8EKI


Conserved Protein Domain Family
Sec39

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pfam08314: Sec39 (This model is not part of the current CDD release)
Secretory pathway protein Sec39
Mnaimneh et al identified Sec39p as a protein involved in ER-Golgi transport in a large scale promoter shut down analysis of essential yeast genes. Kraynack et al. (2005) showed that Sec39p (Dsl3p) is required for Golgi-ER retrograde transport and is part of a very stable protein complex that also includes Dsl1p (in mammals ZW10), Tip20p (Rint-1) and the ER localized Q-SNARE proteins Ufe1p (syntaxin-18), Sec20p and Use1p. This was confirmed in a genome-wide analysis of protein complexes by Gavin et al (2006).
Statistics
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PSSM-Id: 518178
Aligned: 63 rows
Threshold Bit Score: 341.98
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
8EKI_D         7 YLLACIFASRADTRNIKK-LSTRLGSQSK-------------YLEILCVLW-PELDDPknllflRELEEEVQspegEE-- 69   Saccharomyces ...
XP_002548758 106 VYTIQLVSSSTDIDKLQAfLRLLNAKVLSsdtneftfttknnLLNAILVHTyPLNLEL------EELTKLAN----LL-- 173 
XP_004181677   7 YLLTCIFASRGDSLNLKIiLKNEKVNGVNfv----------eKLNIVCVLW-PELDDP----------SNLK----FLft 61  
XP_001644473   6 YLLCTIFAARADITNSSL-LYDQANGNFTq-----------eCFDALCILW-PELMDP----------NGLS----FVfq 58  
XP_003684281   7 YLLATIFASTADVEKLTI-LKNSFTNSSE-------------LLDIICVLW-PELDDP------ILLRNFLT----NLel 61  
XP_003672426   7 YLLACVFASKADSTNLSQ-ILRHVHYSLD-------------FIKAACILW-PELDDP----------MNLI----SLfp 57  
XP_003678515   7 YLLACLFASRADSENLIR-VLHHVEYSMK-------------FVKIVCILW-PELSDP----------LSLR----FLfn 57  
XP_003957702   7 YLLTCVFASRADVKNISK-LTYRFQNSLD-------------FINAIVVFW-PELDDP----------LNLR----LLl- 56  
XP_007873105  11 LYIAVQYASAPSLQTLSE-LILKFPYIFSkr----------vILSI-LNFV-PECIDP------DEYLSLIF----DEky 67  
EPB88423     175 IAQAIEYARSENNVALDAiFMHHGSDVLEhr-------------lFILSQI-PETADP------SLF---------DL-- 223 
8EKI_D        70 ------------TT-DEDVIVe--------lLESDSSLIPL---IESDTTTRSNRYHELQEfi-------------sKKL 112  Saccharomyces ...
XP_002548758 174 ------------ID-PSNITKtd------etDSFDVEEFAFglpTQIENESSLLATAQDLMvdtnvqssyigglkfgSTP 234 
XP_004181677  62 ddeemtddsdliRSyDGDDIYrnpadlvvniLKNNEELISI---IESDHNCLNERYDHMVDyintk------lsviqTLK 132 
XP_001644473  59 ----------qgPS-DDQVQLsdpndlmmnlLEVDNKLIPI---IELEHDIVHERSEKVKDfvskril-----------q 113 
XP_003684281  62 -----------nDL-NADENPidednilvslLETGEDLVPI---IEMDVETVSERVSTVKEyinrrlv-----------e 115 
XP_003672426  58 tielgnddndnnAS-ANDDGSlsdenlvvklLENNPDLIPL---VEVGNTIVNTRYLSTKYfieskl----nglyssNII 129 
XP_003678515  58 -----------hQK-DAQVKPmtdeelvvslLEKDSMLIPM---VEINNETVSNRRQQLEQfinskw---------dslt 113 
XP_003957702  57 --------------eDGETEYldddsllvslLSGDSDLISM---IELEKSLLMERFHTAKNyvdskl------------- 106 
XP_007873105  68 ------------------------------eGEDDMDSSQIsktQNINNAALSQKLKKLHIy--------------qDET 103 
EPB88423     224 ------------PH-VTHDHEdswleepwrkEKDAVEQDWVqtlIRVQVPEETEYLERL------------------KGG 272 
8EKI_D       113 NN---KTL--ENFEEWLRERILICNemiPETPLLYSVLWETA-------KSKVL-STKFIGW---VEGVLKPLDHLNKRL 176  Saccharomyces ...
XP_002548758 235 D---------DLLLSFIQAKTIQLSkyfDNVNDIMPLYERVS-------------SDAFQSW---FAGVISP-----YKY 284 
XP_004181677 133 GSldvLNTelSLKYTWLKNRIILVNnfyPMDTIFNRTLWSLKvfr--dkPINDQsHSIFFNW---INGTIYPLYYINQRL 207 
XP_001644473 114 leqdsLITfdNILSNWLRRRILVCDefnPNNVLFNEPLW----------ETHSKdDIKFAQW---ISGIIKPLSYLNLRS 180 
XP_003684281 116 vtldeITSfdDTVSSWLRKRILLCDelnPFNVLFNKKLW----------KEIKPiDPEFMGW---VNGILEPLDFINNSS 182 
XP_003672426 130 PLetsLSSleDLQSLWLQIRILVCNeviPEMTSFYEPLWTHSnf---------hiNKEGKDW---IECIIEPLNYINSRL 197 
XP_003678515 114 sIndiDTSssSSSISWLSKRILLCNdsyPGDVFFYEPLWnll-----ikDGVVSeKDRLFQW---IKGIIIPLHSISIRT 185 
XP_003957702 107 ----hrlslnDINTNWLTKRILICNelyVQDTLFYQPLW----------EFVQNqDESFDNW---IHGVVLPLNHMNKRL 169 
XP_007873105 104 KTnncISD--EELYAWFISRALQIE---EETGLISFSRKLVL-------TSKYPiPPKVQEWgrgIVSTLESVINRQYNN 171 
EPB88423     273 IEttpYPTsaSVIASWYLDRAHAAD----SIGLSSSALEICRyarvmgvTGIDE-QVSEYEW---LCKYVY-LAKAKLDQ 343 
8EKI_D       177 HLi----fKINEWEKMPDSELFKIIFDGVe-DmQg-YIGIADVIEDELAPTLSYGKK------W---------------- 228  Saccharomyces ...
XP_002548758 285 YYd--------hYGQVYNGATLQEYLSAG--------ETLKNKFEMLITPLSAGKVSni--eqWianviipiimyhnndf 346 
XP_004181677 208 NKt----lKIQEFENLKTEDVINMILNSQ-------ETLKKETIVNELFPYIRYN------------------------- 251 
XP_001644473 181 GSkt---lKIKDFENFKPVDIINLILGNIndD-EynLSIDASIIIQELIPYLKYS------------------------- 231 
XP_003684281 183 DIrv--qfRIIDFEALTPNNVIELLTKNLleN-EysFNNKNVQQIDCLISYLNYT------------------------- 234 
XP_003672426 198 GSk----lKIKDFSKMDPIAVFPLILEGG-------------DMKKELIPYLQYT------------------------- 235 
XP_003678515 186 HAm----tKIIDFEKMNATVTFPLILDGK--------------IFHELIPYLDFT------------------------- 222 
XP_003957702 170 NKn----iRIKEYIDMNPSDLLDATFSKK--------VISVNEIVNELIPYLSYKNLd---------------------- 215 
XP_007873105 172 PLlefnvpTLREFETLNHKEVIDILLQHLe------NEEILEEIKSSIIPYISYCQKssktniW---------------- 229 
EPB88423     344 EGay---vDLKTFQRISSYEILEGLLSSTn------AANIVDDMLRLALPWISMANKrkhvndh----------nsakke 404 
8EKI_D       229 ETF----------------I-----TEFFNKQQFS----------LKsdtnyqLFiKLYY--SLE--KGVKDNSEASRKL 273  Saccharomyces ...
XP_002548758 347 RPLnewlfysdmgatvtkgSnktspVTKYSVWSSCisslnrhfelEE------FK-----------------------VI 397 
XP_004181677 252 NCFdl------------------ylESFFNSDKIQinnlsdyqrfKS------LF-IEINeeIRSffGNLDELTSINSKF 306 
XP_001644473 232 KAYdi------------------flDIVFNPSVFRfdtavnyynfRQ------LYs----------lLSNEIPIEFKEKL 277 
XP_003684281 235 NSFtl------------------flEQKFNTNSFLfkkkqnylvfDA------IFt----------kFNESNVMADKENF 280 
XP_003672426 236 KSFts------------------flNNFCTVTQFPmdnqenyellDN------LId----------iLPSVLPQDEIHTF 281 
XP_003678515 223 NLSne------------------fiENYFTNENFLlatvqnydifRN------IFf----------aFSNETSKSNFDKV 268 
XP_003957702 216 STYel------------------fiNDFFNMERFPlkdrinyeafRS------IL------------DQVPRYLADCTSF 259 
XP_007873105 230 DSLwswllnfsfkqknlnlI-------------------------KL------IS------------FNNVISSEKYSEF 266 
EPB88423     405 FLLyrwlldpa------vvdahldwCCVVFEHSKPtiavedriikDD------LD------------------------L 448 
8EKI_D       274 QSNVVDILF---HNSEN----LFNLSSLTHKLDELWSILsgf----------------------pdeITIEEqKTITALE 324  Saccharomyces ...
XP_002548758 398 IETYLAACYyfsFKEDTdvvsSVDIMKSYEVIHDTLSLLrgssktlapgsqdidygnipmdcasfneFNTPS-NPLSALF 476 
XP_004181677 307 QTNSLDIIL------KNnkwlITQFKGTK----EINELIiri----------------------dhnIEAK--KYGNCFK 352 
XP_001644473 278 EELSLKIIY------DNsanmL-NVTSSS----ELEQLLtqf----------------------spgTKVKS-TSLTANN 323 
XP_003684281 281 QKAALSIIF------ENskelM-NIISMD----ELKQLLdaf----------------------dqnIETA--NGINSKI 325 
XP_003672426 282 KTSLLRIIF------ENsgnlL-KFTTLA----TLSNLVnvta--------------------dnsvMLTDY-DNLHYYD 329 
XP_003678515 269 CGNVANILF------ENssnlL-NFKSLE----ELKNILnri----------------------pkdTPIAK-YDITVAD 314 
XP_003957702 260 YESSLEIVF------ENsedlL-KIASPT----NIKELLsgi----------------------pndITLEK-YGINVKN 305 
XP_007873105 267 SKYAIASCY---CLQSTe---EENIHSMKIILQNLKQNLnietnsntsvlnd---ikisslnvftpeNIQDY-SELITPN 336 
EPB88423     449 SRLVLAIVY--------------SGNGSMEYLVRLFECLpifddinensndptdmaaimpkatspmaIFMEL-QSVGEYG 513 
8EKI_D       325 mKQFMEFFIKCST----------KFSFKEIF-AI-TQEEE--SAQLAHFSSLCHEE-FNKAN-----EISSFLQAMYETV 384  Saccharomyces ...
XP_002548758 477 hSECIPELKHAIEtcqkl-fpinKLTLKKYLqFN-YDPSS--IDLEREILRITSNI------------NHSNWQQLMRSV 540 
XP_004181677 353 iKKILRIIENIFHndit-------ytiDEINdTI-ENNNK--EQQVSKFTEFLENLmKNGYSfriekLITNSE------- 415 
XP_001644473 324 lKWFAHYMNLCFQgy----------slSDIN-AI-CQSSE--QEQLAHFASMVKGKiCNSQSqqtidVISNLISE----- 384 
XP_003684281 326 lLSYIHLISIFLQdy----------slKEVH-LI-SKENE--ASQLLHYTSMIKAKiMSKGFktsssTAVNEILSVITGS 391 
XP_003672426 330 lQKYLLFMQNFSKskd---------sfKDLY-LI-NKGTE--SSQLAHFASICKEElSANANkp--sINNAKIKDIFDSI 394 
XP_003678515 315 vTEYIRYMEVMLSny----------slKEVY-TI-SQEEE--SAQLAHFASSCKEElMAALNnneesTLSQKLNSLYT-- 378 
XP_003957702 306 lLTYIENIDSFLSdf----------spKDIY-AI-RNEEE--TAQAAHFGSICTDFiLHNNEhntekKLNLIVDMLKKEL 371 
XP_007873105 337 -SDSLSLLEIMIKtvliinstkeICKITLSEaVCyRNKDK--KSQISLLHKMIPQN-PHFLSk----LNDSEWIKLRNNI 408 
EPB88423     514 lTQMMDTLQGHLGsaet------laryNAHVpLRwYLEDQsvEAQRQLCVRMSSQAaGGVESggakfDRDDDWRELLDDM 587 
8EKI_D       385 LDI-SK---DDKIFTRI-SMDEKLYSILEILLQMNEFAYIEAII----ERF-DYS---NNT-QIYE------LLVKFFWH 444  Saccharomyces ...
XP_002548758 541 DlfkssfvseenTNGQV-SSIIIERLLFANL-----FDVADELFfndsLLP-------ISTnQFYS------LVEEKFWA 601 
XP_004181677 416 -NI-KD---IKFVFNKFeTTEEIERLVIDILMNYREFDLVGDI---------------LGShSDEDsqi-ndIVIKYYWK 474 
XP_001644473 385 -SK-IK---EKQIFTNL-TIDKQISIFVEILLELGEFDLLQNFv------------------TLNNskleenVLEKYFWN 440 
XP_003684281 392 -AS-NS---EQIVFTHI-PPKRQISVLIDLLLELGEFDLLQDLm------------------EEQNsqleeaGLEKYFWH 447 
XP_003672426 395 -VH-ED---NDMVLSHL-TIERKISILLETVLDLGEFDVLEEVv------------------TQYKekfitkLLLKFFWI 450 
XP_003678515 379 -LS-NA---SSSVFNRL-STKIQQSILLETVLDMGQFDILHEFm------------------SEYGsnletdLLEKYFWK 434 
XP_003957702 372 -NS-AE---DDKIFDKL-SFDKELSILFETFLTLGDFELLKRFn---------NLpevNESaAFKSte--iiLLEKYFWQ 434 
XP_007873105 409 Kwlhd----vslIYKNI-PEIEYESFLLYNILRTTKFNLAENIYikrnKGNmP-----LKDvMVEK------ICIEIFLE 472 
EPB88423     588 IrlngD---GQGIFGKL-ENAEILEIFFYSLLRCGRFKLAKELI--------------FGSkRIMDmtkaehLVIDAERE 649 
8EKI_D       445 FFNNASN-GLRKEPEMKKASQTLQIIQKHM-------SQrAGTNLTKLEVLLEISDKL-SHYSINLNKSHngardtAFKP 515  Saccharomyces ...
XP_002548758 602 SLNHAVN-LNEKSGLLYNAHQCLNLFDKLVlkk-dleES-SRQQIVKFKHLFKAMHAL-KNFKIVIVSSDadr-nkPLTP 676 
XP_004181677 475 TIKKFNNdGTKKNVEMLNIEKILTILKH---------RK-EVNEYHYLRQLVNNCYEL-SKYSI--------------KP 529 
XP_001644473 441 FFNNATN-GLKSRPEIKKAEKTLQLMd----------VQ-NSTVYKHLHTLLKVADTL-SRYSINLGKGI------PFKP 501 
XP_003684281 448 FFNNASN-GLKSRPEMKKAQKTVKLLl----------EQ-NEPKFKHLEILLHIADLL-SYYSINLGKGV------IFKP 508 
XP_003672426 451 YFNNSTN-GSKKSLGMTKCRKVLNLLSLEAhtkgrqdLI-TKEELNSLQTLLDVSDDL-SKYSMNLGKGH------IFKP 521 
XP_003678515 435 FFNNATN-GSCKRAEMIKSQKTLNLLl----------KQ-DAKKYERLQSLLDVADEI-SRYSMNLGRGI------IFKP 495 
XP_003957702 435 FFNNSSN-GSRTRPDMTKAKKTLNLLl----------VE-NEAKYKHLDTLLDVSNEL-STFSMNLGKGI------PFKP 495 
XP_007873105 473 FFDSSSN-GNITKGNMKNAYNLLQTIKQYY-------NS-EQ--LESFSYLVKVTNTL-YHYS------H------KFKP 528 
EPB88423     650 FFDNATS-GNMNSGSMKQAWDCLKIL-----------PP-STE-IKKEVDLIEATHTLiYEYKVQDHPGI------TLMP 709 
8EKI_D       516 SNILEY---RDcPLDIISNLLELNPRLYKDLPTTKSLL-----F---GIY--------DSlsinREGQTGKVEVDLMVLH 576  Saccharomyces ...
XP_002548758 677 YALINSfadNN-VMNLITIVLEQNPKSYLAFEKLYRILndlliFfg----------------edGDGENNFYFKKLKTAC 739 
XP_004181677 530 IDIIQYk--QE-PIKIISKMLENNNGLYKEFEI---FNekvynNlqiEI-------------------TNDERIEIINLQ 584 
XP_001644473 502 CNIFEFk--YN-PSKLISILLELNRDLYKDVANSMNLIdqlveAmqiSREhl---------------dRESEYNKILVIH 563 
XP_003684281 509 SNIFDFk--NH-PSQIISKLLELNDGLYKDKNTTSLMLkelfeGmnlDITgd---------------fFVQEQIRVSEFH 570 
XP_003672426 522 SNILDFe--TK-ETGLISILLESNNSIYKDISVTFEIMkklnvAmacQCPfinhnqlkPAqk----kdVIVAYMRLLTLH 594 
XP_003678515 496 SNILDFq--ED-PYQLISTLLELNSSLYKDILVTFTILkklytAlekSSLrs--------------tnFDYEYDKLLIIH 558 
XP_003957702 496 CNIIDFk--ND-PFDIVSILLELNSSLYKNTSTTFAIIkklykVferEPAdp---------------nFTVEFNKILSLH 557 
XP_007873105 529 VQIRLH---NN-PFEILEDFLSSNPGIYKSIDEVMEICndlllStnkNYL-----------------YQKEIQAKILCII 587 
EPB88423     710 IQIRQS---QN-RLELISKLINNRAGMYQRHEQVLELVrklgyG-----------------------NDLLAKVKTLAML 762 
8EKI_D       577 IDYALVNLDFGTAYELGKQVFeicqeagQHMMKAL---------------GDEHWLTFYQMGKFVDP------------- 628  Saccharomyces ...
XP_002548758 740 IESALIDNNFNYAYTQSIELFkffedk------------------pndrrIDELWLTFYQVGKYISPewfdepe------ 795 
XP_004181677 585 IINSLKNFDFNFAYQMIQDLFanyq----------------------aesYQKYWETIYLFVKFTDPkwfdinnygdnsr 642 
XP_001644473 564 IDHALVNMDFTFAFQKSKELLrr-------------------------dsVSTYWATVFQVCKFINPnw----------- 607 
XP_003684281 571 IDNALANLDFYFAYHESKELLtk-------------------------seNKTPWATVFQVCKFSDPnw----------- 614 
XP_003672426 595 IDYSLVNMDFNFAYKLTMELFd------KFKTYIGqqsetsgiatderfnLCDYWLTIYQVGKFIDPnw----------- 657 
XP_003678515 559 IDHALVNMDFPFAFNMTKELLeremks------------------enddlIRDHWLTIFQVGKFVDPnw----------- 609 
XP_003957702 558 IDYSLVNMDFKFAYEKTVELLerllst------------------detehLGDYWLTIFQVCKFNDPew----------- 608 
XP_007873105 588 AETALSQNEFDFAYDICINHLfslfeavd--------------iktrealSNIIWKSCLQISKNYETees---------- 643 
EPB88423     763 ASAALVEGDYLESYKLCQITT----------TAAVnkdasnhnkkyndevDQSAWQICFNLGKvda-------------- 818 
8EKI_D       629 --NWvdNEIPTEIIVLQMSILGRLLEVCP-LEEVEIVTSQWSTL------ELELSARdLVKDKYALDGQ 688  Saccharomyces cerevisiae ...
XP_002548758 796 ------ktidlevLTKQREILSLTIATLSlGENSKIVINQWQSL------NDKIQRVsLENDIDKVKQQ 852 
XP_004181677 643 neSS--DELPINIIITKLEIIEELSNICP-VEESEKVINYWSEL------ELELATRdIIYEAEYIEKD 702 
XP_001644473 608 ----idSEVPTEYLILQLELLGDLLSVCP-ADGLDIVVSQWSGA------ELELSTRnLIDDKYSIENM 665 
XP_003684281 615 ----ldNETPTEILVLQFELSSDLLQSCP-TEEMEIVISQWSSL------ELELLTRdIINDQYSIgns 672 
XP_003672426 658 ----ldNEIPTEILMQQMKILSKLLYVCP-VEEVEPIISYWSGL------ELELSIRdLVNDKYSLEk- 714 
XP_003678515 610 ----ldNEIPTEILMSQMEVLAELLNVCP-VEEIEIITSHWSGL------ELELSARdLVKDKYSLAs- 666 
XP_003957702 609 ----tdNEIPTEILLFQMDILSKLLHICP-MDQMEAVTSRWSSL------EMELSTRdLINDKYSLEHQ 666 
XP_007873105 644 ----------lenIKKKMFLLSKVINICP-KEYLVEVLNVWKRF------EKEQLSI-RSKKLSEFNDn 694 
EPB88423     819 ----------fddISRRLDVLSMALTLSP-AENIGDVLTVWRKLggnsfnQIELAQLsASNNNNDqnls 876 
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