Conserved Protein Domain Family
CALCOCO1

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pfam07888: CALCOCO1 
Calcium binding and coiled-coil domain (CALCOCO1) like
Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.
Statistics
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PSSM-Id: 489262
Aligned: 10 rows
Threshold Bit Score: 385.402
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
A2BGD5       114 KPLEELVTLEEEGQG--EEVGEDMLLVIPRAQLLQS----------------RLQECLKERAELLQALEAADQNVEREkg 175 zebrafish
1_pfamImport   1 KPLDELVTLEERREGeeEEEGEGMLLVIPRAELLQA----------------RLEECLRERAELLQAREASQRGREED-- 62 
3_pfamImport   1 KPLEDLVTLEEEPHG--EEGSTGMLLVVPRAELLQG----------------RLQECLRERAELLQAQEVANRRREKDqe 62 
NP_956415    114 RPLDELVTLEKTGEG--EEDGDDLLLVVPKALILQN----------------LLEGCQRELHELHKKFEAVNGDVENErq 175
2_pfamImport   1 RPMDELVTLEEASD---DGAGTDMLLVVPKATLLET----------------QLEESRQQQGVLLQE------------- 48 
4_pfamImport   1 RPMDELVMLEE------SENGSDILLVVPKATVLQN----------------QLEESQQERNDLMRL------------- 45 
Q9P1Z2       122 RPMDELVTLEE------ADGGSDILLVVPKATVLQN----------------QLDESQQERNDLMQL------------- 166 human
5_pfamImport   1 KPLEDLVTLEE-SHG--EEEGTDMLLVVPRAELLQVsrtqnrlvkavmglkiRLQECLQERAELLQAHEAANRQREKEkm 77 
XP_005478100 114 KPLEDLVTLEEDSHG--EEAGTDMLLVVPRAELLQN----------------RLQECLRERAELLQVQEAVKEQREKEke 175
XP_005813248 114 KPLEDLVTLEDESHG--EDGGTGMLLVIPRAELLQS----------------RLQECLQERTELLREQEAAKKQRERDre 175
A2BGD5       176 rrerdRGSWEHTRKELERKIDDLKEEVREYRE--------KVEDMKkkqkEVEDLGEALTEEKRALLAQKEANEQRIREl 247 zebrafish
1_pfamImport  63 -----REEWDRQRRELSERLGRAREEASRLREtrqvsagrDVRRGPrpprAGGRAGQVTAARRPRQARAAHESGSRLKE- 136
3_pfamImport  63 ehkraREAWDRRHRALERDVARLQEELKQSRE--------KVEGME----EVQAFGESLAQEKSALLDASEASKVRIKEl 130
NP_956415    176 rwktdRDEFEILRSDMRSQIEELKTNLRHSTE--------KTEELEqkhkEAQISSESMSAEFNALLAERAENQQRIKEl 247
2_pfamImport  49 -----SCRLKDEVKELRSHMAELEAALGSLRD--------DHTKLAaqykELSDSSAEVSKQKDTLSLQEAEHLARIREl 115
4_pfamImport  46 -----KLQLEGEVAELKSRVQELETVLQVTKE--------EQTKLMekykGLARAHGELKEERDVLSKQQGDHVARILEl 112
Q9P1Z2       167 -----KLQLEGQVTELRSRVQELERALATARQ--------EHTELMeqykGISRSHGEITEERDILSRQQGDHVARILEl 233 human
5_pfamImport  78 eyrgaREAWDRRHRELE------------------------------------------SEEKSTLLEANEESRVRIREl 115
XP_005478100 176 eykraREAWDRRRKELEGDIARLQKELKQTLE--------KLDELEkkqkEEKALGESLAQEKIALMDAREASEARIREl 247
XP_005813248 176 dykreKQQWDRQRRGLEREVSRLKEELAQSDQ--------KIEEMEmkqkDETALRDCLAQEKAALMEVKAAKEQLIREl 247
A2BGD5       248 eedikiltqrgleretDLERMRERAK----------------------------KSAAQKREDEDEHKNLKLKMEQTEKE 299 zebrafish
1_pfamImport 137 ----------------RLRRLTQQQE----------------------------QAVRQKGEEEEERKALQGKLLSSEEE 172
3_pfamImport 131 eediktlaqrsveketELERMKERAK----------------------------RAGAQRKEEEGDRKSLQSKLEQTEGE 182
NP_956415    248 eqdsatltqqkqdieaELERMKERVK----------------------------KMTIQRRDEETERRDLQ--------- 290
2_pfamImport 116 egdiqamgekmllretELDRVKDTVKsllr---------------------eqeQIHNQLKEEYAEKEQYQVKLQASVEE 174
4_pfamImport 113 eddihaisekvlekevELDRQEDLVAgcasqesaklgvrksvkdtvkaltqeqeKLLGQLKEEQADKEQSQADLQASQVE 192
Q9P1Z2       234 eddiqtisekvltkevELDRLRDTVKaltr---------------------eqeKLLGQLKEVQADKEQSEAELQVAQQE 292 human
5_pfamImport 116 eedvrtltqrtvdretEMERMKERAK----------------------------RAGAQRKEEESERSALQSKLEQTEAE 167
XP_005478100 248 eddikslaqraveketELERIKERAR----------------------------RAGALRKDEESERRSLQTKLEQTESE 299
XP_005813248 248 eediktltqraveretELERMKDRAK----------------------------RAIALRKEEETENKGLQNKLDQTEAE 299
A2BGD5       300 LHSLSAEFQSLRSSLAQRDTHALQLRDTITTLTHKLNSAHRKEAANELALNELRSVQERLNVSEHCVETLRGELRDMVAQ 379 zebrafish
1_pfamImport 173 LRRMCSEFQSLRGSLAERETQALTLRDTISTLTLRLNTAQQREVENESLRQELSSLRERLCASERRVEGLGAELEVVGGQ 252
3_pfamImport 183 LRSLSKEFQVLRNSLAQRDTSVLQLQNSITTLTQKLTAAHRKEAQNEATLKEMRSLRERLNLSERAAEALKSDLSAMVAQ 262
NP_956415    291 -------------------------------------------LENEQMHADLRTLQERLEASERSTEALRRDLSELGSL 327
2_pfamImport 175 SRSLASDLQEAKNLHGEKISQTLVLQEDVNKLQQKLATANRRTAQMEALCEQLRSTQDVLAASQQKVALLGEELASVASI 254
4_pfamImport 193 CCRLSTDLQKAKSHQDQQASELQRLQEEVTRTQNLLDEAQQHIAELEPLKEQLRGSQELAVSSQQKAALLGEELASTASA 272
Q9P1Z2       293 NHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAA 372 human
5_pfamImport 168 LRSLSKEFQGLRNSLAQRDTSVLQLQSTITTLTQKLTAAHRKEAEHEATLKEMRSLRERLNTSERTSEGLKSNLSSMVTQ 247
XP_005478100 300 LKSLSKEFQGLRNSLAQRDTSVLQLQNTITTLTQKLTTAHRKEAENEASLKEMRSLRERLHMSERAAEGLKSDLSSMVTQ 379
XP_005813248 300 LRSLSKEFQVLRNSLAQRDTSVLQLQNTITTLTQKLTTAHRKETESEASLKEMRSLRERFHISERTVEGLKSDLSSLAAQ 379
A2BGD5       380 RDSAHAELHQARLQAAQLTLQLADASLALREGRANWAQERETLQQNAEIDKVRLERQNDEIQQKEEMLQKARMEREKAVV 459 zebrafish
1_pfamImport 253 RDRGQTELHQARLEAAQLTLQLAETRLAMREGRARWQGEREALQQSAQMDRERIAELSEALQQAEARLQEERMEREKAEV 332
3_pfamImport 263 RDHGQAEMHQARLQAAQLTLQLADSSLAMREGRARWAQERQNLQRTAEKDHERLEKLSTEMQRTEERLQEERMERVKLEV 342
NP_956415    328 QSHSHAELHQVRLQSAQMSLQLSQANLALREGQSTWAQERETLRQSAELDKDRVQKLSRELQKKEEWLQEERSEREKLEV 407
2_pfamImport 255 RDRTISDLHKSRLEAAETNIKLADMTLKWKEGKGQWWKEKTTLLQNMEAEKDKILKLSAEVLRLEKSLQEERSQRQVLRV 334
4_pfamImport 273 RDRTMAELHRSRLELAEANNRLMELSLQWREDKGSWSKERTGLLQNVEAEKDKILKLSAEVLRLEKAVQEERTQRQGLKA 352
Q9P1Z2       373 RDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKT 452 human
5_pfamImport 248 RDRTQSELHQARLQAAQLTLQLADASLALREGRARWAQERQSLQLSAEKDHERLQTLNAEIQKMEETLQEERMEKVKLEV 327
XP_005478100 380 RDQGQAELHQARLQAAQLTLQLADSSLALREGRAHWAQERQNMQRSAEKDHERLEKLSQEMQAMEEMLQEERMERVKLEV 459
XP_005813248 380 KDHVQAELHQARVQAAQLTIQLADASMALREGRANWAQDRQSLQNAAELDQEHSERLNAELQKMQERLQEETMERVKLEV 459
A2BGD5       460 ELGREKDCNR-----------ELKASLRVAQKEKEQLQTEIQEVMEYSRQLERRLEVLSDCKWSETALLQSS-------- 520 zebrafish
1_pfamImport 333 ELARDRDCNR-----------ELKSSLRLGQREKEHLLHQQQELLQYVRQLEQRLEAVADAKWRDAASDSNS-------- 393
3_pfamImport 343 ELGRERDCNRvqlsetcrelqELKASLRVAQKEKEQQLAEKQELMEYICQLEQKMGTAVGAKWSAAPIAYTGdrffss-- 420
NP_956415    408 ELGIEKDCNR-----------EQRASLRALQKEQEQHQLEKQELLDHIHVLELRLDTETDAKWAEAAATPICqfaksy-- 474
2_pfamImport 335 ELAQERDSSLvqvsesrrelrELRAALQVAQKEKEQLQAEKQELLIYIRRLEERLEKVADDKWSESVLVDKEetaleapa 414
4_pfamImport 353 DLAQEKDSSLvqlseskreltELRSALRVFQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWSEDAATEDEeat----- 427
Q9P1Z2       453 ELAREKDSSLvqlseskreltELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNEDATTEDEeaavg--- 529 human
5_pfamImport 328 EIGREKDCNRvqlcetrrelqELKASLRVTQKEKEQLLAEKQELMQYICQLEQKTGMVSSAKWSTAPLLFPGlca----- 402
XP_005478100 460 ELGREKDCNRvqlsetrrelqELKASLRVAQKEKEQLLAEKQELMEYICQLEQKMGTVASAKWSLAPVASTG-------- 531
XP_005813248 460 ELGREKDCNRvqlserrrelqELKASQKVAQKEKEQLRAEKRELMEYICQLEQKTGTVTTARWDAAPIASTG-------- 531
A2BGD5       521 -------RAESPlLSDSEDENPEALQdthSSGPLNHYSLCEQP--QSDLLLPATPPPSPRh--pSTVVISQPAPLSS--- 586 zebrafish
1_pfamImport 394 -------RPDSP-VSESEEDSPEALQ---PPHPLGAYSLCDPPtfTTEALLLATPPPSPQ----GGVVISQPAPLSS--- 455
3_pfamImport 421 --vhpadLPASV-LSDSEDENPEALQplrPPRPLGHYSLCEQG--QPDSLLLATPPPSPReverSTVVINQPAPLSS--- 492
NP_956415    475 --lhraaYIDS---LSSIDEKP-LLE---SSSELSLSALDSEQ-------HNESTENNPKdnedD--VMQEDLEVQPfss 536
2_pfamImport 415 semfirdALDSP-LSDSEDECPEDMR---LPAQIGSYSLCDNR-------AATTTPPCARgp-aRTVVISQPAPIASqik 482
4_pfamImport 428 -----lgYTTAV-LSDSEDEYPEDMR---LPA----HGLCERG-------GPGCNPSGPRdt-pAHVVISQPSPIAPhtt 486
Q9P1Z2       530 ------lscpAA-LTDSEDESPEDMR---LPP----YGLCERG-------DPGSSPAGPRea-sPLVVISQPAPISPhls 587 human
5_pfamImport 403 -----agRPSSA-TSDSEDENPEALQplrPPRPLGNYTLGEQG--GPGSLDLTTPPPSPReaerSTVVINQPAPLSS--- 471
XP_005478100 532 -------RPDSV-LSDSEDENPEALQilhPPRPLAHYSLCEQG--QPDSLLLATPPLSPRevsrREVVINQPAPLSL--- 598
XP_005813248 532 -------RPETA-LSDSEDESPEALQilhPPRSLGHYSLCEQG--QPDSLLLSTPAVAQRdtdrSAVVINQPAPLSL--- 598
A2BGD5       587 --PHQPSAR 593 zebrafish
1_pfamImport 456 --PRQQDSE 462
3_pfamImport 493 --PRQADAD 499
NP_956415    537 giADQMLSE 545
2_pfamImport 483 qpPEDSSSD 491
4_pfamImport 487 rlHDDSSSD 495
Q9P1Z2       588 gpAEDSSSD 596 human
5_pfamImport 472 --PRQASAD 478
XP_005478100 599 --PHQATTD 605
XP_005813248 599 --PHQANAD 605
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