1SS6,6OPC


Conserved Protein Domain Family
SEP
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pfam08059: SEP (This model is not part of the current CDD release)
SEP domain
The SEP domain is named after Saccharomyces cerevisiae Shp1, Drosophila melanogaster eyes closed gene (eyc), and vertebrate p47. In p47, the SEP domain has been shown to bind to and inhibit the cysteine protease cathepsin L. Most SEP domains are succeeded closely by a UBX domain.
Links
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Statistics
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PSSM-Id: 518048
Aligned: 148 rows
Threshold Bit Score: 72.1246
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1SS6_A         16 LKLWKSGFSLDNGE----LRSYQDPSNAQFLESIRRGEVPAELR---RLA-HGGQVNLDMEDHRDEDFVk-PKG--AFKA 84  human
22_pfamImport   1 ITMWRDGFSVDNGA----LRSYT-----ELRERVQQGHVLAEIF---PRT-QRGAIFVSLEDHRLENYVs-PTAptD--- 63 
21_pfamImport   1 VRLWRDGFSVDNGA----LRSYNDPHEREFLARIRQGHVPAELY---PQA-ESGAVHLSLEDHRHENYVa-PAT--TPTY 69 
XP_009030747  148 LKFWRDGFSVDNGP----LRSMQDPANMEFLEDIKDGKIPREFA---TLMrGYQQINLSMEDHSSQEYVk-PKV--TLQA 217
23_pfamImport   1 LRVWSNGFTVDEGQ----LRNLENPGDREFLNLITTGQVPPEIA---PS--NGSAVRLKVEDHRFETFKn-HPRk-QV-P 68 
XP_001898751  120 LVMWENGFTVDGGP----LRLYSDMRNHSFLQTIGEGRVPGEII---RQY-PGKIIYLRME-RRSEPRVv-ESKp----- 184
KLU85010      229 LHLWEDGFSINEDP----LIKYE-RDVSTYLDEIAKGKVPEDIRkrmGIR-PNEEVDVTVQQHAQQKWRqlPYVy-RP-- 299
XP_002049465  161 LHLWSEGFSLDDGS----LRLYEVPENERFLSAIMRGDFPDEMQe------LGQRIELRVRDHTNESYRelSRKq----- 225
XP_001960933  175 LHLWSEGFSLDDGT----LRPYAVPENERFLRAVLRGDFPDEMV-----D-NRPRVELSVQDHTNERFRt-LSR--KQ-- 239
XP_004993044  185 LVLWKNGISVDDGKevpvLRPYE--QSASIIGAIQAGVVPPELR---VK--YGAAIDLELVDKRGENFTp-PSRp----- 251

1SS6_A         85 FTGEGQ 90  human
22_pfamImport  64 FPGTGR 69 
21_pfamImport  70 FTGKGH 75 
XP_009030747  218 FSGHGf 223
23_pfamImport  69 FSGQGH 74 
XP_001898751  185 FTGEGQ 190
KLU85010      300 WMDEGn 305
XP_002049465  226 FMGFGR 231
XP_001960933  240 FLGPGR 245
XP_004993044  252 FGGAGH 257
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