4MFV


Conserved Protein Domain Family
CTNNBL

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pfam08216: CTNNBL 
Catenin-beta-like, Arm-motif containing nuclear
CTNNBL is a family of eukaryotic nuclear proteins of the catenin-beta-like 1 type that contain an armadillo motif. A human nuclear protein with this domain is thought to have a role in apoptosis. The interaction of CTNNBL1 with its known partners (the Prp19-CDC5L complex and AID) is mediated by recognition of NLS (nuclear localization signal) motifs. The RNA-splicing factor Prp31 is also an interactor, with recognition also occurring through the NLS. CTNNBL1 uses its central armadillo (ARM) domain to bind NLS-containing partners.
Statistics
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PSSM-Id: 400498
View PSSM: pfam08216
Aligned: 96 rows
Threshold Bit Score: 87.5678
Threshold Setting Gi: 927381079
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4MFV_A        28 KRLLQIIDRDGEEEE---EEeePLDESSVKKMILTFEKRSYKNQELRIKFPDNPEKFMESELDLNDIIQEMHVVATMPDL 104
A0CXT5        28 QQDMQFREQN--------VE--LFDERQLREMIFQLENNYKLNSDQRMRYPNQPEKFIDSEVDLDEDLRKLLILPAYPQL 97  Paramecium tetr...
Q22CU9        45 EQLEALINQQAQNQ----EA--AFDEEVLTKIINQLAVRKTKNEELRSQFANKPEKFQDSEIDLDEIIQKFNSLSAYPEL 118 Tetrahymena the...
Q7R9L8         9 IDIDEILKQAEN------VE--CVDEDSIKKLATVLKKKKNINERDRIEHPDKPEKWVASEVDLDEILVNIKNLSVCTNL 80  Plasmodium yoel...
Q8IHX9        12 VDVEEILKQAEN------IE--CVDENSIKKIGVLLKKKKTKNERDRMEYPEEPEKWVSSEVDLDEILVNLKNLSVCTNL 83  Plasmodium falc...
XP_002265451  38 LSLLEAVEKSQTT-----VE--VLDLKTLKKLVLAFERRLRDNIEARLKYPDQPDKFADSEIELHDEIQRLKTLAGGPEL 110 wine grape
XP_006384127  36 LSLLDAIEKSQSLSKsqpIE--TLDPKTLKKLILSFERKYKENIESRLKYPDQPEKFADSEIDLHNELHKLKILSSAPEL 113 black cottonwood
XP_003553114  32 LSLLEAIEKSQNA-----VE--ALDLRALKKHVLSFERRLKDNIEARLKYPNQPDRFADSEVELHEELQKLKVLAGAPEL 104 soybean
ABO09895      32 LSLLEALEKSSHNG----VE--ALDLKTLKKLVLSFERRLRDNIAARLKYVENPEKFADSEVDLHDDLQKLKVLAGAPEL 105 thale cress
EEY69790      40 AKISAIVDGAEAQE----GD--ALDARALKSMANSLKKHVRRNALAREKHAYDPTKFLESELALDSELTRWKQVAAKPEL 113 Phytophthora in...
4MFV_A       105 YHLLVELNAVQSLLGLLGHDNTDVSIAVV 133
A0CXT5        98 YPIFYSSNALPIVIQLLLHNNESISNDVI 126 Paramecium tetraurelia
Q22CU9       119 LPKFTESSAVVNLLQLLYHENTDIVVDVI 147 Tetrahymena thermophila SB210
Q7R9L8        81 YKSMIESDIFGDIINLLNHPNNDIVIEVI 109 Plasmodium yoelii yoelii
Q8IHX9        84 YKSMIDSDIFGEIIDLLNHPNNDIVIEVI 112 Plasmodium falciparum 3D7
XP_002265451 111 YPDLVNLNVIPSILGLLSHDNSDIAVDVV 139 wine grape
XP_006384127 114 YPDLINLNTIPSVLSLLSHENTDIAIDVI 142 black cottonwood
XP_003553114 105 YPDLVNLNVVPSIVDLLNHDNTDIAIDVV 133 soybean
ABO09895     106 YPDLVASNTVPSIVNLLSHENSDIANDVV 134 thale cress
EEY69790     114 FAVMIELQVPRVLLGLFAHENLDIRLAVL 142 Phytophthora infestans T30-4
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