3NO8,3GBW,3HWJ


Conserved Protein Domain Family
PHR
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pfam08005: PHR (This model is not part of the current CDD release)
PHR domain
This domain is called PHR as it was original found in the proteins PAM, highwire and RPM. This domain can be duplicated in the highwire, PFAM and PRM sequence. The C-terminal region of the protein BTBD1 includes the PHR domain and is known to interact with Topoisomerase I, an enzyme which relaxes DNA supercoils.
Links
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Statistics
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PSSM-Id: 518022
Aligned: 48 rows
Threshold Bit Score: 111.923
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3NO8_A         18 NRFQQVESR--WGYSGTs-DRIRFSVNK-----RIFVVGFGLYGSIHGPT----------DYQVNIQI------------ 67   human
XP_001024457  315 SRFGKSQQG--WVLSEt--EALTFEINKe---qDIWLKGFGMYEVISLPKdctndrenngNLNLDIKL------------ 375 
Q17551       1503 SRFRRRSAQptWDMSDGcaDAIAFRVDSe----GIKLHGFGIYLPTEPDR-----------RNFVGEImml--------s 1559 Caenorhabditi...
4_pfamImport    1 SRFMRTNQTrtWNTGNGspDAICFSVDKp----GVVIAGACVYGGMGV-------------LEYELELlddqsn-sacgd 62  
6_pfamImport    1 SRFTRTNQSrsWNTGNGspDAICFSVDRp----GIVIAGVGIYGGAGV-------------YDYELELlddqnn--tgnd 61  
3_pfamImport    1 SRFTRTNQSrtWNTGNGspDAICFQVDRp----GISIAGVGVYGGIGH-------------YEYELELledqsslsgses 63  
3HWJ_A          4 NRFTKTSQGrsWNTGNGspDAICFAVDKp----GIVVVGFAVYGG-GGIH----------EYELEVLV------------ 56   house mouse
XP_046440286 1730 SRFTSSSQNrsWNTGNGspDAICFTVDRp----NVSVIGVGVFGGGGS-------------YTYELELlelir---sasd 1789 common water ...
XP_042937074 1580 NRFRRTAAHasWDVSNGacDAIALSVDVt----GITLHGVGVYCAHHd-----------qEQSFVCEVlln-------gg 1637 Brugia malayi
XP_001025994  220 NRFGQFLDN--WTLDGi--NAITFQQNQnmfekDIWLIGFGVFEAQNMSAlps-----ppKLTVCLSEgk---------- 280  Tetrahymena t...

3NO8_A         68 -IHTDs-----------nT--VLGQNDTGFSCDG---SAS-TFRVMFKEPVEVLPNVNYTACATLK-GPD-SHYGTKGMR 127  human
XP_001024457  376 ----Fqg---------gnTsgKVLHEETIQISRDlhaNYDhIIELNLQKPLKLETKQKYTITMKPN-RDCiSYFGYNGCY 441 
Q17551       1560 pDSSEkw---------tcLlrVTAEMSSE--------EKE-VGIVRFPEYVLLSPGVTYAVKVNMM-KNTkTFCGEGGVT 1620 Caenorhabditi...
4_pfamImport   63 pSPAQrw---------ttLevIKGTFGPDDC------VSD-IAELKFAKPVPIKENVKYAIRLRNQ-GGr-TSNGDGGLN 124 
6_pfamImport   62 pSHTQrw---------ssLdfTRGTFGPDDC------AND-IVELKFDKPVLIKENVKYAIRLRNR-GGr-TSNGDGGLS 123 
3_pfamImport   64 hTHTQrw---------nsLeiTRGSFVPEDF------APD-IIEIKFDRAVPIKENIKYAIRLRNH-GGR-TNNGDGGLN 125 
3HWJ_A         57 -DDSEhagdsthshrwtsLelVKGTYTTDDS------PSD-IAEIRLDKVVPLKENVKYAVRLRNY-GSR-TANGDGGXT 126  house mouse
XP_046440286 1790 aAQTLsw---------hsLavVRGSYGPEDS------IND-VAEIKFDRPVPIKENTRYTFRLRNQ-GGk-THNGDGGVL 1851 common water ...
XP_042937074 1638 dAAHEqw---------nvLekVVGTL-ANKFEPC---QRE-VCLLRLTKVIKLQPGCTYAIRLQIN-GGk-TFCGEGGIG 1701 Brugia malayi
XP_001025994  281 -----------------iAeeKLILRQQIQLSNQiqfKNK-MATIYLEKALKLNPKYQYTLSIT-SdQTYlTYAGFNGCV 341  Tetrahymena t...

3NO8_A        128 KVTHespttGAkTcFTF---CYAA-GNNNGTSVEDGQIPEVIFY 167  human
XP_001024457  442 QTSD----------FKYydsIVSKdLKNNSSGVLLGQFPVFYFE 475 
Q17551       1621 QVHLl----NG-ArLFF---SGCS-MSQNGTTVQRGQLPYLIYS 1655 Caenorhabditis elegans
4_pfamImport  125 TVKGp----DG-ItFSF---STCS-LSFNGTTQTRGQIPQILYY 159 
6_pfamImport  124 VVKGa----DG-TtFTF---TACS-LSFNGTTQTRGQIPHILYY 158 
3_pfamImport  126 SVKGs----DN-TtFTF---STCS-LSFNGTTLTRGQIPVILYY 160 
3HWJ_A        127 TVQCp----DG-VtFTF---STCS-LSSNGTNQTRGQIPQILYY 161  house mouse
XP_046440286 1852 SIKGp----DG-TtFNF---SACL-LSFNGTNHIRGQLPYILYC 1886 common water flea
XP_042937074 1702 TVRLc----NG-SrMHF---ESCN-LSLNGTSLSRGQIPFVLYS 1736 Brugia malayi
XP_001025994  342 DTKD----------FTYfesQIVRpISNNGTNTMMGQFPYLVYE 375  Tetrahymena thermophila SB210
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