Conserved Protein Domain Family
LNS2

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pfam08235: LNS2 (This model is not part of the current CDD release)
LNS2 (Lipin/Ned1/Smp2)
This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain (Pfam: PF04571). SMP2 (also known as PAH1) is involved in plasmid maintenance and respiration, and has been identified as a Mg2+-dependent phosphatidate phosphatase (EC:3.1.3.4) that contains a haloacid dehalogenase (HAD)-like domain. Lipin proteins are involved in adipose tissue development and insulin resistance.
Statistics
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PSSM-Id: 518136
Aligned: 69 rows
Threshold Bit Score: 281.699
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001730129  603 KTLRLSSDQL--KQLGLRKGTNTITFSVTSSYSGVAT-CRARIFLWDCDQPVVVSDIDGTITKSDALGHVFTLMGRDWTH 679 
XP_002677637  287 HRLRPSKEYLelIHSHMTDGRSSISF---IDPNGGLEpVKAYIFEFSPQDKIIISDIDGTITKSDIMGQVYSRMGKDYTH 363 
XP_013059023  241 REVYLPDTYI--EKMHLVPGPNKTVYRLS----GTPIfLTCNIYLWNETDKIIISDIDGTVTKSDIVGYIYGAMGKDWTH 314 
EJW03258      403 LTLKLSSKQL--ERMELKPGKNELQFKIDG---TNQC-ISTNCYFWENDVKIIISDIDGTITKSDKLGHVYTMIGKDWTH 476 
EPR77660      334 KCFILDSSGL--KKLGLTYGPNEVIFKVDG---AEQR-LSSTIYLWKDTDRIVVSDIDGTITKSDVMGHICDFVGKDWTH 407 
XP_008073550  506 RTLNLSSHDL--HKLHLQYGRNTLEYKLA---GMDKR-IEVCMYLWNENDKIIVSDIDGTITKSDVWGHIYDLVGKDWTH 579 
Q8SWG3        343 FSLKLNSEEL--RMLNLKEGKNQVVFKISG---LNKQ-LEGSIYLWRSNAKIIVSDIDGTITKSDVWGHLYGMMGKDWTH 416  Encephalitozo...
EEQ81584      334 YSLKLNHKEL--SKLDLKYGKNTIIFKVGG---VNKQ-LDGHIYFWDYDEKVIISDIDGTITKSDLWGHIYCLIGKDWTH 407 
EOB15583      342 YSLRLNSDEL--EKLNLIYGQNTVIFKVGG---IDKQ-LGGHIYLWDANDKIIVSDVDGTITKSDVWGHIYSLMGKDWTH 415 
EED44513      363 FTMVLNSKEL--GNLNLNYGRNEALFKISG---MDEN-LEAAIYLWDETDKIVVSDIDGTITKSDVWGLISSYIGTDWTH 436 
XP_001730129  680 LGVAKLYHDIAKNGYRLMYLTSRAIGQADITRDYLRNINQNNYQLPDGPVIMSPDRLIASLHREVILRKPEVFKMACLRD 759 
XP_002677637  364 PGIAKLFQSIAENNYKFIYLSARPITMSQLTREYINSVYQDGYKMPPGPIITSPNKAFSALAREVVIRRPETFKINCLGS 443 
XP_013059023  315 LGIAALYNKIVENGYKIVYLSSRPIGHIGFTKAYLERVEQEEQNLPAGPVILFPGRLLSAIYREMV-QGPEEFKISVISE 393 
EJW03258      477 AGVAGLFTKIVKNDYKIVYLSSRPIGQMEYTKKYLSGIKQNGCELPDGPVLLSPDGLFGAIYREMILKRPEEFKIACLKT 556 
EPR77660      408 KGIAKLLTKIERNGYHIVYLSSRAIGQHQRTENMLNRVSQDEYSLPQGPIILSPDGIFGALYRELIRRRPEDFKISCLKT 487 
XP_008073550  580 GGVAALFTKIISNNYRIMYLSNRAMPMYFRTRRYLGKIKQNECTLPDGPIVLSPKSVLSSLYTEV-RNQSHIFKIDCLQQ 658 
Q8SWG3        417 HGVASLYTKIVRNGYKIVYLTARPLGQSFSTKSYLKNVCQDGYKLPDGPVILSPDGVFAALYRELIIRRPEDFKIAYLKT 496  Encephalitozo...
EEQ81584      408 GGVASLYSKLYRSGYKIMYLTARPLQQSFSTKKYLTNVDQDGAKLPDGPIILSPDGLFAALYREIIIKRPEDFKIACLEN 487 
EOB15583      416 GGIASLFTKIKKHGYKILYLTARPLQQSFATKNYLRRVNQDGYNLPEGPVLLSPDGVFAALYREIVIKKPEDFKIACLTD 495 
EED44513      437 LGIASLFSKLHENGYKIIYLSARSLGQSANTKEYLYSVEQDNHKLPDGPILLNPDGLFSAIYREIIAKNPDEFKIHVLNS 516 
XP_001730129  760 IARLFGidpsqpdseHRT--PFYAGFGNRITDALSYRSVNIPSSRIFTIDSNGEVKMEllELAGYHTSYPNMTDLVDQMF 837 
XP_002677637  444 IASLFP-----------TdfPFYSGFGNRPTDCISYVSVNIDPTRCYRINKQGKLLVQ--ATKVTYNSYAEIESQLLKHF 510 
XP_013059023  394 IKGLMSq------------gRIYAGFGNKESDRIAYEVCEIDPGRIFIVNTMSEISTG--RKGIVKLTHCSLYDIVDGVF 459 
EJW03258      557 LQSLFSt------------nPLFGGFGNRQTDVITYRTVGIDISRIFTIDSYGVIIPE--CSTTISGSYLTLNSIVDNIF 622 
EPR77660      488 IKDIFN-----------GynPFIAGFGNRINDVITYKALDICDSKIFTTNPKGEVYLE--LKGTLVSTYSTLNTFVDSIF 554 
XP_008073550  659 IEQLFY---------GRK--PFFAGFGNRISDLLSYKVLGIAKSMIFIIDRDGSICEG--MKRKISASYLTLNHFANTIF 725 
Q8SWG3        497 IQELFG-----------DtnPFVAGFGNKITDVITYKALEVPLSRIFTINHKGELYVE--LVKTLSGTYRTMNDFVDSMF 563  Encephalitozo...
EEQ81584      488 LKAIFG-----------GnnPFVAGFGNRITDIITYKSIEISPIRIFTVNESGRLYGE--FIGELTSTYKSLNDFMDSLF 554 
EOB15583      496 IMKIFN-----------GvnPFVAGFGNRITDVITYKSLNISPTRIFTINPEGELSGD--FTNSLSKTYKSMNDFIDKIF 562 
EED44513      517 IKQLFSp--------EYRddAIIAGFGNKLTDVIAYKTINIPTNRIYTINSYGQIQSE--YSKSLIGTYSTLNEFIDTIF 586 
XP_001730129  838 P 838 
XP_002677637  511 P 511 
XP_013059023  460 P 460 
EJW03258      623 P 623 
EPR77660      555 P 555 
XP_008073550  726 P 726 
Q8SWG3        564 P 564  Encephalitozoon cuniculi
EEQ81584      555 P 555 
EOB15583      563 P 563 
EED44513      587 P 587 
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