4OK4,4FNV,4MMI,5JMF,3AFL


Conserved Protein Domain Family
Hepar_II_III
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pfam07940: Hepar_II_III (This model is not part of the current CDD release)
Heparinase II/III-like protein
This family features sequences that are similar to a region of the Flavobacterium heparinum proteins heparinase II and heparinase III. The former is known to degrade heparin and heparin sulphate, whereas the latter predominantly degrades heparin sulphate. Both are secreted into the periplasmic space upon induction with heparin.
Links
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Statistics
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PSSM-Id: 489299
Aligned: 53 rows
Threshold Bit Score: 90.5347
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4OK4_B       375 ILLGDGADGDQGALSIHRLge--ghNH-MALVAKNTSQG--------MGHGHFDKLNWLLYDNGNEIVTDYG---AARYL 440 Saccharophagus ...
WP_000424785 308 APTEDDKVFPKSGYAIFRNdwskeeKA-TYVLFTAAYHV--------DYHKHSDDLNLYIYSNGE-IITEAG---PNGYN 374 Bacillus
Q0AT38       367 RLLRDGPDGNQGGLAILRM------GA-GELAQTLVAKHtg----qgMGHGHFDKLSLILYDGGQEILTDYG---AARFL 432 Maricaulis mari...
WP_015481708 397 MMLSDGSKGDEGGIGILRYnn---kDEtMALVYKYAAQG--------LSHGHYDKLSFSLYENGDEVLQDYG---LSRFV 462 Polaribacter sp...
4FNV_A       418 TPNNDMKLFDQAGYYVLRNgw--tpAS-TVMILSNNKSNdasnslsaYSHNQPDNGTFELYHNGRNFFPDSGvctYYTSG 494 Bacteroides the...
4MMI_A       362 APNFLSKALSNAGFYTFRSgw--dkNA-TVMVLKASPPG--------EFHAQPDNGTFELFIKGRNFTPDAG---VFVYS 427 Pedobacter hepa...
5JMF_A       382 LPDYMSXGFLKSGFFVFRNsw--gmDA-TQMVVKAGPKG--------FWHCQPDNGTFEMWFNGKNLFPDSG---SYVYA 447 Bacteroides the...
Q2YCG2       490 PPRANSIAFHDIGWVAMHSaivdplR--TSVYFRSSPYAa-------FGHSHADNNSFVLVSRDEPLLIASG---YYDWE 557 Nitrosospira mu...
WP_012198519 473 EKLERVKWFKDIGWVAINKdmkdpkEH-IFLLTKSSPYGs-------VSHSHGDQNSFVLFAYGEPLIIKSG---YYIGF 541 Lachnoclostridi...
3AFL_A       490 ADLPALAVFDDIGWATIQKdmedpdRH-LQFVFKSSPYGs-------LSASHGDQNAFVLYAHGEDLAIQSG---YYVAF 558 Agrobacterium f...

4OK4_B       441 NveakygghylAE-NNTWAKQTIAHNTLVVNEQ--S------HFYG-DVTTADLHHPEVLsfysgED-YQLSSAkEANAY 509 Saccharophagus ...
WP_000424785 375 Y----------KDpFTEYAYSSFAHNTLIVDGK--Gl----pRTDR-QYEKVYLSDYEIN-----KDkVEATGI--NLRY 430 Bacillus
Q0AT38       433 NvpskdggrylPE-NSSWARQTIAHNTVVLNET--Shh--ggDWRRaQESWPSIALFEQR-----DGvNVVSAS-ISDAY 501 Maricaulis mari...
WP_015481708 463 NveqkngggylKE-NKTYAKHTIAHNTVVQNGV--Shy--kyDFET-GSKNHPEQFIFDAt---dAKfQIVSAK-ESNAY 532 Polaribacter sp...
4FNV_A       495 Gd---------ND-LRYWFRGIDKHNTLSIGKQ--------------NIKKAAGKLLKSE-----EGaTELVVF-ENQGY 544 Bacteroides the...
4MMI_A       428 Gde------aiMK-LRNWYRQTRIHSTLTLDNQ--N------MVIT-KARQNKWE----T-----GNnLDVLTY-TNPSY 481 Pedobacter hepa...
5JMF_A       448 Geg------evME-QRNWHRQTSVHNTVTLDNXnlEt----tESVT---------XLWQP-----EGnIQTLVT-ENPSY 501 Bacteroides the...
Q2YCG2       558 G----------SPhWKQWYWQTKAHNAITFDGGk-Gq----aEKTG-SGKMTAKGQLTEFq---sNGkVDFTEGdATPAY 618 Nitrosospira mu...
WP_012198519 542 N----------TTmHRNFRRQTLSHNSILINGK--Gqy--agMDKA-KQLSAKGHICEVKe---sDNlVYIKED-ATAAY 602 Lachnoclostridi...
3AFL_A       559 N----------SQmHLNWRRQTRSKNAVLIGGK--GqyaekdKALA-RRAAGRIVSVEEQ-----PGhVRIVGD-ATAAY 619 Agrobacterium f...

4OK4_B       510 -----DGVEFVRSMLlvnVPSlEHPIVVDVLNVSADKAstfdlpl--yfngqiIDFSFKV-KdnKNV------------- 568 Saccharophagus ...
WP_000424785 431 -----TGVEHSRTVSy-mKDE-EKIVVKDLVKSDKRHE---------------YKLLWHV-A--SDItvhv--------- 476 Bacillus
Q0AT38       502 p----DATLTRTTFQlqsENT-ASPLILDVFDVVADEPsqidlptyfagqltdFDIAFER-F--GSQ------------- 560 Maricaulis mari...
WP_015481708 533 -----PGTEMHRTLImikDDAlEKPFIVDVFNLQSNSKn-------------qYDLPFHY-F--GQIiatsfdytvpksl 591 Polaribacter sp...
4FNV_A       545 -----DNLKHRRAVFy--VNK-KFFVLVDEGIGNAEGT---------------INLSFNL-CegTAS------------- 587 Bacteroides the...
4MMI_A       482 -----PNLDHQRSVLf--INK-KYFLVIDRAIGEATGN---------------LGVHWQL-K--EDS------------- 522 Pedobacter hepa...
5JMF_A       502 -----KNFKHRRSVFf--VDN-TYFVIVDEVSGSAXGS---------------VNLHYQM----PKG------------- 541 Bacteroides the...
Q2YCG2       619 eg--aLQQARRRLWYl--RNK-NVLIIHDSLRSATPRQ---------------FEWNIHAlN--PFEikep--------- 667 Nitrosospira mu...
WP_012198519 603 qltapELTKYTREIYf--VDD-SYFILVDTVESEDKSD---------------VEWLLHS-L--SKFqiee--------- 652 Lachnoclostridi...
3AFL_A       620 qvanpLVQKVLRETHf--VND-SYFVIVDEVECSEPQE---------------LQWLCHT-LgaPQT------------- 667 Agrobacterium f...

4OK4_B       569 -------------MKMLGkrNGYQh-------------lWLRNTApvgDAseratWilddrfySYAFVTStpsk----kq 618 Saccharophagus ...
WP_000424785 477 ----------rdrIVELFrnNHKVmemevttvtgvsiraLNEQTKpqvSG-----W-------VFPKMGEkrga----tt 530 Bacillus
Q0AT38       561 -------------QTALGa-GNGYqhlwve----aqseiAADRAR---FT-----W-------LTENRFYtyhalvsepf 607 Maricaulis mari...
WP_015481708 592 ttlgdkygynhiwNEGSG--TANAesi----------qfTWLDNR---RF-----Y-------TLTSATSkn-------d 637 Polaribacter sp...
4FNV_A       588 -------------EVVMDtdKNGVh--------------TAFSNN---NN-----I-------IVRTFANkavtcspftg 625 Bacteroides the...
4MMI_A       523 -------------NPVFDktKNRVy--------------TTYRDGnnlMI-----Q-------SLNADRT---------- 553 Pedobacter hepa...
5JMF_A       542 -------------EIANSreDMTFl--------------TQFEDGsnmXL-----Q-------CFGPEGM---------- 572 Bacteroides the...
Q2YCG2       668 ----------gsiEVKQKaaRACIn--------------MLQPHAiefAQn-----------nRFDAPPQippsrnendq 712 Nitrosospira mu...
WP_012198519 653 ----------etiEVNGK--MAGMtakivy----cssniESITQS---DI-----F-------TEVDEKE---------- 691 Lachnoclostridi...
3AFL_A       668 -----------------GrsSFRY---------------NGRKAGfygQF-------------VYSSGGTpqis---ave 699 Agrobacterium f...

4OK4_B       619 nVLIAELGAN--DPNYNl----RQQQVLIrrveka-kqasfvSVLEPHGkydgslettsga-ysnvksvkhvseNGKDVV 690 Saccharophagus ...
WP_000424785 531 iEVDISGSNVecITEFRl----KDFKLGRddli------pynLEKTFKStrnlryhfeeaknqkhkdklfvvfsAMAPEY 600 Bacillus
Q0AT38       608 eARIVRTGAN--DPDFNl----RTQQGIL-------------LRVPSAEsarfisvfephgrydpaqeitvaseSGIDEI 668 Maricaulis mari...
WP_015481708 638 eIIFARVGAN--DPKFNl----RKDPSIIirknnk-qnttfaSIIESHGtynpvkevaanayssfsnievissyEDYTAI 710 Polaribacter sp...
4FNV_A       626 rIAYLVDGAYntRQSYTi----DMNKSADetar------yitVILPVNGs------------------------TDTSSI 671 Bacteroides the...
4MMI_A       554 -SLNEEEGKV--SYVYNke-lkRPAFVFEkpkknagtqnfvsIVYPYDG-------------------------QKAPEI 604 Pedobacter hepa...
5JMF_A       573 -SMKXEPGWC--STAYRkr-ykRMNVSFNvxkdnenavryitVIYPVXXs------------------------ADAPXF 624 Bacteroides the...
Q2YCG2       713 gGARTTNDQW--HGRFQ-----TKERMAA-------------VEFLAVVd------------------------IDCKNI 748 Nitrosospira mu...
WP_012198519 692 -TDGLDNQWHltMKTGKa----KKHIIVS-------------VIVPYKMeqkklv--------------nsvrdDQGMDI 739 Lachnoclostridi...
3AFL_A       700 gFPDIDPKEFegLDIHHhvcatVPAATRHrl---------vtLLVPYSLk------------------------EPKRIF 746 Agrobacterium f...

4OK4_B       691 VVD 693 Saccharophagus degradans 2-40
WP_000424785 601 KFA 603 Bacillus
Q0AT38       669 R-S 670 Maricaulis maris MCS10
WP_015481708 711 KVV 713 Polaribacter sp. MED152
4FNV_A       672 SAK 674 Bacteroides thetaiotaomicron VPI-5482
4MMI_A       605 SIR 607 Pedobacter heparinus
5JMF_A       625 DAK 627 Bacteroides thetaiotaomicron VPI-5482
Q2YCG2       749 PIE 751 Nitrosospira multiformis ATCC 25196
WP_012198519 740 YLY 742 Lachnoclostridium phytofermentans
3AFL_A       747 SFI 749 Agrobacterium fabrum str. C58
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