Conserved Protein Domain Family
GSG-1

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pfam07803: GSG-1 
GSG1-like protein
This family contains sequences bearing similarity to a region of GSG1, a protein specifically expressed in testicular germ cells. It is possible that overexpression of the human homolog may be involved in tumorigenesis of human testicular germ cell tumors. The region in question has four highly-conserved cysteine residues.
Statistics
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PSSM-Id: 400245
View PSSM: pfam07803
Aligned: 36 rows
Threshold Bit Score: 141.225
Threshold Setting Gi: 558105306
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_008121446  23 RRGRALLAVGLNLLALLFSATAFGTTHWCEGTQRVPKPTCGP-LARTNCLDY--GyreeeeaaaarlhgngSA-NASaph 98  green anole
XP_008268949   4 ARRQRALTLLPIGLALTLSLIAVSSSHWCQGTRRVTKPLCQDpVGGPHCIHP-------------------IEsSGSgrs 64  rabbit
XP_023369754   4 ARRQRALTLLPVCLALAFSLTALGSSHWCEGTRQVVKPLCQDqLGGLHCIHF--------------------SqGGGgrr 63  small-eared galago
XP_014953911   5 TRQQRALALLPVCLALAFSLTAVGSSYWCEGTRRVAKPLCRDrPGVLHCIHY-----------------------SRggs 61  sheep
EFB20586       8 arrqPALTVLPVCLALAFSLTALGSSHWCEGTRKVAKPLCLDePGRLQCIHF--S----------------GShGSGgrr 69  giant panda
XP_008115421   6 RKSRSMLSLGLNSLALCFSVSAFCTSYWCEGTHKVVKPPCLSaVKKGNCVPV--N----------------SNdTMDgnv 67  green anole
XP_006010778   6 RKNRALLSVVLNSLALLFSVSAFCTSYWCEGTHKVVKPPCLSvIRGKNCILP--N----------------INsSEEsnt 67  coelacanth
A4IIV4         5 RRNRSLLSVVLNLLALSFSVAAFFTSYWCEGTHKVVKPPCLSaVKSKNCQAL--Alnss---------stgSD-ATDtng 72  tropical clawed...
6_pfamImport   1 RRARSLLSLTLTSLALATSILAFSTSYWCEGTHKVVKPLCLSpVKTKNCGHSlvDfapg---------tgaRQ------- 64 
XP_003964327   6 QMRSPRNSFIQTLASLFLGGVALMSSYWCVGKQKVPKPLCTP-TKHSNCIPV--P-------------------GVS--- 60  torafugu
XP_008121446  99 gpSDSVVHYSWETGDDRFLFRYFHAGIWYSCEENINDPG-----------------------EKCRSFIDLAPAS 150 green anole
XP_008268949  65 daGGQAVQYIWEMGDDKFIQRRFHVGLWLSCEETFSSTG-----------------------EVCRSFQSVVPAE 116 rabbit
XP_023369754  64 ddESRAVQYIWEVGDDKFIQHRFHVGLWQSCEESFHSTD-----------------------EKCRSFWTIIPAE 115 small-eared galago
XP_014953911  62 dnSSQAVQYIWEMGDDKFVQRRFHVGLWQSCEETLGSTG-----------------------ENCRSFQSVIPAE 113 sheep
EFB20586      70 dnGSQAVQYIWETGDDKFLQCRFHVGLWQSCEESLGSAG-----------------------EKCRSFQSVIPAE 121 giant panda
XP_008115421  68 tmDPHVVQYIWETGEDKFSFRYFHTGFWFSCEEHHGA-------------------------EKCRSFIELPPES 117 green anole
XP_006010778  68 ivDPNLVQYIWETGEDKYTFRYFHTGFWLSCEAHHAG-------------------------EVCRSFIELTPSS 117 coelacanth
A4IIV4        73 tlNPNVVHYNWETGDDKYAFKYFHTGFWFSCEKHQGE-------------------------EACRSFIELSPDS 122 tropical clawed frog
6_pfamImport  65 --LANAVHYIWETGEDKYMFRYFHTGFWHSCEKHYDGKGlerhisnteintlllesfsmysgEKCRSFIELTPAS 137
XP_003964327  61 --NSSNIQFFWETGDDRFVFPTFHTGLFISCEEDIYADEw---------------------eEKCRGFYTLTPGS 112 torafugu
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