1QD1


Conserved Protein Domain Family
FTCD_N
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pfam07837: FTCD_N (This model is not part of the current CDD release)
Formiminotransferase domain, N-terminal subdomain
The formiminotransferase (FT) domain of formiminotransferase- cyclodeaminase (FTCD) forms a homodimer, and each protomer comprises two subdomains. The N-terminal subdomain is made up of a six-stranded mixed beta-pleated sheet and five alpha helices, which are arranged on the external surface of the beta sheet. This, in turn, faces the beta-sheet of the C-terminal subdomain to form a double beta-sheet layer. The two subdomains are separated by a short linker sequence, which is not thought to be any more flexible than the remainder of the molecule. The substrate is predicted to form a number of contacts with residues found in both the N-terminal and C-terminal subdomains.
Links
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Statistics
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PSSM-Id: 517922
Aligned: 134 rows
Threshold Bit Score: 109.887
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1QD1_A         3 LVECVPNFSEGKNQEVIDAISRAVAQT----PGCVLLDVDSGPSTNRTVYTF------------VGRPED---VVEGALN 63  pig
XP_002278962  46 LLCCKLYISESRNHTALDSIERAARLD----GETVIVNKFQDRAYNRIGYTLvsyi-----vhdSTGNIIyspLQQTLLS 116
XP_015573975   2 LLCCKLFISESRNRTALDSIERAARLN----PETVIVNKFEDRAYNRIRYTLvsyv-----vldSIGTAIyspLQQTVLV 72 
Q75ID2         6 VICCKLYISESQNAKVVDAITRIGQKD----PEVVLLSKFEDDHYNRVRYTLasyi----inenSTGEVKfspMRRVLLE 77  Japanese rice
XP_004982519  29 FICCKLYISESRNPTAIDAIDLAAKTD----PQVAVLSKFEDCLYNRVRYTLvsyi-----iddSSTEVIyspIRKVLLA 99 
XP_002466878  20 FIFCKLYISETRNTMAMDTIEHASKSD----AQVVVVSQLGDHHYNRFRYTLvsyi----vddsSTGEVIyspIRKVLLA 91 
XP_005850624   1 -----VYVSEARDGDILRQLESVARQA----PGACLANLFTDEPYNRTNFTL--------------VGRSvpaLAAAAST 57 
XP_001419526  11 AFAAVVYVSEGRRTAVLDVIERVAREAtaprRPVALVNVFRDAEYNRTGFTL--------------AGRDvddVRRAALD 76 
XP_002501051  16 GLVAVVYVSEGKDADAVNVLQTVAEKAcq-qHGTRVLNVFRDDEYNRTGFTLgvgv----asvaGHATPSvepLKQSALA 90 
XP_003057262  14 GLVAVVYVSEGKNEGVVANLERTAEETce-kHGAKVVNVFRDVEYNRTGFTLgmgiasaaslepAALSGAvepLRQSALA 92 

1QD1_A        64 AARAAYQLIDMSRHHGEHPRMGALDVCPFIPVRg---VTMDECV-------------------RCAQAFGQRLAEEL-GV 120 pig
XP_002278962 117 MVEAAYEAINLELHHGAHPRLGVVDDIVFHPLa---rASLEEAA-------------------WFAKMAAADIGNKF-QV 173
XP_015573975  73 MVEAAYGAINLESHCGAHPRLGVVDDIVFHPLs---wASLDEAS-------------------WLAKAVAAEIGSRF-QV 129
Q75ID2        78 MIEKAFSTINLETHTGTHPRIGVIDDMSFHPLn---qATMEDAA-------------------QLAKTVASDIGNFL-QV 134 Japanese rice
XP_004982519 100 MMEAAFSAINLELHSGAHPRMGVNDDLSFHPLg---qATMEDAA-------------------SLAKQVASDIGNGF-QV 156
XP_002466878  92 MIEAAFATINLESQSGTHPRIGVVDDLSFHPVg---qATIEDAA-------------------SLAKQVASDIGNGL-QV 148
XP_005850624  58 LARAALALLDLRQHAATHPRLGCVDHISCHPLPtseaGSAAAAAaaadagelrqrqqdeagaaALAVAIASELGSGPqAV 137
XP_001419526  77 VAQVSLREVDMRAHDATHPRVGVVDHVSCHALA----GERAGAA-------------------KLAKSIGEGLGTL--GV 131
XP_002501051  91 LTEQALKTIDLRNHSATHPRCGAVDHISCHAVGd---APDDLAA-------------------QLAKCLGEGIGDRL-KV 147
XP_003057262  93 LTEKALSLIDLRTHTATHPRCGVVDHISCHAIGd---ADDAAAA-------------------CLAKTLGERIGVES-RV 149

1QD1_A       121 PVYLYGEAARtaGRQSLPALRAG--EYEALPEKL-KqaeWA-----------------------PDFGPSAFVPSWGATV 174 pig
XP_002278962 174 PVFLYDAAHP--MGKPLDIIRRElgYYRPN-F-MgNq--WSgwdmpe------------vlsekPDEGPTMVSRARGIVM 235
XP_015573975 130 PVFLYAAAHS--TGKALDTIRRElgYYRPN-F-MgNq--WAgwtmpd------------illekPDEGPQQVSRARGITM 191
Q75ID2       135 PVFLYGAAHP--TGKPVTAVRRElgYFQPN-Y-MgIq--WMgqvlpd------------ilpvkPDEGPDHVSRERGAIM 196 Japanese rice
XP_004982519 157 PVFLYAAAHP--TGKSVGAIRRElgYYRPN-H-MgNq--WSgtmlpd------------vlpisPDEGPTNVSSERGATT 218
XP_002466878 149 PVFLYAAAHP--TGKSVGAIRRElgYYRPN-Y-KeNq--WLgsvlpd------------vlpvkPDVGPTHVSHKRGATT 210
XP_005850624 138 PVYTYGWAHQ--QRQPLDAVRRQlgYFQGSS--------WHgglqapaaeaagaadaelqlplaPCFGPAVVPARSGVCC 207
XP_001419526 132 PVKLYGDAAS--DGIGLDEIRRRsgYFSGAAGGR-----WTgefav-------------ergfaFDYGPSDVPEREGFGM 191
XP_002501051 148 PVLLYGLASS--TGTQLADLRRKygYFRRTSQDVg----WSgahrvg------------dgqveADYGPSTIPPESGILM 209
XP_003057262 150 PVLLYGNASG--VGTQLAALRRRygYFKETAARTgG---WAgehvvd------------ggevlSDYGPSIVPPEAGVVM 212

1QD1_A       175 AGAR 178 pig
XP_002278962 236 IGAR 239
XP_015573975 192 IGAR 195
Q75ID2       197 IGAA 200 Japanese rice
XP_004982519 219 VGAT 222
XP_002466878 211 VGVT 214
XP_005850624 208 VGAG 211
XP_001419526 192 VGAV 195
XP_002501051 210 LGAT 213
XP_003057262 213 LGAT 216
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