Conserved Protein Domain Family
Nairovirus_GP38

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pfam07948: Nairovirus_GP38 
Nairovirus GP38
This entry represents the GP38 secreted glycoprotein from nairoviruses, including CCHFV and Dugbe virus. It is encoded in the glycoprotein precursor complex (GPC) from the M segment of nairovirus genome. It has a novel fold composed of a 3-helix bundle and a beta-sandwich. Although its function is unknown, it is immunogenic in humans and, therefore, an interesting vaccine target.
Statistics
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PSSM-Id: 489305
Aligned: 3 rows
Threshold Bit Score: 393.516
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q02004        115 TKFLMLLGFIPKGEVNHLENACNRE-GKNCTELILKERIARFFSETEKESCYNTYLEKHLRSV-SP---EVSLTPYrVLG 189  Dugbe virus (...
1_pfamImport    1 QRILAKMGMAVDFTDDELDTWCYRR-YSNCSSNDIESRIRDFFLITDRSECFDEVLVKRLCETtSP---IIDRAWK-IAG 75  
A6XIP3         51 QRILSAMGMDSDPSNEALNGVCQSIhSNGCNANELKLRLADFFIDTNSSQCYDEILVKKPCSS-LTpahNSHWVP---RG 126  Hazara virus ...
Q02004        190 LREDILLKEIDRRIIRFETDSQRVTCLS----ASLLKPDVfiR-EQRIDAKPsnGPKIVPVDSVACMNLEANVDVRSNKL 264  Dugbe virus (...
1_pfamImport   76 LKEEVVLREMGRRIFRFFTPALKVTCMSgslnPSNQFVRF--Y-NPTLERTS--GPTIQNYDGMHCLNIENGLIKPSKVV 150 
A6XIP3        127 LDKSEVDKIFDTKLKLFFSQSRKVTCLSa---SALNPSQFvkHfQVKIQETS--GPAKQSLRSLHCVNLVWSHSHKGEKE 201  Hazara virus ...
Q02004        265 VIQSLMTTVKISLKNCKVVVNSRQCIHQQTGSGVIKVPKFE--KQqggtwSSYIAGVYTATIDLLDENNQNCKLFTECIV 342  Dugbe virus (...
1_pfamImport  151 VINVLMTTVDIRLESCRAFINAQQCTYTQHADGLVRVPTFVgpHG-----EKRIIGAYTMSFNLTDEKNKACTIKTTCVV 225 
A6XIP3        202 VVHVLQSAVPVKLKNCLAMLNFRQCYYNQQSEGPVVVPSYQ--HNg----EKWVTGAYTMTVEVDKHADGPCEISTTCIT 275  Hazara virus ...
Q02004        343 KGRELVKGQSELKSFNIEVLL 363  Dugbe virus (isolate ArD44313)
1_pfamImport  226 KGKEVKKGQSQLRGFPTTIRL 246 
A6XIP3        276 EGSEIKPGVHSLRGFKTTLVI 296  Hazara virus (isolate JC280)
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