SYKSDLL------------------------------ 329 
ERM93568     287 MEDGV-VYAICELQEECDLWGTTIMKKYMEFRKLGKITADIN-SYSKNLL------------------------------ 334 
XP_002468432 299 GDDGV-AYAIIELQEECDSRGTQILRRYADYRKLARLASDIN-SYTKNLL------------------------------ 346 
XP_002681378 226 GGEKCtIYLINSLQHVCDKMVKKVLDVYEKKRELNDILTAVS-KKPNTLP------------------------------ 274 
ERS99807     415 nspALGVDS---PRRSEDeGGVNMREIDGLLNEIAIMLSRWSLYSRFLANKCRddeaeaaaqaeadakdtkkeksgkdgq 491 
XP_001638516 319 ---------------SEKsERYDPRDMEVLLGEVVLMNTRTEMYLRFLEKKIQadyen---------------------- 361 
EFJ37060     304 ---DIVAQSkllMSAGGAaEGPDLRSIEMFLEEILLLIQTSEDYTQYMIGRVRe-------------------------- 354 
1_pfamImport 127 ---------------VGAaEGPDPREIELYLEEILSLMQLGEDYTEFMVSTIKg-------------------------- 165 
XP_028218458 344 -------------AVGGGpEGPDPREVELYLEEILSLMQLGEDYTEFMISKIKa-------------------------- 384 
Q8L838       331 --------------PGGAsEGPDPREVELYVEEILSLMQLGEDYTEFMVSKIKs-------------------------- 370  thale cress
XP_004243228 330 ---------------SVGiEGPDPRDIEVYLEEILSLTQLGEDYTGYMISKIRg-------------------------- 368 
ERM93568     335 --------------SVGVlEGPDPREIEMYLEEILALTQLGEDYTEFMVSKIGg-------------------------- 374 
XP_002468432 347 ------SAMgsmASAAGGnEGPDPREIELYLEEILALTQLGEDYTEFMVNKIRg-------------------------- 394 
XP_002681378 275 --------------IKKDlNTNDPRVLDLILEEIAEISSNIEVYKQFIAGKCIniktd---------------------- 318 
ERS99807     492 dgqdskdssteraTAATPDERPLVIPSVLAQSNLQRKVAArLITPYSLMSTFFFRRSVEKAFQLEETPG-Dlslnmadal 570 
XP_001638516 362 ---------lpdeDVQECADVNKVLDKLINNSGVNRRMQE-LIGSYITMEEYFMRETAMKAVKMDYYEGeP--------- 422 
EFJ37060     355 -------------AGSSGAQLSPRSTTSFKVGSFYRAVQE-LTSHYRLLEEYFMAENVRKAIKLDEFP------------ 408 
1_pfamImport 166 -------------LSSVDPELGPRATKAFRNGNFSRSIQD-ITGYYVILEGFFMVENVRKAINIDEHV------------ 219 
XP_028218458 385 -------------LTSVDPELLPRATKAFRSGSFSKVAQD-LTGFYVILEGFFMVENVRKAIKIDEHM------------ 438 
Q8L838       371 -------------LTSVDPELLPTATKAFRNKSFSKAIQD-VTRYYVILEGFFMVENVRKAIRIDEHV------------ 424  thale cress
XP_004243228 369 -------------LSSVDPELGPRATKAFRSGNFSKVVQD-ITGYYVILEGYFMVENVRKAIKIDELV------------ 422 
ERM93568     375 -------------MAALDPQLAPRATKAFRSGSFSIMAQE-LSGYYVILEEFFMVENVRKAIRIDEHV------------ 428 
XP_002468432 395 -------------LRDVKPELGPRAMKAFRNGNFNKMEQD-LTGFYVIFEEFFMVENVRKAIRIDEPI------------ 448 
XP_002681378 319 --------------------gkneMYTLTKEPIIYRRIQE-LMSFYIPIDMSFMKQSFFKAIQLESDEDeD--------- 368 
ERS99807     571 dnNPPYIISAVDDVMYIVNAVIQKCMSTLQRDVVVGVIPPVGRVLGSDFIGMIQRKM 627 
XP_001638516 423 --DEAVTSSMVDDVFFIVQKSVRRSLSSSCVDAVCAMLNHASSLLSSEYCDVLKTKV 477 
EFJ37060     409 --ANSLTTSVVDDVFYVLQSCTRRAVSTSNVHLTLSIVTCAANLLGNEYKDALQRKM 463 
1_pfamImport 220 --PDSLTTSMVDDVFYVLQSCLRRAISTSNINSVLALLSGSISLLGNEYQEALQQKM 274 
XP_028218458 439 --PDSLTSSMVDDVFYVLQSCLRRAISTSNISSVVAVLSGASSLLGNEYHEALQHKT 493 
Q8L838       425 --PDSLTTSMVDDVFYVLQSCLRRAISTSNISSVIAVLSYAGSLLGNDYHEALQQKI 479  thale cress
XP_004243228 423 --FDSLTTSMVDDVFYVLQSCCRRSISTSNINSVIAVLSSAVSLLGGEFNEALQQKV 477 
ERM93568     429 --PDSLTTSMVDDVFYVLQSCCRRAISTSKVNSVLAVLSGAVNLLSNEYQEALQRKM 483 
XP_002468432 449 --PDGLTTSMVDDVFFVLQSCCRRAASTASINSVLAVLGGATSLLSNEYQEALQWRM 503 
XP_002681378 369 --ESSKYSSIINDVFFILQKSLSRAMDSQNVSVVCAIVNHINGILATDYFEFVKKDv 423 
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