Conserved Protein Domain Family
Inhibitor_I29

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pfam08246: Inhibitor_I29 
Cathepsin propeptide inhibitor domain (I29)
This domain is found at the N-terminus of some C1 peptidases such as Cathepsin L where it acts as a propeptide. There are also a number of proteins that are composed solely of multiple copies of this domain such as the peptidase inhibitor salarin. This family is classified as I29 by MEROPS.
Statistics
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PSSM-Id: 400519
View PSSM: pfam08246
Aligned: 58 rows
Threshold Bit Score: 42.2448
Threshold Setting Gi: 74876166
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WGS:AAAA:OsI_00905  49 FSRWMAQYGKAYsWPIEHEKRYQIWKDNSNFIGSFRseteissgvgAFAPQTVtdsFVGMNRFGDLTPGEF 119 long-grained rice
Q4UDK0             129 FNDFNKHHDRKHnNYRHKKASYNNFRNNLNDINEHN----------SKPNMSY---TKSMNHFGDVSPKDF 186 Theileria annulata
XP_001633385       245 FDKYVKKHKKNYkDNKEHHTRREHFKHNLRFIHSKN-----------RRHAGY---YLAMNHLGDRSDKEL 301 starlet sea anemone
Q23030              82 FNDFILKFDRKYtSVEEFEYRYQIFLRNVIEFEAEE-----------ERNLGL---DLDVNEFTDWTDEEL 138 Caenorhabditis ele...
Q54UH2             161 FIQWSNQFNRTY-RADQFLLKYEAFKDSSRFIEQYKr---------ENQNSTM---ELGLTQFSDMTHDEF 218 Dictyostelium disc...
Q7QCZ7             216 FDKFRHHHRRQYaSSMEHEMRFNIFRNNLFKIEQLN----------KFERGTA---KYGVTKFADMTVAEY 273 Anopheles gambiae ...
WGS:AAAA:OsI_24608  85 HQEWMNKFNREYkDEAEKAYRFEIFKSTVRFAEKFNa--------eQVKEHGYckcILGTTQFADLTLEEF 147 long-grained rice
P00786              33 FTSWMKQHQKTY-SSREYSHRLQVFANNWRKIQAHN-----------QRNHTF---KMGLNQFSDMSFAEI 88  Norway rat
Q7KWP5              29 FTAWMTSNQRTY-ASSEFTNRYNTFKSNLDFINQWN----------SKGSKT----VLALNEFADISNEEY 84  Dictyostelium disc...
Q7XB87             168 FEDWMKEHGRIYiTKKEKAHRYENFKKAMKGINELNik------rgMRSPLA------APTELADYTDEEV 226 Japanese rice
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