Conserved Protein Domain Family
Vps54

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pfam07928: Vps54 
Vps54-like protein
This family contains various proteins that are homologs of the yeast Vps54 protein, such as the rat homolog, the human homolog, and the mouse homolog. In yeast, Vps54 associates with Vps52 and Vps53 proteins to form a trimolecular complex that is involved in protein transport between Golgi, endosomal, and vacuolar compartments. All Vps54 homologs contain a coiled coil region (not found in the region featured in this family) and multiple dileucine motifs.
Statistics
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PSSM-Id: 400331
View PSSM: pfam07928
Aligned: 108 rows
Threshold Bit Score: 84.0993
Threshold Setting Gi: 67473143
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EPS39259             779 EQRFILPESGLAVLRLMERYECLFAMI-P--VSVA-DVAGNMLEFLKLFNSRVCQVILGAGATK-SAGLKH--ITTKHLA 851  Dactyl...
EAY10366             480 DSKFGVTASALTMLEIIWNYLEAARRI-K--GTAD-DFTIKLAAAISNYSRQCMYYIYEGAAAK-QGKFKN--TSTRHLS 552  Tricho...
A0BQ00              2108 NSKYKVTQAFLFFLQAISQYLHLFESY-S--VINY-EQTQKLVELIKCYNSLATQYILGAGAVH-FGKIST--ITAKNLA 2180 Parame...
XP_001013161         815 NKKYMFSEGFLVFLKQVQKYIGIMAESkI--QYSK-EYFIRFISLLRQYNTFSREFIVLAKGKNpQFPQMNgkVTVKNLA 891  Tetrah...
Q23QT8               772 NQTYKLTSAFLQILKMIYEYLHLIDYF-K--SMRE-TSSKKLIELLKFYNSYANELLIGGGAFQ--LGVQ---VSAVNLA 842  Tetrah...
EFC49812             699 NEKFPICSSFLHLVRMTKNFLDLLSPE-HqkFINSlELSTRICNLYGTFNIDVKNLILKAGAINsKSGLKT--ITAKHLV 775  Naegle...
WGS:AATM:SJAG_03963  731 sDTFSCVATSSKLLHVLVDYARFASQV-P--RFSS-DCYASVLELYRVVNSRVYQLIMGAGAVR-SAGLPR--VLGKHIA 803  Schizo...
O14093               707 KQSLHIVRSSVTLLETLDDYGKLLAHF-S--RLAP-EFQTGMLDMFRTLNSRVYQLILGAGTVR-SSGLSK--VLGKHIA 779  Schizo...
EPY51498             700 NQSIHMVNASVRLLETMNQYGQLVYHF-P--RLSH-YLYYGMIDLLRTLNSRVYQLILGAGTVR-SSGLSR--VLGKHIA 772  Schizo...
XP_652343            572 NETYFMTNTMSILLPTLERYREIIIKF-P--LLGE-CALSSAKDMLILYNNSMRRLILGKELIQ-KGVVQR--IGATMFT 644  Entamo...
EPS39259             852 LASQALSIVVAVIPYVREAVRRHl----gPAATGGTILAD-FDRIKRNYQEHQSEIHSKLISIMSDR 913  Dactylellina haptot...
EAY10366             553 LASANIEFMARLISYITPRLETVg----aN----RNIVSVqMQNVSKNLIENENKLNTQICKVLTNk 611  Trichomonas vaginal...
A0BQ00              2181 ISSICLRLFLYLLDPLSNKLFKVinqqqqTEFTNLQQIQNdFATIKVDYENHNAEVMAKLTTIVQDR 2247 Paramecium tetraurelia
XP_001013161         892 TSSLNLTFLIKIFDKIKERLVQN------TDVSKEIIDAE-FQKIKIDIQNHISEIFGTIPNIIKDm 951  Tetrahymena thermop...
Q23QT8               843 LSSVCLQFALKIFPQMTERIIGLy----kEDRDLAENIEDqFSRLSDEYNNHNINIQKTISDILikl 905  Tetrahymena thermop...
EFC49812             776 LTYEVLGAVIAFLTQVKIYIENA-------DSYLKGKLSK-FDNLLTDLKEHKKSIFQKLFDIMKDv 834  Naegleria gruberi
WGS:AATM:SJAG_03963  804 LAAQMIRFLQSSLKIMVQFLETT---------GGINPGLE-VEKLNRDFSFHLQQVQNKFVALMREK 860  Schizosaccharomyces...
O14093               780 LASQTIALFQLSLNSMCRYLSRV---------TGTRLTNE-TNKLDQDFTVHHLQIHDKFVSLMRER 836  Schizosaccharomyces...
EPY51498             773 LASQTVTLFQALSTSMVKFLSKY---------SGIRQTQE-LLSLENDFDLHHDQITEKFIALMKER 829  Schizosaccharomyces...
XP_652343            645 TTHQTLLLLSLITPYLHHYLSPN-----------VIISGRiLDGIEDLMKAQCTDIRNALTIIVRNR 700  Entamoeba histolyti...
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