7A5F


Conserved Protein Domain Family
COX24_C

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pfam08213: COX24_C (This model is not part of the current CDD release)
Mitochondrial mRNA-processing protein COX24, C-terminal
This domain of unknown function is found at the C terminal end of Mitochondrial small ribosomal subunit protein mS38, also known as Mitochondrial mRNA-processing protein COX24 in yeast which is involved in the splicing of the COX1 mRNA. COX24 is a component of the mitochondrial ribosome (mitoribosome), responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane. This domain is also found in COX24 mammalian homologue Aurora kinase A-interacting protein. This entry also includes uncharacterised proteins from bacteria.
Statistics
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PSSM-Id: 518125
Aligned: 41 rows
Threshold Bit Score: 27.6266
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7A5F_d6      127 CKNVLKIRRRKMNHHKYRKLVKKTRFLRRK 156 human
CCA73112     311 MDSVKRKKKKKMNKHIYKKRRKRERAQRRR 340
XP_001729436 306 LDSVRRKRRKKMNKHKYKKLRKRQRAERQR 335
KDE07499     482 LDSTRRKRKKKITKHKYKKRRKAQRALRQR 511
XP_007375496  48 ADSVKRKRKLKMKKHKLRKRRRLQRSLKKR 77 
XP_003329132 245 FDSVFRKKKRKMKVHKYKKRRKARRTLKKR 274
Q9P7H5       143 LTSVKRKRKLKMNKHKFKKRLRRQRALRKR 172 Schizosaccharomyces pombe 972h-
XP_009267846 127 LDSVKRKRKKKMNKHKYRKRRKAHRAERKR 156
XP_007326459 256 MDSVKRKRKKKMKKHKLKKRRRLTRSQRLK 285
ESK94593     232 MESTKRKRRKKMKKHKLKKRRRLTRQQRHN 261
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