Conserved Protein Domain Family
Fucose_pyrophosphorylase

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pfam07959: Fucose_pyrophosphorylase (This model is not part of the current CDD release)
Fucose pyrophosphorylase domain
This entry represents the fucose pyrophosphorylase domain found at the N-terminal of the bifunctional L-Fucokinase/GDP-Fucose Pyrophosphorylase (FKP) enzymes such as FKGP from Arabidopsis and L-fucose kinase from animals. In fucose-1-phosphate guanylyltransferase from human, this is the main domain of the protein, which catalyzes the formation of GDP-L-fucose from GTP and L-fucose-1-phosphate and functions as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids. In the salvage pathway of GDP-L-fucose, free cytosolic fucose is phosphorylated by fucokinase to form L-fucose-L-phosphate, which is then further converted to GDP-L-fucose in the reaction catalyzed by GDP-L-fucose pyrophosphorylase. The structure of this domain has been determined; it consists of a typical Rossmann fold and a left-handed beta-helix fold inserted on it. This domain contains a loop region that is critical to the GDP-fucose pyrophosphorylase activity of FKP and may be the putative GTP binding site during catalysis (which contains the HXGGXSXRXP(X)5GK motif).
Statistics
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PSSM-Id: 517991
Aligned: 36 rows
Threshold Bit Score: 326.199
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CBJ29017       113 PQGLAAARVLLVHSGGDSQRSPTQCVCGKAWSALNSCGdsgsg-----rcntPMDLLLEHLSRLFSGGSSGSl--EPgTL 185 
XP_003290380    23 SDILKNKRILLLLNGGIHQHAPLVNLCTKSFSMLPLNNkfvgd-----spvyPIDILLSNLNVILPH--------AQpGF 89  
10_pfamImport    1 ADVLHDAHILILHTG----RDFPWSSCSRAFCWLPLesa-----------dqSVHAPLCCLDLLLDRLGRQVcpgSPpGV 65  
14_pfamImport    1 ADVLDDAHILILHTG----RDFPWSSCSRAFCWLPEekp-----------gqKVQAPVCVLDLLLDRLSTQIcpgSPpGV 65  
4_pfamImport     1 ADVLDEAHVLILHSG----RDFPWSSCSRAFCWVPAPeep----------ncRVQAPVCCVDLLLDRLSTNIcpgSPpGV 66  
XP_004175035    80 ADVLRDARILILHMG----RDFSFDDCGRAFTCLPAedp-----------gaPAEALVCNLDSLLGTMTHRLcvgSPpGV 144 
11_pfamImport    1 SDVLQNAWILILHMG----RDFSFDDCSRAFTCLPLedp-----------saPVEALTCNLDNLLATLTCQVsggSPpGV 65  
5_pfamImport     1 SDVLQSAWILILHMG----RDFPFDDCGRAFICLPVenp-----------qaPVEAVVCNLDCLLDIMTHRLgpgSPpGV 65  
Q7TMC8          82 SDVLHSAWILILHMG----RDFPFDDCGRAFTCLPVenp-----------qaPVEALVCNLDCLLDIMTHRLgpgSPpGV 146  house mouse
XP_002176423    83 DD--EACSILVIHAGGESSRCPTQMILGKAWTSLPTMSsvgspgvatcrlqtPVHVWLRICERLFRGIPNG-------SI 153 
CBJ29017       186 VVTACDVMLLVPPEvaATADWSFDQQsga-agGVAGLAIAADAaKYASNHGVYCLDg-----gGGGGGqe---sHGITGV 256 
XP_003290380    90 MVCSTESLIFL-----DLNDKNLNSPsswqkpGVSVITMDVGP-DYYTNHGVCRLN-------------------EKDEI 144 
10_pfamImport   66 WVCSTDMILHIPPDfvlsw---------egfsGVRVLALPGDV-SYALNHGVYLSD-------------------QQGRV 116 
14_pfamImport   66 WVCSTDMILSVPTHcvlsw---------egfsGVRVLAVPGDV-SYAADHGVYLSD-------------------SQGRV 116 
4_pfamImport    67 WVCSTDMILNIPPDftlsw---------ngfsGVRVLALPGDA-SYAADHGVYLSD-------------------PQGQV 117 
XP_004175035   145 WVCSTDMLLTVPSTpginw---------dgfqGVRVIAVPGSP-AYARNHGVYLTN-------------------EQGLV 195 
11_pfamImport   66 WVCSTDMLLTVPSVpkidw---------hgftGARVVAMPGSF-SYAKQHGVYLAD-------------------GQGFV 116 
5_pfamImport    66 WVCSTDMLLSVPPNpgisw---------dgfrGARVIALPGSS-AYARNHGIYLSD-------------------SQGFV 116 
Q7TMC8         147 WVCSTDMLLSVPPNpgisw---------dgfrGARVIAFPGSL-AYALNHGVYLTD-------------------SQGLV 197  house mouse
XP_002176423   154 VVLAADTLLRLPDSk-FAIDWEAHAD------TVFGLAVPAPL-ATASNHGVFVLPpmrtnavPGASDqssepvIQVEPC 225 
CBJ29017       257 RKYLQKPSREEAEASGAFlnpggmaapknesgnpnhdpSANPEVAIDSGVVVFSGAATRALTSLAHsetfkgctsr---- 332 
XP_003290380   145 LEIAYKRSAEYLSNNGFI--------------------SKEDKASIYTGLVFFCQKTTEKLLYLHNtppldsctyl---- 200 
10_pfamImport  117 RDIVYKGREEQLVPAV----------------------MPDGKVPLVSGPVFFSSLVSEKLLLTHVtppldgctyl---- 170 
14_pfamImport  117 RDIIYRGTREEIQRAL----------------------MPDGKVPLVSGPVFFCRSVSEKLLQTHVsppldgctyl---- 170 
4_pfamImport   118 RDIIYRGTREQIQQAV----------------------MHDGKVPLVSGPVFFSRSISEKLLQAHVtppldgctyl---- 171 
XP_004175035   196 RDIIYKGTEAQIQQCA----------------------GPDGTVPLVCGIVFFSSDAAEQLLATHVvppldactym---- 249 
11_pfamImport  117 QDIIYQGSEDQIQRCV----------------------GSDGKVPLVSGIVFFSSEAAEQLLATHVipplnactyl---- 170 
5_pfamImport   117 LDIYYQGTEAEIQRCA----------------------RPDGRVPLVSGIVFFSVETAERLLATHVsppldactym---- 170 
Q7TMC8         198 LDIYYQGTKAEIQRCV----------------------GPDGLVPLVSGVVFFSVETAEHLLATHVsppldactym---- 251  house mouse
XP_002176423   226 HDVLQKPSQSTLQAHCQFk------------------qNGQACAWIDTGVIVFLPTTATILRRLAFddellsrctastlq 287 
CBJ29017       333 ----------------gvaggasalRLELYSDLLLALrtgggtgesAEGTLDAYLEA-----------CGHVLPPDHDVS 385 
XP_003290380   201 ----------------gvdsgsqllKFGVFPDILCAMt--------KHETLESYLNQpc-------fpGSNK----KLVE 245 
10_pfamImport  171 ----------------gldsgapplQISLFLDVLKCLc--------SDVTQDRFVSEdrtgcsspvgpQG------ATVR 220 
14_pfamImport  171 ----------------gvdsgapplQISLFLDLLKCLc--------SDLTQDQFVNEgragcsptdglQG------ATVR 220 
4_pfamImport   172 ----------------gldsgapplQVSLFLDLLKCLc--------SDLTQDQFVTEdragcsspvgpEG------ASVR 221 
XP_004175035   250 ----------------gldsgappiQLSLFFDIVLCMa--------GGMTEEDFVKG-----------GGD-----ASVR 289 
11_pfamImport  171 ----------------gldsgappiQLSLFFDILLSMa--------RGVSEEAFVNGlgpr----tggSGDNTQSEAALW 222 
5_pfamImport   171 ----------------gldsgarpvQLSLFFDIVLSMa--------RNVSKEDFLVGrpp-----emgQGDVGIA-AYLQ 220 
Q7TMC8         252 ----------------gldsgaqpvQLSLFFDILLCMa--------RNMSRENFLAGrpp-----elgQGDMDVA-SYLK 301  house mouse
XP_002176423   288 smqnrhladgdspesalikaqdasfRFDLYTDLLQALp--------MVASMDDRLDNgkvt----qgpSYAVLRE--SFR 353 
CBJ29017       386 KARREIWDALSGFPLGAL--LLQGATFVHLGTT-PELMEMLTLRLpefiEPYGLTARASSVVGa---------ACSVEN- 452 
XP_003290380   246 GARKIVWKTFRDIELHSIk---iKGNYYYFKNP-MDFLNFIHNNG-----KYQISRKMHSFIAtk--------------- 301 
10_pfamImport  221 RGREELWRILRGTPLTVA--YVPGGCYDYLTLSgKQHVERLSRDWt--------DRNVLSHI--------------QKEr 276 
14_pfamImport  221 AGRAELWRILRGAPLSLV--YVPGGCYDYLTLSgKQHVDRLTSDWt--------VGNTLSHI--------------QNEn 276 
4_pfamImport   222 RSRAELWRLLRGETCTLLysYVPGGCYDYLTLSgKHHVQRLCCDWm--------NRNTLSHIQ------------FQREs 281 
XP_004175035   290 NARSVLWTALRGFPLSMA--CIPNASYDYMTASaSDHIRSLTLLPss-aSHLRFCKTAHSHV--------------DQPc 352 
11_pfamImport  223 SARAVLWKTLHTMPLIMG--NIVTDLYIYV-----------------------------SHVFcafhlllflpVLLQEPg 271 
5_pfamImport   221 GARAELWRELRDQPLTMA--YVPDGSYSYMTSLaSELLHSLTVPStp------rAQTVHSQV--------------EELe 278 
Q7TMC8         302 GARAQLWRELRDQPLTMV--YVPDGGYSYMTTDaTEFLHRLTMPGva------vAQIVHSQV--------------EEPq 359  house mouse
XP_002176423   354 SCR-----------LSVM--TIPSGRFLHLGTT-RELLDFYTHGC-----HSNTEPLTASMSPpqal------------c 402 
CBJ29017       453 --DPPAVVVNSSL------HGAGVVAGGAVVEHCYFdRDG---WEVGAGSLISGIRSLEed--cHLRLRGGMCLQQTDLd 519 
XP_003290380   302 -sPCNGVVINSIL------LGNGKCSDTSIIYSSVL-SGN---WSVGEDSIVFGAKSLSa----NYHIKDRMIVNEIRLk 366 
10_pfamImport  277 gvDPGARIINSVL------EEDVAVATGAVVQHCHL-KGP---LKVPAGCLLSGLSSAAsqclrQLDLGADIIVQGHHI- 345 
14_pfamImport  277 llSEGARIINSIL------DGGVTVATRAVVQHCHL-QGP---LDVPSGCLLSGVDVSAsaclrRLALSSDIIIQGHRI- 345 
4_pfamImport   282 avRDGGRVINGVL------EGDIAVATGAVVQHCHL-QGP---LEVPSGCLLSGLPLMTsqclrQLQLADDIIIQGHRI- 350 
XP_004175035   353 llEDGSSVTNCVL------EGAVQLAAGSVIQHCHL-QGP---LVIGPGCLLSGLDVDSspalrGCPL-RDVVLQGHRV- 420 
11_pfamImport  272 llEEGCSVTNSLL------EGAVFVGPGTAIQHCCL-KGP---LQIHSGCLLTGLDGDSsealrGHHL-KDVVIQGHAV- 339 
5_pfamImport   279 llEPGSSVVSCVL------EGPVWLGPGSVLQHCHL-RGP---IHISTGCFLSGLDIAQsealhGMEL-RDLILQGHHM- 346 
Q7TMC8         360 llEATCSVVSCLL------EGPVHLGPRSVLQHCHL-RGP---IRIGAGCFVSGLDTAHsealhGLEL-HDVILQGHHV- 427  house mouse
XP_002176423   403 reFGTSLALTRRLeaftlvGPYGQIDPSAIIMHSSI-QDSlsmESVGSl---------------PMVIPDNTIVQQVRRv 466 
CBJ29017       520 r--asPEETASRFVVSLFGARDDIKAHYSADRARVCGATWEAFFgytgataeDVWGGI-EEg-dRKLWSARLFPVLTR 593 
XP_003290380   367 pikmkHSSNETPRALLVLGIQDDLNLYFTDPNATIANRTWEEFLktsgiapeELWSKGl----pRILRTARLFPIIVD 440 
10_pfamImport  346 -----QLGDLKLRVYTVMGAQDPLEASFGDRGASFLNQSWSRFCsrtgiqpeEVW----LKpeqRSLLEARLFPVFSP 414 
14_pfamImport  346 -----QLGELKLNMYTVTGAHDDLQVPFNDSGASFLNQTWTVFFsssgikpeELW----VKgehCSLLEARLFPVLHP 414 
4_pfamImport   351 -----EVGGLKLSVYTVTGAQDVLEASSEDSGASFLNHGWSLFFsrtgiqseELW----VRgerRSLLAARLFPVLHP 419 
XP_004175035   421 -----RLRDLPCRVFTLTGRLDDWQSP--VEKATYLNVPWAEFFqrtglregDLWDAEmPRg-sRCLLSARLFPVLHA 490 
11_pfamImport  340 -----RLKGLSCKVFTLSGRHNRWE----VQDGTYLNARWSDLFlrtgirreDLWSGDvLPg-rGCLLNAHLFPVLHA 407 
5_pfamImport   347 -----RLHGSLGRVFTLTGRLDNWE----VGA-LHLPHLCPPNVpsppvrdwDLWDPDtPPt-eRCLLSARLFPVFHP 413 
Q7TMC8         428 -----RLHGSLSRVFTLAGRLDSWER---QGAGMYLNMSWNEFFkktgirdwDLWDPDtPPs-dRCLLTARLFPVLHP 496  house mouse
XP_002176423   467 p---qDEADTCACTLVVLGVDDKIKSLDG-----LYGRPLQDFMswaglsesDLWD---EEadhKMVWNARLHPSIKP 533 
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