Conserved Protein Domain Family
CTNNBL

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pfam08216: CTNNBL (This model is not part of the current CDD release)
Catenin-beta-like, Arm-motif containing nuclear
CTNNBL is a family of eukaryotic nuclear proteins of the catenin-beta-like 1 type that contain an armadillo motif. A human nuclear protein with this domain is thought to have a role in apoptosis. The interaction of CTNNBL1 with its known partners (the Prp19-CDC5L complex and AID) is mediated by recognition of NLS (nuclear localisation signal) motifs. The RNA-splicing factor Prp31 is also an interactor, with recognition also occurring through the NLS. CTNNBL1 uses its central armadillo (ARM) domain to bind NLS-containing partners.
Statistics
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PSSM-Id: 518127
Aligned: 82 rows
Threshold Bit Score: 308.329
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q5KD46       1300 EQILDIFDAAGEGEQG---PALDLPALRRQIGKFQRIVLKNAEQRGKYSDDPSKFIDSESDLDTSLKAFLPLTQNPPLfY 1376 Cryptococcus ...
Q9VHJ7         85 LNILKYVENEEADG-----DVLDEQSLKKLILVFEKRNLKNQEMRIKFADSPEKFMDSEVELHTVIQELKGVATVPDL-Y 158  fruit fly
XP_001847449   71 LDILKFVETEEVEGG----EVMDEAGLKKILLLFEKRVLKNQEMRIKFPDNPEKFMESEIELNDIIQELHAVATVPDL-Y 145 
XP_009028187   99 EKVAKILEDDSTES-----DILDEGTVRRLIIQFEKRYQKNQEMRIKYPDAPEKFMESEIELNDTIQEMHMIASMPET-Y 172 
Q8IHX9         12 VDVEEILKQAENI------ECVDENSIKKIGVLLKKKKTKNERDRMEYPEEPEKWVSSEVDLDEILVNLKNLSVCTNL-Y 84   Plasmodium fa...
Q7R9L8          9 IDIDEILKQAENV------ECVDEDSIKKLATVLKKKKNINERDRIEHPDKPEKWVASEVDLDEILVNIKNLSVCTNL-Y 81   Plasmodium yo...
A0CXT5         28 QQDMQFREQNV--------ELFDERQLREMIFQLENNYKLNSDQRMRYPNQPEKFIDSEVDLDEDLRKLLILPAYPQL-Y 98   Paramecium te...
Q22CU9         45 EQLEALINQQAQNQE----AAFDEEVLTKIINQLAVRKTKNEELRSQFANKPEKFQDSEIDLDEIIQKFNSLSAYPEL-L 119  Tetrahymena t...
XP_002998437   40 AKISAIVDGAEAQEG----DALDARALKSMANSLKKHVRRNALAREKHAYDPTKFLESELALDSELTRWKQVAAKPEL-F 114  Phytophthora ...
XP_002130495  110 mkLLEMWEEKVKAKDLndeEQYDDQKVKKLILSFEKKVYKNQEMRIKFPDNPEKFMESELDLNDVVMEMKILATMPEQ-Y 188  vase tunicate
Q5KD46       1377 PELVK-SGIIPIFANLLSHENTDIAMDVVEVIQELTDEDVGgevddlDHEEEtgsetrmaMGQLIDELLNNSLLDLLVSN 1455 Cryptococcus ...
Q9VHJ7        159 PILVD-LHGLHSLLELLAHQNTDIAVAVVDLLQEVTDVDILg-----ESQEG--------AESLIEALRKEQICALLVQN 224  fruit fly
XP_001847449  146 PLLVE-LNGVSSLLELLSHQNTDISVAVVHLLQELTDVDILh-----ESLEG--------AETLIEALRNQQAAGLLVQN 211 
XP_009028187  173 EIVIRgSTTIQTLLQLLNHENTDVSIAVVDLLKEMTDGDVMd-----DNEEE--------AEMLIDALLQGQILALLVQN 239 
Q8IHX9         85 KSMID-SDIFGEIIDLLNHPNNDIVIEVIDIIKEITNPSNIy----eLDKEL--------NDIMIHYLNKKKLCHFLINV 151  Plasmodium fa...
Q7R9L8         82 KSMIE-SDIFGDIINLLNHPNNDIVIEVIDIIKEITNPSNIy----eLNKSV--------NLMLIDYLNKNKLNHFIINT 148  Plasmodium yo...
A0CXT5         99 PIFYS-SNALPIVIQLLLHNNESISNDVIQFLKELVAPE--------SEVEPk------iIIQLYDCLIRNYLIESLGEL 163  Paramecium te...
Q22CU9        120 PKFTE-SSAVVNLLQLLYHENTDIVVDVINFFHEVITMELEk-----KFYDN--------LLKLYFKIVKNKFFESIVAN 185  Tetrahymena t...
XP_002998437  115 AVMIE-LQVPRVLLGLFAHENLDIRLAVLSLLGELTDVDDAa-----TSLEP--------ARLLTKHLMDEKLLPLLVSN 180  Phytophthora ...
XP_002130495  189 HYLVE-LRSVNSLLALINHANTDIAIAVIDLIQELTEVDSVt-----ENEEG--------ANLLADALMDGQAGSLIVQN 254  vase tunicate
Q5KD46       1456 LSRLDES---E--DTDS--QGVFHILGVFENLLsFMPPLADQIVEETALLQWLLQRIKk------KEYDSNKQYASEIIA 1522 Cryptococcus ...
Q9VHJ7        225 LERLNEQv-kE--EA----DGVHNTLAIVENLTeIDSEFVKEAAEQG-LLAWLLKRLRgk-----sPFDPNKLYCSEILS 291  fruit fly
XP_001847449  212 LEKLDEGv-kE--EA----DGVHNTMAIFENLMeIKSEIAKEIAEQG-LMQWILKRLRmk-----mPFDANKLYCSEIMS 278 
XP_009028187  240 LERLDETl-kE--EA----QGIHNSLAILENMVeLKPEVSLQAGQQG-FLQWIVNKLKmk-----aPFDDIRLYCSEILS 306 
Q8IHX9        152 LDKINEE------ENDEyyNAMTSILNILDNIFeLENDLQNDLLKNSKLLFFLLNRINneik----sddSNSLYASEIFV 221  Plasmodium fa...
Q7R9L8        149 LDKINEE------ESEEyyNAISSILNIFENIFeLENSLQNDLLTNSKLLFFLLKRINneik----sddQNSLYASEILV 218  Plasmodium yo...
A0CXT5        164 IVKNEEK------SQEEv-NLLHDCFEVIENMVdIKSSISKEIGLRSKIIQYLVKRVEdn----sQTLDDNRLYASELLV 232  Paramecium te...
Q22CU9        186 LQRLDEK------VQDEy-DAVHKLLGIIESLLeVNPEYSGQLCSETQFLKWVLKRISpefqlvtKVIDDNKLYLTEILP 258  Tetrahymena t...
XP_002998437  181 LYQLAAAvenTqaEEET--TGIYNSLQILENMAdLEPQVCVQAAETS-ILPFLLQQVSp-----gRKFSENKLYASEILS 252  Phytophthora ...
XP_002130495  255 LERLDESv-kE--EA----TGVHNSLGVVENLLeLKPEFGLNFAQQG-FVAWLLKRLKak-----iPFSGNKLYASEILS 321  vase tunicate
Q5KD46       1523 ILLQ---DSRANVLKLGq------------------LD-------GMDVMLQVLSQYLKTDPGDSEEVEFMENVFDSVCS 1574 Cryptococcus ...
Q9VHJ7        292 ILIQ---TENENRLLLGs------------------LD-------GVDVLLQQLAVYKRHDPASNEEQEYMQNLFNCLCS 343  fruit fly
XP_001847449  279 ILLQ---DTNENRILLGn------------------ID-------GIDVLLQQLAAYKRHDPTSTEEQEFMENLFNSLCS 330 
XP_009028187  307 ILLQ---MYQENRQILGe------------------VD-------GIDVLLSQLSIFKKHDPSTPEEIEYMENLFNSLCS 358 
Q8IHX9        222 LLILrinQFSQNV-----------------------YDdfyyiisIFNPILKYISKYKDKDPESINKKEILLNYFQALGN 278  Plasmodium fa...
Q7R9L8        219 LLILrinQFAQNV-----------------------YNdfyytisIFNFILKYISKYKDKDPPNINKKEILLNCFQALGN 275  Plasmodium yo...
A0CXT5        233 VLTQ---QTKENLEIIGr------------------SG-------GIESLLMVLNQYRKKDPETAEEKEILNNVYDLLTL 284  Paramecium te...
Q22CU9        259 IIL----SDEENQIRFQk------------------LK-------GIESLLQYLQSYEKKDPTCEEEKETFLNVVDCLCL 309  Tetrahymena t...
XP_002998437  253 ILLQ---SGAEPREEFVawtgkdrpsedkttekqgkVD-------LMDDLLQALAPYRKKDPDSEEEEELVGNLVNALCS 322  Phytophthora ...
XP_002130495  322 ILLQ---SHDEIRKLVGe------------------LE-------GIDILLQQLAAFKRHDPKGAEEVEFMENLFNCLCS 373  vase tunicate
Q5KD46       1575 SLAQPEMKKAFFDAEGVELMVLMMKE-KRLAKTRAIKVLDYALQtESGSPACERFVQALGLKTFFSAFMssasskaggkk 1653 Cryptococcus ...
Q9VHJ7        344 ALMARENRDRFLSGEGLQLMNLMLRE-KKMSRNGSLKVLDHAMAgQDGRDNCNKFVEILGLRTIFPLFMk---------- 412  fruit fly
XP_001847449  331 ALMAAENREKFLKGEGLQLMNLMLRE-KKLSRNGSLKVLDHAVSgPDGRDNCNKFVDILGLRTIFPLFMk---------- 399 
XP_009028187  359 SLMLPTNRTRFLKGEGLQLMNLLLREkKKLCRTSAIKVLNHSMVgSEGVDNCNKFIDILGLRTIFPLFMk---------- 428 
Q8IHX9        279 LLLLNKNKNVFQNTIGFELMLKLLSE-RKFLCFPSLKIFAILLN---DIETCNKFIEMNGLKYLFCLFMl---------- 344  Plasmodium fa...
Q7R9L8        276 LLLLNENKKIFESANGLELMLKLLSE-RKFLCFPSLKIFAIVLT---NKDVCNKFVELSGLKYLFCLFMl---------- 341  Plasmodium yo...
A0CXT5        285 LLIQEENQEYFQSYEGLQLMIKIIQG-KTSQSIRAYSLMLLAIN--NHKENCQKLISIGGLSIIFPILEr---------- 351  Paramecium te...
Q22CU9        310 FLVQRNYQEVFRNSDGIQLMIKLITA-KNYSSKSALRILSYALV--NNEQNCLKFVDLQGLKFAFPILM----------- 375  Tetrahymena t...
XP_002998437  323 VLLVPEAQTQFRRLEGLELLLRFMKDrKRFVFSGALRAMDHALM--ASARNCERLIEIGGLRSVFSVFMgrhg----kyk 396  Phytophthora ...
XP_002130495  374 SLLLVDNRSKFLHGEGLQLMNLMLRE-KKMSRNSALKVLDHAMSgPDGASNSAKFVDILGLRTLFPIFMk---------- 442  vase tunicate
Q5KD46       1654 sKSKlgaaaATSAIEDeEHMLGILASLFTNLASDS--PERIRVIAKFVEGGYEKVERLLEVREAAEGRLGSVIKEIEYER 1731 Cryptococcus ...
Q9VHJ7        413 -TPKrnkqrLISADEHeEHVTSVIASMLRNCKGTH----RQRMLAKFTENDHEKVDRLLELHLKYLAKVEAIDKEIDQQA 487  fruit fly
XP_001847449  400 -TPKrnkkrLLSTDEHeEHVVSVVASMLRNCKGPQ----RQRLLAKFTENDFEKVERLMELHFKYLEKVEEVDREVDQQI 474 
XP_009028187  429 -PPHvhkkaGPNKQELeEHIVSIVASLVQNSEGSQ----RQRLLNKFTENDHEKVDRLMELHFKYLQRAEAVEADIEKQR 503 
Q8IHX9        345 --RDikkqnHMSVFEFeENIIIIISNLSLFCTGTF----QGRVLSKFGEKKCEKIIRLLEIRQKYHEIIIKDKKKKQKNK 418  Plasmodium fa...
Q7R9L8        342 ---RtlnksKTNTLEFeENIITIISNLCIYCTGTS----LGRVLNKFGEKKCEKIIRLLEIRQKYSDIIIN-EKKKEKDK 413  Plasmodium yo...
A0CXT5        352 --KGlkhkdKNKQFEIdETSVQIIKQLLRRNTDAA---FKQRVFDKCVE----KLESLKKLRMEYVEVIPLIDPEEYDN- 421  Paramecium te...
Q22CU9        376 -KKGikakkPEDAQKIeEQITSIIKNIIKETTAIQ----QDRVINKFRE-DIIKVDRLFELHEQYQKVMKLIEYKMQDPA 449  Tetrahymena t...
XP_002998437  397 sSGStkasqASEKAKEeENAASLVASMCAWVSEKApaDGYSRLHAKFVENDMEKVDRLVDLFAKYQERVERSQNEE---- 472  Phytophthora ...
XP_002130495  443 -PPKknkkvGSSRKDHeEHVISIISSMLQNLSGSH----RQRLIAKFTENDFAKVDRLMELHFKYYERVQRVDNRLDAER 517  vase tunicate
Q5KD46       1732 EVMQAneEe-----ITDveETEWYLRKMDAGLASLQNADYVLAWVCM--------------EDDGAMTHARLLLSRKNMN 1792 Cryptococcus ...
Q9VHJ7        488 KDPTI---------DEDeeAENNYIKRLTGGLFTLQRIDYILLEVSA--------------TGDTVKQRVLQILNLRGAS 544  fruit fly
XP_001847449  475 NAG-----------EEEedEDAIYIKRLSGGLFTLQLIDYIILEISS---------------TDVVKQRILQILSLRNAS 528 
XP_009028187  504 EAIQSqgRs-----LTAddEDEFYMNKLEAGLFTLQLVDYIIVEACLl-------------CPDTVRGRVMQILNLRGGT 565 
Q8IHX9        419 NQVNEnlKkmniqiDEDskKDLEYIELCDKGYLIYQLTDVILIALFYm-------------NNTYICNNIFIHLYTRNID 485  Plasmodium fa...
Q7R9L8        414 LLINKnlQklniqiDDDckKNLEYIELCDKGYLTYQLTDVILISLFFm-------------NNSYISNNIFIHLYTRNID 480  Plasmodium yo...
A0CXT5        422 --------------FEEkqLEKIYFDLLGKGLIVIESIDVILLELIYkdld-------vqiDQQEIISSVKQMLKYTGEK 480  Paramecium te...
Q22CU9        450 YLKTLeeF------EAQnvEETIYRQKLDEGLSILENVDFIIAFLNQckdelvsakvkkniKVHQLRDEILGVLVQNKQH 523  Tetrahymena t...
XP_002998437  473 --------------EEEedDDSRYLRRLDAGLFVLERTAFVVAHLCQ--------------FSKKVRAYVMVKFHERSID 524  Phytophthora ...
XP_002130495  518 TRLLVegE------DEEeiEEDFYLRRLDAGLFTLQQTDYVLVDICAs-------------GSSSIKQRVLQILNLRSGS 578  vase tunicate
Q5KD46       1793 FK-TIAA---VLT 1801 Cryptococcus neoformans
Q9VHJ7        545 MK-TIRS---IMR 553  fruit fly
XP_001847449  529 MK-TIRH---VMR 537 
XP_009028187  566 VQ-TIKN---IMK 574 
Q8IHX9        486 IQ-SIYE---NIL 494  Plasmodium falciparum 3D7
Q7R9L8        481 IQ-SIYE---NIL 489  Plasmodium yoelii yoelii
A0CXT5        481 E--DIDYynpLLQ 491  Paramecium tetraurelia
Q22CU9        524 FDpSAKNkkrKMF 536  Tetrahymena thermophila SB210
XP_002998437  525 SE-SLVA---VLR 533  Phytophthora infestans T30-4
XP_002130495  579 VK-SIRT---IIR 587  vase tunicate
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