1QEX,5HX2


Conserved Protein Domain Family
T4_gp9_10

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pfam07880: T4_gp9_10 
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Bacteriophage T4 gp9/10-like protein
The members of this family are similar to gene products 9 (gp9) and 10 (gp10) of bacteriophage T4. Both proteins are components of the viral baseplate. Gp9 connects the long tail fibers of the virus to the baseplate and triggers tail contraction after viral attachment to a host cell. The protein is active as a trimer, with each monomer being composed of three domains. The N-terminal domain consists of an extended polypeptide chain and two alpha helices. The alpha1 helix from each of the three monomers in the trimer interacts with its counterparts to form a coiled-coil structure. The middle domain is a seven-stranded beta-sandwich that is thought to be a novel protein fold. The C-terminal domain is thought to be essential for gp9 trimerisation and is organized into an eight- stranded antiparallel beta-barrel, which was found to resemble the 'jelly roll' fold found in many viral capsid proteins. The long flexible region between the N-terminal and middle domains may be required for the function of gp9 to transmit signals from the long tail fibers. Together with gp11, gp10 initiates the assembly of wedges that then go on to associate with a hub to form the viral baseplate.
Statistics
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PSSM-Id: 400296
View PSSM: pfam07880
Aligned: 3 rows
Threshold Bit Score: 335.086
Threshold Setting Gi: 1002351788
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1QEX_B   7 KKLIDTGEIGNASTGDILFDGGNKINSDFNAIYNAFGD-QRKMAVANGTGADGQI---IHATGYYQKHSITEYA------ 76  Escherichia virus T4
Q6WHG0  12 RQRLETGTAGSVGTGDTIHNGGNKLRDNSDEFYHINADfELTEAGENYIPAYNDTsprPFAGGYWQRIPPSSTAggsggp 91  Vibrio phage KVP40
5HX2_H   2 KQNINIGNVVDDGTGDYLRKGGIKINENFDELYYELGD--------------GDV---PYSAGAWKTYNASSGQt----- 59  Escherichia virus T4
1QEX_B  77 ------TPVKVGTRHDIDTSTVG--VKVIIERGELGDC---------VEFINSNGSISvTNPLTI--QAIDSIKGVS--- 134 Escherichia virus T4
Q6WHG0  92 nntnllTSIITGGKYDIDTSALGggASMTLNLPKIGTTagmakrgerIEFQNTTATLD-TNPIVIapSAGDAIVGATeln 170 Vibrio phage KVP40
5HX2_H  60 ------LTAEWGKSYAINTSS----GRVTINLPK-GTVndy---nkvIRARDVFATWN-VNPVTLvaASGDTIKGSA--- 121 Escherichia virus T4
1QEX_B 135 GNLVVTSPYSKVTLRCIssDNSTSV-----WNY----SIESMFGQKESPAEGT-WNISTSGSVD-IPLFHRTEYNMAKLL 203 Escherichia virus T4
Q6WHG0 171 GTQIVRNNYCHIICTVI--DDGTGLagtpqWGI----KIIPILGDFGAPVNDTiYTIPETVTVT-MPLFDTLSYAACKLM 243 Vibrio phage KVP40
5HX2_H 122 ---------VPVEINVRfsDLELVYcapgrWEYvknkQIDKITSSDISNVARKeFLVEVQGQTDfLDVFRGTSYNVNNIR 192 Escherichia virus T4
1QEX_B 204 ------------VTCQSVD----GRKIKTAEINILVDTVNSEVISSEYAVmrVGNETEEDEIANIAFSIKENYVTATISS 267 Escherichia virus T4
Q6WHG0 244 ------------VYAENSDpaqgGAVTRRMSSELLLLNNVTDVYIDEYSV--INTDKDFGNLVLIEPRVDNGTIVLDITS 309 Vibrio phage KVP40
5HX2_H 193 vkhrgnelyygdVFSENSDfgspGE------------NEGELVPLDGFNIr-LRQPCNIGDTVQIETFMD-GVSQWRSSY 258 Escherichia virus T4
1QEX_B 268 S--TVGM 272 Escherichia virus T4
Q6WHG0 310 NddNVSI 316 Vibrio phage KVP40
5HX2_H 259 TrrQIRL 265 Escherichia virus T4
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