Conserved Protein Domain Family
TMPIT

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pfam07851: TMPIT 
TMPIT-like protein
A number of members of this family are annotated as being transmembrane proteins induced by tumor necrosis factor alpha, but no literature was found to support this.
Statistics
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PSSM-Id: 400279
View PSSM: pfam07851
Aligned: 40 rows
Threshold Bit Score: 297.193
Threshold Setting Gi: 1091662024
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007248714   9 LKEWENLEKEFQQIQDTQqlymq-kldevSKLQNSFAASISHHRKFLKDLSQSLKKCSKGLT-------------EEEAK 74  Mexican tetra
EFC40706       9 NEDWSECSTDQEKIESSFdklikekradlFYSESDVKKKAEKQKKRLRSCVAMIESVEKAg--------------SSNEE 74  Naegleria gruberi
XP_001783309  23 EDRVASLAKSCRSLKEAA-----------SAHSSRWQHEADTLSKQAINHVSTLKKLQVDVGsas-------ekdEIDQQ 84  Physcomitrella ...
ERN08213      11 LEEVSHLLDRAKELQDSA-----------SSFLSKMKHEEQSILQRVSALQSDLKKLQACVAsas-------aseTLDKR 72  Amborella trich...
XP_002518967  14 EEEVERVVEQAKQVQEAA-----------ASLISRSTNDEQSLRQRALSLESSIRRCRSLFDsll-------srnLIHPK 75  castor bean
Q93XX0         4 EEEVKQIIDEVKELHDSA-----------ASFISSSSQQELSLRQKASAVDSSIRRLHSTIVsn----------kNLDPK 62  thale cress
XP_004352427  16 KKELEELEKSQNGVKEKGlkfke-qiavgFKSLDEICNTLDKQEKESSKLLQRITLLQSGGG-------------DKSND 81  Cavenderia fasc...
Q54IK2        34 KNEVFELKKSHEQCKEKGikvkk-dindvFKHADDITNTLAKHEKESSQLISRIKHLNAK---------------EKQLD 97  Dictyostelium d...
EGC34020      31 KNEILELKRSNLSCQEKGikikk-eindvYKQVDDIAGTLAKHEKESSHLQSRLKQILTK---------------EKQID 94  Dictyostelium p...
XP_018674989   8 LEEAARLAEAARELQEAA-----------AILISRTRNEEQSLRQRAVALESDLRRLQSSLDstvrkkgqsatggGVDPK 76  wild Malaysian ...
XP_007248714  75 --QVEEIKGQMQERPNLLS--QMESYLPKK-NGIYLSLVLG-SVNVNLLSKQS-KASYKDEYEKFKLGVTVIAFLLAFIC 147 Mexican tetra
EFC40706      75 --LIKDLQEKKLKIKHYIKklDVINKQTLNtGGKFVELFLGkESSAVLVGDDSkKFNFKKEYESFKYKCTVWNIPFTLLL 152 Naegleria gruberi
XP_001783309  85 --TADKLEEELYRARTMLYngEVSSLLPAKaNGVFLRMLLG-PTNVRATLKDG-RYKVKEEYNAYRDRTALMFLAFPVIL 160 Physcomitrella ...
ERN08213      73 --EAEKLEEELSRAKCMIAdgDVSSLLPSKsNGKFLRMFLG-PISVRATRKDV-QLKVKEEYNNYRDRTAVMFLLFPFAL 148 Amborella trich...
XP_002518967  76 --LADKLDEDLQRARCMMVdgDAAAFLPSKaQGGFLKMFLG-PINVRASRKDV-QLKVKEEYNSYRDRTALLFLLFPSLL 151 castor bean
Q93XX0        63 --LVEKLEEDLHRARCMLVdgETSSFLPSKpQGRFVRMFCG-PVNVRALRKDV-QLKVKEEYNRYRDKTALLFLFFPATL 138 thale cress
XP_004352427  82 --AVVEMKQKIQSIKTSIK--QSKKTFTPEtGGVFVRLFLG-QVNVKHYREGE-RFRLKTEYEKFKFKTNPQFILFVALL 155 Cavenderia fasc...
Q54IK2        98 --ITKELSAHLDQIKVNVK--RAKVSFTPEtGSIFVRLFLG-QVNVKHMRENE-KFRLKQEYEKFKKKTNPQFILFVVLL 171 Dictyostelium d...
EGC34020      95 nnIIKELTDDLEQIKMNVK--RSKGLFTPEtGSIFVRLFLG-QVNVKHLRENE-KFRLKTEYEKFKKKTNPQFIIFVVLL 170 Dictyostelium p...
XP_018674989  77 --IAEKVDEELCRARCVINdgDVASLLLSKtHGRFLKMFLG-PVNVRATRKEV-QLKVKEEYNSYRDRTAFLFLLFPSTL 152 wild Malaysian ...
XP_007248714 148 EFFVNYR---VLDA----LLNFLLVWYYCTLTIRESVLISNGSRIKGWWVVHHYISTILSGIMLTW-----PDGELYQMF 215 Mexican tetra
EFC40706     153 YFFIQSR---AIDT----LYQLYLTYFYLTLALRENILAVNGSNIKAWWIRHHYLSIFLVITMLTW-----PETAFYQAY 220 Naegleria gruberi
XP_001783309 161 LVLKNKIwngCFPAlpvqVYQAWLLFFYTSLALRENILRVNGSDIRPWWVYHHYCAMVMALVSLTWg---hPSCIRKQQG 237 Physcomitrella ...
ERN08213     149 LILRYAIwkgCFPAwavqLYQAWLLFLYTSLALRENILRINGSDIRPWWIYHHYCAMMMALVSLTWeikgqPDCYQKQRG 228 Amborella trich...
XP_002518967 152 LILRSWLwdgCLPAfpvqLYQAWLLFLYTGLALRENILRSNGSDIRPWWIYHHYCAMVMALVSLTWeikgqPNCAQKQRG 231 castor bean
Q93XX0       139 LILRSYYwggCLPAfpvqLYEAWLLFLYAGLAMRENILRANGSDIRPWWLYHHYCAMAMALVSLTWeikgqPNCVQKQRG 218 thale cress
XP_004352427 156 FMFPSNS---FITT----SWQIWLLYYYVTLALRENILLVNGSSIRPWWIMHHYLSIAGALTNLLW-----PLSTSFTDL 223 Cavenderia fasc...
Q54IK2       172 LLYPQSS---FVTT----SWQIWLLYYYITLALRENILLVNGSSIKPWWIMHHYLSIAGSLTNLLF-----PLSESFSYF 239 Dictyostelium d...
EGC34020     171 LLYPHSS---FVTT----SWQIWLLYYYITLALRENILLVNGSSIKPWWIMHHYLSIAGSLTNLLF-----PFSEAFTYF 238 Dictyostelium p...
XP_018674989 153 LLLRSWVwdaCLPAlpvqLYQVWLLYLYTTLALRENILRVNGSDIRPWWICHHYCAMLMALISLTWeikrqPDCAYKQRG 232 wild Malaysian ...
XP_007248714 216 RIQFWGYCLYQCFVQFLQYYYQSGCLYRLKALGERHNLDLTveg-----fqsWM----WRG-LTFLLPFLFFGHSWQFFN 285 Mexican tetra
EFC40706     221 RPYFLLYALYASIVQVLQYKYQKERLYVRTAIGKSNMMDVAnsd------ssQVvvesSLA-LVFLLPFIFIGQIFQVYN 293 Naegleria gruberi
XP_001783309 238 VQLFLGWAVMQGVAMLLQNRYQRRRLYTRIALGKAGRMDVV-----------WGetagVKGqLGILYPLLFILQGFQFFI 306 Physcomitrella ...
ERN08213     229 IELFLTWAMMQGVAMLLQNRYQRQRLYTRIALGKANRMDVV-----------WGetasVEGqLWLLYPVLFILQGFEAYI 297 Amborella trich...
XP_002518967 232 VQLFLQWAMMQGVAMLLQNRYQRQRLYTRIALGKAKRMDVV-----------WGetagVDGqLWLLCPILFILQGFEAYV 300 castor bean
Q93XX0       219 VHLFLQWAMMQGVAMLLQNRYQRQRLYTRIALGKAKRMDVV-----------WGetagVDGqLWLLCPILFILQVFEAYV 287 thale cress
XP_004352427 224 LPMMTMFSGAQGIVQILTNRYQQGQLYRMVAIGKANIMDVTsenmi--sdpgW-----TPS-ALFLLPFLLFVHCFQMYN 295 Cavenderia fasc...
Q54IK2       240 LPQVTYFSGCQGLVQILTNRYQQGRLYKLVAMGKANIIDVTgesegwgndpgW-----TPS-ALFLFPFLLFVQFFQLYN 313 Dictyostelium d...
EGC34020     239 LPQVTYFSGCQGLVQILTNRYQQGRLYKLVAMGKANIIDVTgesegwnndpgW-----TPS-AMFLLPFLLFVQFFQLYN 312 Dictyostelium p...
XP_018674989 233 VQLFLMWAMMQGVSMLLQNRYQRQRLYTRIALGKAKRMDVV-----------WGetagVEGqLWLLCPILFILQGFEAYV 301 wild Malaysian ...
XP_007248714 286 SITLFRMANL-PQCK-----EWQVFMCGVCFLVLFTGNVLTTLAVVRHKLKEK 332 Mexican tetra
EFC40706     294 AYKLFDWGLLhPESFggitvEWQVYANGLLFLILALGNFVTTTEVLVKKVKRV 346 Naegleria gruberi
XP_001783309 307 GILLLKTAIV-EDKS-----EWQIVVCGLLLVLMACGNFINTVATLVAKAKIK 353 Physcomitrella patens
ERN08213     298 GILLLMTAVT-SSVS-----EWQVVVCGGLLVIMASGNFANTVQTLSAKLRFK 344 Amborella trichopoda
XP_002518967 301 GLQLLRTAFV-RVVS-----EWQVIFCGMLLVFMAVGNFFNTVQTLMVKSRFK 347 castor bean
Q93XX0       288 GLLLLRKTVT-GVVN-----EWQVMVCGILLVVMAVGNFINTVETLMAKSRVK 334 thale cress
XP_004352427 296 GFVFLTYSYFkYHTYy---iEWQVIACGLILVSLGIGNLVTTSNIYLNKWKSY 345 Cavenderia fasciculata
Q54IK2       314 SFSFFAFAYQrSGYV-----EWQVFSCGFIFLCLGLGNLLTTLSVYYQKWKNF 361 Dictyostelium discoideum
EGC34020     313 SFSFFYFAYQrDGNV-----EWQVYMCGLIFLLLGFGNLFTTISVYYQKWKNI 360 Dictyostelium purpureum
XP_018674989 302 GLLLLRTAFV-GVIC-----EWQVIACGILLVLMAIGNFANTMQTLIAKSRFK 348 wild Malaysian banana
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