3K8P


Conserved Protein Domain Family
Sec39

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pfam08314: Sec39 
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Secretory pathway protein Sec39
Mnaimneh et al identified Sec39p as a protein involved in ER-Golgi transport in a large scale promoter shut down analysis of essential yeast genes. Kraynack et al. (2005) showed that Sec39p (Dsl3p) is required for Golgi-ER retrograde transport and is part of a very stable protein complex that also includes Dsl1p (in mammals ZW10), Tip20p (Rint-1) and the ER localized Q-SNARE proteins Ufe1p (syntaxin-18), Sec20p and Use1p. This was confirmed in a genome-wide analysis of protein complexes by Gavin et al (2006).
Statistics
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PSSM-Id: 400556
View PSSM: pfam08314
Aligned: 67 rows
Threshold Bit Score: 337.741
Threshold Setting Gi: 444322043
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3K8P_D                7 YLLACIFASRADTRNIKK-LSTRLGSQSK-------------YLEILCVLW-PELDDP----KNLLFLrel--------e 59   baker's...
XP_002548758        106 VYTIQLVSSSTDIDKLQAfLRLLNAKVLSsdtneftfttknnLLNAILVHTyPLNLELeeltKLANLL------------ 173  Candida...
XP_004181677          7 YLLTCIFASRGDSLNLKIiLKNEKVNGVNfv----------eKLNIVCVLW-PELDDP----SNLKFLftddeemtddsd 71   Tetrapi...
XP_003672426          7 YLLACVFASKADSTNLSQ-ILRHVHYSLD-------------FIKAACILW-PELDDP----MNLISLfptielgnddnd 67   Naumovo...
CCC72177              7 YLLACLFASRADSENLIR-VLHHVEYSMK-------------FVKIVCILW-PELSDP----LSLRFLfn---------- 57   Naumovo...
XP_002495557          7 VILAAIFAARADSTNCET-LWTFFHSSDE-------------LFDIICSLW-PELDDP----TKLQFLfd---------- 57   Zygosac...
EDO16615              6 YLLCTIFAARADITNSSL-LYDQANGNFTq-----------eCFDALCILW-PELMDP----NGLSFVfq---------- 58   Vanderw...
XP_003684281          7 YLLATIFASTADVEKLTI-LKNSFTNSSE-------------LLDIICVLW-PELDDPillrNFLTNLel---------- 61   Tetrapi...
WGS:AFWA:PNEG_01189  11 LYIAVQYASAPSLQTLSE-LILKFPYIFSkr----------vILSI-LNFV-PECIDPdeylSLIFDEky---------- 67   Pneumoc...
EPB88423            175 IAQAIEYARSENNVALDAiFMHHGSDVLEhr-------------lFILSQI-PETADPsl-----fDL------------ 223  Mucor c...
3K8P_D               60 eeVQ-SPEGEEttdedvivelLESDSSLIPL---IESDTTTRSNRYHELQEfiskklnnktL--------------ENFE 121  baker's...
XP_002548758        174 --ID-PSNITKtd------etDSFDVEEFAFglpTQIENESSLLATAQDLMvdtnvqssyiGglkfg-----stpdDLLL 239  Candida...
XP_004181677         72 liRSyDGDDIYrnpadlvvniLKNNEELISI---IESDHNCLNERYDHMVDyintklsviqtl--kgsldvlntelSLKY 146  Tetrapi...
XP_003672426         68 nnAS-ANDDGSlsdenlvvklLENNPDLIPL---VEVGNTIVNTRYLSTKYfiesklnglySsniipletslssleDLQS 143  Naumovo...
CCC72177             58 -hQK-DAQVKPmtdeelvvslLEKDSMLIPM---VEINNETVSNRRQQLEQfinskwdsltSindid-----tsssSSSI 127  Naumovo...
XP_002495557         58 psEK-SSSGHStnpqdllvelLETDEQLISM---VEMDSDTITQRRQAISRyaaeymkqvtPydri-------kfvTPMG 126  Zygosac...
EDO16615             59 qgPS-DDQVQLsdpndlmmnlLEVDNKLIPI---IELEHDIVHERSEKVKDfvskrilqleQdsli-------tfdNILS 127  Vanderw...
XP_003684281         62 -nDL-NADENPidednilvslLETGEDLVPI---IEMDVETVSERVSTVKEyinrrlvevtLdeit-------sfdDTVS 129  Tetrapi...
WGS:AFWA:PNEG_01189  68 --------------------eGEDDMDSSQIsktQNINNAALSQKLKKLHI----------Yqdetkt--nncisdEELY 115  Pneumoc...
EPB88423            224 --PH-VTHDHEdswleepwrkEKDAVEQDWVqtlIRVQVPEETEYLERLkggiett--------------pyptsaSVIA 286  Mucor c...
3K8P_D              122 EWLRERILICNexiPETPLLYSVLWETAksk-------vlSTKFIGW---VEGVLKPLDHLNKRLHLIf----KINEWEK 187  baker's...
XP_002548758        240 SFIQAKTIQLSkyfDNVNDIMPLYERVS------------SDAFQSW---FAGVISP-----YKYYYDh--------YGQ 291  Candida...
XP_004181677        147 TWLKNRIILVNnfyPMDTIFNRTLWSLKvfrdkp-indqsHSIFFNW---INGTIYPLYYINQRLNKTl----KIQEFEN 218  Tetrapi...
XP_003672426        144 LWLQIRILVCNeviPEMTSFYEPLWTHSnf--------hiNKEGKDW---IECIIEPLNYINSRLGSKl----KIKDFSK 208  Naumovo...
CCC72177            128 SWLSKRILLCNdsyPGDVFFYEPLWnllikd----gvvseKDRLFQW---IKGIIIPLHSISIRTHAMt----KIIDFEK 196  Naumovo...
XP_002495557        127 DRLRKRLITSNelsDQLPMQYHPVWkvv---------sikDEELPKW---IEGIVEPLDHLNKRLNSSi----KIKEFEN 190  Zygosac...
EDO16615            128 NWLRRRILVCDefnPNNVLFNEPLWeth---------skdDIKFAQW---ISGIIKPLSYLNLRSGSKt---lKIKDFEN 192  Vanderw...
XP_003684281        130 SWLRKRILLCDelnPFNVLFNKKLWkei---------kpiDPEFMGW---VNGILEPLDFINNSSDIRvq--fRIIDFEA 195  Tetrapi...
WGS:AFWA:PNEG_01189 116 AWFISRALQIE---EETGLISFSRKLVLtsk------ypiPPKVQEWgrgIVSTLESVINRQYNNPLLefnvpTLREFET 186  Pneumoc...
EPB88423            287 SWYLDRAHAAD----SIGLSSSALEICRyarvmgvtgideQVSEYEW---LCKYVY-LAKAKLDQEGAy---vDLKTFQR 355  Mucor c...
3K8P_D              188 XPDSELFKIIFDGVe-DXqGYIGIADVIEDELAPTLSYG-----------------------KKWETFI----------- 232  baker's...
XP_002548758        292 VYNGATLQEYLSAG-------ETLKNKFEMLITPLSAGKvsnieqwianviipiimyhnndfRPLNEWLfysdmgatvtk 364  Candida...
XP_004181677        219 LKTEDVINMILNSQ------ETLKKETIVNELFPYIRYN-----------------------NCFDLYL----------- 258  Tetrapi...
XP_003672426        209 MDPIAVFPLILEGG------------DMKKELIPYLQYT-----------------------KSFTSFL----------- 242  Naumovo...
CCC72177            197 MNATVTFPLILDGK-------------IFHELIPYLDFT-----------------------NLSNEFI----------- 229  Naumovo...
XP_002495557        191 MDPLSVFDMILNTP------DENPDTVLQRELMPYMANG-----------------------DYYERFL----------- 230  Zygosac...
EDO16615            193 FKPVDIINLILGNIndDEyNLSIDASIIIQELIPYLKYS-----------------------KAYDIFL----------- 238  Vanderw...
XP_003684281        196 LTPNNVIELLTKNLleNEySFNNKNVQQIDCLISYLNYT-----------------------NSFTLFL----------- 241  Tetrapi...
WGS:AFWA:PNEG_01189 187 LNHKEVIDILLQHL-----ENEEILEEIKSSIIPYISYCqkssk--------------tniwDSLWSWLlnfsfkq---- 243  Pneumoc...
EPB88423            356 ISSYEILEGLLSST-----NAANIVDDMLRLALPWISMAnkrkhvnd--------hnsakkeFLLYRWLldpavv----- 417  Mucor c...
3K8P_D              233 -------TEFFNKQQFSlksdtnyqlfIKLY-------YSleKGVKDNSEASRKLQSNVVDILF------HNSenlF-NL 291  baker's...
XP_002548758        365 gsnktspVTKYSVWSSCisslnrhfelEEFK----------------------VIIETYLAACYyfsfkeDTDvvsSvDI 422  Candida...
XP_004181677        259 -------ESFFNSDKIQinnlsdyqrfKSLFieineeiRSffGNLDELTSINSKFQTNSLDIIL------KNNkwlItQF 325  Tetrapi...
XP_003672426        243 -------NNFCTVTQFPmdnqenyellDNLId---------iLPSVLPQDEIHTFKTSLLRIIF------ENSgnlL-KF 299  Naumovo...
CCC72177            230 -------ENYFTNENFLlatvqnydifRNIFf---------aFSNETSKSNFDKVCGNVANILF------ENSsnlL-NF 286  Naumovo...
XP_002495557        231 -------HSFLTTKDFPlntnynfevfYQLI-------LSlgLRGQETNKYLERFKRQCAYILF------KNGpnyL-NI 289  Zygosac...
EDO16615            239 -------DIVFNPSVFRfdtavnyynfRQLYs---------lLSNEIPIEFKEKLEELSLKIIY------DNSanmL-NV 295  Vanderw...
XP_003684281        242 -------EQKFNTNSFLfkkkqnylvfDAIFt---------kFNESNVMADKENFQKAALSIIF------ENSkelM-NI 298  Tetrapi...
WGS:AFWA:PNEG_01189 244 ---------------------knlnliKLIS-----------FNNVISSEKYSEFSKYAIASCYcl---qSTE---EeNI 285  Pneumoc...
EPB88423            418 -dahldwCCVVFEHSKPtiavedriikDDLD-----------------------LSRLVLAIVY--------------SG 459  Mucor c...
3K8P_D              292 SSLTHKLDELWSILSgfp----------------------deITIEEqKTITALExKQFXEFFIKCSTKF----SF---- 341  baker's...
XP_002548758        423 MKSYEVIHDTLSLLRgssktlapgsqdidygnipmdcasfneFNTPS-NPLSALFhSECIPELKHAIETCqklfPInkl- 500  Candida...
XP_004181677        326 KGTK----EINELIIrid----------------------hnIEAK--KYGNCFKiKKILRIIENIFHNDit-yTI---- 372  Tetrapi...
XP_003672426        300 TTLA----TLSNLVNvtad--------------------nsvMLTDY-DNLHYYDlQKYLLFMQNFSKSKd---SF---- 347  Naumovo...
CCC72177            287 KSLE----ELKNILNrip----------------------kdTPIAK-YDITVADvTEYIRYMEVMLSNY----SL---- 331  Naumovo...
XP_002495557        290 GTKY----RLNQVLLtig----------------------deTPVGD-LGITVETlLAYSSLTDKLFHGY----HM---- 334  Zygosac...
EDO16615            296 TSSS----ELEQLLTqfs----------------------pgTKVKS-TSLTANNlKWFAHYMNLCFQGY----SL---- 340  Vanderw...
XP_003684281        299 ISMD----ELKQLLDafd----------------------qnIETA--NGINSKIlLSYIHLISIFLQDY----SL---- 342  Tetrapi...
WGS:AFWA:PNEG_01189 286 HSMKIILQNLKQNLNietnsntsvlnd---ikisslnvftpeNIQDY-SELITPN-SDSLSLLEIMIKTVliinSTkeic 360  Pneumoc...
EPB88423            460 NGSMEYLVRLFECLPifddinensndptdmaaimpkatspmaIFMEL-QSVGEYGlTQMMDTLQGHLGSAetlaRY---- 534  Mucor c...
3K8P_D              342 --KEIF-AI-TQEEE--SAQLAHFSSLCHEEfNKA------NEISSFLQAXYETVLDI-SK---DDKIFTRI-SXDEKLY 404  baker's...
XP_002548758        501 tlKKYLqFN-YDPSS--IDLEREILRITSNI------------NHSNWQQLMRSVDlfkssfvseenTNGQV-SSIIIER 564  Candida...
XP_004181677        373 --DEINdTI-ENNNK--EQQVSKFTEFLENLmKNGysfrieKLITNSE--------NI-KD---IKFVFNKFeTTEEIER 435  Tetrapi...
XP_003672426        348 --KDLY-LI-NKGTE--SSQLAHFASICKEElSANan--kpSINNAKIKDIFDSI-VH-ED---NDMVLSHL-TIERKIS 413  Naumovo...
CCC72177            332 --KEVY-TI-SQEEE--SAQLAHFASSCKEElMAAlnnneeSTLSQKLNSLYT---LS-NA---SSSVFNRL-STKIQQS 397  Naumovo...
XP_002495557        335 --QDLY-AI-SKDDE--SVQESHFASLSRKClETVvs---eETTMKELKELLKH--GK-SS---NNVIFSRL-SEQKKLS 398  Zygosac...
EDO16615            341 --SDIN-AI-CQSSE--QEQLAHFASMVKGKiCNSqsqqtiDVISNLISE------SK-IK---EKQIFTNL-TIDKQIS 403  Vanderw...
XP_003684281        343 --KEVH-LI-SKENE--ASQLLHYTSMIKAKiMSKgfktssSTAVNEILSVITGS-AS-NS---EQIVFTHI-PPKRQIS 410  Tetrapi...
WGS:AFWA:PNEG_01189 361 kiTLSEaVCyRNKDK--KSQISLLHKMIPQN-PHFl----sKLNDSEWIKLRNNIKwlhd----vslIYKNI-PEIEYES 428  Pneumoc...
EPB88423            535 --NAHVpLRwYLEDQsvEAQRQLCVRMSSQAaGGVesggakFDRDDDWRELLDDMIrlngD---GQGIFGKL-ENAEILE 608  Mucor c...
3K8P_D              405 SILEILLQXNEFAYIEAI----------IERFDYSNntqiyeLLVKFFWHFFNNASN-GLRKEPEXKKASQTLQIIQKHX 473  baker's...
XP_002548758        565 LLFANL-----FDVADELffnd--sllpISTNQFYS------LVEEKFWASLNHAVN-LNEKSGLLYNAHQCLNLFDKLV 630  Candida...
XP_004181677        436 LVIDILMNYREFDLVGDI----------LGSHSDEDsqi-ndIVIKYYWKTIKKFNNdGTKKNVEMLNIEKILTILKH-- 502  Tetrapi...
XP_003672426        414 ILLETVLDLGEFDVLEEV-------------VTQYKekfitkLLLKFFWIYFNNSTN-GSKKSLGMTKCRKVLNLLSLEA 479  Naumovo...
CCC72177            398 ILLETVLDMGQFDILHEF-------------MSEYGsnletdLLEKYFWKFFNNATN-GSCKRAEMIKSQKTLNLLl--- 460  Naumovo...
XP_002495557        399 IIIEILLEFGNFSFLHEL-------------IITYQykvneeVLVKYFWHFFNMASS-GQRHKRDLANAEKLVNLLl--- 461  Zygosac...
EDO16615            404 IFVEILLELGEFDLLQNF-------------VTLNNskleenVLEKYFWNFFNNATN-GLKSRPEIKKAEKTLQLMd--- 466  Vanderw...
XP_003684281        411 VLIDLLLELGEFDLLQDL-------------MEEQNsqleeaGLEKYFWHFFNNASN-GLKSRPEMKKAQKTVKLLl--- 473  Tetrapi...
WGS:AFWA:PNEG_01189 429 FLLYNILRTTKFNLAENIyikrnkgnmpLKDVMVEK------ICIEIFLEFFDSSSN-GNITKGNMKNAYNLLQTIKQYY 501  Pneumoc...
EPB88423            609 IFFYSLLRCGRFKLAKELi---------FGSKRIMDmtkaehLVIDAEREFFDNATS-GNMNSGSMKQAWDCLKIL---- 674  Mucor c...
3K8P_D              474 s------QRAGTNLTKLEVLLEISDKL-SHYSINLNKshnGArd--tAFKPSNILEYr--DCPLDIISNLLELNPRLYKD 542  baker's...
XP_002548758        631 lkk-dleESSRQQIVKFKHLFKAMHAL-KNFKIVIVS---SDadrnkPLTPYALINSfadNNVMNLITIVLEQNPKSYLA 705  Candida...
XP_004181677        503 -------RKEVNEYHYLRQLVNNCYEL-SKYSI----------------KPIDIIQYk--QEPIKIISKMLENNNGLYKE 556  Tetrapi...
XP_003672426        480 htkgrqdLITKEELNSLQTLLDVSDDL-SKYSMNLGK---GH-----IFKPSNILDFe--TKETGLISILLESNNSIYKD 548  Naumovo...
CCC72177            461 -------KQDAKKYERLQSLLDVADEI-SRYSMNLGR---GI-----IFKPSNILDFq--EDPYQLISTLLELNSSLYKD 522  Naumovo...
XP_002495557        462 -------EENAPKYTHLRILLDVTKDI-CDYSINWGR---SL-----PFRPSHLLKFk--EDPFGLISLLLESNRRLYKD 523  Zygosac...
EDO16615            467 -------VQNSTVYKHLHTLLKVADTL-SRYSINLGK---GI-----PFKPCNIFEFk--YNPSKLISILLELNRDLYKD 528  Vanderw...
XP_003684281        474 -------EQNEPKFKHLEILLHIADLL-SYYSINLGK---GV-----IFKPSNIFDFk--NHPSQIISKLLELNDGLYKD 535  Tetrapi...
WGS:AFWA:PNEG_01189 502 -------NSEQ--LESFSYLVKVTNTL-YHYS---------H-----KFKPVQIRLH---NNPFEILEDFLSSNPGIYKS 554  Pneumoc...
EPB88423            675 -------PPSTE-IKKEVDLIEATHTLiYEYKVQDHP---GI-----TLMPIQIRQS---QNRLELISKLINNRAGMYQR 735  Mucor c...
3K8P_D              543 LPTTKSLLFGIYDSlsiNREg------------qTGKVEVDLXVLHIDYALVNLDFGTAYELGKQVFeicqeag------ 604  baker's...
XP_002548758        706 FEKLYRILNDLLIFfged------------gdgeNNFYFKKLKTACIESALIDNNFNYAYTQSIELFkffedk------- 766  Candida...
XP_004181677        557 FEI---FNEKVYNNlqiEI---------------TNDERIEIINLQIINSLKNFDFNFAYQMIQDLFanyq--------- 609  Tetrapi...
XP_003672426        549 ISVTFEIMKKLNVAmacQCPfinhnqlkpaqkkdVIVAYMRLLTLHIDYSLVNMDFNFAYKLTMELFdkfktyigqqset 628  Naumovo...
CCC72177            523 ILVTFTILKKLYTAlekSSLrs----------tnFDYEYDKLLIIHIDHALVNMDFPFAFNMTKELLeremks------- 585  Naumovo...
XP_002495557        524 VPATYSILQKLLVAfeiAKQgt----------tdSEENLVKVLVLHIDHALVNMDFQFAYENTRDLLkk----------- 582  Zygosac...
EDO16615            529 VANSMNLIDQLVEAmqiSREhl-----------dRESEYNKILVIHIDHALVNMDFTFAFQKSKELLrr----------- 586  Vanderw...
XP_003684281        536 KNTTSLMLKELFEGmnlDITgd-----------fFVQEQIRVSEFHIDNALANLDFYFAYHESKELLtk----------- 593  Tetrapi...
WGS:AFWA:PNEG_01189 555 IDEVMEICNDLLLStnkNYLy-------------QKEIQAKILCIIAETALSQNEFDFAYDICINHLfslfeavd----- 616  Pneumoc...
EPB88423            736 HEQVLELVRKLGYGn-------------------DLLAKVKTLAMLASAALVEGDYLESYKLCQITTtaavnkdasn--- 793  Mucor c...
3K8P_D              605 ---qhxxkalGDEHWLTFYQXGKFVDPnw-------------vdNEIPTEIIVLQXSILGRLLEVCP-LEEVEIVTSQWS 667  baker's...
XP_002548758        767 -----pndrrIDELWLTFYQVGKYISPewfdepe----------ktidlevLTKQREILSLTIATLSlGENSKIVINQWQ 831  Candida...
XP_004181677        610 -------aesYQKYWETIYLFVKFTDPkwfdinnygdnsrnessDELPINIIITKLEIIEELSNICP-VEESEKVINYWS 681  Tetrapi...
XP_003672426        629 sgiatderfnLCDYWLTIYQVGKFIDPnw-------------ldNEIPTEILMQQMKILSKLLYVCP-VEEVEPIISYWS 694  Naumovo...
CCC72177            586 -----enddlIRDHWLTIFQVGKFVDPnw-------------ldNEIPTEILMSQMEVLAELLNVCP-VEEIEIITSHWS 646  Naumovo...
XP_002495557        583 --------knIIDCWPTILQVGKFVDPnw-------------rdGETPTEIIFLQLEILGELLQICP-VDEVEAVASQWS 640  Zygosac...
EDO16615            587 --------dsVSTYWATVFQVCKFINPnw-------------idSEVPTEYLILQLELLGDLLSVCP-ADGLDIVVSQWS 644  Vanderw...
XP_003684281        594 --------seNKTPWATVFQVCKFSDPnw-------------ldNETPTEILVLQFELSSDLLQSCP-TEEMEIVISQWS 651  Tetrapi...
WGS:AFWA:PNEG_01189 617 ---iktrealSNIIWKSCLQISKNYETees------------------lenIKKKMFLLSKVINICP-KEYLVEVLNVWK 674  Pneumoc...
EPB88423            794 -hnkkyndevDQSAWQICFNLGKvda----------------------fddISRRLDVLSMALTLSP-AENIGDVLTVWR 849  Mucor c...
3K8P_D              668 TL------ELELSARdLVKDKYALDGQ 688  baker's yeast
XP_002548758        832 SL------NDKIQRVsLENDIDKVKQQ 852  Candida tropicalis MYA-3404
XP_004181677        682 EL------ELELATRdIIYEAEYIEKD 702  Tetrapisispora blattae CBS 6284
XP_003672426        695 GL------ELELSIRdLVNDKYSLEk- 714  Naumovozyma dairenensis CBS 421
CCC72177            647 GL------ELELSARdLVKDKYSLAs- 666  Naumovozyma castellii CBS 4309
XP_002495557        641 AL------ELELLTRdLIKDPYSLEKS 661  Zygosaccharomyces rouxii
EDO16615            645 GA------ELELSTRnLIDDKYSIENM 665  Vanderwaltozyma polyspora DSM 70294
XP_003684281        652 SL------ELELLTRdIINDQYSIgns 672  Tetrapisispora phaffii CBS 4417
WGS:AFWA:PNEG_01189 675 RF------EKEQLSI-RSKKLSEFNDn 694  Pneumocystis murina B123
EPB88423            850 KLggnsfnQIELAQLsASNNNNDqnls 876  Mucor circinelloides f. circinelloides 1006PhL
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