7USW


Conserved Protein Domain Family
TMC
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pfam07810: TMC (This model is not part of the current CDD release)
TMC domain
These sequences are similar to a region conserved amongst various protein products of the transmembrane channel-like (TMC) gene family, such as Transmembrane channel-like protein 3 and EVIN2 - this region is termed the TMC domain. Mutations in these genes are implicated in a number of human conditions, such as deafness and epidermodysplasia verruciformis. TMC proteins are thought to have important cellular roles, and may be modifiers of ion channels or transporters.
Links
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Statistics
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PSSM-Id: 517904
Aligned: 72 rows
Threshold Bit Score: 118.399
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
7USW_A         667 CWETIIGQEIVKLVTMDLIFTILSILVIDLFRGLWIKYCSSWwc--wdIETTFPeYGEFKVAENVLHIINNQGMIWLGLF 744  Caenorhabdit...
26_pfamImport    1 CWETMFGQELAKILVADTLLGIVITIVADYGRALFVRYCNDCscifwdLETQFPgYSDFQIAENILSLVNNQANIWLGMF 80  
EFX79477       458 CWETMFGQELVKLTIMDLVFTTISILIIDFIRAVFVRVFNGCwc--wdLEKYFPqYGEFKIAENILHLVNNQGMVWMGMF 535 
EEC08501       398 CWETMFGQEIVKLTIMDLVMTIASTLITDFIRALIVRYANDCwc--wdLEQGFPgYGDFKIAENILHLVNNQGMVWMGMF 475 
XP_002007984  1049 CWETSLGQELSKVIVFDGLMSIVAPLCIDFLRALFVRYVNQNwc--wdMEKTFPqYGDFKIAENILTLINNQGQVWMGIF 1126
XP_002422885   807 CWETMFGQELVKLTVMDLMLTILSVLLLDFFRAIFVRVMNKCwc--wdLEKKFPqYGDFKIAENILHLVYNQGMVWMGMF 884 
XP_002710920   572 CWETAVGIEFMRLTVSDMLVTYITILVGDFLRACFVRFMNHCwc--wdLEAGFPsYAEFDISGNVLGLIFNQGMIWMGSF 649 
ELK04029       520 CWETAVGIEFMRLTVSDMLVTYITILLGDFLRACFVRFMNYCwc--wdLEAGF--------ANQVCGFCPSR----MGSF 585 
E7FFT2         585 CWETTVGVEFVKLTISDIQVTYLTILIGDFLRAFIVRFLNYCwc--wdLEAGWPsYGEFDISGNVLGLVFNQGMIWMGAF 662  zebrafish
XP_036787741   499 CWETYVGQEMLKLSIIDMLFTVASILLIDFFRGLFVRYLSDFwc--wdLESKCPeYGEFKIAENVLHLVYNQGMIWMGAF 576  Chinese pang...

7USW_A         745 FAPLLPAINNIKLIILMYIRGWAVMTCNVPAREIFRAS 782  Caenorhabditis elegans
26_pfamImport   81 FSPGLPGINTIRLCILMYLQSWAVLTSNIPHETVFKAS 118 
EFX79477       536 FSPGLPAINIFKLFLLLYIRSWAVLTCNVPHEVIFKAS 573 
EEC08501       476 FSPGLPAINTVKLCIMMYVRSWAVLTCNIPHETVFKAS 513 
XP_002007984  1127 FSPGLVLINLVKLMIMMYFRSWIVLTCNVPHEVVFKAS 1164
XP_002422885   885 FSPGLPAINLVKLVIMMYLRSWAVLTCNVPHEVVFRAS 922 
XP_002710920   650 YAPGLVGINVLRLLTSMYFQCWAVMSSNVPHERVFKAS 687 
ELK04029       586 YAPGLVGINVLRLLTSMYFQCWAVMSSNVPHERVFKAS 623 
E7FFT2         663 YAPGLVGINVLRLLSSMYYQCWAVMACNVPHERVFKAS 700  zebrafish
XP_036787741   577 FSPCLPAFNVLKLIGLMYLRSWAVLTCNVPHQQVFRAS 614  Chinese pangolin
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