7WTS


Conserved Protein Domain Family
RRP12_HEAT

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pfam08161: RRP12_HEAT (This model is not part of the current CDD release)
Ribosomal RNA-processing protein 12, HEAT repeats
Ribosomal RNA-processing protein 12 (RRP12) is a member of pre-ribosome-associated HEAT repeats-containing proteins. RRP12 is required for nuclear export of both pre-40S and pre-60S ribosomal subunits, and it is also required for the late maturation of the 18S and 5.8S rRNA of the pre-40S ribosomes and for maturation of the 25S and 5.8S rRNA of the pre-60S ribosomes. This entry represents a conserved domain of RRP12, which consists of HEAT repeats.
Statistics
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PSSM-Id: 518098
Aligned: 106 rows
Threshold Bit Score: 155.029
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7WTS_K        425 LSPHSQVLTAATQSLKEILKECVAPHMADIGSVt----sSASgpaQSVAKMFRAV-EEGL-TYKFHAAWSSVLQLLCVFF 498  human
5_pfamImport    1 ESSSTTVHKSSCGALNLMFQACVDQSMVTQMAGslgrghAAS---GPLADTLSAL-ESLL-QYRFQRSWPQSLPLLGRLF 75  
XP_015792059  424 QSDSKIVHINLATALQQIIQSILSPSLFELD----------G---KVLSNIMDDF-EKGL-SFKYQNAWGYICNIIGTLM 488 
Q7QD52        468 SSEKLDVVSAASNALKDILYECVQPCCADEVEVe-----KHR---ASLEKSLKYI-IDVLcTAPFGHASKQVLIILAIAF 538  Anopheles gam...
Q16NI7        470 GSDKMEVVSAASNALKDILYECVQPCCEDDEVE------KHR---VPIEKVLKSI-SEVLtSSPFGHASNQVLIILAIAF 539  yellow fever ...
Q9VYA7        461 LSDQKELVAGVSNCIKELLQDCVSRACATAEDAq-----CNR---QSVSRIIASL-HKML-NAPFGEISRFVILIFSFVF 530  fruit fly
XP_002055272  470 LSERGELVVGVSNCIKELLQDCVSRACATKQLAd-----QYR---ASVTKIIGAL-HKVL-NAPFGEISKYVILIFSIVF 539 
XP_002071851  456 LSERTELVVGVSNCIKELLQDCVARACSTSESAq-----QNR---QPVSRIIAAI-HKVL-NSPFGEISKYVILIFSIVF 525 
NP_497319     425 EAGNEQLAQVTYQSLTRVIENSIQ----------------DD---AACGKFLLSQlHVAM-TMKSASVWKFILRAQMKLY 484  Caenorhabditi...
XP_020306187  423 DLGKDSVALITYKVISRIIEHCVQ----------------SN---EELASYSVDLcEEAL-NPRSTGVWQYVLRTETRIF 482  African eye worm
7WTS_K        499 EACGRQ---AHPVMRKCLQSLCDL----RLSPH--FPHTA-ALDQAVGAAVTSMGPEVVLQAVPLEIDGs---EETL--- 562  human
5_pfamImport   76 LHLRGA---SYPLLVNVLRGLGELhdalTSVPSaaLPGVTsALNEAVSFAIQGMGTERVLGVLPLAPTGatpvAEGGl-- 150 
XP_015792059  489 EHIGKQ---APNLVSRFIEILKNL----REGYN--TKFLG-DIDSALSKAIKFIGPEVILSIVPIQQDLl---GSTQ--- 552 
Q7QD52        539 DTTGRY---FGETLAPALTTLGA-----RYDPQ--SSNRI-QIEHAVLQAVGSMDTQLVLKCIPLAGSD----GKID--- 600  Anopheles gam...
Q16NI7        540 DIAGKH---FGPVLAPALKTLGN-----RYDPQ--SSTRI-QIEHAVLQAVGSMDTGLVLECIPLAEAS----GKID--- 601  yellow fever ...
Q9VYA7        531 EACGKL---FGSELTPPLMTICK-----RYDTQ--SAHRL-QIEHTVISAIKALGPELVLTAIPLADGK----GVMQ--- 592  fruit fly
XP_002055272  540 EACGKH---FGSELIPSLATIGK-----RYESQ--GALRL-QIEHTLISAIKALGPELVLRALPLSDAK----GELS--- 601 
XP_002071851  526 EACGQH---FGTELTPSLLTIAK-----RYDSQ--SALRL-QIEHTLISAIKSLGPELVLTAIPLNGGIs--gGNIL--- 589 
NP_497319     485 ETCGEGl--QGAELTKVMEDLARL----RQSDDcfc---ktELDFTIGAAVRHIGVAHVMNILSLEVDP----DAAIlst 551  Caenorhabditi...
XP_020306187  483 EVCKGAinhES--FARALKTLAAL----RNDVNcci---ipDIDLAIGIAVRHIGAENVLRVLPLELDP----QNVSlvt 549  African eye worm
7WTS_K        563 DFPRSWLLPVIRDHV--QETRLGFFTTYFLPLANTLKSKAmdLA-Q-AGSTVESKIYDTLQWQMWTLLPGFCTRPTDVAI 638  human
5_pfamImport  151 AEARAWLLPLLTEHTgaAPSRLAFFQSYVLTTAKACDGAAksGR----LTANEARTQRFRVVQLWGLLPGFCARPSDVAS 226 
XP_015792059  553 -FAHDWLLPLLRDNI--EKSELGIFKKHFVPLANAIEIKMkkME-K-EKKAKLVKLYSAIYNQIWSLLPSFCRNPTDI-G 626 
Q7QD52        601 -LDRTWMLPLLREGL--QHSSFELFNSVILKLAYQCYMLWqkFK-E-TDNKHQSHIFELLCCQLWGLFPGFCRKPKDV-S 674  Anopheles gam...
Q16NI7        602 -LERTWVLPLLREGL--NQSRLEIFNNVILKLAYQCYVLWnkFK-E-SDNKQQAHIFELLCCQLWGLFPGFCRRPKDI-Q 675  yellow fever ...
Q9VYA7        593 -LERSWLLPLLREGA--NGASLQFFKEKIVALAMDCQLKWkeFA-E-AKNNSSSHIYELLCCQLWGLFPGFCRQPRDP-E 666  fruit fly
XP_002055272  602 -LERSWLLPLMREGS--NGASLQFFKEHVVPLALNSQSQWrkYSlE-EKNLSNAHIYELLCCQLWGLFPGFCRQPRDP-E 676 
XP_002071851  590 -LERSWLLPLLREGA--KGASLQFFKEHIVPLAIQCQAKWreYA-D-AKNTASAHIYELLACQLWGLFPGFCRQPRDP-E 663 
NP_497319     552 DFTRSWLLPVLRVNI--HNAPISLFISHFLPIAMKIHRRLptLQ-ApQ----VQRLYSTFQFQLWELLPSFCESPSDLET 624  Caenorhabditi...
XP_020306187  550 HFERSWLMPVLRINI--RNQSIAFALQYFLPLAYRLRKEAp-------SDVVRQKTFVTISDQLWDLLPGLLSSATDFVQ 620  African eye worm
7WTS_K        639 SF-KGLARTLGMAISER--PDLRVTVCQALRTLITKGC------------QAEADRAEVSRFAKNFLPILFNLYGQP 700  human
5_pfamImport  227 TF-GNLAPTLANAMQDVnyPGILPVVCAGLQALVAGVKsrcgaevgggdaAAKADLEKLSHTTTRFLPKLFALVDPG 302 
XP_015792059  627 LFnVEFAKLINKKIMEN--ANIRGHCLAALRNLITT--------------TSEKELGTIKSFAKRYLASFFQLYTNP 687 
Q7QD52        675 NF-RLIAKTLGMVLNEN--PDLRAPILDGLKELIKHLE-------------TPSEREEIGRFAKNFLPRLFNIYTTK 735  Anopheles gambia...
Q16NI7        676 NF-RLIAKTLGTVLNEN--PDLRSPILDGLKELIPHLE-------------TDSDKAEVGKYAKNFLPRLFNIYTTK 736  yellow fever mos...
Q9VYA7        667 YL-RYLAPTLGAAVEKN--PEFRPPIYDGLMELLGDNQ-------------SAECHQAIGQYAKNFLPRLFNIYTQK 727  fruit fly
XP_002055272  677 YL-RKLAPTLGDALEHN--PEFRAPIYDGLLELLDDSQ-------------SPECHAAIGQYARNFLPRLFNIYTQK 737 
XP_002071851  664 YL-RQLAPTLGVALEKN--PEFRPPIYDGLVELLDENQ-------------SAESLAVIGQYAKNFLPRLFNIYTQK 724 
NP_497319     625 AF-PDIAPILGAALNER--KDLRMTVLNAIRRALRFcle---------pdAPAERVEVMSRYAKNFMPIFFNMYTGS 689  Caenorhabditis e...
XP_020306187  621 NF-PHLAEILSKVLLEQ--RDLRLIVLSSLRSALRYalq---------pdATEAKKDVMRFFAYSFLRKLFTLYTLS 685  African eye worm
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