1CFR,3MQY


Conserved Protein Domain Family
Bse634I

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pfam07832: Bse634I 
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Cfr10I/Bse634I restriction endonuclease
Cfr10I and Bse634I are two Type II restriction endonucleases. They exhibit a conserved tetrameric architecture that is of functional importance, wherein two dimers are arranged 'back-to-back' with their putative DNA-binding clefts facing opposite directions. These clefts are formed between two monomers that interact, mainly via hydrophobic interactions supported by a few hydrogen bonds, to form a U-shaped dimer. Each monomer is folded to form a compact alpha-beta structure, whose core is made up of a five-stranded mixed beta-sheet.The monomer may be split into separate N-terminal and C-terminal subdomains at a hinge located in helix alpha3.
Statistics
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PSSM-Id: 400264
View PSSM: pfam07832
Aligned: 4 rows
Threshold Bit Score: 357.646
Threshold Setting Gi: 440923797
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1CFR_A         1 MDIISKSGEG--NKYTINSAiAFVAYASHID--INTT-EFSKVLSGLRDFINDEAIRLG---GKISDGSFNKCNGDWYEW 72  Citrobacter fre...
Q9FDD9         8 SNCIEEYQEN--GKTKVRIK-PFNALIELYDnqIPTG-NIKENLDKLQNYVMKVADAKGl--TKPASAAFSNTRGTWFEV 81  Geobacillus ste...
WP_006198986   2 FNNTEWLTENsnGKFRINSRaIYRDLSSKIVnkLDQNlSVSEILDWMRNETSKAFREKYs--QNPQVGALNKATGGWNEL 79  Nodularia spumi...
3MQY_A        47 GEVIPGFASA--GINGMDYR---DVIGRPVEnaVTEGtHFFR--DDFRVDSNAKAKVAGdifEIVSSAVMWNCAARWNSL 119 Streptomyces gr...
1CFR_A        73 LIG------IRAIEFFLESETN-FI---VVKMPNAT----------SFDVMSIYKSCLSEFIYDLRSKL--SLNNVNLIT 130 Citrobacter fre...
Q9FDD9        82 MIA------IQSWNYRIKRGYNdYL---IIKMPNVK----------TFDFRKIFDDETREKLYQLEKSLltHKQQVRLIT 142 Geobacillus ste...
WP_006198986  80 MAT------SLLSEIVLNINQEnEVciaVFSMPNSRpqiegvdqsyS-SFLNLFKNEYFANINNASAKIkpFKDNIFMPS 152 Nodularia spumi...
3MQY_A       120 MVGegwrsqPRYSRPTLSPSPRrQVa--VLNLPR------------SFDWVSLLVPESQEVIEEFRAGL--RKDGLGLPT 183 Streptomyces gr...
1CFR_A       131 SNPDFSIIdirgrreELKSmlKDISFSNISLSTISEID---NLYKNFIDYAELEHIKSFLSVKTTFRPDRRLQLAHEGSL 207 Citrobacter fre...
Q9FDD9       143 SNPDLLII-------RQKDliKDEYNQPIDKFTHENVDtalTLFKHLERKCKWDSLVAGIGLKTSLRPDRRLQLVHEGNI 215 Geobacillus ste...
WP_006198986 153 PDDIIAVIe------DEKN--SKIVNSLLEQQARDPDTl--ALYNSFKGKLGIKEVKAAISLKTSNRPDRRYQPLFEAAM 222 Nodularia spumi...
3MQY_A       184 STPDLAVVvl---peEFQN--DEMWREEIAGLTRPNQIllsGAYQRLQGRVQPGEISLAVAFKRSLRSDRLYQPLYEANV 258 Streptomyces gr...
1CFR_A       208 MKALyTHLQTRTWtinptgiRYYAAATS-IGNADVIGLKT---VATHSITDVKSLPQSAVDEIFKINSVLDVDSCLSHIL 283 Citrobacter fre...
Q9FDD9       216 LKSLfAHLKMRYWnpk-aefKYYGASSEpVSQADDDALQT---AATHTIVNVNSTPERAVDDVFSLTSFEDIDKMLDQII 291 Geobacillus ste...
WP_006198986 223 VKAM-GYVLQQIW-------KYFMVVSE-LTPADRTIFSTa--IAPHGVALEKNL--KLVDGTYLYSRKADLLPLVNDAI 289 Nodularia spumi...
3MQY_A       259 MQLL-LEGKLGAP-------KVEFEVHT-LAPEGTNAFVTyeaASLYGLAEGRSAVHRAIRELYVPPTAADLARRFFAFL 329 Streptomyces gr...
1CFR_A       284 SS 285 Citrobacter freundii
Q9FDD9       292 KK 293 Geobacillus stearothermophilus
WP_006198986 290 KK 291 Nodularia spumigena
3MQY_A       330 NE 331 Streptomyces griseus
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