4C20,1FUI


Conserved Protein Domain Family
Fucose_iso_N2

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pfam07882: Fucose_iso_N2 (This model is not part of the current CDD release)
L-fucose isomerase, second N-terminal domain
The members of this family are similar to L-fucose isomerase expressed by E. coli (EC:5.3.1.3). This enzyme corresponds to glucose-6-phosphate isomerase in glycolysis, and converts an aldo-hexose to a ketose to prepare it for aldol cleavage. The enzyme is a hexamer, with each subunit being wedge-shaped and composed of three domains. Both domains 1 and 2 contain central parallel beta- sheets with surrounding alpha helices. The active centre is shared between pairs of subunits related along the molecular three-fold axis, with domains 2 and 3 from one subunit providing most of the substrate-contacting residues.
Statistics
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PSSM-Id: 517942
Aligned: 40 rows
Threshold Bit Score: 322.26
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4C20_A       191 AYLSMGSVSMGIGGSIVNPDFFQEYLGMRNESVDMTEFTRRMDRGIYDPEEFERALKWVKENVKEGFD-HN-----REDL 264 Streptococcus p...
5_pfamImport   2 AYVNLGGIAMGIAGSFCNAEMFQKYFGIRAEWVDMTEIVRRITLGIYDHDEFDKALSWVKANCKEGFD-CNagkdlPEII 80 
7_pfamImport   2 AYVGIGSVSMGIMGSFCNPQFFQDYLGIRAEWVDMTEVLRRMKLEIYDHEEFERALAWTKAHCPEGFD-KN-----PPEK 75 
4_pfamImport   2 SYVGIGAVAMGIAGSFCDADFWQEYLGIRAEWVDMVEVTRRVELGIYDHEEYERALKWVKENCPEGFD-KN-----PENI 75 
WP_014856256 185 SYLSVGAVSMGIAGSVVDTHFIYDYLGMKSEFVDMTEIIRRINEKIYDSEEFNKAIKWVAANCREGED-PN-----DPPV 258 Melioribacter r...
CDC04394     181 TYLSLGTMSMGIASSVVSSDFLRNYLGMRTAYVDMSEMERRIQKKIYDPNEFKYAKEWVKSNLKIGED-HN-----PSAN 254
1_pfamImport   2 GYLSIGGCSMGIAGSIVDQSFWENYLGIRVQAVDMTEVRRRMDQKIYDEAEFDLAMQWADSVFKFAED-KN-----RPDL 75 
WP_012226729 175 TYLSIGGVSMGIAGSIVDHAFFRSWLDMRVQAVDMTELRRRLDRKIYDTAELETAQAWADARFRFGIE-RN-------AR 246 Gluconacetobact...
WP_014271178 190 SYLSIGGCAMGIAGSIVDQDLLQSYLGMRTEAIDMCEIERRIVEEIYDHEEFKKAIKWVKENCIQPKDtVN-----EEKY 264 Sphaerochaeta p...
Q8XNL5       174 SYVNIGASSMGIAGSQVDISFFEDYLGMLVEFVDMTEILRRIHLEIFDPIEYDKALNWIKENCREGID-INegkdlPDIV 252 Clostridium per...
4C20_A       265 VLSRE-EKDRQWEFVIKMFMIGRDLMVGNPRLAEL--------------GFEEEAVGHHALVAGFQGQRQWTDHFPNGDF 329 Streptococcus p...
5_pfamImport  81 RKSKVvDPDKDWAFITKMTMIMRDILYGNPKLDEM--------------GWHEEALGKNAIAGGFQGQRNWTDWLPNADF 146
7_pfamImport  76 KHTDA-QKEEEWAFVVKMTLICRDLMLGNPKLAEM--------------GWEEESMGRNGILGGFQGQRMWSDWQPNGDF 140
4_pfamImport  76 RHTPE-QKEKEWEFVVKMTLICRDIMLGNDKLNDVrpvgaeaehsgpkdGWHEEALGRNAILGGFQGQRQWTDFMPNGDF 154
WP_014856256 259 --SGE-QRKSEWETVVKMTMIFRDLMVGNPKLAEL--------------GFEEEALGHNAIAAGFQGQRQWTDFMPNGDF 321 Melioribacter r...
CDC04394     255 QKSAE-EKEKDWDECIKMAIIMKDMMEGNPRLSAL--------------GYEEEANGYGAICSGFQGQRAWTDFHVNADF 319
1_pfamImport  76 KLDEA-GRRKTFRESVLMAMIFRDMMQGNPKLKKI--------------DREEESLGYQAIAGGFQGQRHWTDFYPNGDI 140
WP_012226729 247 PRDAA-GKREILSESLAMTLCIRDMMHGNARLAAM--------------GWAEEALGYDAIAAGFQGQRHWTDQYPNADV 311 Gluconacetobact...
WP_014271178 265 RRSEE-QLEKDWEYCTKMTMIGRDLMIGNKELKKI--------------GFGEESLGHNALFAGFQGQRQWTDHWPNGDF 329 Sphaerochaeta p...
Q8XNL5       253 KKSKViPADKDWEFIAKQAIIIRDILYRNEKLGDL--------------GWEEEARGRNAIAGGFQGQRQWTDWLPNGDF 318 Clostridium per...
4C20_A       330 METFLNTQFDWNGIRKPFVFATENDSLNGVSMLFNYLLTN 369 Streptococcus pneumoniae TIGR4
5_pfamImport 147 TEAIMASSFDWNGKKAPTPFATENDTLNGVAMMLGTLVSG 186
7_pfamImport 141 TEAFMNTTFDWRGKKQPIPFATENDGLNAVSMMFGNLLTN 180
4_pfamImport 155 TEAMLNTTFDWNGKKEPLTFATENDGLNGLSMLLGKLVTG 194
WP_014856256 322 LEAILNSSFDWNGIREPYIVATENDSLNGICMLFGLLLTN 361 Melioribacter roseus
CDC04394     320 MEAILNSGFDWNGQRPPFIISTENDCMNAVTMLFGYLTTy 359
1_pfamImport 141 AETLLNSTFDWNGPRAPLPFATENDSLNGACLLFGYLLTG 180
WP_012226729 312 AEALLNSSFDWSGARAPSILATENDCLNGATMLFGLLMSG 351 Gluconacetobacter diazotrophicus
WP_014271178 330 METMLCTSFDWNGIREPFVMATENDFLNGIGMLFGKLLTN 369 Sphaerochaeta pleomorpha
Q8XNL5       319 TEAIMASTFDWNGPRQVTAFATENDTLNGVSMLLGTLLTN 358 Clostridium perfringens str. 13
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