3QM0


Conserved Protein Domain Family
HAT_KAT11

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pfam08214: HAT_KAT11 
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Histone acetylation protein
Histone acetylation is required in many cellular processes including transcription, DNA repair, and chromatin assembly. This family contains the fungal KAT11 protein (previously known as RTT109) which is required for H3K56 acetylation. Loss of KAT11 results in the loss of H3K56 acetylation, both on bulk histone and on chromatin. KAT11 and H3K56 acetylation appear to correlate with actively transcribed genes and associate with the elongating form of Pol II in yeast. This family also incorporates the p300/CBP histone acetyltransferase domain which has different catalytic properties and cofactor regulation to KAT11.
Statistics
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PSSM-Id: 400497
View PSSM: pfam08214
Aligned: 25 rows
Threshold Bit Score: 305.477
Threshold Setting Gi: 74626348
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3QM0_A         5 LNDFLSSVLPVSEQFEYLSLQSIPLE-THAVVTPnKDDKr---VPKsTIKTQHFFSLFHQG-------KVFFSLEVYVYV 73  baker's yeast
XP_001383510   4 LLSRIADVIPVSVNVQLFHIQSKPVSvRSPVHFSsRDPH----KPQ-TFKIRHFLQLLSNAd------LVVLGIEVFVYV 72  Scheffersomyces...
Q6BUC7        15 LLESLSYNLPKG-NYKLFHIQSQPFQcKHLLIYHkKNAQ----RPAlTIKIKHFISLIDDDn------LVIMGIEVYIYL 83  Debaryomyces ha...
Q2U3X2        29 LGDLLAKVLPTGVKVTIRHISSAPTPcTALFTPPpGE------ESEsTFCENHFLTVSVNAdehdgpeIIVFGIEVLVYS 102 Aspergillus oryzae
XP_001274100   8 LGDLLARVLPTGVKVTIRHVSSAPNPcVALFAAPpGE------EPEsTFCENHFLSVSIISdddddseVIVFGIEVHVYG 81  Aspergillus cla...
EAW17837       8 LGDSLAKVLPTGVKVTIRHISSAPSPcAALFAAPpGE------EPEsTFCENHFLAVSISPdeneepeVIVFGIEVLVYG 81  Aspergillus fis...
Q6FVT3         2 LQAILKEVLPQDSSFEILHLQSPPSE-SAPLVN---NTSkqnrAT--TIKTEHLFCLAYKG-------RIFYGLELYVYI 68  [Candida] glabrata
EDO17576       3 INSYLKDALPENENFELLHILSVPKE-THPIVTQnISTRr--dSKNvTIKTQHFFSLFYHS-------KVIFGLEVYVYI 72  Vanderwaltozyma...
EDK47598       3 LTQQLSFVLPHNESFKLIYVQSKPVSvKAPILFR-KNAQplllKPQdTLKIRHFFILVQND-------LIILGVEIYTYI 74  Lodderomyces el...
Q6CK78         3 LECYIKDALPFGHEFEIINLQSIPRE-TSPITFPkREAEdvngKTVkTIKTQHFVALCFEE-------KVVFALEIVVYF 74  Kluyveromyces l...
3QM0_A        74 TLW----DEa---DAERLIFVSKADTNGYCNT-R-----VSVRDITKIILEFILSIDPNYYLQKVkpairst-------- 132 baker's yeast
XP_001383510  73 QVF----KE----KVERFIFISKCDTVGSTQL-D-----FRVGDVIKQFLTWLIDFNLYDYKIKQsskgeneedeerkpn 138 Scheffersomyces...
Q6BUC7        84 TVF----DN----HLKHSIFISKADTTGLSTQ-K-----YKINKLIDDILQYLIQYDIRNYCRKIklrssemvnrsgsnp 149 Debaryomyces ha...
Q2U3X2       103 T------------AHLTTVFVSKADSTGFLHLlknapkvSLIRRISNGFLSFLVQTHQRPGVRLV--------------- 155 Aspergillus oryzae
XP_001274100  82 T------------AHLTTIFVSKADSTGYLHLlknapkvSLLRLISNAFLSFLVQTRQRPGVRLM--------------- 134 Aspergillus cla...
EAW17837      82 T------------AHLTTIFVSKADSTGYLHLlknapkvSLLRLISNAFLSFLVQTRQRPGVRLM--------------- 134 Aspergillus fis...
Q6FVT3        69 TCN----HDneveKTERLVFVSKADTNGYCDI-R-----VNIKLVTLQLIRYVLSINPDYYLHRVipkerdykksgrtnl 138 [Candida] glabrata
EDO17576      73 TLYnstiDShpklDAERLIFISKADTSGYSDI-R-----VNVKDITNSILSYLLSIDPNFYLKNVkpiqrkrdiytkqli 146 Vanderwaltozyma...
EDK47598      75 QVF----DD----HIDQYIFVSKCDTTGLQKLsS-----FKVADVVEVVIKYIINYNILLYKIKLkhkkktkstikeske 141 Lodderomyces el...
Q6CK78        75 SLN----SAnn-gPVERLLFVSKADTNGYCDL-R-----LDIGQITKSIIAYILAISPGHYLRAVkplirkalsgakiik 143 Kluyveromyces l...
3QM0_A       133 ----------------------------------------------------------cpreiltKICLFTRPASQYLFP 154 baker's yeast
XP_001383510 139 tlssiveklndpny----------------------ynsisyynkdptkharstpllqlpevetvKLVLFTRAANQYLYP 196 Scheffersomyces...
Q6BUC7       150 tinslnriidklregts-----------------yyksipyynevvipstsdsletivppgriqtSISLFTRASEQYLFP 212 Debaryomyces ha...
Q2U3X2       156 ------------------------------------------------------------------VSLFARAQNQYLFP 169 Aspergillus oryzae
XP_001274100 135 ------------------------------------------------------------------VSLFARAQNQYLFP 148 Aspergillus cla...
EAW17837     135 ------------------------------------------------------------------VSLFARAQNQYLFP 148 Aspergillus fis...
Q6FVT3       139 itkatnsrkalkila---------------------drlqnhnliepeifnafytkfhsgkelvtKIALFTRPADQYLFP 197 [Candida] glabrata
EDO17576     147 lgststrkglkilsn---------------------rrrkgfrldnekinknlfshftcnqniitKITLFTRPSEQYLFS 205 Vanderwaltozyma...
EDK47598     142 vngtlalikklqkriavgrtkipyhhheeekeeeadadaddalislgkstvkasnlfalplrhnlRLCLFTKTAPQYLFP 221 Lodderomyces el...
Q6CK78       144 rstsvqraleilsnr--------------------pldskgitsrvkipdqdlyvsfpvpteivtKVSLFTRAEPQYLFS 203 Kluyveromyces l...
3QM0_A       155 DSSKNSKKHILNGEELMKWWGFILDRLLiec-------------------fqNDt-QAKLRIPGEDPARVRSYLRGMKYp 214 baker's yeast
XP_001383510 197 NSHKNAHKHCLSGVQLLKWWIKTIDSIVs-----------------------NKw-ECKVAIPGHPVHFNAKFIESTKNp 252 Scheffersomyces...
Q6BUC7       213 NSSKNERKHVIGGDDLLNWWIKLINRTLlnq------------------akeSSw-NCRLHIPGSDNVSISKKLPAPNNn 273 Debaryomyces ha...
Q2U3X2       170 GSIENSGKHVLDDRGLIKWWCRVVDPILreyepesgshekglldramesaksSA--TAFLIVPGCDKFETRGFFPGTAKs 247 Aspergillus oryzae
XP_001274100 149 GSIENPEKHVLDDRGLIKWWCRVVDPILreyepetgskekglldqtkesaksSA--TAFLIVPGCDKFETRGFFPNTAKs 226 Aspergillus cla...
EAW17837     149 GSIENPEKHVLDDRGLIKWWCRVIDPILreyepetgshekalhdqtkesaksSA--TAFLIVPGCDKFETRGFFPITARs 226 Aspergillus fis...
Q6FVT3       198 NSSKNPNKHNLDGDGLLKWWASLLDNLLvsd------------------fnlNKt-KAKIRIPGEDKYRFRRYTNALKCg 258 [Candida] glabrata
EDO17576     206 KSSESGNKHILAGSTLLKWWISLIDKNIlhn------------------fkqDT--KAAMQIPGESSLEIKRYFKSLLYp 265 Vanderwaltozyma...
EDK47598     222 NSSKNPSKHNITGQTLLKWWIPIINRAT------------------------LSwlQHKLLIPGSDTIATAKFIENYPN- 276 Lodderomyces el...
Q6CK78       204 NSSKNPRKHVLSGDKLLKWWLKIVDQIVved-------------------fdNKt-KATLQIPGEEKRVISNYLRNTAYq 263 Kluyveromyces l...
3QM0_A       215 ------lWQVGDIFTSKEN-----------------------------------Sl-------AVYNIPLFPDDPXARFI 246 baker's yeast
XP_001383510 253 -------WYLGHIFSPADA-----------------------------------K--------AVYTIPLFPDDPKGRFL 282 Scheffersomyces...
Q6BUC7       274 v-----aWSIGSIFDKDAE-----------------------------------Kl-------AINQIPLFPDDPKGRFL 306 Debaryomyces ha...
Q2U3X2       248 ddkerprWLNSYPLHQLCD-----------------------------------Ntn----apPRCLVPRFPDDPKTRFL 288 Aspergillus oryzae
XP_001274100 227 ddkerprWLNSYPLHQICD-----------------------------------Npn----apPRCLVPRFPDDPKTRFL 267 Aspergillus cla...
EAW17837     227 ddkdrprWLNSYPLHQLCD-----------------------------------Npn----apPRCLVPRFPDDPKTRFL 267 Aspergillus fis...
Q6FVT3       259 ------iWTHGDIFSDNDS-----------------------------------Ds-------VIKCIPMFPDDPKSRFM 290 [Candida] glabrata
EDO17576     266 ------nWQVGDIFGGTDT-----------------------------------Sl-------AVYKIPLFPDDPKSRFI 297 Vanderwaltozyma...
EDK47598     277 -------WRQGHIFGETSDrketersdrdmeaseddndneinnsnqnkdkigklDkgmaceplAVYNIPLFPDDPKGRFL 349 Lodderomyces el...
Q6CK78       264 ------nWTVGDIFSESPQ-----------------------------------Di-------ALYRIPLFPDDPKGRFL 295 Kluyveromyces l...
3QM0_A       247 HQLAEE--------------DRLLKV-SLSSFWIELQERQEFKLSVTSSVMGISGYSLatp----slfPSSADviVP--- 304 baker's yeast
XP_001383510 283 EHLIVE--------------NRYRDV-NVEQFYEELGYRQEFLLGELVGLIGCELDNVkl-------vQKEAA--TPens 338 Scheffersomyces...
Q6BUC7       307 EHLIVE--------------NRYKST-SLKQFWQELGFRQEFRLGNVVGIIGCEREER----------GINTVetTQdv- 360 Debaryomyces ha...
Q2U3X2       289 LNLDDElpqkleaagskegaGQWRSVkSLDQFWEMMSFRQECSAGRLVGFLWLv--------------------iNPpg- 347 Aspergillus oryzae
XP_001274100 268 IDLDDElpdsaglegskqdpGQWRSVkSLAQFWEMMSFRQECSAGRLVGFLWLv--------------------iNPpg- 326 Aspergillus cla...
EAW17837     268 IDLDDElpestgaagskensGHWRSVkSLAQFWEMMSFRQECSAGRLVGFLWLv--------------------iNPpg- 326 Aspergillus fis...
Q6FVT3       291 KQLFEE--------------NRIQTT-SLDTFWTELQERQEFKLSVVVSVMGISGIYEidt-----nyKPSTDvyRC--- 347 [Candida] glabrata
EDO17576     298 RQLVEE--------------GRILSV-KLSTFWTELQERQEFRLSETVSVIGIEGYLSklp----iyiPGTDDiiIS--- 355 Vanderwaltozyma...
EDK47598     350 EHLIVE--------------NRLQKM-TTARFYKELGYRQEFRLGDCVGLIGCSVDDYryvsnetrpdVGNDYirKTdle 414 Lodderomyces el...
Q6CK78       296 DHLISD--------------GRISKV-NVLTFWTELQARQEFRLGSTVSVIGVSGKYIgrc-----nePERTDiiIP--- 352 Kluyveromyces l...
3QM0_A       305 ------KSRKQFRAIKKYITGEEYDTEEGAIEAFTNIRDFLLLRMATN---LQSLTGKREHRERNQPVPA 365 baker's yeast
XP_001383510 339 ---dtfVSISQYKQVINLIKGEDYSIASDVQSLVRTKLPELIRRQNMKgvdYHKIVGKSSTTAVRAKRPP 405 Scheffersomyces stipitis ...
Q6BUC7       361 ----cvLPLGQYKKILNSIKNADFSDANDIKALISVNIPD-----SMKefcVTNYYTSFEGLNSTTPRTA 421 Debaryomyces hansenii
Q2U3X2       348 ----lvNS---VQMTSSR-------PVFKEKAEGSLTTTVPVY--DKVd----SKPTGTAVSVSTDSQSS 397 Aspergillus oryzae
XP_001274100 327 ----lvNS---VQMASSR-------IVSRDAAKITSETTEPAT--SSEk----HLAGQDGQEDKEALGKE 376 Aspergillus clavatus NRRL 1
EAW17837     327 ----lvNS---VQMTSSR-------VASRDVENVVSESAK-------------TTHDATKQKDEVASVSA 369 Aspergillus fischeri NRRL...
Q6FVT3       348 ------RSKRQFHCIKNYITGEEYDTEEGALESYQNVNDYL-SREGTS---LLTVTGNADYSKFKQNRTT 407 [Candida] glabrata
EDO17576     356 ------GSKNKFNRIKSYITGEEYDTEEGATESYYNVKTYLKERIGTN---LILISGSKKNSLSTRTEQS 416 Vanderwaltozyma polyspora...
EDK47598     415 ifkplvVSVKLYKSFIDLMKLVSYDSIESVQHLVQNYIPEYFLSCGLKhfqYDSIIGLRKVETKSTVDSE 484 Lodderomyces elongisporus...
Q6CK78       353 ------TSKKNFKNLKNYITGEEYDTEEGAEEAYMNIRDIFDMHYSTK---MIKVIGN-HHKIATTKRPE 412 Kluyveromyces lactis
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