2DSJ,1OTP,5OLN


Conserved Protein Domain Family
PYNP_C

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pfam07831: PYNP_C 
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Pyrimidine nucleoside phosphorylase C-terminal domain
This domain is found at the C-terminal end of the large alpha/beta domain making up various pyrimidine nucleoside phosphorylases. It has slightly different conformations in different members of this family. For example, in pyrimidine nucleoside phosphorylase (PYNP) there is an added three-stranded anti-parallel beta sheet as compared to other members of the family, such as E. coli thymidine phosphorylase (TP). The domain contains an alpha/ beta hammerhead fold and residues in this domain seem to be important in formation of the homodimer.
Statistics
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PSSM-Id: 400263
View PSSM: pfam07831
Aligned: 45 rows
Threshold Bit Score: 68.3667
Threshold Setting Gi: 34395900
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2DSJ_B 337 VVREVDAYKVGLAVLALGGGRKRKGEPIDHGVGVYLLKKPGDRVERGEALALVYHRRRG-LEEALGHLREAYAL 409 Thermus thermophilus HB8
Q9RX72 389 FVTRVDALSVGRAVLALGGGRERKGEAIDHGVGVELLKKPGEAVGAGEAVLRLYHRGGRgLERAQALLRAGLET 462 Deinococcus radiodurans
Q8UJ08 349 WLASCATRDLGMVVVELGGGRTKPSDTINPAVGISDILPLGVRVEKGEPIAVVHAASSEdAERAVKRIEDCFGI 422 Agrobacterium fabrum str. C58
Q92T50 349 YLTSCKTRELGMAVIELGGGRIRPDDRIDHRVGLTGLRPLGTKVEKGEPIAFVHAADQSqAEAIAKRVVTLYAI 422 Sinorhizobium meliloti 1021
Q8EHK3 350 YAHSMDTRELGLAVVTLGGGRRKPGDELDYSVGLTQVCALGDKIDASTPIAVIHAQSEEaFAQAEDAVKKAIHI 423 Shewanella oneidensis MR-1
Q74PY8 350 IITAMDTRALGMAVVALGGGRRRATDPIDYSVGLTEMARLGTRVDGQQPLAVIHANNEDdWQQEAEVVRAAITL 423 Yersinia pestis
1OTP_A 350 FVSEMDTRALGMAVVAMGGGRRQASDTIDYSVGFTDMARLGDQVDGQRPLAVIHAKDENnWQEAAKAVKAAIKL 423 Escherichia coli K-12
Q6LUH3 350 YAYAMDTRGLGMAVVGMGGGRRVASDSIDYAVGLSDMIRLGDEVNTDTALCVIHARSEAqWQEAANAVRANITI 423 Photobacterium profundum SS9
Q7MI39 350 VVSAMDTRAIGMAVVAMGGGRRVATDSIDYAVGFDQFIRLGEIASSEKPLAMIHARNEAqWQEAANALQAAIKV 423 Vibrio vulnificus YJ016
Q9S5X9 345 FVSKIDAEKVGIASMMLGAGRKKKEDRIDHSVGIIVEKKLGDSVKKGEAIARLFVSDRSdVESALKLLKEAYVI 418 Thermotoga maritima
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