Conserved Protein Domain Family
C1_4
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pfam07975: C1_4 
TFIIH C1-like domain
The carboxyl-terminal region of TFIIH is essential for transcription activity. This regions binds three zinc atoms through two independent domain. The first contains a C4 zinc finger motif, whereas the second is characterized by a CX(2)CX(2-4)FCADCD motif. The solution structure of the second C-terminal domain revealed homology with the regulatory domain of protein kinase C (pfam00130).
Links
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Statistics
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PSSM-Id: 336887
Aligned: 10 rows
Threshold Bit Score: 76.7514
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q6BZG1 451 YCYGCLLKFPSGIKNTDVNEdgktkmdsLTSSRYRCGKCQNDFCIDCDVFVHESLHNCPGCEN 513 Debaryomyces hansenii
Q6C7M6 377 FCAGCQSKFPVVARDAKNIQad-----gSMTSRYECPTCHSHFCIDCDVFCHEILHNCIGCQA 434 Yarrowia lipolytica
O74995 364 HCFACQLPFPKPPVSPFDES--------TSSMRYACPSCKNHFCLDCDVFAHEQLHECYGCQC 418 Schizosaccharomyces pombe 972h-
Q7PPS5 350 NCYACQKTLASGTDK----------------MVYECDACKQVFCIDCDIFIHETLHSCVGCTT 396 Anopheles gambiae str. PEST
Q9VNP8 355 ECYGCAKALGQGVDKVAD------------KVVFRCGFCKQFFCVDCDIFIHDTLHACVGCNT 405 fruit fly
Q9ZVN9 361 SCFGCQQSLIGAGNKPV--------------PCVTCRKCKHYFCLDCDIYIHESLHNCPGCES 409 thale cress
Q86KZ2 368 TCIGCLSSSEKSILS----------------LFFSCPRCQEIFCLDCDLFIHESLHNCPGCEN 414 Dictyostelium discoideum
Q6CNV5 426 YCFGCQKRFPTLRNNKTGEL--------LTSSRYRCEECDQDFCIDCDVFIHETLHNCPGCES 480 Kluyveromyces lactis
Q759D9 411 NCFSCQKKFPRLRNYKTQDL--------LTSSRYRCENCKCDFCIDCDVFVHEILHNCPGCES 465 Eremothecium gossypii
Q6FTA5 380 NCYSCQMKFPIIKSQKSNQM--------LTSSRYRCEECKNDYCIDCDVFIHESLHTCPGCES 434 [Candida] glabrata
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