4K6J


Conserved Protein Domain Family
WAPL

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pfam07814: WAPL (This model is not part of the current CDD release)
Wings apart-like protein regulation of heterochromatin
This family contains sequences expressed in eukaryotic organisms bearing high similarity to the WAPL conserved region of D. melanogaster wings apart-like protein. This protein is involved in the regulation of heterochromatin structure. hWAPL, the human homologue, is found to play a role in the development of cervical carcinogenesis, and is thought to have similar functions to Drosophila wapl protein. Malfunction of the hWAPL pathway is thought to activate an apoptotic pathway that consequently leads to cell death.
Statistics
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PSSM-Id: 517908
Aligned: 57 rows
Threshold Bit Score: 149.379
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4K6J_A                       16 HVKHFNDVVEFGENQEFTDDIEYLLSGLKSTQPL-NTRCLSVISLATKCAMPSFRMHLRAHGMVAMVFKTLDDSQHHQ-- 92   human...
Vitvi:Vitvi018116.t01.CDS1  104 ataTLMETQEFGEMMEHVDEVNFALDGLRKGQPA-RIRRASLLSLLSICGTAQQRRLLRTQGMAKTIMDAVIGLSFDDsp 182 
F4I7C7                      149 FTSTLLEAQEFGELMEHEDEVNFALDGLRKGHQL-RIRRASLSSLLSICASQHQRRSLRAQGISQSIIDAILVLSLDDip 227  thale cress...
Q9C951                       77 SNSTLMEAQEFGELIENEDEVNFALDGLKKGHKV-RIRRAALSSLLSICESQYQRRSLRALGISQSIIDAILGLCLDDip 155  thale cress...
NP_001368333                217 HIKEANELRESGEYDDFKQDLVYILSSLQSSDASmKVKCLSAISLAKKCVSPDFRQFIKSENMTKSIVKALMDSPEDD-- 294 
XP_019848770                643 NVRQAHECLQHGENLRFRDDVIYLLDSMKTEEPL-LVRCLSTLNLAEQCLNVDFMRQMRSLGLVKKSLLLLKDAQTHP-- 719 
XP_015795049                127 RVKKAHQCAELGEREEFDGDIKFYLDGLSRVNNI-NTRCLSILGLANQCQRAEFRMHLRAHDDMPKIISALMDACSNP-- 203 
8_pfamImport                  1 NVKNSHQMQEIGEFQEMDDDVEYILSALQPDNPV-STRCLSALQLATKCMKPAFKMHVRAHGVVTRFFRALSDAHQDA-- 77  
EDO34596                    228 NVKKVSECLESGEDQEFFDDVEYLLYGLE-SSKV-STRCLSALDIMSRCTNGSFRVNLRAHGTISKIFNLLKDAGEYK-- 303 
XP_002112136                227 HVRESHQCLEQGEDEQLADDIEYLLDGLNPSYPK-NLRCSSITALAKRCTESPFRMYIRAHEIIPKILDLLVDSPSDY-- 303 
4K6J_A                       93 NLSLCTAALMYILSRDRLN-MDLDRAS--LDLMIRLLELEQDASsakll---------------------nekdmNKIKE 148  human...
Vitvi:Vitvi018116.t01.CDS1  183 S-NLAAATIFFVLTSDSHD-DYLLESPtcIRFLLELLKPPMSNAthgkapsigikllglrkdadplrdtnktidsSSTA- 259 
F4I7C7                      228 S-NLAAATLFFALTADGQD-EHFMESPkcIKFLIKLLKPVIVTStegkprnigfkllsllkdvdaardpvkmddpSSSD- 304  thale cress...
Q9C951                      156 S-NLAAATLFFVLTTDGQD-DHFMESPnsIKFLVKLLRPVVSAStkvkprnigsrllsiikdvdaardaasmhdlSSCD- 232  thale cress...
NP_001368333                295 LFALAASTVLYLLTRDFNS-IKIDFPS--LRLVSQLLRIEKFEQrpe--------------------------dkDKVVN 345 
XP_019848770                720 ALKVALVTLSFVMTQSNVEpSELDKKC--TELLVMALSVKDQFLvspageeeppplegkaateykkitdkskallKKCSP 797 
XP_015795049                204 NLALCTSALMYVYNQDRMT-MDIDPNA--LSLMLELLETR---Tdeee-----------------------dsvdKNYKE 254 
8_pfamImport                 78 GLALCTAAIMYVFSQDKLN-MDLDRDS--LELMLNLLgttsageqlag-----------------tagkvtndpqQKIRQ 137 
EDO34596                    304 NLSLCTSAIMYILTQDRQF-IDFDKFI--LEMLIKFISVENSNDvdgse----------------------dieyNKYIH 358 
XP_002112136                304 QLATYTAALFFVLSEDRLI-MDLTDDL--LDVLLKLLQCPNQDHndtn-----------------------dailKSSLQ 357 
4K6J_A                      149 K-IRRL-CEtVHNKH------LDLE---------------NITTGHLAMETL------------LSLTSKragdwfkeeL 193  human...
Vitvi:Vitvi018116.t01.CDS1  260 --IVHKvQE-VLVSCkeikssSGDDngv---------grpELSPKWIALLTMekacfstisledTSGTVRktg----gnF 323 
F4I7C7                      305 --ILSRvQE-LLVNCkemrlnDSYItet---------trpELSTKWVALLAMeracvskisfddTSGSVKktg----gnF 368  thale cress...
Q9C951                      233 --IIDRaQE-ILVNCkelrliDSYKier---------mrpELSTKWVALLVMekaclskisfddTSGTVKksg----gmF 296  thale cress...
NP_001368333                346 M-VWEVfNS-YIEKQev--ggQKVsfdm---------rkeSLTPSSLIIEAL------------VFICSRsvn---ddnL 397 
XP_019848770                798 LlIHAKySD-SSNTNetvdisLQPS---------------TLSLGELATECF------------LSLTSSmnts--vssL 847 
XP_015795049                255 K-VKKLcDE-MKTKGhgkf-----------------lnsnNITAGKLALEAL------------LGLTSKrag----ewC 299 
8_pfamImport                138 R-VKELcDE-IKGSGkakphiIGSEgdsssgsssnssdghRISAATLAMESL------------LSLTSQrag----ewF 199 
EDO34596                    359 R-IKSIlNE-RNRLIpgty-----------------felhDISTFSLARESL------------LSITTErvg----pwF 403 
XP_002112136                358 N-ISLScKD-YLkah-----------------------vdSLNGKALALACI------------FNLVCSrna----vwL 396 
4K6J_A                      194 R----LLGGLDHIVDKVKECVdhl----------------srdEDEEKLVASLWGAERCLRVLESVTVHNPENQsyliaY 253  human...
Vitvi:Vitvi018116.t01.CDS1  324 KekfrEFGGLDAVFEVAMNCHstlegwlk------hgspsirdAKDDANLQSLVLLLKCLKIMENAAFLSKDNQshllgM 397 
F4I7C7                      369 KeklrELGGLDAVLEVVMDCHavmerwve------ydalsvqeKKDNLHKQSLMLLLKCLKIMENATFLSTDNQnhllgF 442  thale cress...
Q9C951                      297 KeklrELGGLDAVFDVVMDCHtvmeswvt------hdtlsvedIKDDLNKQSLMLLLKCLKIMENATFLSTENQihllrL 370  thale cress...
NP_001368333                398 KsellNLGILQFVVAKIETNVnli-----------------adNADDTYS--ILILNRCFRILESSSVFHKKNQaflisH 458 
XP_019848770                848 KedlrTLGAIDVIANRAIALTrqctgyltsgqeeegkeeeereGEEREVDVHFMKLFRQLKLLENILCMSKGNQsyltmF 927 
XP_015795049                300 KeelrNLKGIDFLCNKTIDESnslir------------ddivwEEEIVDKGLLHKIERTLKVIENVTFMNQENQnyiieY 367 
8_pfamImport                200 KdelrKLGGIEHLIKTVSECYesvpe------------raadwHPEAIAK--LRKIERCLRVLNNVCVFNRANQaflleH 265 
EDO34596                    404 KeevrSLGALDHIIDTISESVnwvieek---------gsipegDQNMQAK--IIRIDKCLKLLENVTYQNTSNQtyllhY 472 
XP_002112136                397 KdkvrSIGILDVICDLVIDHKynl-----------------emNPKANRIIVLREVELCCRILETVTFLNKENQdyvigW 459 
4K6J_A                      254 KDSQ------------LIvSSAKALQhceeliqqynraed--sicladskplphqnVtnhvgkavedcMRAIIGVLLNLT 319  human...
Vitvi:Vitvi018116.t01.CDS1  398 KGKGncngsrlsfiklIL-SIIKTL-----------------------------------------------SGLSLSKS 429 
F4I7C7                      443 KKCLgshdsrmsftelTI-SVIKML-----------------------------------------------SGLHLRGG 474  thale cress...
Q9C951                      371 NKSMgshesrlsftelMI-SVIKIL-----------------------------------------------SGLQLR-- 400  thale cress...
NP_001368333                459 RSNIl-----------IS-SLAKFLQvildrvhqlaee-------evkkyisclalM---------------CRLLINIS 504 
XP_019848770                928 DGSIf-----------IS-EISKFLVllgdyliskdl---------strhtcivteT-----------LLGTLRVFLNIT 975 
XP_015795049                368 QGGKf-----------IY-RCIDLIKylknsiifmte---------sqsqlstllsI---------------LRVLTNLT 411 
8_pfamImport                266 RDGLl-----------VQ-LLARIYRqldreipfhptddhtpkeavgvvvrelhqpI---------------LHMLITLT 318 
EDO34596                    473 QKGLl-----------AR-SLSRSLIkihlikptycttrk---aslpghsagsllnA---------------FKLFLNLS 522 
XP_002112136                460 KGYTl-----------VG-NVSRIFSlcvekimsqdkn------tainedsacllaS---------------VRLLLNIT 506 
4K6J_A                      320 NDN-----EWGSTKTgeQDGLIGTALNCVLQV-PKYLPQEQRFDIRVLGLGLLINLVEYSARN 376  human
Vitvi:Vitvi018116.t01.CDS1  430 SSTisideKSRNISDgiSHDSQVDCMADYKVEs------NEN----LFVNYSRKSCSMertsp 482 
F4I7C7                      475 FSSpntnnVNSHYSNggNHDSVLEANRKVTNEvVTISSDTYS----TVGSISTRNGSVSQRSQ 533  thale cress
Q9C951                      401 ----------AHRNEkhPHPQPHLASAVKKGFvTIISSDTCS----TTGFSSIKSLSVSKRNQ 449  thale cress
NP_001368333                505 HDN-----ELCCSKLgqIEGFLPNAITTFTYLaPKFGKENS-YDINVMMTSLLTNLVERCNAN 561 
XP_019848770                976 HDN-----ALASYRVgeQEKIIDSICNFTFKL-AQSVPVIQQFDILVLCLSLLINLLEESSTN 1032
XP_015795049                412 SES-----SEGCFKVgsFTGLFQLLLECLFEL-PSFTVPDSRFDLIVLLLCLEINFVEYCVNi 468 
8_pfamImport                319 HSFdd--qAPGATLVgqQPEMIDITMQILLRI-ARYVPSRCVFDLNLLALTLLLHLARPSEQN 378 
EDO34596                    523 NDS-----EEGSNLIgqQEGFLSTLLFSVLQL-PQYYEASQRFDLHVLGLGLLINLVEHSKQN 579 
XP_002112136                507 HEN-----EIGCKQVgrDKSTIKAAMECIDEI-HEKVDDVRRFDLVILALGLLINLVESNKES 563 
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