Conserved Protein Domain Family
RanGAP1_C
?
pfam07834: RanGAP1_C (This model is not part of the current CDD release)
RanGAP1 C-terminal domain
Ran-GTPase activating protein 1 (RanGAP1) is a GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state. Its C-terminal domain is required for RanGAP1 localisation at the vertebrate nuclear pore complex, and is sumoylated by the small ubiquitin-related modifier protein (SUMO-1). This domain is composed almost entirely of helical substructures that are organised into an alpha-alpha superhelix fold, with the exception of the peptide containing the lysine residue required for SUMO-1 conjugation.
Links
?
Statistics
?
PSSM-Id: 517919
Aligned: 12 rows
Threshold Bit Score: 233.055
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
XP_023204727 397 EQENISSSSNNNKPSTPMS---APR-PPDVSSFLSFPSPDKLLKLGTKRTLLVQQQVDVTDARKTAEAFLKIASVYKEEn 472
3_pfamImport   2 EEEEEEEKSQVNKMSTPVS---APR-PPDVSSFLTFPSPDKLLKLGAKRALLVQQEVDTTDGRKTAEAFLKIASVYKEEn 77 
XP_003443169 396 EEEEEEEESTGNKFSTPQS---APR-PPEVSSFLSFPSPDKLLKLGPTRALLIEQQVDVSDAAKTAEAFLKIASVYKEDn 471
XP_007259137 392 HNCVNGTKENGKDKGSPAK---TNLcSPDLISFFHSPTSEKLFNLGAKRTQLIEQQLDFSDAAKIADFFLQICSVYEEE- 467
XP_005156211 396 ENGLNGTKDVIEEKEEPPH-------SSELMSFLVSPSAEKLISLGAKRVQLIEQQVDVTDANKVSEVFLKISSVYKDE- 467
XP_014347472 404 ESPADQQIISSTGGHTPVSs--PP--LVDAATFLAFPSPDKLLKLGPKRSFLIAQQTDVSDVEKVVQSFLKITSVYKEE- 478
NP_001116940 404 ENRTKPNKI-SSHVSTPAA---PPKlPVDASTFLSFPSPEKLVRMGPKRSTMIMQQIDVADTEKVVQTFIQVSSVYRDD- 478
XP_005039751 394 QESLTPKKIIDSQASTPVP---SP--PVDVATFLAFPSPEKLLRLGPKCSVLIAQQTDTSDVEKVVATLLRISSVFKDE- 467
XP_007502634 393 EVTTPSKKILDTHVGEPPSvl---csPSDVSTFLAFPSPEKLLRLGPKSSLLIAQQTDTSDPEKVVSAFLKVTSVFKDD- 468
2_pfamImport   1 EETEEEGDDEPNKMSTPPS---APR-PPDVSSFLCFPSPDKLLRLGKERAELIQQQVDVSDVTKSVEAFLKISSVYKEEd 76 
Q08BV5       387 EEEEEEEKTELNQFSTPPS---APR-TPDVSSFLSFPSPDKLLRLGEKRSVLIQQQVDVLDVCKTAEAFLKISSVYKDNd 462 zebrafish
XP_007661361 410 DQKSTPKKIQGTQVGEPAPvicSPP-PVDVSTFLAFPSPEKLLRLGPKSPVLITQQTDTSDPEKVVSTFLKVSSVLKDD- 487 platypus

XP_023204727 473 NDVKNAVLDTIDALLSKAFS-TPSFQGYSFVSILLVLLGLIKSEDK-IKPVVVVPGHLHALEHVVRQDYFPKENVAVLEA 550
3_pfamImport  78 NDVKRAVLDTIDALLSKAFN-DTSFQGYNFVSALLVLLGLIKSEDK-VKPVLVVPGHLHAIEHAVRQDYFPKESVAVLKA 155
XP_003443169 472 NEVKNAVLDSIDGLLRKAFT-SSSFQGYSFVSSLLVLLGLIKSEDK-VKPVIVVPGHLQALEHVVRQDYFPKESVAVLEA 549
XP_007259137 468 VEVKQVVLETADTLLRKGFS-SPHFQTYLFISSLMVNMGLLKGEKK-TKKMGVLPGHLIVLNHCVGQDYFPVDQADVLLI 545
XP_005156211 468 PEVKQAVFETTDALLRKAFSnSPHSQSYSFISSLMVNLGLLKSEDKkVKKVSVLPGHLLTLEHAVSQEFFPADQAGVLES 547
XP_014347472 479 TVVKSAVVETTDALLRKAFS-SPAFHSADFISSLLVHMGLLKSEEK-IKSVSSVYGPLVALNHVVQQDYFPRTLVPILTA 556
NP_001116940 479 SEVKAAVEETIDGLMKKAFE-SRGFQENLFITSLLVHMGLLKSEDK-IKTVQHLNGPLLTLNHMVQQNYFPKSLVPILLA 556
XP_005039751 468 APVKTAVHETTDALMKKAFG-SATFNSDAFITNLLVHMGLLKSEEK-IKTVPSLYGILMTLNHMVQQDYFPKSLAPVLSA 545
XP_007502634 469 LAVKTAVQDAVDALMKKAFA-SATFNSNAFITRLLIHMGLLKSEDK-IKAVPNLYGPLMALNHMAQQEYFPKSLTPVLLA 546
2_pfamImport  77 PEVKAAVLDSIGKLHTHLFW------------FIFLPLALL-SEDK-VKPVAVVAGHLLCLEHAVKQSYFPREHIAVLHA 142
Q08BV5       463 AEVKSAVLESIDAVLSKAFF-TPSFQGLAFVSSLLVMVGLLKSEDK-LKPVKVVPGHLLCLEHAVKQSYFPREHITVLNA 540 zebrafish
XP_007661361 488 VSVKTAVQETIDALMKKAFS-TSTFNSDAFITSLLVHMGLLKSEDK-IKAIPNLTGPLMALNHAAQQDYFPKSLAPVLVA 565 platypus

XP_023204727 551 FMSR 554
3_pfamImport 156 FMSR 159
XP_003443169 550 FMSR 553
XP_007259137 546 FLSR 549
XP_005156211 548 FVSR 551
XP_014347472 557 FMSK 560
NP_001116940 557 FISK 560
XP_005039751 546 FVTK 549
XP_007502634 547 FVTK 550
2_pfamImport 143 FMTR 146
Q08BV5       541 FMSR 544 zebrafish
XP_007661361 566 FVTk 569 platypus
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap