4LIT,4BXF,4CCM


Conserved Protein Domain Family
JmjC_2
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pfam08007: JmjC_2 (This model is not part of the current CDD release)
JmjC domain
This entry includes proteins with a JmjC domain that belong to the cupin superfamily, including Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66, Ribosomal oxygenase 1/2, and 50S ribosomal protein L16 3-hydroxylase from Escherichia coli. Proteins are bifunctional, acting as histone lysine demethylases and ribosomal histidine hydroxylases.
Links
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Statistics
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PSSM-Id: 518023
Aligned: 29 rows
Threshold Bit Score: 126.214
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4LIT_A 129 ALMRPFRELPD-WRIDDLMISF----------SVPGG--GVGPHLDQYDVFIIQGTGRRRWRVG------EKLQMKQHCP 189 Escherichia coli K-12
Q7T3G6 154 QFHQPQRFQDElWRIQERLECFfgclvgsnvyITPAGaqGLPPHYDDVEVLILQLEGQKHWRLYe-----PTVPLAREYS 228 zebrafish
Q6DDJ7 133 QFHQPQRFNDAlWHIMEKLECFfgalvgsnvyITPQDsqGLPAHYDDVEVFILQLEGEKRWRLYn-----PVVPLARDYS 207 African clawed frog
Q8IUF8 136 QFHQPQRFKDElWRIQEKLECYfgslvgsnvyITPAGsqGLPPHYDDVEVFILQLEGEKHWRLYh-----PTVPLAREYS 210 human
Q8CD15 136 QFHQPQRYKDElWRIQEKLECYfgslvgsnvyMTPAGsqGLPPHYDDVEVFILQLEGTKHWRLYs-----PTVPLAHEYS 210 house mouse
Q9H6W3 297 RLLCPQAFSTTvWQFLAVLQEQfgsmagsnvyLTPPNsqGFAPHYDDIEAFVLQLEGRKLWRVYrp---rVPTEELALTS 373 human
Q849M1 106 ELHPPI------ARLCEAIERElhtrvqanlyASWSAteGFGVHWDDHDTVIVQLDGAKRWRIYgttrpfPLYRDIADPG 179 Streptomyces violaceo...
Q7N884  96 lVANGIINETKiDQLAKACSSFtdshpfsslyLSYGEksSFKPHWDSRDIFAIQLSGKKRWIIYkpsfpdPVYLHQSKDM 175 Photorhabdus laumondi...
O01658 399 QLVNPQTYDDRiWYLCEVIQEQfgcfvgantyLTPAGssGFAPHWDEIDAFLLQVEGRKYWRVWap---eSAEEELPLES 475 Caenorhabditis elegans
4BXF_A 113 QFHQPQRFKDElWRIQEKLECYfgslvgsnvyITPAGsqGLPPHYDDVEVFILQLEGEKHWRLYh-----PTVPLARECS 187 human

4LIT_A 190 HPDLLQVDPF--EAIIDEELEPGDILYIPPGFPHEGYALE--NAMNYSVG-FRAPNTREL 244 Escherichia coli K-12
Q7T3G6 229 LEPEGRIG----APTHDFILQAGDLLYFPRGTIHQADTPA---GAGHSTH-LTLSTYQNM 280 zebrafish
Q6DDJ7 208 VVPEDQIG----SPTHDFVLKPGDLLYFPRGVIHQAQAL---PGSSHSTH-VTISTYQNn 259 African clawed frog
Q8IUF8 211 VEAEERIG----RPVHEFMLKPGDLLYFPRGTIHQADTPA---GLAHSTH-VTISTYQNn 262 human
Q8CD15 211 VESEDRIG----TPTHDFLLKPGDLLYFPRGTIHQAETPS---GLAYSIH-LTISTYQNn 262 house mouse
Q9H6W3 374 SPNFSQDDLG--EPVLQTVLEPGDLLYFPRGFIHQAECQDgvHSLHLTLStYQRNTWGDF 431 human
Q849M1 180 EAPT--------EPVADLVLWPGDVLYVPRGVWHAVSADQgvRSLHVTCG-LQTHTATDL 230 Streptomyces violaceoruber
Q7N884 176 ENTYPCPS----EPYDDFVLETGDVLYLPRGWWHNPLPLGe-ETIHLSVG-IFPPYAHEY 229 Photorhabdus laumondii subsp. laumondii
O01658 476 SDNFTEDDMKgrEPVFEGWIEKGDMIYIPRGYIHQARTDSkvHSLHVTVStGRQWSFANL 535 Caenorhabditis elegans
4BXF_A 188 VEAEERIG----RPVHEFMLKPGDLLYFPRGTIHQADTPA---GLAHSTH-VTISTYQNn 239 human
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