Conserved Protein Domain Family
RNA_polI_A34

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pfam08208: RNA_polI_A34 
DNA-directed RNA polymerase I subunit RPA34.5
This is a family of proteins conserved from yeasts to human. Subunit A34.5 of RNA polymerase I is a non-essential subunit which is thought to help Pol I overcome topological constraints imposed on ribosomal DNA during the process of transcription.
Statistics
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PSSM-Id: 489455
Aligned: 71 rows
Threshold Bit Score: 36.1989
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007326994  71 DEDVEVWVIRVPESIKPKHLEGLSFDLDEptsspsrrKKRTTALigslKRKH-NSYDIWSLGDdhdedqgekTTEptslI 149
4_pfamImport   1 GPDVEVWLIQAPADFAPASLNGRPVPLSGs-------GTVKGKL----AGKR-QRYRVLSSRG---------PR-----A 54 
NP_001102886  37 GPDTEVWLIRAPADFAPQCLNGRRVPLSGs-------KTVKGKL----DGKK-HRYRVVTSGP----------------Q 88 
Q76KJ5        37 GPDTELWLIQAPADFAPQCLNGRRVPLSGs-------KTVKGKL----DGKK-HRYRVFTSSP----------------Q 88  house mouse
7_pfamImport   1 GPDTELWLIQAPADFTPDCLNGRLVPLSGs-------QVVKGKL----AGKR-HRYRVLSSNG-----------S----Q 53 
Q0VD10        37 GPDTELWLIQAPVDFAPDCLNGRLVPLSGs-------QIVKGKL----AGKR-HRYRVLSSSG---------PR-----A 90  cattle
3_pfamImport   1 DPDTELWLIQAPVDFAPDCLNGRLVPLSGf-------RIVKGKL----AGKR-HRYRVLRSSG----------P-----Q 53 
XP_004767649  37 DPDTELWLIQAPVDFAPDCLNGRLVPLWGs-------QIVKGKL----AGKR-HRYRVLRSSG----------P-----Q 89 
ELK12752      35 SPDTELWLIQAPVDFPPDCLNGRLVPLCGs-------QIVKGKL----AGKR-HRYRVLSSSG----------P-----Q 87 
1_pfamImport   1 DGGSELWLIKSPASFNPDSFNGSKIPVVGm-------KTRTSQ-----NGSGqQVYNILSTPG----------G-----P 53 
XP_007326994 150 GGDELkslscLLPRNTKNGKLYAapKPIARHILVSAQPAQPTTTstdsdsptemVYTNPPRENyPPElLTHRFMPYGSLV 229
4_pfamImport  55 GGATL-----LAPSAEAGGGLTCa-PAPLGSLRILEGPQGWRPGap------lqPIPASPPPQvPPG-LRPRFCAFGGSP 121
NP_001102886  89 AGEAT-----LLMSSMEAGGRLAcaPAPNGSLRIMEGPQEYLISrvp-----lqPIPTSLPPQiPAG-LRPRFSAFGGSP 157
Q76KJ5        89 AREAT-----LLASSSEAGGRLTcaPAPSGSLRIMEGPQEYLLSrvp-----lqLIPTSLPPQiPAG-LRPRFSAFGGSP 157 house mouse
7_pfamImport  54 AGEAT-----LLAPSAEVGGGLTcaPSPQGSLRIFEGPQESLTGtl------lqPIPASPPPQiPPG-LRPRFCAFGGSs 121
Q0VD10        91 GGEAT-----LLAPSAEAGGGLTcaLAPQGSLRIFESPQESLTGtl------lqSIPASPPPQiPPG-LRPRFCAFGGSP 158 cattle
3_pfamImport  54 AGEAI-----LLAPSGEVGGGLTcaPAPQGSLRIFDGPQESPSGtl------lqPIPASPPPQiPPG-LRPRFCAFGGSL 121
XP_004767649  90 AGEAI-----LLAPSREAGGVLTcaPAPQGSLRIFDGPQESPPGtl------lqAIPASPPPQiPPG-LRPRFCAFGGSL 157
ELK12752      88 AGEAT-----LLAPSVEAGGGLTcaPAPQGSLRILEGPHESPSGtl------lqTIPASPPPQiPPG-LRPRFCAFGGSP 155
1_pfamImport  54 GGMRL-----LTTGRETD--RVLcaPAFEGYINICESFGDLNSSqe------pkAIPANPAPRiPEG-LKQRFQPFGGAA 119
XP_007326994 230 kts----------tdsDNDEDEndtavtSRMDNEVVMTevdsnvqsDVAKKEERAIKSSSSKKKDkkvee-eediEVEEE 298
4_pfamImport 122 pvpgp-------gaalALESPT------SERRKKRRQK--------PAAPGTQEAVNGLGALEGD-----------TASG 169
NP_001102886 158 pvtgp-------gsasVLRSPT------SGKRKKKRKD--------AEASDTQEAVNRHEAMKVEtaw----gdlGMDVK 212
Q76KJ5       158 pvtgp-------gsasALRSPT------SGKRKSTRKGt-------DASSDTQEAVNRHGAMEVKtal----gnlGVSVK 213 house mouse
7_pfamImport 122 pv-----------tglGSVLAS-------GKRKKKRHI--------PEASFPQEALPEHGALEVDtal----gspEMDVG 171
Q0VD10       159 pvtgp-------gsvlALKSLA------SGKRKKKRHL--------PEASVPQEAVNEHGALEVDtal----gslELDVG 213 cattle
3_pfamImport 122 pvtgp-------gsvlALKSPA------SRKRKKKRHI--------PEASVPQEVVNGLGALEVDtal-----gsPDVDV 175
XP_004767649 158 pvtgs-------gsvlALKSAA------SRKRKKKRHT--------PETLVPQEAVNGLGALEVDtvl----gspDGDVG 212
ELK12752     156 pvtgp-------gsvlALGSPT------SGKRKKKKHK--------PEASFPQEAMNGHGTLEVDtgl----gspKMDAG 210
1_pfamImport 120 psradrepcaspplarRIKLEP------PEAEEGDRRR--------KKKKKRDKHQEREETEQEHlqaegleqdeSEGAE 185
XP_007326994 299 RQKEKKEKKKSGRK------------------RKGEEG---VSPKKSKKS 327
4_pfamImport 170 RPETDARGPEAAEPaa---------------aVSEALEpplPSSSKRKKR 204
NP_001102886 213 KKRKRHHVDEEAEAkgme-----------plaELAELPvpsATGSKKRKK 251
Q76KJ5       214 KRKRYFMQEEMEAKtm---------------ePVAELPvpsATSSKKRKK 248 house mouse
7_pfamImport 172 KKKKKQQLHELERRdsla----------tepaAEMSEPlgmLFPSTTKKR 211
Q0VD10       214 KKEKKHQLKELEATeplat--------epvaeMLEPPGtlsPSTTRKRKK 255 cattle
3_pfamImport 176 GKKKKQEPQELEVMgpgaa--------epmaeTSEPPGallPSTTTKKKK 217
XP_004767649 213 KKKKKQELREPVVMeplaa--------eptaeTSEPPGapfPSTTTKKKK 254
ELK12752     211 RKRKKQQLKEPEVMelvaa--------eptaeMLEPLGvlsPSTSKKKKK 252
1_pfamImport 186 RRKKKKKKKGKEREevdikeepvevkteplhlGYADEEdvgKKKKKKKKR 235
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