9G40


Conserved Protein Domain Family
Cnn_1N

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pfam07989: Cnn_1N (This model is not part of the current CDD release)
Centrosomin N-terminal motif 1
This domain has been identified in two microtubule associated proteins in Schizosaccharomyces pombe, Mto1 and Pcp1. Mto1 has been identified in association with spindle pole body and non-spindle pole body microtubules. The pericentrin homologue Pcp1 is also associated with the fungal centrosome or spindle pole body (SPB). Members of this family have been named centrosomins, and are an essential mitotic centrosome component required for assembly of all other known pericentriolar matrix proteins in order to achieve microtubule-organising activity in fission yeast. Cnn_1N is a short conserved motif towards the N-terminus. Motif 1 is found to be necessary for proper recruitment of gamma-tubulin, D-TACC (the homolog of vertebrate transforming acidic coiled-coil proteins [TACC]), and Minispindles (Msps) to embryonic centrosomes but is not required for assembly of other centrosome components including Aurora A kinase and CP60 in Drosophila.
Statistics
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PSSM-Id: 518013
Aligned: 74 rows
Threshold Bit Score: 36.7451
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
9G40_u         61 KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASK 129  human
Q0U191        510 KEQNSKIDKLSKENFDLKLKIHFLDQALQNRSDEGVKDMISKNVQLQTDLATEKKETQSLRKKLRDLER 578  Parastagonospora nodorum...
XP_003848466  364 KEQNSKIDKLTKENFDLKLKIHFLDQALQNRSDDGVRELIEKNVQFQTDLANERKEAQSLRKKMKEMEK 432 
XP_007931775    4 KEQNAKTDALTKENFDLKLKIHYLSEALHKHSEEGVDELIATNVQLQTDLANERKDANALRKKLREYET 72  
XP_016756935  164 KEQNAKMDALTKENFDLKLKIHFLSQALQNRSEDGIKELVDTNVQLQTDLANERKENATMRKRMRDMEM 232 
EME39757       37 KEHTKHLDTLTKENFDLKLKITFLEDAIRTRSQDGVEDLINQTVSLQTELAHERRETQSMRRKVRTLEQ 105 
XP_007872108  226 REQSNVIDSLRKEKWDLQMKVFFLQQYRDRSRDESVEEIIKQNIELATTVRELSKTNKNLKRIIRDMEM 294 
CCG80674      204 KESSAQIDALLNENWGLKMKIMFMDQHFEQDRE--KAELIAENVRLQTNGFNFVQQVKARDKTIRSLQK 270 
XP_001316634  351 KKQDEAIKNLQKENENLKNEIKILEENQKSGENDGWGDDEDENTELKNQIDQLKKENDNLKKQIQNLQT 419 
CCE88857      117 KELQGESQKLETENYNLKIKLATLTRFLDQTPE-EQRELLSQNVELKQQILQLTREIQTLKDSVRDLNf 184 
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