Conserved Protein Domain Family
LNS2

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pfam08235: LNS2 
LNS2 (Lipin/Ned1/Smp2)
This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain (pfam04571). SMP2 (also known as PAH1) is involved in plasmid maintenance and respiration, and has been identified as a Mg2+-dependent phosphatidate phosphatase (EC:3.1.3.4) that contains a haloacid dehalogenase (HAD)-like domain. Lipin proteins are involved in adipose tissue development and insulin resistance.
Statistics
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PSSM-Id: 400509
View PSSM: pfam08235
Aligned: 76 rows
Threshold Bit Score: 270.915
Threshold Setting Gi: 124457893
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001730129         603 KTLRLSSDQLKQLGLRKGTNTITFSVTSSYSGVAT-CRARIFLWDCDQPVVVSDIDGTITKSDALGHVFTLMGrDWTHLG 681  Malass...
EIJ88311             241 REVYLPDTYIEKMHLVPGPNKTVYRLS----GTPIfLTCNIYLWNETDKIIISDIDGTVTKSDIVGYIYGAMGkDWTHLG 316  Nemato...
WGS:AFBI:EDEG_00238  403 lTLKLSSKQLERMELKPGKNELQFKIDG---TNQC-ISTNCYFWENDVKIIISDIDGTITKSDKLGHVYTMIGkDWTHAG 478  Edhaza...
Q8SWG3               343 FSLKLNSEELRMLNLKEGKNQVVFKISG---LNKQ-LEGSIYLWRSNAKIIVSDIDGTITKSDVWGHLYGMMGkDWTHHG 418  Enceph...
XP_002995255         334 YSLKLNHKELSKLDLKYGKNTIIFKVGG---VNKQ-LDGHIYFWDYDEKVIISDIDGTITKSDLWGHIYCLIGkDWTHGG 409  Nosema...
EOB15583             342 YSLRLNSDELEKLNLIYGQNTVIFKVGG---IDKQ-LGGHIYLWDANDKIIVSDVDGTITKSDVWGHIYSLMGkDWTHGG 417  Nosema...
EED44513             363 FTMVLNSKELGNLNLNYGRNEALFKISG---MDEN-LEAAIYLWDETDKIVVSDIDGTITKSDVWGLISSYIGtDWTHLG 438  Entero...
XP_007604176         300 fSLTLNSDELKSLNLNPGKNEVVFKISG---INKQ-LDASIYFWNANDKIIVSDVDGTITKSDVRGHLYNLMGrDWTHSG 375  Vittaf...
ELA47946             506 RTLNLSSHDLHKLHLQYGRNTLEYKLA---GMDKR-IEVCMYLWNENDKIIVSDIDGTITKSDVWGHIYDLVGkDWTHGG 581  Vavrai...
A0D325               143 lsrVPTSKTIQSLKLKHGLNTITYEVECKRLGLQH-IECQLFMIKQNQKIFISDIDGTITKSPTKGMILSTFGrDYTQDH 221  Parame...
XP_001730129         682 VAKLYHDIAKNGYRLMYLTSRAIGQADITRDYLRNInqNNYQLPDGPVIMSPDRLIASLHREVILRKPEVFKMACLRDIA 761  Malass...
EIJ88311             317 IAALYNKIVENGYKIVYLSSRPIGHIGFTKAYLERVeqEEQNLPAGPVILFPGRLLSAIYREMV-QGPEEFKISVISEIK 395  Nemato...
WGS:AFBI:EDEG_00238  479 VAGLFTKIVKNDYKIVYLSSRPIGQMEYTKKYLSGIkqNGCELPDGPVLLSPDGLFGAIYREMILKRPEEFKIACLKTLQ 558  Edhaza...
Q8SWG3               419 VASLYTKIVRNGYKIVYLTARPLGQSFSTKSYLKNVcqDGYKLPDGPVILSPDGVFAALYRELIIRRPEDFKIAYLKTIQ 498  Enceph...
XP_002995255         410 VASLYSKLYRSGYKIMYLTARPLQQSFSTKKYLTNVdqDGAKLPDGPIILSPDGLFAALYREIIIKRPEDFKIACLENLK 489  Nosema...
EOB15583             418 IASLFTKIKKHGYKILYLTARPLQQSFATKNYLRRVnqDGYNLPEGPVLLSPDGVFAALYREIVIKKPEDFKIACLTDIM 497  Nosema...
EED44513             439 IASLFSKLHENGYKIIYLSARSLGQSANTKEYLYSVeqDNHKLPDGPILLNPDGLFSAIYREIIAKNPDEFKIHVLNSIK 518  Entero...
XP_007604176         376 IAPLYSKIVKNGYRIIYLTSRPLGQSFSTKSYLKQVsqDDCTLPDGPVIHNPEGVLEAIYKEVILKRPEEFKIACLKQIK 455  Vittaf...
ELA47946             582 VAALFTKIISNNYRIMYLSNRAMPMYFRTRRYLGKIkqNECTLPDGPIVLSPKSVLSSLYTEV-RNQSHIFKIDCLQQIE 660  Vavrai...
A0D325               222 ICEFYNRLTQRNYLILYMSARSMVQYESTKEYLLRQqqQGIQLPPGPLFLSPQELLEAFTIEVIKKQTDILKSQMLNDL- 300  Parame...
XP_001730129         762 RLFGidpsqpdsEHRT--PFYAGFGNRITDALSYRSVNIPSSRIFTIDSNGEVkMEllELAGYHTS-YP--NMTDLVDQM 836  Malass...
EIJ88311             396 GLMSq------------gRIYAGFGNKESDRIAYEVCEIDPGRIFIVNTMSEIsTG--RKGIVKLT-HC--SLYDIVDGV 458  Nemato...
WGS:AFBI:EDEG_00238  559 SLFSt------------nPLFGGFGNRQTDVITYRTVGIDISRIFTIDSYGVIiPE--CSTTISGS-YL--TLNSIVDNI 621  Edhaza...
Q8SWG3               499 ELFG-----------DtnPFVAGFGNKITDVITYKALEVPLSRIFTINHKGELyVE--LVKTLSGT-YR--TMNDFVDSM 562  Enceph...
XP_002995255         490 AIFG-----------GnnPFVAGFGNRITDIITYKSIEISPIRIFTVNESGRLyGE--FIGELTST-YK--SLNDFMDSL 553  Nosema...
EOB15583             498 KIFN-----------GvnPFVAGFGNRITDVITYKSLNISPTRIFTINPEGELsGD--FTNSLSKT-YK--SMNDFIDKI 561  Nosema...
EED44513             519 QLFS--------PEYRddAIIAGFGNKLTDVIAYKTINIPTNRIYTINSYGQIqSE--YSKSLIGT-YS--TLNEFIDTI 585  Entero...
XP_007604176         456 SLFN-----------GrnPFIAGFGNRITDVVTYKTMDIPENKIYTVNALGHIqAE--YSKATVGT-YH--TINEFIDSI 519  Vittaf...
ELA47946             661 QLFY---------GRK--PFFAGFGNRISDLLSYKVLGIAKSMIFIIDRDGSIcEG--MKRKISAS-YL--TLNHFANTI 724  Vavrai...
A0D325               301 -VFTigv---------tgTIQGGMGDRLNDIQAYKMANIEYERILLINKKGEIv---rVNNEMKEEkFTikEIIQKMDQI 367  Parame...
XP_001730129         837 FP 838  Malassezia globosa CBS 7966
EIJ88311             459 FP 460  Nematocida parisii ERTm3
WGS:AFBI:EDEG_00238  622 FP 623  Edhazardia aedis USNM 41457
Q8SWG3               563 FP 564  Encephalitozoon cuniculi
XP_002995255         554 FP 555  Nosema ceranae BRL01
EOB15583             562 FP 563  Nosema bombycis CQ1
EED44513             586 FP 587  Enterocytozoon bieneusi H348
XP_007604176         520 FP 521  Vittaforma corneae ATCC 50505
ELA47946             725 FP 726  Vavraia culicis subsp. floridensis
A0D325               368 F- 368  Paramecium tetraurelia
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