Conserved Protein Domain Family
RED_N

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pfam07808: RED_N 
RED-like protein N-terminal region
This family contains sequences that are similar to the N-terminal region of Red protein. This and related proteins contain a RED repeat which consists of a number of RE and RD sequence elements. The region in question has several conserved NLS sequences and a putative trimeric coiled-coil region, suggesting that these proteins are expressed in the nucleus. The function of Red protein is unknown, but efficient sequestration to nuclear bodies suggests that its expression may be tightly regulated of that the protein self-aggregates extremely efficiently.
Statistics
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PSSM-Id: 400248
View PSSM: pfam07808
Aligned: 26 rows
Threshold Bit Score: 137.831
Threshold Setting Gi: 74866287
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002952015  55 DKSNAE-DAEDDGAPKYRDRAEERRRGKN-LDY------------EDASAVlSALSGSGGVGGDAG--GDLGTVDLSKLS 118 Volvox carteri ...
XP_011623112  13 ARRKEE-KQDEPELPKYRDRAKERREDQN-PDY------------EP-----TELGSFHAVAPPGT--VDLRIADAHKIS 71  Amborella trich...
XP_003546528  14 IRRKEE-KPEEPEVPKYRDRAKERREDQN-PDY------------EQ-----TELG-FHAVAPPGT--VDIRSSDAHKLS 71  soybean
O48713        13 ARRREE-KLEESDNPKYRDRAKERRENQN-PDY------------DP-----SELSSFHAVAPPGA--VDIRAADALKIS 71  thale cress
XP_003577889  17 ARRKEEnKKEEPETPRYRDRAKERREDQN-PDY------------EP-----TELGSFHAVAPPGApgADLRLADAQKIS 78  stiff brome
EGT35793      72 EADEDE-AHLKNILKNYRDRAAERRKQGDvSTQntlnynlidffqEKEDTT-KLTAAYRAVPGDAR--TAQDQADLRKQA 147 Caenorhabditis ...
Q9N4U5        73 EADEDE-AALKNILKNYRDRAAERRKQGD----------------EKEDPS-KLTAAYRAVPGDAR--SAQDQADLRKQA 132 Caenorhabditis ...
XP_002117518 120 EKSEED-QWKKEIANKYRDRAKERRDGVD-TDY------------QNAAS--HTDTRYRTIGPLGE--SGDSAAERRIKE 181 Trichoplax adha...
EFX85643      76 EKKEEE-EILAELAKKYRDRAKERRDG---GEA------------SGPDAL-ATLGAYRAVAPDIK--STMDAAERRKQM 136 common water flea
XP_015789168  84 sKKQEE-GVLSELSKKYRDRAKERRDGAN-PDY------------QNEDPV-KSMEAYRAVAPDFK--STFDAAERRKRM 146 two-spotted spi...
XP_002952015 119 EEETKYLGGDMRFTHLVKGLDYALLHKTRTEITKKKDDdgdGDDDEgraggGADAGSKAEAArdaqaraNARANAASAag 198 Volvox carteri ...
XP_011623112  72 IENSKYLGGDLEHTHLVKGLDYALLHKVRSEIDKKPEQ---EEEVD-----------------------GKTRGSKDD-- 123 Amborella trich...
XP_003546528  72 IEKSKYLGGDVEHTHLVKGLDYALLNKVRSEIDKKPET---GDDVE-----------------------GKSRSAKED-- 123 soybean
O48713        72 IENSKYLGGDVEHTHLVKGLDYALLNKVRSEIVKKPDG---EDGDG-----------------------GKTSAPKED-- 123 thale cress
XP_003577889  79 IEKSKYLGGDLEHTHLVKGLDFALLNKVRSEIDKKPDA---EDGKD-----------------------AKARETKED-- 130 stiff brome
EGT35793     148 ILESKYLGGDLEHTHLVKGLDYSLLNKVRSEMTAEDEE---DDEDM------EALETKAAAKpseasslTQELAQSQS-- 216 Caenorhabditis ...
Q9N4U5       133 ILESKYLGGDLEHTHLVKGLDYSLLNKVRSEIDKSDDD---DDDDIdtafdEKVTSSSSSSKpseasllAQELAQSHS-- 207 Caenorhabditis ...
XP_002117518 182 IQESKYLGGDMEHTHLVKGLDFALLQKVREQMTTDERDeiiEEEDLstqnkVKQVET----------------------- 238 Trichoplax adha...
EFX85643     137 IQESKFLGGDMEHTHLVKGLDYALLQKVRSEIEQFEEE---DDEQL-----EQAVEGEKKEG-------EKEVEKKKEg- 200 common water flea
XP_015789168 147 IEESKFLGGDIKHTHLVKGLDYALLHKVKAELVEKDDD---NDDEE--------------EEkirgrhrRSSESDSK--- 206 two-spotted spi...
XP_002952015 199 rkEEVRFTAPLARSVFN-TLFSAPRAN-VREMYLPRRTAFVYDFDNEdSLDTDIPTTLRRPKSECPpAVE-TLFAGMDDA 275 Volvox carteri ...
XP_011623112 124 --QPLSFRTATAKSVYEwIVKPQTVVK-TNEMFLPGRMAFVFDMEED--YAHDIPTTVHRSKADCP-VPQeMVTVSVDGS 197 Amborella trich...
XP_003546528 124 --QQVSIRTATAKSVYQwIVKPQTISK-TNEMFLPGRMTFIYNMEGG--YHHDIPTTLHRSKADCP-VPEeMVTVNVDGS 197 soybean
O48713       124 --QRVTFRTIAAKSVYQwIVKPQTIIK-SNEMFLPGRMTFVYDMEGG--YTHDIPTTLYRSKADCP-VPEeFVTVNVDGS 197 thale cress
XP_003577889 131 --RAISFRTAIAKSVYQsIVKSQSTPK-ANEMFLPGRMAFIYNMEDG-LITNDIPTTLHRSKADCP-VPEeMVTVSVDGS 205 stiff brome
EGT35793     217 -------DNRMVRSLHR-VLFKNEIPL-RNDMFAKGRMAYVVELEEE---DTDIPTTLLRSLHDLP-RAEsAQSIQANSL 283 Caenorhabditis ...
Q9N4U5       208 -------ENRMVRSLHR-VLFKNEVPL-HNQLFAKGRMAYVVELEDE---ETDIPTTLLRSLHDLP-RAEsAQSIQANNL 274 Caenorhabditis ...
XP_002117518 239 --EEISFRTRLAKNIHN-IVFKSSLPL-RNEFFASGRMAYAVDLNDD-EGESDIPTTIIRSKADFQ-NAEtQSDISTNDI 312 Trichoplax adha...
EFX85643     201 -dDEIQFKTIIGKNIFR-AVFRSKPPE-RNEHFLPGRMAYLIELEDE-NAESDIPTTVLRSKADCP-GLEsLATLSTNDI 275 common water flea
XP_015789168 207 --EDFMPKSTMATNILA-LLKEEKLSNeRNELFLPGRMAYTIDLEDP-FID-DIPTTIIRSKADCP-NTDsLSELSINNI 280 two-spotted spi...
XP_002952015 276 VLDRIARILSYVRTTADGKRLKR 298 Volvox carteri f. nagariensis
XP_011623112 198 VLDRIAKIMSYLRLGSSGKVLKK 220 Amborella trichopoda
XP_003546528 198 VLDRIAKIMSYLRLGSSGKILKK 220 soybean
O48713       198 VLDRIAKIMSYLRLGSSGKVLKK 220 thale cress
XP_003577889 206 VLDRIAKIMSYLRLGSSGKVLKK 228 stiff brome
EGT35793     284 IISKLAHVLSHLRAEPKkkkkde 306 Caenorhabditis brenneri
Q9N4U5       275 IILKLSHVLSHLRAEPKkkkkee 297 Caenorhabditis elegans
XP_002117518 313 VINKLTQILAHLRQGLRSKKLKK 335 Trichoplax adhaerens
EFX85643     276 VINKLTQILSYLRQGKIGKKLKK 298 common water flea
XP_015789168 281 VINKLIQITNYLRQGGA-PRKKR 302 two-spotted spider mite
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