Conserved Protein Domain Family
Inhibitor_I29

?
pfam08246: Inhibitor_I29 
Cathepsin propeptide inhibitor domain (I29)
This domain is found at the N-terminus of some C1 peptidases such as Cathepsin L where it acts as a propeptide. There are also a number of proteins that are composed solely of multiple copies of this domain such as the peptidase inhibitor salarin. This family is classified as I29 by MEROPS.
Statistics
?
PSSM-Id: 489485
Aligned: 53 rows
Threshold Bit Score: 42.6255
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_015636903  49 FSRWMAQYGKAY----SWPIEHEKRYQIWKDNSNFIGSFRseteissgvgAFAPQTVtdsFV-GMNRFGDLTPGEF 119
Q6DHT0        26 FHAWKLKFGKSY----RSAEEESHRQLTWLTNRKLVLVHNmm-------aDQGLKSY---RL-GMTYFADMSNEEY 86  zebrafish
Q9JIA9        29 WQDWKIKYNKSY-----SLKEEKLKRVVWEEKLKMIKLHNre-------nSLGKNGF---TM-KMNEFGDQTDEEF 88  house mouse
NP_001005695  27 WLLWKNTHNKDY----EDEIEDLQRRITWEKNLNLVNMHNle-------ySMGMHTY---EL-GMNHLADMTSEEI 87 
Q24HI2        36 HDDYVLSLARLYr---PHLNVEHLEFQHFKESVRRVREHN----------KKVNATY---TLsIDSPFAFMSDEQF 95  Tetrahymena thermop...
Q75PZ5        54 yRLYKRKYNKRD----EEINLEHRRFMTYLKNVKEIEKHNer-------yERNEETY---EL-AINHLADMLPEEF 114 Brugia malayi
XP_002901472  40 FVDYALDYEKSYrndaNDHDVVQLRFRSFATNLERIQTHNea-------yERGEHSF---TL-GLNDLADLADAEY 104
XP_001633385 245 FDKYVKKHKKNY----KDNKEHHTRREHFKHNLRFIHSKN-----------RRHAGY---YL-AMNHLGDRSDKEL 301
Q4DC63        55 FDRFLQEYGKKY-----DAREYVRRRALFEQTLARVRTHN----------EAGNHLY---VM-GINHMSDWTPEEL 111 Trypanosoma cruzi
Q9VNK6        30 WDQYKAKYNKQY-----RNRDKYHR-ALYEQRVLAVESHNql-------yLQGKVAF---KM-GLNKFSD-TDQRI 87  fruit fly
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap