1SS6,6OPC


Conserved Protein Domain Family
SEP

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pfam08059: SEP 
SEP domain
The SEP domain is named after Saccharomyces cerevisiae Shp1, Drosophila melanogaster eyes closed gene (eyc), and vertebrate p47. In p47, the SEP domain has been shown to bind to and inhibit the cysteine protease cathepsin L. Most SEP domains are succeeded closely by a UBX domain.
Statistics
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PSSM-Id: 400413
View PSSM: pfam08059
Aligned: 164 rows
Threshold Bit Score: 66.7068
Threshold Setting Gi: 835892923
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1SS6_A        17 KLWKSGFSLDNGELRSYQDPSNAQFLESIRRG-EVPAELR---RLAHGGQVNLDMEdHRDEDFVK-PKGa-fKAFTGEG 89 
EDW49183     162 HLWSEGFSLDDGSLRLYALPENERFLRAILRG-DFPEEML------RVPRVQLSVQdHTNESYRHlSRKq----FMGPG 229 Drosophila seche...
XP_001952475 208 KVWKEGFTINDGELHSIDRPENREFLLLVARGeEIPPLLLkeaNVSSEDELHVSVEdHRYEEYV--PSKpkkKIFGGSG 284 pea aphid
Q28DT0        62 KMWKNGFTINDGYLRDYSGAENRQFMDSVRKG-ELPEELQ---KTFDKEEIAVNVEdRKNEEYL--LRKpniDAFSGLG 134 tropical clawed ...
XP_016282673 102 KLWQNGFTVN-GEFRSYGDGASQQFLNAIRKG-ELPSELR---GRFSQEEVAVRVEdKKEQVFV--PRKpafAPFSGRG 173 gray short-taile...
XP_015206906  60 KLWKNGFTVNDEGLRSYSDDENQQFLDSIKKG-ELPLELE---RAFVDEELEVKVEdLKDEMYK--PKRktfHPFTGRG 132 spotted gar
XP_003200800  67 RLWKNGFTLNDEDLRSYTQEENQEFLEAIKKG-ELPLELE---GRAEDEELEVNVEdMKDEVYV--PKKkifHPFTGRG 139 zebrafish
XP_007654073  67 RLWKNGFTVNNDELRSYTDSASQQFLDSIKKG-ELPLELQ---KVFDKEEVDVKVEdKKNVVYV--SKKpvfQPFSGPG 139 platypus
XP_008115271  66 KLWKNGFTVNDGELRSYTDVANQRFLDSIKKG-ELPPELQ---KICGKEEVAVKVDdKKHEVYT--LKKpvfHPFSGQG 138 green anole
XP_005044407  65 KLWKNGFTVNDGELRSYTDVANQQFLESIKKG-ELPFELQ---KVFDKEEVEVKVEdKKDKVYLS-SKKpvfHPFSGHG 138 Collared flycatcher
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