Conserved Protein Domain Family
COPIIcoated_ERV

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pfam07970: COPIIcoated_ERV (This model is not part of the current CDD release)
Endoplasmic reticulum vesicle transporter
This family is conserved from plants and fungi to humans. Erv46 works in close conjunction with Erv41 and together they form a complex which cycles between the endoplasmic reticulum and Golgi complex. Erv46-41 interacts strongly with the endoplasmic reticulum glucosidase II. Mammalian glucosidase II comprises a catalytic alpha-subunit and a 58 kDa beta subunit, which is required for ER localisation. All proteins identified biochemically as Erv41p-Erv46p interactors are localised to the early secretory pathway and are involved in protein maturation and processing in the ER and/or sorting into COPII vesicles for transport to the Golgi.
Statistics
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PSSM-Id: 517998
Aligned: 154 rows
Threshold Bit Score: 152.376
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_014174682 141 CYGATPPQhaikTGCCNTCDEVREAYASSSWAFGKGENVEQCQREHYAERIDEQRH--EGCRIEGGLRVNKVVGNFHIAP 218
XP_001319353 138 CYGAAS-------GCCNTCKDVKNAFKKKGRVPPSLSTIRQCR----DAVIDYNHIrnESCHVYGTVIVPPTHGTIVMNS 206
XP_001309782 122 CYGTEFAEg---SRCCNTCEDVVSHHIKAGRPLTNVTTWQQCINE------KYDFTgkEKCQIFGNHHVSAIDGGIRILP 192
XP_001299739 123 CYGAESSQ----RKCCQTCEDVVAAYQEKGWGIGNLSSWAQCRAE------GVMFDgkERCQAYGNLHVNAIEGGFHLAP 192
XP_001313964 144 CYGALPQG-----KCCNSCEDVINAFKAKGWGIDGIDRWQQCIDEGYADLGK------ESCNVYGDINVAHISGFLYFA- 211
XP_001582023 138 CYLSTDKK------CCNTCREVMDVFKAKGLTYYASFRWEQCIREGVLDFGN------ETCRIKGKLKVKKQSGNFHIAL 205
XP_001580938 129 CHGLKPEG-----ECCNTCDEVKAIFEARGEDFN-PLPFDQCM-----GNVNFKKDmsESCLIEGTIHTFKSPGQFHIAP 197
EAY11795     130 CYGLLPEG-----SCCNSCEQTLLLHIMNGKAAN-TKDWPQCQ-----GKNPGKVYenEKCRIKGKVCLNKAQGNFHIAP 198
XP_001307985 130 CYNLSTNP----DECCNSCLKVQLLSLMQNKPVD-FSKYRVCN--NYEKKPNVSLS--EKCLVKGKLTVNRIPGSFHIAP 200
XP_001295947 103 CYDFYDNR-----FCCNGCEKLKEIYHSNNKTAT-PENWTQCK-----PENKQKFDpnEKCHVKGKISVNRVPGSFHLAI 171
XP_014174682 219 GRSFSN--GN------MHV-------HDL--KNYWdmPT---PNLHSFTHTVHSLRFG-PQLPESlqktlagggakgqpw 277
XP_001319353 207 GDSYGAqmNTttsslgISI-------D-----------------DFNFTHKINDIYIGeNDLGD---------------- 246
XP_001309782 193 RFSSNE-------------------------------EPf--TKLLNLTHYIDHITFGtSFGP----------------- 222
XP_001299739 193 GINVFSr--------fGHV-------H----------DFsplVDTLNLTHEIEHISFG-APIDK---------------- 230
XP_001313964 212 --------LEdykvgdKHPkdisrlsH-----------------KYNLTHTINYLEFG-PRVSHEp-------------- 251
XP_001582023 206 GANTNDnyKG-------HS-------HDL--SSVD--------ASHKLNHVIHSLTFG---------------------- 239
XP_001580938 198 GRNTKFrrTG-------HQ-------HDTglSP-----------EASCPHTIHEFYVG-QKYDNVr-------------- 237
EAY11795     199 GTNMKEr-YG-------HV-------H----------DLsgqLPNFDLSHVIQGMRVG-PKIPLTy-------------- 238
XP_001307985 201 GTNVPQs---------AYL-------H----------DLssmQMFHDMTHSIQRLRFG-PHIPRTs-------------- 239
XP_001295947 172 GQSIED--YG-------HQ-------H----------ILlddYQTITFDHDIIDLRFG-ANIPMTs-------------- 210
XP_014174682 278 tnhhiNP-----------------LDGVmq--qTsdpnFNYMYFIKIVPTSYLAL-GWektfrgfvddhdsadvgsygll 337
XP_001319353 247 -----HP-----------------LKGIkk-vqKevgrYKGLYFIRTLREQKGSLq------------------------ 279
XP_001309782 223 -----QP-----------------LDDAli-vqSepgqFHYRYDLKAVPTVMHNQdGS---------------------- 257
XP_001299739 231 -----SP-----------------LDNTrv-vqKkpgqIHYRYNLKAVPTVKEVNgK----------------------- 264
XP_001313964 252 -----GP-----------------LDGLtv-lqEepglMQYNYDLEVVPTKWFSSrGF---------------------- 286
XP_001582023 240 -----EPvdyykpqltdvemqlpeLNGSn--------yWMVTYYLHAAPERISTT-DK---------------------- 283
XP_001580938 238 -----SP-----------------IRGKif-rdRdslpRIYLYDLFITKVLHTFNdAL---------------------- 272
EAY11795     239 -----NP-----------------LRYVqq-iqNpnqpVVYRYDLVVTPAVYKSGnRI---------------------- 273
XP_001307985 240 -----NP-----------------LDNFksfqqIpthdRTYFYNLLITPVIFYRDgVE---------------------- 275
XP_001295947 211 -----HP-----------------LRGThi--kStgepLATEYNLIITPIVFYADgQY---------------------- 244
XP_014174682 338 adgsVE-THQ----YSVTSHKRSLQGgdDAaeghqerlhARGGIPGVFFSYDISPMKVVNREERAkTFAGFLAGLCAIIG 412
XP_001319353 280 -------VYR----ATSSHYDRYREGttGK-------------FPGLYFNYDVSPIIVMYKRDT--TVLNFVIELMAILG 333
XP_001309782 258 ----IThGFQ----YAVDSAKIPITDrtRL-------------GEGIFFNYYFATVAVVGKPDRF-TIYILISRLFCIFG 315
XP_001299739 265 ----VHrFFR----FTVNYAEIPVTArgRY-------------GPGIFFVYSFAPVAITSTYDRP-NITVLLARLISIFG 322
XP_001313964 287 ----PVsTYK----FHPMITQKNFTEkvNRg------------VPGIFLNYNLAPISLVQYEVIS-SPWKLITSVCAIVG 345
XP_001582023 284 ----ID-SYR----YSAFPSRRKVTNk------------TKKGFPGIVFYYDFAPMIVVYQPTHG-SIRSIIVDICGIVG 341
XP_001580938 273 ----QYtSYE----YSYNLGAKIFNPgsFY-------------QPGIYFKYMFSPMTIVERSISK-NPMRFLVTSVGVLA 330
EAY11795     274 ----LGkGYD----YTAMINRFFVGNsgG--------------APGIYFHYSFTPYGVTVNATYL-TIAQIFTSIFGFMS 330
XP_001307985 276 ----YLkGYE----YTAFSEAIDTFQlfGI-------------SPGLFFQYQFTPYTIVVSANRQ-NFLQFISNTFGVIS 333
XP_001295947 245 ----IEkGFEyvyfYSMTYHL----------------------VPGIYFYYSFTPYTIAVTWQSR-SFRSFLISTGGLLS 297
XP_014174682 413 GTLTVAAAVD 422
XP_001319353 334 GIYSLGSLLD 343
XP_001309782 316 GGFFLARLID 325
XP_001299739 323 GSFMLARLID 332
XP_001313964 346 GCFTCVSLAD 355
XP_001582023 342 GAFSFAAIID 351
XP_001580938 331 GIFAFLNAVg 340
EAY11795     331 GAYAIFSIID 340
XP_001307985 334 GIYACLSILD 343
XP_001295947 298 GIYAIFSMVs 307
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