1OJM,1F1S,1HM2


Conserved Protein Domain Family
Lyase_8_N
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pfam08124: Lyase_8_N (This model is not part of the current CDD release)
Polysaccharide lyase family 8, N terminal alpha-helical domain
This family consists of a group of secreted bacterial lyase enzymes EC:4.2.2.1 capable of acting on hyaluronan and chondroitin in the extracellular matrix of host tissues, contributing to the invasive capacity of the pathogen.
Links
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Statistics
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PSSM-Id: 518078
Aligned: 12 rows
Threshold Bit Score: 368.272
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1OJM_A         12 WNGII------AGNQyYDSKNDQMAKLNQELEGKVADSLSSIssQADRIYLWEKFSn--------YKTSANL--TATYRK 75   Streptococcus...
Q82JQ0         45 WLVLA------LGAG-YDPTAEPYASRLRRTGELARGYRATM--APAAASLWPGHP---------FDPPSGI--TQSYSR 104  Streptomyces ...
WP_011691558   50 WVDQI------TGRKvLVAGDNDFVTALAALDKKARTAIDLLerSAGRLTVFSDLS---------LAKDTDL--VTTHTR 112  Arthrobacter ...
Q8DZB2        347 WNDVT------IGNHvYDTNDSNMQKLNQKLDETNAKNIEAIklDSNRTFLWKDLDn--------LNNSAQL--TATYRR 410  Streptococcus...
Q8CWU3        310 WNGII------AGNQyYDSKNEQMAKLNQELEGKVADSLSSIssQADRIYLWEKFSn--------YKTSANL--TATYRK 373  Streptococcus...
Q8A3J0         19 WDLVLpcpsicTSALqNDDFDILMKKIRDGVAENPN--------IDKALELYDDVQgcfididyaRRDRTNWmpLIHVDR 90   Bacteroides t...
Q59288         26 G----------TAELiMKRVMLDLKKPLRNMDKVAEKNLNTLq----pDGSWKDVPy-------kDDAMTNWlpNNHLLQ 84   Pedobacter he...
Q82ZM8        271 WKMRL------LGTTqYD-NDADVQQYRAQIATESLALWQTLnqAADREYLWERKPs--------DTVSADY--TTQFTN 333  Enterococcus ...
Q837L8        241 WRNQL------VSKE-YDSTNQALVDYVQKISNEATELDQTMnkEPNRSYLWPLEPg--------NTPSADL--TTQFTK 303  Enterococcus ...
Q5DYT2         47 WAENY------LGDP-AITFDQTLKNMVTSTNSSAQKHWDSMtpQPNASGIWDDLPlid----kdTTLGPNI--RNSYQR 113  Aliivibrio fi...
1F1S_A         89 WNDVT------IGNYvYDTNDSNMQKLNQKLDETNAKNIEAIklDSNRTFLWKDLDn--------LNNSAQL--TATYRR 152  Streptococcus...
1HM2_A         16 spalliaqqtgTAELiMKRVMLDLKKPLRNMDKVAEKNLNTLq----pDGSWKDVPy-------kDDAMTNWlpNNHLLQ 84   Pedobacter he...

1OJM_A         76 LEEMAKQVTNPSSRYYQDETVVRTVRDSMEWMHKHVYNSEKS-IVG--NWWDYEIGTPRAINNTLSLMKEYFS---DEEI 149  Streptococcus...
Q82JQ0        105 LWTMTQAYVQEGTGSTGDAGLLADIVRGLDHVSATVYNPTTT-RYG--NWWEWQIGSPRLLMDIVAALHDRLS---AARR 178  Streptomyces ...
WP_011691558  113 LATMATAWATPGSEHFADAGLLAAIRAGLADANSLCYNASKE-EQG--NWWSWEIGTPKALADTMVLLHAELT---AAER 186  Arthrobacter ...
Q8DZB2        411 LEDLAKQITNPHSTIYKNEKAIRTVKESLAWLHQNFYNVNKDiEGSa-NWWDFEIGVPRSITGTLALMYNYFT---DAEI 486  Streptococcus...
Q8CWU3        374 LEEMAKQVTNPSSRYYQDETVVRTVRDSMEWMHKHVYNSEKS-IVG--NWWDYEIGTPRAINNTLSLMKEYFS---DEEI 447  Streptococcus...
Q8A3J0         91 LYDFVFAYTHPKNSYYQNEDLYHKIVKGLEYWHHRNPHCN--------NWWYNQIAEPQKLGILLIQMRVGKRqipEVLE 162  Bacteroides t...
Q59288         85 LETIIQAYIEKDSHYYGDDKVFDQISKAFKYWYDSDPKSR--------NWWHNEIATPQALGEMLILMRYGKKpldEALV 156  Pedobacter he...
Q82ZM8        334 IKKLALGYYEPSSELFEKPEVYDAIVKGIEFMIDTKKYNGTY-YTG--NWWDWQIGSAQPLTDTLILLHDDLLntdAEKL 410  Enterococcus ...
Q837L8        304 LQKLALAYGTKGSTLYQDDKLAATIIDGLDFMVTQKGYDGKK-YHG--NWWDWQIGVPQKFLNILMILEDKVS---PEKQ 377  Enterococcus ...
Q5DYT2        114 LFTMAKAYRLRDGNLENNQLMLNDIMTAMNYINQNFYFVNQL-EYG--NWWQWELAIPKDIHNILVLLFDDIKdnyQTII 190  Aliivibrio fi...
1F1S_A        153 LEDLAKQITNPHSTIYKNEKAIRTVKESLAWLHQNFYNVNKD-IEGsaNWWDFEIGVPRSITGTLSLMNNYFT---DAEI 228  Streptococcus...
1HM2_A         85 LETIIQAYIEKDSHYYGDDKVFDQISKAFKYWYDSDPKSR--------NWWHNEIATPQALGEMLILMRYGKKpldEALV 156  Pedobacter he...

1OJM_A        150 KKYTDVIEKFVPDPeh---------frKTTD-NPFKALGGNLVDMGRVKVIAGLLRKDDQEISSTIRSIEQVFKLVDQGE 219  Streptococcus...
Q82JQ0        179 AAACAAVGHFIPDD-------------MLRD-YSGTSTGANRVDLCRGVALSGILGRAPDRIALARDALSPVFPYVTQGD 244  Streptomyces ...
WP_011691558  187 AAYCAAIDHFVPDPwq---------qfPPKR-GKITSVGANRVDLCQAVTIRSLVDEDAEKLTHAVAGLSEVWQYVSAGN 256  Arthrobacter ...
Q8DZB2        487 KTYTDPIEHFVPDAgff--------rkTLVN--PFKALGGNLVDMGRVKIIEGLLRKDNTIIEKTSHSLKNLFTTATKAE 556  Streptococcus...
Q8CWU3        448 KKYTDVIEKFVPDPehf--------rkTTDN--PFKALGGNLVDMGRVKVIAGLLRKDDQEISSTIRSIEQVFKLVDQGE 517  Streptococcus...
Q8A3J0        163 TKVLQRMRKDGGHP--------------------ARWTGANRTDIALHWIYRACLQKNDVDLKTAVENVYSPLSYTVK-E 221  Bacteroides t...
Q59288        157 HKLTERMKRGEPEK----------------------KTGANKTDIALHYFYRALLTSDEALLSFAVKELFYPVQFVHYEE 214  Pedobacter he...
Q82ZM8        411 NKFTAPLMLYAKDP-------------NIQW-PIYRATGANLTDISITVLGTGLLLEDNQRLVQVQEAVPSVLKSVSSGD 476  Enterococcus ...
Q837L8        378 QIYTNALSSYVPDPfkqlytkpqgtfvDLAFiPNFVTSGANRTDLALTVLGLGILQKDSGKINQASSSIVDVFKLVTKGD 457  Enterococcus ...
Q5DYT2        191 TNHLNATRYFTPDPthlgvs--pgaaeSTNP-NYRESTGGNRTDNAQVVLIRGMLENNSEEISQAIAALPAVIEYVSEGD 267  Aliivibrio fi...
1F1S_A        229 KTYTDPIEHFVPDAey---------frKTLV-NPFKALGGNLVDMGRVKIIEGLLRKDNTIIEKTSHSLKNLFTTATKAE 298  Streptococcus...
1HM2_A        157 HKLTERMKRGEPE----------------------KKTGANKTDIALHYFYRALLTSDEALLSFAVKELFYPVQFVHYEE 214  Pedobacter he...

1OJM_A        220 GFYQDGSYIDHTNVAYTGAYGNVLIDGLSQLLPVIQKTKNPIDKDKMQTMYHWIDKSFAPLLVNGELMDMSRGRSISRAN 299  Streptococcus...
Q82JQ0        245 GLYADGSFVQHTWVAYSGTYGQVLLDGLGRLFSLFAGSTWDVTDPNRQIILDSVEQAYAPLIHDGLVMDSVNGRAISRGY 324  Streptomyces ...
WP_011691558  257 GFFTDGSFIQHSTTPYTGSYGVVLLTGLSKLFALLGGTGAEVSDPSRDILFKTVEGSFAPFMVAGAMADSVRGRSISRES 336  Arthrobacter ...
Q8DZB2        557 GFYADGSYIDHTNVAYTGAYGNVLIDGLTQLLPIIQETDYKISNQELDMVYKWINQSFLPLIVKGELMDMSRGRSISREA 636  Streptococcus...
Q8CWU3        518 GFYQDGSYIDHTNVAYTGAYGNVLIDGLSQLLPVIQKTKNPIDKDKMQTMYHWIDKSFAPLLVNGELMDMSRGRSISRAN 597  Streptococcus...
Q8A3J0        222 GFQHDNSYFQHGVQLYIGGYGDEILKGVTQVALYTKGTKYALDDERIQFLRHFMCGTYYQVIRGQYMLFDVLGRGVSRNN 301  Bacteroides t...
Q59288        215 GLQYDYSYLQHGPQLQISSYGAVFITGVLKLANYVRDTPYALSTEKLAIFSKYYRDSYLKAIRGSYMDFNVEGRGVSRPD 294  Pedobacter he...
Q82ZM8        477 GLYPDGSLIQHGYFPYNGSYGNELLKGFGRIQTILQGSDWEMNDPNISNLFNVVDKGYLQLMVNGKMPSMVSGRSISRAP 556  Enterococcus ...
Q837L8        458 GFYQDGSFIQHNNIPYTGSYGNVLVKGVGQILAITADSSFQMDATLVTEFVENVDRAFLPLIYKGEMLPTVNGRSISRAP 537  Enterococcus ...
Q5DYT2        268 GYYTDGSFLQHSDIAYNGTYGNVLLGGLGIQMNAVAGSPWSMDNQTISNVYNIINQSYEPLLYKGAMMDMVNGRSISRSA 347  Aliivibrio fi...
1F1S_A        299 GFYADGSYIDHTNVAYTGAYGNVLIDGLTQLLPIIQETDYKISNQELDMVYKWINQSFLPLIVKGELMDMSRGRSISREA 378  Streptococcus...
1HM2_A        215 GLQYDYSYLQHGPQLQISSYGAVFITGVLKLANYVRDTPYALSTEKLAIFSKYYRDSYLKAIRGSYMDFNVEGRGVSRPD 294  Pedobacter he...

1OJM_A        300 SE---------GH--VAAVEVLRGIHRIADMSEGETK--QRLQSLVKT 334  Streptococcus pneumoniae
Q82JQ0        325 LKsddlhvmrgDH--FHGQALIAAIALLAGGAGPQER--ARWHARIKG 368  Streptomyces avermitilis
WP_011691558  337 NT---------GF--DLGASTIESILLLARAVDPVTA--RRWRSLCLA 371  Arthrobacter sp. FB24
Q8DZB2        637 AS---------SH--AAAVEVLRGFLRLANMSNEERN--LDLKSTIKT 671  Streptococcus agalactiae serogroup V
Q8CWU3        598 SE---------GH--VAAVEVLRGIHRIADMSEGETK--QRLQSLVKT 632  Streptococcus pneumoniae R6
Q8A3J0        302 AT---------QK--SHAALFAKRMLEL---APAHID---EYNAIIAR 332  Bacteroides thetaiotaomicron
Q59288        295 IL---------NKkaEKKRLLVAKMIDL-KHTEEWADaiARTDSTVAA 332  Pedobacter heparinus DSM 2366
Q82ZM8        557 ETnpf----ttEF--ESGKETIANLTLIAKFAPENLR--NDIYTSIQT 596  Enterococcus faecalis
Q837L8        538 AV---------GKt-GYGSTTMYNLLIVAKFAPNNYQ--KKFQEAVKY 573  Enterococcus faecalis
Q5DYT2        348 EQ---------NH--DVGLNIVNSMLFYTNGPDSDKN--KQLSSLIKT 382  Aliivibrio fischeri ES114
1F1S_A        379 AS---------SH--AAAVEVLRGFLRLANMSNEERN--LDLKSTIKT 413  Streptococcus agalactiae
1HM2_A        295 IL---------NKkaEKKRLLVAKMIDL-KHTEEWADaiARTDSTVAA 332  Pedobacter heparinus
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