6BBG


Conserved Protein Domain Family
Orai-1

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pfam07856: Orai-1 (This model is not part of the current CDD release)
Mediator of CRAC channel activity
ORAI-1 is a protein homologue of Drosophila Orai and human Orai1, Orai2 and Orai3. ORAI-1 GFP reporters are co- expressed with STIM-1 (ER CA(2+) sensors) in the gonad and intestine. The protein has four predicted transmembrane domains with a highly conserved region between TM2 ad TM3. This conserved domain is thought to function in channel regulation. ORAI1- related proteins are required for the production of the calcium channel, CRAC, along with STIM1-related proteins.
Statistics
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PSSM-Id: 517934
Aligned: 27 rows
Threshold Bit Score: 100.4
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6BBG_A        13 YLSWRKLQLSRAKLKASSKTSALLSGFAMVAMVEVQLdh---dtN--VPPGMLIAFAICTTLLVAVHMLALMISTCILPN 87  fruit fly
XP_009030020  17 SLQWRQFHLSKAKLKATSRISALLSGFAMVAMVETDFkqdlarpEdnTPPELIVTFSVITTLVVAVHLLALMISTCILPN 96 
XP_004993864   5 PARRRQLALFTHKLEQTGGTSALLSGFALVAMVELNLpegrthvEefDNNPVFYIFSAVTSVLIALHLFALMVSTSVLPY 84 
XP_002287927  37 DDARRAVDEKAQQLKVLANQSALVAGFSMVVLVESNIpp-------dINGALLTLFGGVTACVIALMLVSTLNATYMLVA 109
EFJ20400      85 EKNRRDVEEKSEQLKAISNLAALFAGFAVVTLTQFTIap------dpVLTVWIAFYGVLTAIAVGLMTISMVTCTLILGS 158
EFJ26564      26 ELNRRDVEEKSEHLRSLSWITGLVTSFTMTAPVEFNTpk-------sIRAGRLMPYAICTAIVPTLMTTSTIICVYLLGC 98 
XP_002506166  93 EKNRRDVEEKSEQLKSISNLSALIGGFAVVAFVELQFsdpnetpE--RNEGLIVAYAATTALVVALMLNSMVLCSFMLCS 170
XP_003056729  92 EKNRRDVEEKSEQLKSISNLSALIGGFAVVAFVELQFhdpetrpS--QSEALITAYAATTALTVGLMLNSMVLCSFMLCS 169
XP_001689548  80 DRNRTEVMEKTEQLKAVSSLSALLAGFALVGFLEFQFvvs-----enYNKALLPLFALTTSITVGVEVAAVVLTSLMLAN 154
XP_001419702  95 EKNRRDVEEKGEQLRTTSNLSALISGFAVVALVELQFsdptvkaF--QSEALIAAYAGATAVTVALMLNAMVLCSFMLSN 172
6BBG_A        88 IETVSNLHSIS--LVH------------------ESPH-----------------------------ERLHWYI----ET 114 fruit fly
XP_009030020  97 IETVGYLNSNA--AVL------------------DSPH-----------------------------IHLQWYI----EI 123
XP_004993864  85 LKSA--IEDIDhhLAQralta---------rakgQALHnligpqdtlfddttdtshdngllervkhlDQFSSYI----SK 149
XP_002287927 110 ILRYdcv-------------------------nrEVP--------------------------------FDEFWrkrcEP 132
EFJ20400     159 ILKNGKSYVNEeaEEEfmfkcrdfvksyrtgdkpPSPR-----------------------------RTFEAFWeircED 209
EFJ26564      99 ILRMGKSFVSEhaEEEfmalchsyaesaapsqppPVPS-----------------------------RTFQNFWaarcKD 149
XP_002506166 171 ILRNGKTYVSDeeEADylfrcrrfahefklgdapPRPH-----------------------------RSFERHWetrcED 221
XP_003056729 170 ILRNGKTYVSEdeEAEylyrcrrfaleftsgdkpPLPK-----------------------------RSFERHWetrcED 220
XP_001689548 155 ILRTAKSYVNEqeEAEfmhrcqafmanyrpgdrpPAPV-----------------------------RTFAVHWarrcEH 205
XP_001419702 173 ILRNGKSYVSEdeEAEflyacrkfalsyapgdtpPQPQ-----------------------------RSFERYWetrcEA 223
6BBG_A       115 AWAFSTLL---G------LILFLLEIAILCWVKFYdlSPp--AAWSATVVLIPVMIIFMaFAIHFYRSLVSHKYE 178 fruit fly
XP_009030020 124 AWIFSTGI---G------ILLFLAQMAILAWVRFYtvNKl--APIASMAIIVPTFLILIaFAFHFYRQLIKAKCE 187
XP_004993864 150 AWFFANGV---G------IALFLLQLALISYIKFLahTPg--AGWTGVGTLSPAFVLFMvFIYRFYRKIVGSQST 213
XP_002287927 133 DWKMALRTfsyG------IPLFMVVVALVAWVSFWdhESlyySASVVTAISVMVLILWFgSTERKWGEFLRMSDA 201
EFJ20400     210 DWKRAFQFfawGrplnsrVLSFLFSLIPIGWIKFY--NSr-lTAGLFMGVIAVSIIVWG-FVQYLWGGYLTKTFR 280
EFJ26564     150 YWNTAFSLffwG------VSFFLALLCTMGFIKF---SDd-rVALSFTTVIGISFVAWL-GIQVKWGYYLKKEYE 213
XP_002506166 222 DWRHAFRMftcG------VPVFLVNVSCMSWLKFH--YSp-lASWTVTAIAAVASLGWL-HTQNNWGFHIAKSQA 286
XP_003056729 221 DWRHAFRMftcG------VPVFMVNIACMAWLKFN--YSy-aAAGTATAVAVCATAGWA-RTQMNWGWHISRRYH 285
XP_001689548 206 EWRIAFRLfstG------IPFFFVNLALAGWIKFHdaQTp-vAPIIVTLIMGFSLMYNV-YTHRKWGEYLMADGS 272
XP_001419702 224 DWRKAFRMftyG------VPMFLTTLTLSAWLKFW--YSt-vTCSIVTGVAAVAIGLWW-RTQSAWGWHLMKRSE 288
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