4CL1,4CL1


Conserved Protein Domain Family
HCV_NS5a_1b

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pfam08301: HCV_NS5a_1b (This model is not part of the current CDD release)
Hepatitis C virus non-structural 5a domain 1b
The molecular function of the non-structural 5a protein is uncertain. The NS5a protein is phosphorylated when expressed in mammalian cells. It is thought to interact with the ds RNA dependent (interferon inducible) kinase PKR. This region corresponds to the 1b domain.
Statistics
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PSSM-Id: 518170
Aligned: 20 rows
Threshold Bit Score: 107.454
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4CL1_A         66 GPCTPLPAPnYKFALWRVSAEEYVEIRRVGDFHYVSGMTTDNLkCPCQIPsPEFF--TELDGVRLHRFAPPCKPLLREEV 143  Hepatitis C v...
Q69422       1963 GSARPDPTD-WTSLVVNYGVRDYCKYEKLGDHIFVTAVSSPNV-CFTQVP-PTLRaaVAVDGVQVQCYLGEPKTPWTTSA 2039 GB virus-B
O41914        180 GETSPLLAS-DMPKVVPFGTSGWAEVVVTPTHVVVRRTSCYKL-LRQQILsAAVAepYYVDGIPVSWEADARAPAMVYGP 257  GB virus C
O56074       2056 GDAEPEVPA--GPALYQIGVAEWVQLVRKDKTLVVGASSVYHL-HIDELRrAIRGppMFVGGVGVSWEAPLQQPPLVYRA 2132 Pegivirus A
O41892       2037 GGATPVVPP-RGPKTYQLGCADWIEALVVSGTVTVTASSAYDL-TAAEVRrAVKAspCFAGDLPVSWEAPICRPAMVYRG 2114 Pegivirus A
O56073       2045 GAAEPAPPP-RGLKTYQFGYKDWVEALVMEGTMTIHATSCYET-TAAELRrAARTrpCFSQGVACSWEAPMSPPAMVYRT 2122 Pegivirus A
O91936       2069 GPSVPAPAPnYKFALWRVGAADYAEVRRVGDYHYITGVTQDNLkCPCQVPsPEFF--TELDGVRIHRYAPPCNPLLREEV 2146 Hepatitis C v...
O39929       2068 GPGVPIPAPnYKFALWRVSAEDYVEVRRVGDFHYVTGVTQDNIkFPCQVPaPELF--TEVDGIRIHRHAPKCKPLLRDEV 2145 Hepatitis C v...
3_pfamImport    1 GPSVPIPSPnYRKALWRVAAEEYVEVVRHGDNHYIVAATSDNLkCPCQVPsPEFF--TEVDGIRLHRYAPACRPLLRDEI 78  
O92530       2066 GPSVPVPEPnYHKALWRVSAEDYVEVVRVNDHHYIVGATADNLkCPCQVPaPEFF--TEVDGVRLHRFAPPCRPLMRDDI 2143 Hepatitis C v...
4CL1_A        144 SfRVGLHEYPVGSQLPcePEPDV 166  Hepatitis C virus (isolate H77)
Q69422       2040 C-CYGPDGKGKTVKLP--FRVDG 2059 GB virus-B
O41914        258 GqSVTIDG--ERYTLPhqLRMRN 278  GB virus C
O56074       2133 GqSVRFDD--VRYSLPhtLALPP 2153 Pegivirus A
O41892       2115 GqTIQLDG--VRRTLPcgLPLGA 2135 Pegivirus A
O56073       2123 GqTITIDG--VRKMLPctLVLGA 2143 Pegivirus A
O91936       2147 CfSVGLHSFVVGSQLPcePEPDV 2169 Hepatitis C virus SA13
O39929       2146 SfSVGLNSFVVGSQLPcePEPDV 2168 Hepatitis C virus ED43
3_pfamImport   79 TySVGLSTYIIGSQLPcePEPDV 101 
O92530       2144 TfSVGLSTYVVGSQLPcePEPDV 2166 Hepatitis C virus (isolate VN235)
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