3I0X,4EJZ


Conserved Protein Domain Family
OGG_N
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pfam07934: OGG_N (This model is not part of the current CDD release)
8-oxoguanine DNA glycosylase, N-terminal domain
The presence of 8-oxoguanine residues in DNA can give rise to G-C to T-A transversion mutations. This enzyme is found in archaeal, bacterial and eukaryotic species, and is specifically responsible for the process which leads to the removal of 8-oxoguanine residues. It has DNA glycosylase activity (EC:3.2.2.23) and DNA lyase activity (EC:4.2.99.18). The region featured in this family is the N-terminal domain, which is organized into a single copy of a TBP-like fold. The domain contributes residues to the 8-oxoguanine binding pocket.
Links
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Statistics
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PSSM-Id: 489296
Aligned: 52 rows
Threshold Bit Score: 68.4249
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3I0X_A        13 VIVRNVEN--FELKDIF--DCGQCFR--WH-------RQ-ENGn--YIGIAFE-----KVVEVQk----IG--------- 58  Clostridium ace...
Q54CZ3        45 KLFKNK----LDLKKTL--FSAQSFI--WKeiv--inEI-VNE---YVGVIGD-----NIIVLRykegsEQ--------- 96  Dictyostelium d...
XP_001564449  16 RVLTSSLKakVNLQLTL--CGGQCFH--WY-------PTpRCT---FVGVLNH-----SVFELR-----EVrcaaklkkq 71 
Q81A49        10 SIAVPKE---FCFQENLryLSRSNNEcmFH-------IE-DNK---IYKVI-PvqdvnPLVEISv---nTD--------- 62  Bacillus cereus...
Q5WD74        11 IIALPEE---FDMNANLgyLKREKNEcmYE-------TE-NDH---ITRMI-AigeirSLIQISv---iDN--------- 63  Bacillus clausi...
P37878        11 VITLPEI---FDMNANLgyLTREKNEcmYE-------IE-NNI---ITKVI-AigeirSLVQVSv---iNN--------- 63  Bacillus subtil...
Q4Q2Y3        13 RVLTSSLKakVSLQMTL--CGGQCFH--WY-------RTpRGT---FVGVIGD-----GVFELR-----EVqcraklqnq 68  Leishmania major
Q4CPV5         6 ALPSPAA---VNLPMTL--CGGQCFR--WR-------RTpRGT---WVGVVER-----GAYELS-----DAahppefqav 58  Trypanosoma cruzi
2_pfamImport   1 SLLCDYNQ--LQLKATL--LGGQSFR--WKnykptalDQ-HETe--FIGVFAN-----IVWVLRq----TE--------- 53 
Q9V3I8        26 VIGLSLEE--CDLERTL--LGGQSFR--WR-------SIcDGNrtkYGGVVFN-----TYWVLQq----EE--------- 74  fruit fly

3I0X_A        59 ------------EDVVIYNIN----------------------------------------------------------- 67  Clostridium ace...
Q54CZ3        97 ------------DIIEYKFIDsekrinh------------------------------------------------dsel 116 Dictyostelium d...
XP_001564449  72 delqhvasqqraPTLGKRRQEsrsaplasesdinvskhfsccwieyrrlwpladpqcfsekvpmstpssslwstgpppsl 151
Q81A49        63 ------------GNIQIRCLEepyts----------------------------------------------------ek 78  Bacillus cereus...
Q5WD74        64 ------------KQMVVQFLNdsrps----------------------------------------------------ee 79  Bacillus clausi...
P37878        64 ------------KQMIVQFLNdsrpv----------------------------------------------------eq 79  Bacillus subtil...
Q4Q2Y3        69 e-lqrtasqrpaSTRAKRRRAasspastseaamgqnyccsccwieyrrlwplahplrlrgkgrtsplpsslrhtaassah 147 Leishmania major
Q4CPV5        59 hprgeekrgmrsSLSHPSDDLsgdvfwfrcl------------------------------------------hrepkna 96  Trypanosoma cruzi
2_pfamImport  54 ------------RELQYRIVGeqpypnkanrdvtkspspepqqplgn---------vrnlaevrlkvaepseyatggell 112
Q9V3I8        75 ------------SFITYEAYGtss-------------------------------------------------------p 87  fruit fly

3I0X_A        68 --EEEFKNVWSEYFDLYRDYGEIKKEL-----SR-DP----------LLK-------------------------KSVdf 104 Clostridium ace...
Q54CZ3       117 mkMQDRISTLQNYFYLDLDINQLFKKWrndeiGNdDNgdkklhqlnhQFR-------------------------KSCdk 171 Dictyostelium d...
XP_001564449 152 arEESDEEILSHYLSLDVDLDQLWQDWtaspqTRkHP----------LVQylvgnrlqlysllsdrnqrvcehdkAQQsl 221
Q81A49        79 siREAVVNYVKEWFDLTTDLAPFY-TL-----AKhDL----------LLQ-------------------------GPIeq 117 Bacillus cereus...
Q5WD74        80 wqREKIVKYIHEWFDLNTDLTPFY-EM-----AKaDP----------LLK-------------------------KTVet 118 Bacillus clausi...
P37878        80 wkREEIVKYIHEWFDLDNDLTPFY-EM-----AKaDP----------LLK-------------------------MPArk 118 Bacillus subtil...
Q4Q2Y3       148 tvGESDEEMLSRYLSLDVDLDQLWQEWtdspeTRkHP----------LVEylvgsrrqrqllrsghgqrvcehdeAQAnl 217 Leishmania major
Q4CPV5        97 ldLSTEACFLRHYLALDVDLQKLWRRWtrdnpMRdHP----------LVRylt--------------------snAGKgp 146 Trypanosoma cruzi
2_pfamImport 113 ypASYYEQLLRIYFRLDVDLEQQYQQW-----IRcHE----------HFA-------------------------NSAtk 152
Q9V3I8        88 laTKDYSSLISDYLRVDFDLKVNQKDW-----LSkDD----------NFV-------------------------KFLs- 126 fruit fly

3I0X_A       105 gEGIRI-LRQDPFEIL 119 Clostridium acetobutylicum
Q54CZ3       172 fIGLRL-TRQNPVDCL 186 Dictyostelium discoideum AX4
XP_001564449 222 yISIRH-VRQDLHSCL 236
Q81A49       118 yYGLRTlGIPDLFEAL 133 Bacillus cereus ATCC 14579
Q5WD74       119 fYGLRVvGIPDLFEAL 134 Bacillus clausii KSM-K16
P37878       119 fYGLRViGIPDLFEAL 134 Bacillus subtilis subsp. subtilis str. 168
Q4Q2Y3       218 yIPIRH-VRQDLHSCL 232 Leishmania major
Q4CPV5       147 sVNIRH-LRQNIHETL 161 Trypanosoma cruzi
2_pfamImport 153 fYAVRQ-LDQDPVENL 167
Q9V3I8       127 -KPVRL-LSQEPFENI 140 fruit fly
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