Conserved Protein Domain Family
cwf21

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pfam08312: cwf21 (This model is not part of the current CDD release)
cwf21 domain
The cwf21 family is involved in mRNA splicing. It has been isolated as a subcomplex of the splicosome in Schizosaccharomyces pombe. The function of the cwf21 domain is to bind directly to the spliceosomal protein Prp8. Mutations in the cwf21 domain prevent Prp8 from binding. The structure of this domain has recently been solved which shows this domain to be composed of two alpha helices.
Statistics
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PSSM-Id: 518176
Aligned: 138 rows
Threshold Bit Score: 27.8189
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_013022283  56 SKHERR---RRIESKVLLFREELlahtES---Q-Qtrypdegseeretekgegegegdrnamfdgakqteesgkylshde 128 
Q7Q7V4       747 DELRRVr-lREIEVKIVQYQDEF----ESgtrQ----------------------------------------------- 774  Anopheles gamb...
XP_046448915 774 NEDQRGklrELELKVVRYQDELE----AGlhnQ----------------------------------------------- 802 
XP_003137568 763 LDEERRkilREIEVKVVKYQDEL----ES---Q----------------------------------------------- 788 
Q8IKW9        60 IEHAEK---RRIELEVLLYEEKM----RQ---E----------------------------------------------- 82   Plasmodium fal...
Q7RN35        60 IEHSEK---RKIELEVLLYEEKI----KE---E----------------------------------------------- 82   Plasmodium yoe...
XP_002176041  52 SEHEQK---RLLESKVLAYREEL----QE---S----------------------------------------------- 74  
O14161        55 SEHECR---RQIESKLLLYREQLleevSS---QhStdaaasdsntnfgtenp------------kppkaiikdeqsqskt 116  Schizosaccharo...
XP_002260366  60 IEHSEK---RKIELKVLMYEEKL----RE---E----------------------------------------------- 82   Plasmodium kno...
XP_003968074 779 MNEEKRtklREIEVKVMKFQDEL----ES---G-Krp------------------------------------------- 807  torafugu
XP_013022283 129 aQkRDEEIELLVQEYREKLWKE 150 
Q7Q7V4       775 -VrTGWTLHEEIDSYRMKLLKE 795  Anopheles gambiae str. PEST
XP_046448915 803 -IpGMSVSEQVQQYREHLLRKS 823 
XP_003137568 789 ---RCEDITAQVEKYRASLLKQ 807 
Q8IKW9        83 ---GSKNIEELIKNYRQKLYDE 101  Plasmodium falciparum 3D7
Q7RN35        83 ---GKENIEELINNYRKKLYDE 101  Plasmodium yoelii yoelii
XP_002176041  75 -GkTDEEIKALVSAFRQRLSND 95  
O14161       117 kSlDEADVEILVQKYREQLLKE 138  Schizosaccharomyces pombe 972h-
XP_002260366  83 ---GKKNIQDLVDQYRNQLYEE 101  Plasmodium knowlesi strain H
XP_003968074 808 kK-HGQSIQEQVEHYRDKLLQK 828  torafugu
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