Conserved Protein Domain Family
SHR3_chaperone

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pfam08229: SHR3_chaperone 
ER membrane protein SH3
This family of proteins are membrane localized chaperones that are required for correct plasma membrane localization of amino acid permeases (AAPs). SH3 prevents AAPs proteins from aggregating and assists in their correct folding. In the absence of SH3, AAPs are retained in the ER.
Statistics
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PSSM-Id: 369769
View PSSM: pfam08229
Aligned: 52 rows
Threshold Bit Score: 168.886
Threshold Setting Gi: 557999377
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_016757972   5 GTAPFATFLIIGPTCFFLGVLFALFPYDYNVLWSTPPTIDpavnpreiYFQLQENHLK-FLHASPPLISRILHIVIGTGL 83  Sphaerulina mus...
XP_011110552   3 gaASFWTYLIVCPTSFILGILFTNWSYDFPLLWTSKRLTPe-------MIKAIEAHYV-MLYDSPPLIGRVLHAIILIAL 74  Dactylellina ha...
CAP69338       7 gsGSFATFLIIGR------ILFASFPYDFPLLWSPNPITPl-------HISQIETHLR-FMHAAPPLISRLLHMIIAVGF 72  Podospora anser...
Q7S1L1        20 GSGSFSTFIIIGPVCFFLGILFAQFPYDFPLLWTSEPVQAt-------YYDFLETHVK-FLHASPLIISRILNIVIFVGL 91  Neurospora crassa
XP_003005070   6 pSSPFGTFLIVGCVCFFLGILFASFPYDYPLLWTSAPVPEa-------YYAQLETHLR-FIYAAPPLIGRLLTSIILVGF 77  Verticillium al...
Q9Y876        14 GLKVAARYGVLMSTSFIFALLFHSSVADVNTLW-SPGPES--------AFDAAETYYT-LVAGSHFIVKYTVYTIMGLNM 83  Schizosaccharom...
EST08811       1 --mglRTGLIIGTTSFLLGTLAMHWTADHLILWQSPVTYD--------SVVTAYTYYQdTMVDMPLVFQRLLHGSGTLVA 70  Kalmanozyma bra...
XP_007326481   1 --mgarAGIVVCITSFLLGALFTHWIADSLTLWKSPVTDE--------HLWTAASYYS-IVTKGPREILYLLFALVILGG 69  Agaricus bispor...
EPB92454       5 ymqtakVALILCSCFFSYGTYWSDWAFDYYLLWANPSEYPe-------AITRATFYYA-NQGHIPNILKYVPIANLCIAA 76  Mucor circinell...
XP_007400657   1 --mgfrqAAVLSSVCFFLGVLFICMNVDYRVLF-TPLTED--------VVRDGLEFYT-TFFHSPPAIKALMHAIMGVGI 68  Phanerochaete c...
XP_016757972  84 LGFLIKLFKPTEANLLFDGASLVLYMCGITVYIANIVKGLRTVTAGAYGTkvldeaageslvdkalenregdyIGREDS- 162 Sphaerulina mus...
XP_011110552  75 AAFIAKLYKPSESNALFDGASLVLFMVAVIVYGSNTIKGMQIIKGGDYGEd----------------------IPQAQS- 131 Dactylellina ha...
CAP69338      73 LGFFTKLYRAAESNFLFDGGSLLLYLIAAGVYITNVVTPMNALAEQLEGEggekyavhn------gpltgeveLTREES- 145 Podospora anser...
Q7S1L1        92 LGFFMKLFRPAESNVLFDGASLILYVIGVGVYTSNIVKGMRTITAGIWDMedfagikhd------gpvsgeviLGREDT- 164 Neurospora crassa
XP_003005070  78 IGFFVKLFKASEANVLFDGASLVLYFIGVGVYLTNIVRGLRAVGEGIWDDpdweakang-----nagegdglvLGKEDS- 151 Verticillium al...
Q9Y876        84 IFHLIQATGAKGDDKLFFYSSTLLYLTALILFIVNVAPSMLVVKLQNYVQ-----------------------FPRNMH- 139 Schizosaccharom...
EST08811      71 LLIISKALGGRESNWLFDGASLFLFGAAGLVYYHKIVPSLATLPPKAPSPgs-------------------aaVDARDAv 131 Kalmanozyma bra...
XP_007326481  70 STILWSFGDGQAGNLMFDGGSIFLFGMTAVMYVYAVLPNLLTHFENLPPHglkd----------------pfpRTLRQS- 132 Agaricus bispor...
EPB92454      77 AGFVTGLLTMTDGNLLFDGASLVLMMFGITTYLSSVKPAITVVSESADVN------------------------EITTS- 131 Mucor circinell...
XP_007400657  69 IGLVGKLVRMDEGAKWFDGSSLAAYIFALSVYLSVGLPASRTIATPVEG------------------------VDTREDq 124 Phanerochaete c...
XP_016757972 163 ---LRVLAASDTILALVLVGVLVLQAGQ---WYAQRKEQEEMEM-MDAKRDEKIAAKAEKKAEGK 220 Sphaerulina musiva SO2202
XP_011110552 132 ---LQVVAASNTIMALVLIGVLLLQAGQ---WYAERKEKEELDAmSEGLNNADSPTVSKKELKEK 190 Dactylellina haptotyla CBS 200.50
CAP69338     146 ---LRVLSASHTILAFVLVGVLVLQAGQ---WYAEKREREDYAAwVARGEPVEVMDSDEEQEKEE 204 Podospora anserina S mat+
Q7S1L1       165 ---MKVLSASNTILAMVLVGVLVLQAGQ---WYAESKEKDDYAK-GDKKEKKNDGQQQQQQQQQP 222 Neurospora crassa
XP_003005070 152 ---LKVLSASNTILALVLVGVLVLQVGQ---AYAERKEREEIEA-LDKKDKEAAAAAAAGKGGAA 209 Verticillium alfalfae VaMs.102
Q9Y876       140 ---LSVLAASHVLVEFLLAGVILIQLGYvfgYHVQSIQQREYAEdMREQELAEKAKLESESATTQ 201 Schizosaccharomyces pombe 972h-
EST08811     132 fapLREIATSHTVLAVALVGVIILQSGQ---YYSERLEERER---IEEDEARIRRRQRRREQEEK 190 Kalmanozyma brasiliensis GHG001
XP_007326481 133 ---TLDLASNNLICSVALTGVLALQAGR---FWAETPDSDDEEFvLVEAPSAEEQQQQQQQRQQE 191 Agaricus bisporus var. burnett...
EPB92454     132 ---LKNIAAAHFIIVLAITGIIGLQITH---YFVMKRSNKDREDgGNQETDQEEDEEDEEEEQEQ 190 Mucor circinelloides f. circin...
XP_007400657 125 ieaLRLLSAGNTIVIALLGGVLFLQAGE---EYARRTEAKELAR-LAELDKKDRSATATSAAGEN 185 Phanerochaete carnosa HHB-1011...
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