Conserved Protein Domain Family
RHSP
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pfam07999: RHSP 
Retrotransposon hot spot protein, P-loop domain
Members of this entry are retrotransposon hot spot proteins (RHSPs). They are associated with polymorphic subtelomeric regions in Trypanosoma. These proteins contain a P-loop (ATP/GTP-binding) motif, represented in this entry, at the C-terminal of the conserved box 1. This domain also includes the retrotransposon insertion site.
Links
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Statistics
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PSSM-Id: 462336
Aligned: 3 rows
Threshold Bit Score: 494.831
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q8WPT5 326 VLVGTAGIGKSVGVGSFLLQRLLHYDSELLRIIAYFVKG-EAYIFFMATNDHPGRVVFYEKENDGVDAVNDLAD-----E 399 Trypanosoma brucei
Q8T9M2 335 VLIGTPGIGKSFSVGSFLLYKLLHYEASQLQIIIYVVRG-KAYVFHKPIGGRAGYVTFYSNYENAFTVVEQIVRdsckvE 413 Trypanosoma brucei
Q4CVP8 172 LLTGTPGIGKSMAAGSYLLYQLLHYDAELLPVVAYSFCGrKAYVFNKTTE----TVTRYMDMSMMIKAVKELSR-----R 242 Trypanosoma cruzi

Q8WPT5 400 WLLGYIIYDFSKDRhqPIPADLPETWPVIVLTSPDPNNYKEWKEPRGCERFCINCYEEVELKAAVA--WRRLSKLEESKI 477 Trypanosoma brucei
Q8T9M2 414 NIKGYVIFDVGKNF--PAPMGPPVGCAGIVLSSPDIKQFYEWSKQNRALHIYINCDTLKDLEAIHIsrWGKIAPAYGWNP 491 Trypanosoma brucei
Q4CVP8 243 GMKGYIIYNVGGRLdtPSPFLPPGGWGMLVVATPEKTSYIHWANEKRAVRIIMNCPDESDVKAMCV--WKKRNQP---PP 317 Trypanosoma cruzi

Q8WPT5 478 TEAHiINVENEWQKIEGWIKKVGPLPRQVLEgDERYKGRVRKINEALAEISRGDDGYYMQVLNGQVEWRQDWTTCMLAKL 557 Trypanosoma brucei
Q8T9M2 492 SDAK-EKIESEWQEIQDRIPIVGPLLRHIVD-SASFTRQCDLIEEAINEMSDVKKESYAKVFQNAATWQTRKASHRLVRV 569 Trypanosoma brucei
Q4CVP8 318 QQAE------YWREVKGRMDKLGPILRYIFY-EGSYKYWIAKCHDLVDGTPSWGIQSY-SVFGTSKLWEGNKVLEYLARI 389 Trypanosoma cruzi

Q8WPT5 558 VRVVTE-NgEECRN---RAVSAYIEQK----LRVWVdtacMRDNYLRKGFRGKAEHTADEFENVGIYAFTMINVVQTIVA 629 Trypanosoma brucei
Q8T9M2 570 VRVKKG-N-LLCDSylcTPLSSYTGQVildfLRPWL----LNKYAAMSALLSNRAIAAYMFEKSGIEALSHENTLIELAK 643 Trypanosoma brucei
Q4CVP8 390 VRARGErNgESPFN---APITAHLASKtlckLAQLMtqaeFNLFVSR--IRDCLMHA--NFGKCAMFAFLNVAFMAAIRR 462 Trypanosoma cruzi

Q8WPT5 630 HLRYLP 635 Trypanosoma brucei
Q8T9M2 644 ELRGLP 649 Trypanosoma brucei
Q4CVP8 463 KLKELK 468 Trypanosoma cruzi
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