Conserved Protein Domain Family
SDA1_HEAT

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pfam08158: SDA1_HEAT 
SDA1, HEAT repeat
SDA1 is a HEAT repeat-containing protein required for 60S pre-ribosomal subunits export to the cytoplasm and may also be required for 60S ribosomal subunit maturation and accumulation. This entry represents the N-terminal domain of SDA1 proteins (also referred to as NUC130), which consists of HEAT repeats.
Statistics
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PSSM-Id: 489427
Aligned: 55 rows
Threshold Bit Score: 368.41
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003647124  79 FVSQVSGCFSKETANFPNELKQLLLE-RHHCLPFRVKEKIITSLTMLRNKDIITPEMLIQTLFPLLIGYSsshsnnmaan 157
XP_001464805  58 YVCHVGHCFPKDAAVIVNIVLELLRAsKGNGLPMDLRLALVKSLILLRAKDLVSTDHTFPLFFELLQERD---------- 127
Q57ZU2        58 FVCHVGHCYPKECEDVAEIVLKLLQDfKGSTMTSDLRLVLVKSLALLRSKNIVSAERSFPLFFELLQERD---------- 127 Trypanosoma brucei
A0EHL2        78 FLSKVAVYYKTDLKFYIEDLMELINH-FQNTLNQGLRKRIIFCLLRLRGKNLIEPFRMIVFLMKLFNCQD---------- 146 Paramecium tetr...
EFJ09596      74 FLAHVTPSYPKELAGFPHQLLNLLEN-ASNRLPSSLRCHLAQALILLRNREKISLVEVLPVMIKLQSSGD---------- 142
XP_003538583  86 FLAHVTPFYPKHLADFPKKLADLLRC-AARTLPSGLRCHLAHALILLSNRKIVDIGETLSLFMELQTLGD---------- 154
XP_002515043  87 FLAHMTPFYPKQLANFPSELSEFLKS-SSKSLPSGLRSHVSQALILLINRKMVDISETLGLFMELQTLGD---------- 155
XP_005843990  92 FIAQVSNSYPKETAGFAGELMELVDT-HQAVLEPALRQTLVRALILLRNRQQLAPTVLLPLLFRLFRVQD---------- 160
XP_002502278  55 FLAQVSASYKADIPSFHVGLIELLEK-HYALLDPHLRRSLVSALILLRNRGSATAAELLPLFFKLFRCQD---------- 123
XP_001422016  53 FIAHVSVVYKEQTKGFSKGVVEVLER-HYAILDPHLRKNLTSALILLRNKGVIGVEVTLPLFFKLFRVKD---------- 121
XP_003647124 158 shaKELRKLLYNNVVSLLKSCNT--GSKNQKLNKSTQALCFNLLeQPDSQ--GVWAARLTRELWRRGIWDDSRAVEIMTQ 233
XP_001464805 128 ---KTLRKLILTHVVSDIRKANMpgAKNGAQINKRAQNFLFSVM-AEDDPvqARCAEMVMIDLYRRRVWSDERTVEVLTK 203
Q57ZU2       128 ---KVLRRVILSHIVSDIRRVNMpgAKNGAAVNKKAQNFLFGVM-ADDDPvqARCAEMVMIDLYRRRVWADERTVEVLTQ 203 Trypanosoma brucei
A0EHL2       147 ---KDLRRIIFRFIIKDIKQFNK--KHRNETLNKQIQNFIIDLI-KKSQEniAKRALQIMIELYKKNIWKDNKCVNIIAQ 220 Paramecium tetr...
EFJ09596     143 ---KNLKKFVSSHLLQNISRMNR--KHRNEAKNRSLQNIIFPVI-QEDDEarAKHAFVLTCELYRRKVWIDPQTANAICN 216
XP_003538583 155 ---RTLKKLAFDHVVHSIRRMNQ--KHKNEAKNRALQNVLFDLL-QKEAEepAKRALVTLCELHRRKVWFDERTANAICT 228
XP_002515043 156 ---RNLKKLAFSHVVHSIRRMNK--KHKNDAKNRVLQNILFEIL-QQEDEgrAKRSLITLCELHRRKVWFDDRTANAICM 229
XP_005843990 161 ---KALRQLVFRHVTADIKNSNR--RQRNDRLNRAVQNFMYAVI-QDEHEgaAKKGLAVATEMWRRHVWRDARTVNVIAA 234
XP_002502278 124 ---KQLRVMIFRHIVADVKGANK--TRRNEALNRQVQNFLAAAL-KDENEaaAKKALAVITELYRRNVWSDARTVNLVAD 197
XP_001422016 122 ---KNLRVLMFRHIVSDAKAANK--KRTDDKYNRTVQSFLHTAI-KDENEatAKKALAVLTEMYRRNIWTDAKTVNLVVE 195
XP_003647124 234 ATLHDDIKIVNSGVLFFL-------GADRErEeNFEESSDDDe--------LDVQSLRHKLKINKKS---------SKRG 289
XP_001464805 204 ACFSKHTPILRTALRFFLlqmpritSVDDE----DGEGGEEQdp------gRTISKLQQKMKIVKKT---------SKRE 264
Q57ZU2       204 ACFSRHTAIIRTALRFFLlqmpkitSMDSK-----NEDDDDDdp------gRAISKMKQKLKIKKKT---------GKRE 263 Trypanosoma brucei
A0EHL2       221 GCFNQNYKIKLLACYFLIe------TTENHvE--IESSEDEAdky---------iqkKGKNKCVKPT---------KARE 274 Paramecium tetr...
EFJ09596     217 ACFHKSPRIMIATLKFLH-------GYENK----YDEDSDESdqe----ddTPSGAVGVSKEAIYKSqhkgtvsskKKKQ 281
XP_003538583 229 ASFHPTSRIMIATLSFLL-------DYEKI-----QDDDDDSdnsdsddekTESPQVVLSRETVYKAshqgtaaskKKKK 296
XP_002515043 230 ACFHSSSRIMIAAMSFLL-------DFEKI----EDDNSDDSdasseddsnTHLPRVLLSKEAVYKAhhkgtvsskKKKK 298
XP_005843990 235 AALHKSPRIMLAALKFFL-------GQDAA-E-AAADGARRS---------------VCGGGHSRRLvlgw-gtnpMRLS 289
XP_002502278 198 ACRHPSPKILVAALKFFL-------GQDEAaE-AAAEAGDDSdddd-------ddapKPKTGVGTAAgts----sgAKKQ 258
XP_001422016 196 ACKHPSQKILIAALKFFE-------GQDEAaE-AAAEAGDGSdsdd--------dpsTRESEIKSRTqgva--sskKKKQ 257
XP_003647124 290 KKLENVVKQIKKKNNNKAt--nVQGYLNFSAIHLLRDPQGFAEKLFAKHLsgkaNNNKfNLEQKISLLQLLSRLIGTHKL 367
XP_001464805 265 RVLKRSVRGAKRKYDRQEkeeaLFAKQHVDPVRLLRDPQQFVERLLAKLQ----KTSE-RFEVRLLYLNVIARTVSEHEV 339
Q57ZU2       264 RILKREVGAVKRKYNKEEkeeeLLAKQHVDPIRLLRNPQQFVERLLARLQ----KTSE-RFEVRVLYLNVIARTVSEHEV 338 Trypanosoma brucei
A0EHL2       275 HRVEREKKMADKKQRKKLs--rLNSNGGFFALDQIYSPQDFAERLFDNLKk---HDSE-RFSVKLAMMHLISRLIHRHKL 348 Paramecium tetr...
EFJ09596     282 AKIERAIRSLKKQQRIKAq---EEKKGSFAPLEHLRDPQEFAEKLFARLQ----NCNE-KFQVKLMMIMVISRCVGMHQL 353
XP_003538583 297 AKLQRAIRSMKRHQRVSSd---RSKNSYYSPLNHLKDAQGFAEKLFSRLR----SCNE-RFEVKMMILKLIARTVGLHQL 368
XP_002515043 299 AKLQRAMRSMKRQHRLSSd---KSSSNYYSPLSHLKDAQGFAERLLSRLQ----TCNE-RFEVKMMMLKLIARTVGLHQL 370
XP_005843990 290 KKLKRAQASVKRQQKRED----GSRQENFAALQLLHDPQGFAEKLFKRLQ----KGHE-RFEARMAVLNVVSRCVGVHKL 360
XP_002502278 259 AKLKRQMASIRKAGRREEg---NNGEARFAAMQLVNDPQAFAEHLFGRLQ----SGSalKFDTKMLLIQVVSRVVGLHRL 331
XP_001422016 258 KKLKRTIKTMQRKERNAD----KAIDSRFAAMQLINDPQAFAELLFGKLQ----VGHm-SYDTKMLCILMMCRIIGMHQL 328
XP_003647124 368 LVLGVYSFLLKYLTPKQTDVTKIMAAAAQSCHDLVPPEYISVVVRKIADEFVSDGVASEVCAAGLNTIREICSRAPLAIE 447
XP_001464805 340 LHLPLYGFLERYMEPSQLHATQLLALSATCVHAMVPPDAIEPLLRTIANHFVSDRSSADAITVGINTIREICKRQPLAMN 419
Q57ZU2       339 VHLPLYGFLERYMEPSQLHSTQLLALSVMCTHRMVPPDALEPLVRAIANHFVSDRSSPDAITVGLNTIREICKRQPLAMN 418 Trypanosoma brucei
A0EHL2       349 LLIPFYTYVQKHLYPNSKDVPKLFAYLAESIHDSIPKEDLQPTIRHLIDQFVNDRCQELTLTMGLRGIYEILQKHPKILD 428 Paramecium tetr...
EFJ09596     354 LLLSFYPHLQRYVS--------------------VPVDAVEPLLKQLVNSFVHDRSRPEIMTRD---------------- 397
XP_003538583 369 ILLEFYSFLQKYIQPHQRDITNLLAAVVQACHDMVPPDAVEPLFKQIVNQFVHDRSRPEAITVGINAVREICMRMPLLMN 448
XP_002515043 371 ILLNFYPFVQKYVQPHQRDITNLLAAAVQACHDMVPPDAVEPLFKQIVNQFVHDRSRPEAIAVGLNVIREICLRMPLLMT 450
XP_005843990 361 LLLNFYPFLQKYIAPSQRDVTVILAALVQACHELVPPEALAPVLRQLVDQFVHDRARPEVMTIGLRTVREICVRCPLVMS 440
XP_002502278 332 HLLHLYPFLQRYVQPNQREVTRLLASAATACHELVPPDALEPLLRQLVNQFVHDRARPEVVAVGINTVREICVRCPLVMH 411
XP_001422016 329 IMLNVYPFLQRYIQPSQLEVTRLLAAAATACHELVPPDALAPMLRQLVNQFIHDRARPEIAAVGLNAVREICARCPLVMD 408
XP_003647124 448 ETLLQDLTEYKGS 460
XP_001464805 420 ADLLKDLAEYKNQ 432
Q57ZU2       419 ADLLKDLVEYKSQ 431 Trypanosoma brucei
A0EHL2       429 KENITYLIHYIKY 441 Paramecium tetraurelia
EFJ09596     398 --LLEDLSMYKKS 408
XP_003538583 449 EDLLQDLALykks 461
XP_002515043 451 EDLLQDLVlykks 463
XP_005843990 441 PELLLDLTAYKKF 453
XP_002502278 412 SDLLQDLAQYKRA 424
XP_001422016 409 EDLLQDLTQYKKS 421
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