Conserved Protein Domain Family
zf-C3HC

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pfam07967: zf-C3HC 
C3HC zinc finger-like
This zinc-finger like domain is distributed throughout the eukaryotic kingdom in NIPA (Nuclear interacting partner of ALK) proteins. NIPA is implicate to perform some sort of antiapoptotic role in nucleophosmin-anaplastic lymphoma kinase (ALK) mediated signaling events. The domain is often repeated, with the second domain usually containing a large insert (approximately 90 residues) after the first three cysteine residues. The Schizosaccharomyces pombe the protein containing this domain is involved in mRNA export from the nucleus.
Statistics
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PSSM-Id: 400358
View PSSM: pfam07967
Aligned: 23 rows
Threshold Bit Score: 114.391
Threshold Setting Gi: 150865770
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001385117 100 PFNADQLVARLKTFTALN-WhipslpscegVVSENTLNELKCARNGWKCvsFSlnn-ntKNHLLCT-TCNQSLVLKfseg 176 Scheffersomyces...
XP_001485757 109 PYSRPQLLHRLASYTALN-Wslpe---salALKLWEVSELKCAQNGWRC--VSirnsnlKNHLVCD-VCHHQLILRynev 181 Meyerozyma guil...
Q0CK85        87 PWDRERFLERLETFRRVDwW----------SPKPTAINEVEWAKRGWVC--TD------VSRVTCAgVCGGSVVVKlpde 148 Aspergillus ter...
CAK48313     208 PWDRERFLERLETFRRVDrW----------APKPSAISEVEWAKRGWVC--TD------VARVTCAgNCGGSVVVKlpde 269 Aspergillus niger
XP_001595977  58 PYDRAEFLKRLKSFSNLTdW----------TPKPARVNEVEWAKRGWVC--QK------KERVRCC-FCNVEILVKlnkk 118 Sclerotinia scl...
Q7RZE5       131 PGDRNQLVRRLATFQELTdW----------TPKPDRVNEIEWAKRGWVC--QG------KERVKCT-LCNNELAVKlnrk 191 Neurospora crassa
Q2GS01       131 PGDRDQLLRRLTTFQELTdW----------TPKPDRVSEVEWAKRGWAC--QG------KERVKCT-LCGRELVVKvnrk 191 Chaetomium glob...
Q5KC46       119 PFSALSLLSRLMTFQPYT-Ys---------PQHPLTLSPVRAAMKGWVN--EG------REGLKCD-VCGARWGLG---- 175 Cryptococcus ne...
O94506        40 PWSREEFLRRLLTYRSR--Wa---------YVNDPQIGEINCCLNGWLC--ES------NNILVCD-VCRNKINLTal-- 97  Schizosaccharom...
EEC71045      95 PWDRADLMRRLATFKAMT-W----------FAKPKVISPVNCARRGWIN--IE------PDVITCE-ACEARLLFS---- 150 long-grained rice
XP_001385117 177 qqqkeysafdydflkNSSIEASCNQLNNALHNKYLDQVVyEGHSPSCSWRNFETPlEGIYYPRpyLNKTnERLLRDYLKN 256 Scheffersomyces...
XP_001485757 182 -----------hdsiFDFDVEEVAQLNVNLARSYLKQITtKAHGTACPWQSLETPlQGVYYMRpfLKNTnETLLAEYRKA 250 Meyerozyma guil...
Q0CK85       149 ld--------eldgyDIEKVQERKEVRSKLVDEYAGLIV-QGHGQNCPWKNRGCD-ATIHRLP--LANH-DTAITGLETR 215 Aspergillus ter...
CAK48313     270 ld--------eldgfDADKVQERKEVRAKLVDEYVERLV-KGHGETCPWRNKGCD-ATIHRLP--LANP-DIAISGLEKR 336 Aspergillus niger
XP_001595977 119 -----------eedgKEKEVYIAENIENALIDKYVELII-TSHDESCPWRQRGCD-DVIFKLP--LNKP-AVTIQTLRER 182 Sclerotinia scl...
Q7RZE5       192 -----------evdgKEIPVLIAADIAESVVDQYVELII-TSHREDCLWRKKGCD-DSLLRLP--LPNP-KLALETLRQR 255 Neurospora crassa
Q2GS01       192 -----------evdgKEVAVLIASEVAESVVDAYAALIV-ESHAEDCLWRKRGCDgEEREEVP--LPAAwEVLVVGLRNe 257 Chaetomium glob...
Q5KC46       176 ----------------GLEKVRDEAMKSNLGERLAKGFE-ERHEKNCAWRICASPgNLYEQLRhlVHPPiTSSLAPLAS- 237 Cryptococcus ne...
O94506        98 -------------qqVDAENDSLNELPEKTKERLEVSLK-EEHQDNCLWRLHKFPpDIYHLSV-------SAELVQVGRR 156 Schizosaccharom...
EEC71045     151 -----------------TPSSWAPQQVEKAAAVFSLKLD-NGHKLLCPWIDNICD-ESLALFP--PTPP-PVLVENYHEG 208 long-grained rice
XP_001385117 257 LKNLM-----DNGMILNE 269 Scheffersomyces stipitis CBS 6054
XP_001485757 251 LSGLVrh--wRVLELQIS 266 Meyerozyma guilliermondii ATCC 6260
Q0CK85       216 YSHVVkl--aDQLPSQDI 231 Aspergillus terreus NIH2624
CAK48313     337 YSNLIkm--aDQLPAADV 352 Aspergillus niger
XP_001595977 183 YDELQqr--aEHLPYLSN 198 Sclerotinia sclerotiorum 1980 UF-70
Q7RZE5       256 YDELCqr--kDFLPYEFN 271 Neurospora crassa
Q2GS01       258 ----------AFIRERVA 265 Chaetomium globosum CBS 148.51
Q5KC46       238 --HLLle--cLALPSLRL 251 Cryptococcus neoformans
O94506       157 FNSLStrlvsTHLPEEMT 174 Schizosaccharomyces pombe 972h-
EEC71045     209 FSSLLr---lSALPRisc 223 long-grained rice
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